Residue-resolved insights into the stabilization of therapeutic proteins by excipients: A case study of two monoclonal antibodies with arginine and glutamate by Tobias M. Prass, Patrick Garidel, Lars V. Schäfer, Michaela Blech

“…Model systems composed of two marketed therapeutic IgG1 monoclonal antibodies with identical Fc domain sequences, trastuzumab and omalizumab, were investigated with commonly used excipients arginine, glutamate, and equimolar arginine/glutamate mixtures. …”
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Assessment of Suspected Breast Lesions in Early-Stage Triple-Negative Breast Cancer during Follow-Up after Breast-Conserving Surgery Using Multiparametric MRI by Lamiss Mohamed Abd El Aziz Sad, Naglaa Lofty Dabees, Dareen Abd El-Aziz Mohamed, Amr Tageldin, Samar Galal Younis

“…All patients were subjected to MRI, including conventional sequences, diffusion-weighted imaging (DWI), and dynamic postcontrast study. …”
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Yeasts with Fermentative Potential Associated with Fruits of Camu-Camu (Myrciaria dubia, Kunth) from North of Brazilian Amazon by Ítalo Thiago Silveira Rocha Matos, Vanderly Andrade de Souza, Giovana do Rosário D’Angelo, Spartaco Astolfi Filho, Edson Júnior do Carmo, Marcos José Salgado Vital

“…Taxonomic identification was performed by ribosomal gene nucleotide sequence analysis by alignment using BLASTN. A total of fifteen yeast colonies were isolated, and three of them presented promising ability to ferment glucose to ethanol. …”
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Multivariate Load Forecasting of Integrated Energy System Based on CEEMDAN-CSO-LSTM-MTL by WANG Yongli, LIU Zeqiang, DONG Huanran, LI Dexin, CHEN Xin, GUO Lu, WANG Jiarui

“…Firstly，preprocess the collected raw load data and calculate the actual load value considering system energy loss； Secondly，the maximum information coefficient （MIC） is used to analyze the correlation between multiple loads and between multiple loads and weather factors，and to extract strongly correlated variables of multiple loads； Once again，the strongly correlated variables of multiple loads are substituted into CEEMDAN，and the load data is decomposed into stationary subsequences； Then，the feature sequence is substituted into the LSTM-MTL shared layer and the CSO algorithm is used to optimize the prediction model，achieving collaborative prediction of multiple loads； Finally，the performance of the constructed model was validated using a multivariate load dataset from a chemical park in Jilin City，Jilin Province，China. …”
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Constructing Attention-LSTM-VAE Power Load Model Based on Multiple Features by Chaoyue Ma, Ying Wang, Feng Li, Huiyan Zhang, Yong Zhang, Haiyan Zhang

“…First, the Prophet data decomposition method is used to decompose long sequences of load data at multiple time scales. Second, the correlation-based feature selection with maximum information coefficient (CFS-MIC) method is employed to select weather features based on their relevance, a subset of features with high correlation and low redundancy is chosen as model inputs. …”
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Problems with studying directional natural selection in humans by S. V. Mikhailova

“…These include bioinformatic analysis of DNA sequences via detection of linkage disequilibrium and of deviations from the random distribution of frequencies of genetic variants, demographic and anthropometric studies based on a search for a correlation between fertility and phenotypic traits, genome-wide association studies on fertility along with genetic loci and polygenic risk scores, and a comparison of allele frequencies between generations (in modern samples and in those obtained from burials). …”
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In-silico formulation of a next-generation polyvalent vaccine against multiple strains of monkeypox virus and other related poxviruses. by Abu Tayab Moin, Nurul Amin Rani, Rajesh B Patil, Tanjin Barketullah Robin, Md Asad Ullah, Zahidur Rahim, Md Foyzur Rahman, Talha Zubair, Mohabbat Hossain, A K M Moniruzzaman Mollah, Nurul Absar, Mahboob Hossain, Mohammed Abul Manchur, Nazneen Naher Islam

“…Two vaccines were constructed using selected T cell epitopes and B cell epitopes with PADRE and human beta-defensins adjuvants conjugated in the vaccine sequence. Both constructs were found to be highly antigenic, non-allergenic, nontoxic, and soluble, suggesting their potential to generate an adequate immune response and be safe for humans. …”
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Expression evaluation of exogenous and endogenous alcohol dehydrogenase genes in transgenic Arabidopsis by Haoqiang Yu, Hong Lv, Fengzhong Lu, Qingqing Yang, Huaming Duan, Wanchen Li, Fengling Fu

“…To detect the differences in expression, protein accumulation, and enzyme activity between transformed exogenous and endogenous genes, the coding sequences (CDSs) of the alcohol dehydrogenase (ADH) genes were cloned from dicotyledonous Arabidopsis, monocotyledonous maize, and prokaryotic Escherichia coli, constructed into expression vector pBI121-cMycNY, and used to transform wild-type Arabidopsis, respectively. …”
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A Multi-Granularity Features Representation and Dimensionality Reduction Network for Website Fingerprinting by Yaojun Ding, Bingxuan Hu

“…The LRCT network effectively leverages the temporal learning advantages of Local Recurrent Networks (Local RNN) and the spatial learning strengths of Convolutional Neural Network (CNN) by designing the local feature extraction block (denoted as LRC Block), which extracts fine-grained local features from 2000-dimensional original sequences and reduces the dimensionality to 125. The network then uses a Transformer Encoder to capture more robust global features from the low-dimensional data. …”
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VEIKIANTIS GENOMAS - VISUMINIS POŽYMIS: DABARTIES ŽVILGSNIS Į GENETIKĄ by Jonas Rubikas

“…The five methodological levels of investigation could be distinguished during the course of genetics development: the organism - feature; the cell - feature; the chromosome - feature; DNA molecule - feature; nucleotide sequence - function. The methodology of the new level is genomics (DNA microarrays) and proteomes. …”
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Multiobjective Optimization of Composite Material Seat Plate for Mortar Based on the Hybrid Surrogate Model by Fengfeng Wang, Chundong Xu, Lei Li

“…First, a fiber continuity model based on dropout sequence is adopted to solve the problems existing in the design of inherent continuity classes for composite layered fibers. …”
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Differences and driving factors of leaf functional traits between old tree and mature tree of Pinus tabulaeformis in the Loess Plateau by Yuting Lei, Zimao Feng, Zhong Zhao

“…Combined with transcriptome and simple sequence repeats (SSR) techniques, the effects of soil property factors and genetic factors on leaf functional traits and the potential molecular mechanisms of traits differences were studied. …”
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Adaptive Evolution Coupled with Retrotransposon Exaptation Allowed for the Generation of a Human-Protein-Specific Coding Gene That Promotes Cancer Cell Proliferation and Metastasis... by Spyros I. Papamichos, Dimitrios Margaritis, Ioannis Kotsianidis

“…Third, we highlight that the initial part of MYEOV long-isoform coding DNA sequence was under positive selection pressure during Catarrhini evolution. …”
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Synthetic, Structural, and Biochemical Studies of Organotin(IV) With Schiff Bases Having Nitrogen and Sulphur Donor Ligands

“…<p>Three bidentate Schiff bases having nitrogen and sulphur donor sequences were prepared by condensing S-benzyldithiocarbazate (<mml:math alttext="chem{NH_2NHCS_2CH_2C_6H_5}"> <mml:msub> <mml:mtext>NH</mml:mtext> <mml:mn>2</mml:mn> </mml:msub> <mml:msub> <mml:mtext>NHCS</mml:mtext> <mml:mn>2</mml:mn> </mml:msub> <mml:msub> <mml:mtext>CH</mml:mtext> <mml:mn>2</mml:mn> </mml:msub> <mml:msub> <mml:mtext>C</mml:mtext> <mml:mn>6</mml:mn> </mml:msub> <mml:msub> <mml:mtext>H</mml:mtext> <mml:mn>5</mml:mn> </mml:msub> </mml:math>) with heterocyclic aldehydes. …”
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Application of Sustainable Education Innovation in the Integrated Teaching of Theory and Practice Adopted in the Auto Chassis Course by Tzu-Chia Chen, Jiuqi Yu, Amir-Mohammad Golmohammadi

“…Furthermore, the conflicts among the enterprise, school, teachers, and students were explored in sequence utilizing technical contradiction solutions. …”
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Phylogeography and hybridization of corvid birds in the Palearctic Region by A. P. Kryukov

“…Several genetic markers were unable to discriminate between pure carrion and hooded crows. Mitochondrial DNA sequences revealed no difference between carrion and hooded crows, but instead two diverged haplogroups within the eastern part of the distribution range of the carrion crow. …”
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Comparative genomics of thermosynechococcaceae and thermostichaceae: insights into codon usage bias by Qiao-Hui Mou, Zhe Hu, Jing Zhang, Maurycy Daroch, Jie Tang

“…In addition, codon context pattern analysis revealed the specificity of the sequence context of start and stop codons among genera. …”
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A Multi-Disciplinary Approach in the Management of Endo-Perio Lesions: A 4-year Follow-Up Case Report by Stephani Dwiyanti

“…It highlights the importance of the identification and elimination of all causative factors as well as the correct treatment sequence to achieve a predictable outcome. The patient was referred to the periodontist after multiple unsuccessful attempts by his previous dentist. …”
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In Silico Design of a Trans-Amplifying RNA-Based Vaccine against SARS-CoV-2 Structural Proteins by Fatemeh Nafian, Ghazal Soleymani, Zahra Pourmanouchehri, Mahnaz Kiyanjam, Simin Nafian, Sayed Mohammad Mohammadi, Hanie Jeyroudi, Sharareh Berenji Jalaei, Fatemeh Sabzpoushan

“…A 50S ribosomal L7/L12 adjuvant was added to its N-terminus to improve stability and immunogenicity. The final RNA sequence was used to design a trans-amplifying RNA (taRNA) vaccine in a split-vector system. …”
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Neural Radiance Fields for High-Fidelity Soft Tissue Reconstruction in Endoscopy by Jinhua Liu, Yongsheng Shi, Dongjin Huang, Jiantao Qu

“…We first construct an EndoTissue dataset of soft tissue regions in endoscopic images and fine-tune the Segment Anything Model (SAM) based on EndoTissue to obtain a potent segmentation network. Given a sequence of monocular endoscopic images, this segmentation network can quickly obtain the tissue mask images. …”
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