Beta-Blocker Therapy Preserves Normal Splenic T-Lymphocyte Numbers Reduced in Proportion to Sepsis Severity in a Sepsis Model by Takeshi Suzuki, Kei Inoue, Toru Igarashi, Jungo Kato, Hiromasa Nagata, Takashige Yamada, Shizuka Minamishima, Hiroshi Morisaki

“…Lymphocyte cell death contributes to sepsis-induced immunosuppression, leading to poor prognosis. …”
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Pyomyoma as a Rare Source of Postpartum Sepsis by A. DeMaio, M. Doyle

“…A high index of suspicion is required to make the diagnosis and can be guided by a classic triad of symptoms that includes abdominal pain, sepsis without an obvious source, and a history of leiomyoma. …”
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Role of Pore-Forming Toxins in Neonatal Sepsis by Andreas F.-P. Sonnen, Philipp Henneke

“…Protein toxins are important virulence factors contributing to neonatal sepsis. The major pathogens of neonatal sepsis, group B Streptococci, Escherichia coli, Listeria monocytogenes, and Staphylococcus aureus, secrete toxins of different molecular nature, which are key for defining the disease. …”
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Insights into the Roles of B Cells in Patients with Sepsis by Xijie Dong, Hao Tu, Shuang Qin, Xiangjun Bai, Fan Yang, Zhanfei Li

“…Sepsis is a life-threatening yet common disease, still posing high mortality worldwide. …”
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Thrombotic Thrombocytopenic Purpura Associated with Pneumococcal Sepsis by Jeffrey R Schriber, John J Freedman, Joseph M Brandwein

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Role of C5 Activation Products in Sepsis by Peter A. Ward

“…Complement activation products are known to be generated in the setting of both experimental and human sepsis. C5 activation products (C5a anaphylatoxin and the membrane attack complex [MAC] C5b-9) are generated during sepsis following infusion of endotoxin, or after cecal ligation and puncture (CLP), which produces polymicrobial sepsis. …”
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Novel Insights for Systemic Inflammation in Sepsis and Hemorrhage by Bolin Cai, Edwin A. Deitch, Luis Ulloa

“…The inflammatory responses in sepsis and hemorrhage remain a major cause of death. …”
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Selected Biomarkers Correlate with the Origin and Severity of Sepsis by Michal Holub, Olga Džupová, Michaela Růžková, Alžběta Stráníková, Eva Bartáková, Jan Máca, Jiří Beneš, Heiko Herwald, Ondřej Beran

“…Our findings suggest that MCP-1, sCD14, IL-6, IL-10, cortisol, and HBP are modulated by the source of sepsis and that elevated MCP-1 and cortisol plasma levels are associated with sepsis-induced organ dysfunction.…”
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Rahnella aquatilis Sepsis in a Premature Newborn by Canan Kuzdan, Ahmet Soysal, Hülya Özdemir, Şenay Coşkun, İpek Akman, Hülya Bilgen, Eren Özek, Mustafa Bakır

“…Here we present a one-month-old boy who was born prematurely at 27th week of gestation by cesarean section with a birth weight of 730 g. He developed sepsis caused by Rahnella aquatilis during the treatment for ventilator associated pneumonia due to Stenotrophomonas maltophilia with ciprofloxacin. …”
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Cyclooxygenase Inhibition in Sepsis: Is There Life after Death? by David M. Aronoff

“…Animal models of sepsis, using the systemic administration of pathogen-associated molecular patterns (PAMPs) or live pathogens, have been used to examine the effectiveness of COX inhibition as a treatment for severe sepsis. …”
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Pathogenic and therapeutic roles of extracellular vesicles in sepsis by Benshuai You, Yang Yang, Jing Wei, Chenglin Zhou, Surong Dong

Subjects: “…sepsis…”
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Evolving concepts in sepsis: we are making progress! by Jean-Louis Vincent

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Potential Pitfalls of the Humanized Mice in Modeling Sepsis by Krzysztof Laudanski, Michael Stentz, Matthew DiMeglio, William Furey, Toby Steinberg, Arpit Patel

“…Although certain viral and protozoan infections can be replicated in humanized mice, whether a highly complex and dynamic systemic inflammation like sepsis can be accurately represented by current humanized mouse models in a clinically translatable manner is unclear. …”
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The Immune Response: Targets for the Treatment of Severe Sepsis by Aline M. Bernard, Gordon R. Bernard

“…The clinical process of severe sepsis is characterized by extreme inflammation interlinked with potent stimulation of the coagulation cascade often followed by a state of relative immune paralysis. …”
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Pneumococcal Bacteremia Presenting as Acute Parotitis and Sepsis by Ashish Kataria, Alan S. Multz

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Neonatal Sepsis due to Coagulase-Negative Staphylococci by Elizabeth A. Marchant, Guilaine K. Boyce, Manish Sadarangani, Pascal M. Lavoie

“…Neonates, especially those born prematurely, are at high risk of morbidity and mortality from sepsis. Multiple factors, including prematurity, invasive life-saving medical interventions, and immaturity of the innate immune system, put these infants at greater risk of developing infection. …”
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Clinical Practice Guidelines for Severe Sepsis Treatment. by Julio Héctor Jova Dueñas, Diosdania Alfonso Falcón, Marcos Diosdado Iraola Ferrer, Inti Santana Carballosa, José Noel Marrero.

Subjects: “…sepsis…”
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Sepsis: the silent killer we should be stopping

“…Discusses global impacts of sepsis, calling for further education in sepsis recognition and treatment. …”
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Review of the Predictive Value of Biomarkers in Sepsis Mortality by Nai Zhang, Yujuan Liu, Chuang Yang, Xinai Li

“…Sepsis is a leading cause of mortality among severely ill individuals, primarily due to its potential to induce fatal organ dysfunction. …”
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Emerging Evidence concerning the Role of Sirtuins in Sepsis by Lulan Li, Zhongqing Chen, Weijun Fu, Shumin Cai, Zhenhua Zeng

“…Sepsis, a dysregulated host response to infection, is a major public health concern. …”
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