Predicting deamidation and isomerization sites in therapeutic antibodies using structure-based in silico approaches by David Hoffmann, Joschka Bauer, Markus Kossner, Andrew Henry, Anne R. Karow-Zwick, Giuseppe Licari

“…The predictive accuracy of the model was evaluated for four different states of the protein structure: (1) static homology models, (2) enhancing low-frequency vibrational modes during short molecular dynamics (MD) runs, (3) a combination of (2) with a protonation state reassignment, and (4) conventional full-atomistic MD simulations. …”
Get full text

Robust proteome profiling of cysteine-reactive fragments using label-free chemoproteomics by George S. Biggs, Emma E. Cawood, Aini Vuorinen, William J. McCarthy, Harry Wilders, Ioannis G. Riziotis, Antonie J. van der Zouwen, Jonathan Pettinger, Luke Nightingale, Peiling Chen, Andrew J. Powell, David House, Simon J. Boulton, J. Mark Skehel, Katrin Rittinger, Jacob T. Bush

“…Data-independent acquisition performed on a Bruker timsTOF Pro 2 consistently identified ~23,000 cysteine sites per run, with a total of ~32,000 cysteine sites profiled in HEK293T and Jurkat lysate. …”
Get full text

Level of pandemic consequences for the indebtedness of the Slovak hospitality sector by Katarina Valaskova, Pavol Durana, Tomas Kliestik, Simona Vojtekova

“…The study focuses on debt ratios that reflect the financial stability of businesses. Friedman’s test was run to determine how the chosen indebtedness indicators developed over the chosen years. …”
Get full text

The interventions of physical education by using augmented reality based mobile learning can significantly improve gross motor skills in elementary school students by Mohammad Faruk, Mohammad Ali, Rudi Susilana, Laksmi Dewi, Norlidah Alias, I Made Sri Undy Mahardika, Imam Syafi’i, Muchamad Samsul Huda, Achmad Rizanul Wahyudi, Laily Mita Andriana, Adi Pranoto

“…The novelty of this study, learning media is packaged into an application that runs on a mobile device. Objective: The aims of the study was to prove that interventions of physical education by using augmented reality based mobile learning can significantly improve gross motor skills in elementary school students. …”
Get full text

Design of Archimedes Screw Turbine by Multi-step Selections on Parameter Pitch Distance, Blade Number, and Blade Angle by Sarjito, Agus Dwi Anggono, Wijianto, Fauzan Anas Wirawan, Sidik Kurniawan, Bagus Dwi Nugroho

“…One of the water turbines called an Archimedes screw turbine (ASTs) is appropriate to run in a low head of just less than 5 m and works at a wide range of discharge operations. …”
Get full text

Assessing customer satisfaction: the case of test prescribers at the clinical biology laboratory of Centre Muraz/ Institut National de Santé Publique, Burkina Faso by Dame Yenyetou, Issouf Sanou, Chérileila Thiombiano, Bakary Diamoutany Sogodogo, Adama Sanou, Soufiane D. Sanou, Mamoudou Cisse, Amariane M. M. Kone, Aline R. Ouoba, Dramane Kania, Michel K. Gomgnimbou, Ibrahim Sangare, Abdoul-Salam Ouedraogo

“…A multivariate logistic regression model was run using R statistical software to identify the variables that best explained overall satisfaction. …”
Get full text

Fast Task Scheduling With Model Predictive Control Integrating a Priority-Based Heuristic by Francesco Liberati, Manuel Donsante, Chiara Maria Francesca Cirino, Andrea Tortorelli

“…On average, the proposed MPC algorithm decreased by nearly 2% the makespan, compared to a state of the art scheduling heuristic, while having a comparable solving time, in the order of milliseconds, and while retaining (contrary to heuristics) all the flexibility and modelling power of the optimization based approaches (which took several hours to run on the test scenarios).…”
Get full text

Rationale and Design of a Randomized, Open‐Label, Parallel‐Group Study of Esaxerenone Versus Angiotensin Receptor Blockers in Older Patients With Uncontrolled Hypertension on Calci... by Kazuomi Kario, Tomohiro Katsuya, Tatsuo Shimosawa, Takashi Taguchi, Ayumi Tanabe, Mitsuru Ohishi, the ESCORT‐HT investigators

“…The ESCORT‐HT study is a multicenter, randomized, controlled, open‐label, parallel‐group study with a 4‐week run‐in period and 12‐week treatment period. This study aims to evaluate the efficacy of esaxerenone as a second‐line treatment for hypertension and to determine whether its BP‐lowering effect is noninferior to that of ARBs in older patients with uncontrolled hypertension on CCB monotherapy. …”
Get full text

Leveraging Next-Generation Sequencing Application from Identity to Purity Profiling of Nucleic Acid-Based Products by Rucha Wadapurkar, Swarda Deo, Renuka Khanzode, Ajay Singh

“…Perhaps NGS adaptation under cGMP compliance needs to be deliberated with the regulatory bodies, especially focusing on the methods qualification and validation part, starting from the sample collection, NGS library preparation, NGS run, and its data analysis pipeline.…”
Get full text

Evolution of Magnetohydrodynamic Turbulence in the Expanding Solar Wind: Residual Energy and Intermittency by Chen Shi, Nikos Sioulas, Zesen Huang, Marco Velli, Anna Tenerani, Victor Réville

“…Here S _2 ( b ) and S _2 ( u ) are second-order structure functions of magnetic field and velocity respectively. In most runs, S _2 ( b ) develops a scaling relation ${S}_{2}({\boldsymbol{b}})\propto {l}_{\perp }^{1/2}$ ( ${E}_{b}\propto {k}_{\perp }^{-3/2}$ ). …”
Get full text

Bayesian calibration and uncertainty quantification for a large nutrient load impact modelZenodoZenodoZenodo by Karel Kaurila, Risto Lignell, Frede Thingstad, Harri Kuosa, Jarno Vanhatalo

“…After that, we constructed a space-filling design for FICOS model runs around the posterior mode and used it to train a Gaussian process emulator for the (log) posterior density of the model parameters. …”
Get full text

Comparison of Resampling Methods and Radiomic Machine Learning Classifiers for Predicting Bone Quality Using Dual-Energy X-Ray Absorptiometry by Mailen Gonzalez, José Manuel Fuertes García, María Belén Zanchetta, Rubén Abdala, José María Massa

“…The highest F-score of 97.5% was achieved using the Grey Level Dependence Matrix and Grey Level Run Length Matrix feature combination with SMOTEENN resampling, which proved to be the most effective resampling technique, while the undersampling method yielded the lowest performance. …”
Get full text

Effects of Coach’s Verbal Encouragement During Small-Sided Volleyball Games on Specific Physical Fitness and Technical-Tactical Behavior of Youth Athletes by Taufiq Hidayat, Irma Febriyanti, Advendi Kristiyandaru, Suroto, Hari Wisnu, Ahmet Kurtoğlu, Amayra Tannoubi, Joseph Lobo, Baglan Yermakhanov, Jarosław Muracki, Edi Setiawan

“…Physical performance including agility t-test (ATT), 10-m sprint test (10-mST), countermovement jump test (CMJT), medicine ball throw test (MBTT), multistage 20-meter shuttle run test (M20-MSRT), and technical-tactical behavior (serve, reception, sets, attack, defense) were measured in pre-test and post-test. …”
Get full text

The Efficient Integration of Dust and Numerical Weather Prediction for Renewable Energy Applications by Xi Chen, Mei Chong, Shian‐Jiann Lin, Zhi Liang, Paul Ginoux, Yuan Liang, Bihui Zhang, Qian Song, Shengkai Wang, Jiawei Li, Yimin Liu

“…Current “Near‐Real‐Time” dust forecasting services can only run after the completion of NWP, failing to meet the timeliness requirements for reporting power generation plans to the grids. …”
Get full text

Dairy Foods in a Moderate Energy Restricted Diet Do Not Enhance Central Fat, Weight, and Intra-Abdominal Adipose Tissue Losses nor Reduce Adipocyte Size or Inflammatory Markers in... by Marta D. Van Loan, Nancy L. Keim, Sean H. Adams, Elaine Souza, Leslie R. Woodhouse, Anthony Thomas, Megan Witbracht, Erik R. Gertz, Brian Piccolo, Andrew A. Bremer, Michael Spurlock

“…A 15-week controlled feeding study to determine if dairy foods enhance central fat and weight loss when incorporated in a modest energy restricted diet of overweight and obese adults. Design. A 3-week run-in to establish energy needs; a 12-week 500 kcal/d energy reduction with 71 low-dairy-consuming overweight and obese adults randomly assigned to diets: ≤1 serving dairy/d (low dairy, LD) or ≤4 servings dairy/d (adequate dairy, AD). …”
Get full text

Effectiveness of cognitive–behavioural therapy: a protocol for an overview of systematic reviews and meta-analyses by Sarah E Lamb, Shona Kirtley, Beth Fordham, Thavapriya Sugavanam, Sally Hopewell, Karla Hemming, Jeremy Howick, Roshan das Nair, Julia Hamer-Hunt

“…The aim of this overview is to map, synthesise and assess the reliability of evidence generated from these systematic reviews of the effectiveness of CBT across all health conditions, patient groups and settings.Methods and analysis We will run our search strategy, to identify systematic reviews of CBT, within the Database of Abstracts of Reviews of Effects, the Cochrane Library of Systematic Reviews, MEDLINE, Embase, PsycInfo, CINAHL, Child Development and Adolescent Studies, and OpenGrey between January 1992 and 25 April 2018. …”
Get full text

Simultaneous Determination of 34 Amino Acids in Tumor Tissues from Colorectal Cancer Patients Based on the Targeted UHPLC-MS/MS Method by Yang Yang, Feng Zhang, Shouhong Gao, Zhipeng Wang, Mingming Li, Hua Wei, Renqian Zhong, Wansheng Chen

“…The chromatographic separation was achieved on an Agilent ZORBAX SB-C18 column (3.0 × 150 mm, 5 μm) with a binary gradient elution system (A, 0.02% heptafluorobutyric acid and 0.2% formic acid in water, v/v; B, methanol). The run time was 10 min. The multiple reaction monitoring mode was chosen with an electrospray ionization source operating in the positive ionization mode for data acquisition. …”
Get full text

Spi-VSTL: Image data collection platform using off-the shelf hardware for vertically supported crops in state-of-the-art glasshouses by Namal Jayasuriya, Malith Weerasekara, Oula Ghannoum, Yi Guo, Wen Hu

“…The proposed platform runs manually on concrete flow and on pipe rail systems found in state-of-the-art commercial glasshouse settings. …”
Get full text

Chip Design of PTP Time Synchronization for Industrial IoT by Yee-Shao Chen, Yuan-Sun Chu, da-Wei Lo, Yen-Ting Chiang, Ting-Chao Hou

“…These optimization methods include compensating clock skew and removing run-trip delay Time is too large mechanism. Finally, this paper designed an IEEE 1588 protocol chip located on the data connection layer based on these methods, and achieved an operating frequency of 434MHz under the 45nm process. …”
Get full text

Metasurface higher-order poincaré sphere polarization detection clock by Hui Yang, Kai Ou, Qiang Liu, Meiyu Peng, Zhenwei Xie, Yuting Jiang, Honghui Jia, Xinbin Cheng, Hui Jing, Yueqiang Hu, Huigao Duan

“…Conventional strategies for detecting SoP, which typically involves a sequence of cascaded optical elements, are bulky, complex, and run counter to miniaturization and integration. …”
Get full text