Intravenous Ketamine for Suicidal Behavior in Severe Depression with Psychotic Features by T. V. Pavan Kumar, Divya Bolla, Raj Kiran Donthu, Anzory Pathak

“…Here, we discuss the experience of treating severe depression with intravenous (IV) ketamine. A patient in his mid-forties presented with a 2-month history of pervasive low mood, altered biological functions, decreased interest, and suspiciousness and was diagnosed with severe depression with psychotic features and suicidal ideas. …”
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Involvement of fractalkine and macrophage inflammatory protein-1 alpha in moderate-severe depression by Rosaria Alba Merendino, Giuseppe Di Pasquale, Filippo De Luca, Laura Di Pasquale, Edoardo Ferlazzo, Gabriella Martino, Maura Carmela Palumbo, Fortunato Morabito, Sebastiano Gangemi

Subjects: “…Moderate-severe depression…”
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Mirtazapine Treatment of a Severe Depressive Episode and Resolution of Elevated Inflammatory Markers by Shahzad M. Alikhan, Jessica A. Lee, Luiz Dratcu

“…This report describes an association between a clinical antidepressant response and a decrease in markers of systemic inflammation observed during pharmacotherapy with mirtazapine in a severely depressed but physically well patient. This observation adds to the evidence that changes in inflammatory responses may be implicated in the mode of action of antidepressants. …”
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Interleukin-18 and CD30 serum levels in patients with moderate-severe depression by Rosaria Alba Merendino, Antonio Enrico Di Rosa, Giuseppe Di Pasquale, Paola Lucia Minciullo, Carmela Mangraviti, Antonella Costantino, Antonella Ruello, Sebastiano Gangemi

“…We evaluated IL-18 and CD30 serum levels in 10 patients affected by moderate-severe depression (MSD). We demonstrated for the first time that serum IL-18 levels of MSD patients were significantly higher than those of healthy donors. …”
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Associations between disease severity, depression, health-related quality of life, and physical activity in adults with sickle cell disease by Adekola B. Ademoyegun, Mutiu A. Adeyemo, Babatunde Y. Adewuyi, Adebukola G. Ibitoye, Olalekan I. Akerele, Taofeek O. Awotidebe, Chidozie E. Mbada

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Do Nonsuicidal Severely Depressed Individuals with Diabetes Profit from Internet-Based Guided Self-Help? Secondary Analyses of a Pragmatic Randomized Trial by Sandra Schlicker, Kiona K. Weisel, Claudia Buntrock, Matthias Berking, Stephanie Nobis, Dirk Lehr, Harald Baumeister, Frank J. Snoek, Heleen Riper, David D. Ebert

“…Clinical meaningful effects were observed in nonsuicidal severely depressed individuals, who do not need to be excluded from web-based guided self-help. …”
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Differential effects of clary sage (Salvia sclarea L.) oil and linalyl acetate on depression levels in diabetic foot ulcer patients with T2DM: a randomized blinded controlled trial by Ji Won Son, Purum Kang, Sun Seek Min, Geun Hee Seol, Geun Hee Seol

“…Of the 29 patients with moderate to severe depression, 9, 11, and 9 were randomized to inhalation of CS, LA, and almond oil, respectively. …”
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Depression and Anxiety in Patients with Chronic Renal Failure: The Effect of Sociodemographic Characteristics by Paraskevi Theofilou

“…Elder patients reported higher scores in the GHQ-28 subscale of social dysfunction and in the CES-D depression scale, while less educated patients presented higher scores in the GHQ-28 subscales of anxiety/insomnia and severe depression. Divorced/widowed patients presented higher scores in the severe depression subscale. …”
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Assessment of depression, PTSD, and insomnia symptoms in a cohort of Palestinian migrants residing in Jordanian camps during the outbreak of the War on Gaza: occurrence and correla... by Omar Gammoh, Saleh Bazi, Ruba Al Akash, Bilal Sayaheen, Mervat Alsous, Albara Alomari

“…The data analysis from 258 participants showed that severe depression was reported in 178 participants (69%). …”
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Kejadian Gangguan Depresi pada Penderita HIV/AIDS yang Mengunjungi Poli VCT RSUP Dr. M. Djamil Padang Periode Januari - September 2013 by Yaslinda Yaunin, Rudi Afriant, Nurul Maulidya Hidayat

“…Djamil Padang in January-September 2013 are not experiencing depression, representing 44,2% and 55,8% for depressive disorder which is mild depression only obtained 25,6%, moderate depression 11,6%, severe depression 4,7%, and very severe depression 14%. …”
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Exploring the relationship between mental health issues and academic performance of undergraduate students in a Ghanaian tertiary institution: a cross-sectional study by Andrew Nketsia Arthur, Joanne Fraikue, Bijoux Adu-Amankwah, Richard Ofori, Dorcas Sekyi, Abena Afrakomah Boateng, Elsie Asamoah, Seth Christopher Yaw Appiah

“…Inferential analysis was conducted using a multilevel logistic regression model and a p-value of 0.05 was considered to indicate statistical significance. Results Severe depression (p = 0.016, ϰ2 = 0.784) was significantly associated with students’ academic performance. …”
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Agitated Depression Associated With Flurazepam Discontinuation by Mohamed Salih, Reem Mohamed Osman, Wala Alim, Leena Khalid, Wafa Sosal, Danya Ibrahim, Yassir Mahgoub

“…We describe a case of a 73-year-old female with a prior history of depression and generalized anxiety disorder who was maintained on flurazepam for 44 years and was admitted for severe depression with psychomotor agitation, prominent vegetative symptoms, thought perseveration, indecisiveness, and psychotic features that emerged following the discontinuation of flurazepam. …”
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Age-Related Features of Depression in Residence of the Arctic Zone by A.V. Klimak, O.A. Kharkova, A.V. Kudryavtsev

“…In the course of studying the age-related characteristics of depression among residents of the Arctic zone, it was found that certain symptoms of depression are more prevalent in young people; however, the chance of moderate to severe depression is significantly higher in older women.…”
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Depression Relapse during Long-Term Remission due to Media-Amplified Fear during the COVID-19 Pandemic by Nobutaka Ayani, Teruyuki Matsuoka, Sumihiro Yamano, Jin Narumoto

“…In this study, we reported two cases where patients experiencing severe depression with delusions of having COVID-19 required inpatient treatment after long-term remission owing to the negative impact of media reports related to the pandemic. …”
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Investigating the Feasibility and Impact of Perinatal Depression Screening and Treatment in Rural Nsambe, Malawi by Waste Kayira, Mark Chalamanda, Kingsley Kanzoole, Kondwani Mpinga, Moses Banda Aron, Ksakred Kelly, Sarah Singer, Enoch Ndarama, Stephanie Smith, Giuseppe Raviola, Basimenye Nhlema, Emilia Connolly, Todd Ruderman

“…Women identified to have moderate and severe depression were treated through a group counselling intervention—WHO Group Problem Management Plus (group PM+). …”
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Depression among Elderly of Chhayanath Rara Municipality, Mugu, Nepal: An Observational Study by Nabina Malla, Lisasha Poudel, Sushma Pokhrel, Vidya Chaudhary, Prajita Mali

“…Of those, 124 (32.04%) experienced mild depression, 115 (29.72%) had moderate depression, and 43 (11.11%) suffered from severe depression. Conclusions: The prevalence of depression in elderly was found higher compared to previous studies and other population. …”
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Is Chronic Inflammation a Possible Cause of Obesity-Related Depression? by Magdalena Olszanecka-Glinianowicz, Barbara Zahorska-Markiewicz, Piotr Kocełak, Joanna Janowska, Elżbieta Semik-Grabarczyk, Tomasz Wikarek, Wojciech Gruszka, Piotr Dąbrowski

“…After evaluation of depression level study group was divided into groups according to the mood status (A—without depression, B—mild depression, and C—severe depression), and serum concentration of TNF-α, sTNFs, leptin, and IL-6 were measured by ELISA. …”
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Comparing self reported and physiological sleep quality from consumer devices to depression and neurocognitive performance by Samir Akre, Zachary D. Cohen, Amelia Welborn, Tomislav D. Zbozinek, Brunilda Balliu, Michelle G. Craske, Alex A. T. Bui

“…Using data from 249 participants with medium to severe depression monitored over 13 weeks, sleep quality was assessed via retrospective self-report and physiological measures from consumer smartphones and smartwatches. …”
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The Effects of Alexithymia on Self-Reflection and Insight in Major Depressive Disorder by Aysu Yakin Olgun, Meliha Zengin Eroglu

“…Aim: We hypothesized that alexithymic depressive patients have low insight, which correlates with more severe depression and anxiety. In this context, we aimed to explore the correlation between insight and self-reflective abilities, alexithymia, as well as the presence and severity of major depression, which is the most diagnosed psychiatric disease in the world. …”
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Depression among outpatients with diabetic peripheral neuropathy: prevalence and associated factors by Besher Gharaibeh, Aya Baniyones, Sawsan Abuhammad, Amat Al-Khaleq O Mehrass

“…Participants completed the Beck Depression Inventory II, Michigan Neuropathy Screening Instrument, and Douleur Neuropathique 4 questionnaires, with recent A1C results obtained from medical records.Results The mean depression score was 16.5, with 98 patients (65%) reporting depression and 20 (13%) indicating moderate to severe depression. Approximately half of the sample experienced neuropathy and neuropathic pain. …”
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