Fusobacterium nucleatum upregulates the immune inhibitory receptor PD-L1 in colorectal cancer cells via the activation of ALPK1 by Coco Duizer, Moniek Salomons, Merel van Gogh, Sanne Gräve, Freke A. Schaafsma, Maaike J. Stok, Merel Sijbranda, Raghuvandhanan Kumarasamy Sivasamy, Rob J. L. Willems, Marcel R. de Zoete

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Lithological and geochemical characterization of ‘adinole’ artefacts from cave deposits in southwest Wales: A material of choice during the late Middle to Upper Palaeolithic by Richard Bevins, Elizabeth A. Walker, Nick Pearce, Duncan Pirrie, Rob Ixer, Ian Saunders, Matthew Power

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Age- and Sex-Specific Risks of Major Cardiovascular Complications and All-Cause Mortality Following Elective Hip and Knee Arthroplasty in the Netherlands: A Dutch Hospital Data Reg... by Mark J.R. Smeets, MD, Maaike G.J. Gademan, PhD, Rob G.H.H. Nelissen, MD, PhD, Suzanne C. Cannegieter, MD, PhD, Banne Nemeth, MD, PhD

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A systematic scoping review of clinical indications for induction of labour. by Dominiek Coates, Angela Makris, Christine Catling, Amanda Henry, Vanessa Scarf, Nicole Watts, Deborah Fox, Purshaiyna Thirukumar, Vincent Wong, Hamish Russell, Caroline Homer

“…The quality of included studies was assessed using the RoB 2.0, the ROBINS-I and the ROBIN tool.<h4>Results</h4>68 studies were included which related to post-term pregnancy (15), hypertension/pre-eclampsia (15), diabetes (9), prelabour rupture of membranes (5), twin pregnancy (5), suspected fetal compromise (4), maternal elevated body mass index (BMI) (4), intrahepatic cholestasis of pregnancy (3), suspected macrosomia (3), fetal gastroschisis (2), maternal age (2), and maternal cardiac disease (1). …”
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Clinical outcome analysis for surgical fixation versus conservative treatment on rib fractures: a systematic evaluation and meta-analysis by Penglong Zhao, Qiyue Ge, Haotian Zheng, Jing Luo, Xiaobin Song, Liwen Hu

“…The Cochrane Collaboration Risk of Bias 2 (RoB 2) and the Newcastle–Ottawa Scale (NOS) tool were employed to assess methodological quality, and relative risks (RR) with 95% confidence intervals (CI) were calculated to evaluate the outcome measures. …”
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Effects of Exergaming on Morphological Variables, Biochemical Parameters, and Blood Pressure in Children and Adolescents with Overweight/Obesity: A Systematic Review with Meta-Anal... by Jordan Hernandez-Martinez, Joaquín Perez-Carcamo, Hassan Melki, Izham Cid-Calfucura, Edgar Vasquez-Carrasco, Pedro Delgado-Floody, Claudio Romero, Tomás Herrera-Valenzuela, Braulio Henrique Magnani Branco, Pablo Valdés-Badilla

“…Methods: A systematic literature search was conducted until September 2024 using five databases: PubMed, Medline, CINAHL Complete, Scopus, and Web of Science. PRISMA, TESTEX, RoB 2, and GRADE tools assessed the methodological quality and certainty of evidence. …”
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Meta-analysis on the chronic effects of exercise on depression in older adults by Melanie Mack, Claudia Voelcker-Rehage, Pinelopi S. Stavrinou, Iuliia Pavlova, Yaël Netz, Burcu Kömürcü Akik, Antonia Kaltsatou, Sandra Haider, Christoforos D. Giannaki, Arzu Erden, Andreea Badache, Michel Audiffren

“…The quality and certainty of the evidence were assessed using GRADE and RoB 2. Results The comprehensive search yielded 20,700 records, of which 145 peer-reviewed articles including 187 effect sizes met the inclusion criteria. …”
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Impact of subgingival periodontal treatment on systemic markers of inflammation in patients with metabolic syndrome: a systematic review of randomized clinical trials by Marie Chavez, Asshly Ramirez, Akram Hernández-Vásquez, Daniel Comandé, Diego Azañedo

“…Risk of bias was assessed using the Cochrane RoB 2 tool, and evidence certainty was evaluated following GRADE guidelines. …”
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Impact of Lower-Volume Training on Physical Fitness Adaptations in Team Sports Players: A Systematic Review and Meta-analysis by Filipe Manuel Clemente, Rodrigo Ramirez-Campillo, Jason Moran, Piotr Zmijewski, Rui Miguel Silva, Morten Bredsgaard Randers

“…Methodological assessments of the included studies were performed using the Rob2 and ROBINS-I instruments, with evidence certainty evaluated through GRADE. …”
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Clinical evidence of acupuncture for amnestic mild cognitive impairment: A systematic review and meta-analysis of randomized controlled trials by Guangyao Lin, Stella Lim Jin Yie, Shanshan Guo, Xuanling Li, Lianwei Xu

“…Methods: We comprehensively searched nine databases on January 09, 2024, to identify relevant articles estimating the effects of acupuncture for aMCI, and then assessed the risk of bias of the included trials utilizing the RoB 2.0 tool which included the domain of randomization process, deviation from intended interventions, missing outcome data, measurement of the outcome, selection of the reported outcome, and overall bias. …”
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Eficácia e Segurança do Isolamento Adjuvante da Parede Posterior em Pacientes com Fibrilação Atrial Persistente: Uma Revisão Sistemática e Metanálise by João Vitor Levindo Coelho Novaes, David de Pádua Brasil, Flavia Maria de Freitas Faria, Isadora Soares Bicalho Garcia, Camila Ribeiro Pimenta, Nathalia Sernizon Guimarães, Marcus Vinicius Bolivar Malachias

“…O risco de viés e a qualidade da evidência foram avaliados usando a ferramenta Cochrane de avaliação de risco de viés (RoB 2.0) e o GRADE, respectivamente. A significância estatística foi estabelecida em 5%, e análises por subgrupos e de sensibilidade foram realizadas. …”
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Use of extracorporeal shockwave therapy combined with standard rehabilitation following anterior cruciate ligament reconstruction: a systematic review with meta-analysis by Jaehyung Shin, Hye Chang Rhim, James Kim, Raymond Guo, Ramy Elshafey, Ki-Mo Jang

“…Two authors independently extracted the outcome measurements and used a revised Cochrane risk-of-bias tool (RoB 2) for RCTs and the Risk of Bias in Non-randomised Studies of Interventions (ROBINS-I) for a cohort study to assess the risk of bias. …”
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Serial measurements in COVID-19-induced acute respiratory disease to unravel heterogeneity of the disease course: design of the Maastricht Intensive Care COVID cohort (MaastrICCht) by Steven J R Meex, Walther N K A van Mook, Iwan C C van der Horst, Jeanette Tas, Coen D A Stehouwer, Rob J J van Gassel, Serge J H Heines, Mark M G Mulder, Nanon F L Heijnen, Melanie J Acampo-de Jong, Julia L M Bels, Frank C Bennis, Marcel Koelmann, Rald V M Groven, Moniek A Donkers, Frank van Rosmalen, Ben J M Hermans, Otto Bekers, Astrid M L Oude Lashof, Fabian H Tijssen, Jan-Willem E M Sels, Chahinda Ghossein-Doha, Rob G H Driessen, Pieter L Kubben, Marcus L F Janssen, Gerry A F Nicolaes, Ulrich Strauch, Zafer Geyik, Thijs S R Delnoij, Kim H M Walraven, Jeanine A M C F Verbunt, Susanne van Santen, Ronny M Schnabel, Marcel J H Aries, Marcel C G van de Poll, Bas C T van Bussel, Joachim E Wildberger, Sander M J van Kuijk, Dennis C J J Bergmans, Paul H M Savelkoul, Alma M A Mingels, Wolfgang F F A Buhre

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Digital Health Solutions for Cardiovascular Disease Prevention: Systematic Review by Yihan Qi, Emma Mohamad, Arina Anis Azlan, Chenglin Zhang, Yilian Ma, Anqi Wu

“…Study bias was assessed using the RoB 2 (Cochrane Collaboration) and the ROBINS-I tool (Cochrane Collaboration). …”
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Short-term and long-term effect of non-pharmacotherapy for adults with ADHD: a systematic review and network meta-analysis by Xinyue Yang, Lin Zhang, Jing Yu, Meng Wang

“…Cochrane Risk of Bias tool version 2 (ROB2) and Confidence in Network Meta-Analysis (CINeMA) were used to assess the risk of bias and the certainty of the evidence. …”
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Hepatobiliary scintigraphy and liver function changes in patients with hepatocellular carcinoma treated with 166Ho-radioembolization by Margot T.M. Reinders, Maarten J.L. Smits, Karel van Erpecum, Joep de Bruijne, Rutger C.G. Bruijnen, Dave Sprengers, Rob de Man, Erik Vegt, Jan N.M. IJzermans, Marnix G.E.H. Lam, Arthur J.A.T. Braat

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Effectiveness of Gastric Cancer Endoscopic Screening in Intermediate-Risk Countries: Protocol for a Systematic Review and Meta-Analysis by Maria Beatriz Mourato, Nuno Pratas, Andreia Branco Pereira, Filipa Taré, Raphael Chança, Inês Fronteira, Rui Dinis, Miguel Areia

“…To minimize the risk of bias, the included studies will undergo a quality analysis according to Cochrane risk of bias tools, RoB 2 of randomized trials and ROBINS-I for nonrandomized trials; Newcastle-Ottawa Quality Assessment Scale for case-control and cohort studies; and National Heart, Lung and Blood Institute study quality assessment tools for cross-sectional studies. …”
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Ultrasound outcomes and surgical parameters of the double-layer purse-string uterine closure technique in cesarean delivery: a systematic review and meta-analysis of randomized tri... by Mahsan Nabighadim, Maryam Vaezi, Mahsa Maghalian, Mojgan Mirghafourvand

“…The risk of bias in the included studies was evaluated using the Risk of Bias 2 (ROB2) tool, while the certainty of the evidence was assessed through the GRADE approach. …”
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Plasmodium falciparum genetic diversity and multiplicity of infection based on msp‑1, msp‑2, glurp and microsatellite genetic markers in sub-Saharan Africa: a systematic review and... by Mwesigwa, Alex, Ocan, Moses, Musinguzi, Benson, Nante, Rachel Wangi, Nankabirwa, Joaniter I., Kiwuwa, Steven M., Kinengyere, Alison Annet, Castelnuovo, Barbara, Karamagi, Charles, Obuku, Ekwaro A., Nsobya, Samuel L., Mbulaiteye, Sam M., Byakika‐Kibwika, Pauline

“…Two reviewers conducted article screening, assessed the risk of bias (RoB), and performed data abstraction. Meta-analysis was performed using the random-effects model in STATA version 17. …”
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Role of preconception nutrition supplements in maternal anemia and intrauterine growth: a systematic review and meta-analysis of randomized controlled trials by Sumera Aziz Ali, Jeanine Genkinger, Ka Kahe, Linda Valeri, Nayab Khowaja, Nancy F. Krebs, Louise Kuhn

“…We used a revised Cochrane risk-of-bias (RoB version 2.0) and GRADE (grading of recommendations, assessment, development, and evaluation) tools to assess the risk of bias and quality of evidence of eligible RCTs, respectively. …”
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