The anti-PD-L1/CTLA-4 bispecific antibody KN046 plus lenvatinib in advanced unresectable or metastatic hepatocellular carcinoma: a phase II trial by Da Xu, Hongwei Wang, Quan Bao, Kemin Jin, Ming Liu, Wei Liu, Xiaoluan Yan, Lijun Wang, Yanqiao Zhang, Guangyu Wang, Yue Ma, Zhigang Ma, Chunhui Zhang, Jiebing Tang, Sha Wang, Jiaohui Pang, Ting Xu, Kun Wang, Baocai Xing

“…No DLT was observed in the safety run-in period. The incidence of serious adverse events and grade ≥3 treatment-related adverse events (TRAEs) was 30.9% and 47.3%, respectively. …”
Get full text

Liquid Chromatography-Tandem Mass Spectrometry Method for the Determination of Vardenafil and Its Application of Bioequivalence by Kok Zheng Gan, Riyanto Teguh Widodo, Zamri Chik, Lay Kek Teh, Mohd Salleh Rofiee, Mohd Izwan Mohamad Yusof

“…The mass transitions m/z 489⟶151 and m/z 390⟶169 were used to measure vardenafil and tadalafil (internal standard), respectively, with a total assay run time of 6 min. The limit of detection was 0.2 ng/mL. …”
Get full text

Weather resilience of the future Swiss electricity system with very high shares of variable renewable energy sources by Collin Killenberger, Nik Zielonka, Jan-Phillipp Sasse, Evelina Trutnevyte

“…Here, we apply the electricity system model EXPANSE for Switzerland to search for resilient cost-optimal and near-optimal system designs in 2035 under various policy scenarios, using data from 25 historical weather years (1995–2019) for electricity demand, solar photovoltaics (PV), wind power, hydropower dams and run-of-river hydropower. In particular, we demonstrate how modeling to generate alternatives (MGA) could be used to define a range of potential system designs for reaching different levels of weather resilience. …”
Get full text

Developing Green Marketing Strategies: A Comprehensive Analysis of Consumer Behaviour and Business Practices by Ahmad Mansour, Hind Al-Ahmed, Anan Deek, Khaled Alshaketheep, Mohammad Al-Ma'aitah, Bara Asfour, Muhammad Alshurideh

“…It is clear that implementing corporate practice according to the customer expectation and practicing transparency would not only increase the brand value but also the customer loyalty and which in longer runs would also help in supporting and implementing sustainable development goals across the world. …”
Get full text

Development and Application of a LC-MS/MS Method for Simultaneous Quantification of Four First-Line Antituberculosis Drugs in Human Serum by Yunliang Zheng, Nana Xu, Xingjiang Hu, Qiao Zhang, Yanpeng Liu, Qingwei Zhao

“…Chromatographic separation was achieved on XSelecT HSS T3 column by gradient elution with a total run time of 5.0 min. MS detection was performed by a triple quadrupole tandem mass spectrometer in the multiple reaction monitoring mode with a positive electrospray ionization source. …”
Get full text

Association of serum magnesium and calcium with metabolic syndrome: a cross-sectional study from the Qatar-biobank by Raneem Alsheikh, Haneen Aldulaimi, Rami Hinawi, Fatima Al-Sadi, Alanoud Al-Baker, Aldana Alkuwari, Muhammad Sameer, Ghalya Al-Abdulla, Zumin Shi, Giridhara Rathnaiah Babu

“…Logistic regression models were run to examine these associations. Results and conclusion MetS was present in more than 19% of the population. …”
Get full text

Fecal microbiota transplantation to prevent acute graft-versus-host disease: pre-planned interim analysis of donor effect by Swetha Reddi, Liliia Senyshyn, Maryam Ebadi, Daniel Podlesny, Samuel S. Minot, Ted Gooley, Amanda J. Kabage, Geoffrey R. Hill, Stephanie J. Lee, Alexander Khoruts, Armin Rashidi

“…Here, we report the results from the single-arm run-in phase which identified the best of 3 stool donors for the randomized phase. …”
Get full text

Visible light photocatalytic degradation of tetracycline using copper ferrite nanoparticles synthesized via Glycine-Assisted combustion method by A. Dinesh, K. Radhakrishnan, V. Renuga, Rajendra P. Patil, Suriyaprakash Rajadesingu, S. Suthakaran, L. Guganathan, Manikandan Ayyar, Madhappan Santhamoorthy, Lalitha Gnanasekaran, Munawar Iqbal

“…The CuFe2O4 NPs had rather high recyclability after the photocatalytic process, they had 90 % of their initial activity, which was tested after the fifth run. This study shows that green synthesized CuFe2O4 NPs are potentially useful as reusable visible-light photocatalysts for breaking down drugs, specifically tetracycline, through oxidation in water.…”
Get full text

Multi-Temporal Analysis and Techno-Economic Evaluation of Offshore Wind Energy Integration to the Western Interconnection by Li He, Shahnawaz Siddiqui, Sameer Nekkalapu, Sohom Datta, Travis Douville, Konstantinos Oikonomou, Manisha Maharjan

“…Through an iterative manner, the proposed approach identifies necessary upgrades to the transmission system based on PF results, builds the upgrades in the PCM, and re-runs. Significant potential benefits of West Coast OSW in interregional energy coordination and resilience to extreme weather conditions from using different generation and transmission scenarios are observed.…”
Get full text

A Low-Cost Layered Double Hydroxide (LDH) Based Amperometric Sensor for the Detection of Isoproturon in Water Using Carbon Paste Modified Electrode by Herve Leclerc Tcheumi, Aude Peggy Kameni Wendji, Ignas Kenfack Tonle, Emmanuel Ngameni

“…In this work, a Layered Double Hydroxide (NiAl-LDH) was obtained by coprecipitation method and used to elaborate an electrochemical sensor for the determination of isoproturon, which is a hazardous pollutant, widely used in agriculture, and its residue is distributed into aqueous environment through run-off and leaching from the soil. Various physicochemical techniques such as FT-IR spectroscopy, X-ray diffraction, and thermal analysis were used to characterize this material. …”
Get full text

Transitive reasoning in the adult domestic hen in a six-term series task by R. Degrande, O. Amichaud, B. Piégu, F. Cornilleau, P. Jardat, V. H.B. Ferreira, V. Colson, L. Lansade, L. Calandreau

“…Then, 12 testing sessions were run, comprising 3 non-rewarded inference trials each: BD, BE, and CE. …”
Get full text

Estimating and forecasting bitcoin daily prices using ARIMA-GARCH models by Quang Phung Duy, Oanh Nguyen Thi, Phuong Hao Le Thi, Hai Duong Pham Hoang, Khanh Linh Luong, Kim Ngan Nguyen Thi

“…The estimation process is run using 3 years of data (2021–2023), while the remaining (Jan 1st 2024 to Jan 17th 2024) is used for forecasting. …”
Get full text

Effectiveness of case-area targeted interventions including vaccination on the control of epidemic cholera: protocol for a prospective observational study by Lauren D'Mello-Guyett, Ruwan Ratnayake, Andrew S Azman, Yap Boum, Francesco Checchi, W John Edmunds, Placide Okitayemba Welo, Nicolas Peyraud, Iza Ciglenecki, Etienne Gignoux, Maria Lightowler, Primitive Gakima, Jean Patrick Ouamba, Joseph Amadomon Sagara, Rollin Ndombe, Nana Mimbu, Alexandra Ascorra, Elisabeth Mukamba Musenga, Berthe Miwanda, Francisco Luquero, Klaudia Porten, Flavio Finger, Miriam Alia, Bachir Assao, Catherine Bachy, Rob D'hondt, Karl Njuwa Fai, Caroline Henry-Ostian, Abdoul-Moumouni Issa-Soumana, Danish Malik, Herbert Mutubuki, Rodrigue Ntone, Isabella Panunzi, Issaka Soumana, Oumar Touré, Mamady Traore

“…Médecins Sans Frontières (MSF) plans to implement CATI in the Democratic Republic of the Congo (DRC), Cameroon, Niger and Zimbabwe. This study will run in parallel to each implementation. The primary outcome is the cumulative incidence of cholera in each CATI ring. …”
Get full text

Selection of promising apple genotypes for columnar growth habit and scab resistance using diagnostic DNA markers by N. I. Savel’ev, A. S. Lyzhin, N. N. Savel’eva

“…The hybrid seedlings that had the dominant Co allele together with the Rvi6 gene in the homozygous dominant state (Rvi6 Rvi6) in their genome have been identified, which can significantly intensify the selection process and run it into 100 % of hybrid seedlings with monogenic scab resistance and up to 50 % of genotypes with columnar growth habit.…”
Get full text

Assessment on Performance and Emission Characteristics of the CRDI Engine Fueled with Ethanol/Diesel Blends in Addition to EGR by C. Dineshkumar, P. D. Jeyakumar, C. K. Arvinda Pandian, N. Rajmohan, P. V. Elumalai, N. Kamesh, Saboor Shaik, Mohsen Sharifpur, Nima Khalilpoor

“…The results indicate that the engine runs smoothly, and E30D70 has chosen an optimum blend. …”
Get full text

Prolegomena zu einer Systematik der syntaktischen Formen ›Satz‹ und ›Periode‹. 1. Teil: Carl Dahlhaus und die Schönbergschule by Stefan Rohringer

“…However, an unconditional linkage of Schenkerian figures with concepts of the Formenlehre tradition runs the risk of countenancing questionable postulates, especially on the part of Formenlehre tradition, so it seems essential to re-evaluate this tradition (at least in its essential parts). …”
Get full text

Application of rice shell activated carbon for reduction of chemical oxygen demand limit and adsorption of iron from abattoir wastewater by Robinson Davi Udo, Samuel Ayegu Tsebam, Kolade Olawale Samson, Precious Nya Umo, Adeniyi Solomon Lawal, Juliet Gordon, Oluwaseun Fetuata, Ibrahim Ademola Fetuga, Olabode Thomas Olakoyejo, Antonio Marcos de Oliveira Siqueira

“…The contact period of 10, 20, 30, 40, 50, and 60 min, the dosage of 0.1, 0.2, 0.3, 0.4, 0.5, and 0.6g, and the temperature of 20, 40, 60, 80, and 100oC were evaluated for the Fe bio-adsorption as well as COD limits reduction in wastewater obtained from abattoir at constant agitation of 200rmp and potential hydrogen level of 5 for all the runs. RS-AC can be used to maintain the amount of iron and COD in aqueous solutions and water treatment, according to the results. …”
Get full text

A Mobile Image-Driven PM2.5 Estimation Framework Using Deep Learning Techniques by Anupam Kamble, Somrawee Aramkul, Paskorn Champrasert

“…Because of the lower number of government-run Air Quality Monitoring Stations, other options for obtaining location-specific PM2.5 concentration values are sought. …”
Get full text

The Role of the Military-Political Elite of Egypt in the Struggle for National Independence in the Post-World War II Period (1945-1952) by I. E. Ibragimov

“…An important aspect of this trend is that, in the run-up to the Egyptian Revolution of 1952, the officers and the military elite became a more prepared and organized than other groups and was able to quickly and almost bloodlessly take power into their own hands.The article notes that it is impossible to solve urgent social problems and overcome economic backwardness without centralized strong leadership. …”
Get full text

Utilizing physical educators to monitor muscular strength and neuromuscular control among children with varied recess time by G. Kate Webb, Yan Zhang, Deborah J. Rhea

“…The purpose of this study was to utilize the physical education setting to examine MusS and NC factors in the Fall and Spring (Time 1 to Time 2) of one school year in a predominately Hispanic sample of second-grade children who received 60 min or 20 min of daily recess.MethodsThis quasi-experimental pre-test/post-test study administered four MusS tests and one NC test to District 1 (N = 59) which received 60 min of recess daily (intervention), and District 2 (N = 49) which received one 20 min daily recess (control). ANCOVAs were run for group differences at Time 2 while controlling for Time 1.ResultsIntervention children significantly outperformed control children on the single leg 3-hop muscular strength test F(1,105) = 13.1, p < .001, n2 = .05, and the neuromuscular control side-step test F(1,105) = 4.77, p = .03, n2 = .04. …”
Get full text