Decoupling Global and Local Structural Changes in Self-aminoacylating Ribozymes Reveals the Critical Role of Local Structural Dynamics in Ribozyme Activity by Yu-Kai Cheng, Hsing-Hui Chu, Ning-Jun Yang, Yei-Chen Lai

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Investigating a new generation of ribozymes in order to target HCV. by Michel V Lévesque, Dominique Lévesque, Francis P Brière, Jean-Pierre Perreault

“…These ribozymes resulted from the coupling of a specific on/off adaptor (SOFA) to the ribozyme domain derived from the Hepatitis Delta Virus (HDV). …”
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Exploring the space of self-reproducing ribozymes using generative models by Camille N. Lambert, Vaitea Opuu, Francesco Calvanese, Polina Pavlinova, Francesco Zamponi, Eric J. Hayden, Martin Weigt, Matteo Smerlak, Philippe Nghe

“…Here, we compare models for their generative power in diversifying a reference ribozyme, based on statistical covariation and secondary structure prediction, and experimentally test model predictions using high-throughput sequencing. …”
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Inducible knockdown of Plasmodium gene expression using the glmS ribozyme. by Parichat Prommana, Chairat Uthaipibull, Chayaphat Wongsombat, Sumalee Kamchonwongpaisan, Yongyuth Yuthavong, Ellen Knuepfer, Anthony A Holder, Philip J Shaw

“…Glucosamine-induced ribozyme activation led to efficient reduction of reporter protein, which could be rapidly reversed by removing the inducer. …”
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A recombinase-activated ribozyme to knock down endogenous gene expression in zebrafish. by Thomas Juan, Tonatiuh Molina, Lihan Xie, Sofia Papadopoulou, Bárbara Cardoso, Shivam Govind Jha, Didier Y R Stainier

“…Using an in vivo reporter strategy, we first show that inserting the T3H48 self-cleaving ribozyme in an intron enables rapid pre-mRNA cleavage, with up to 20-fold reduction in expression, and that this ribozyme displays superior activity compared with other ribozymes. …”
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A hammerhead ribozyme selects mechanically stable conformations for catalysis against viral RNA by Man Lu, Zhiqiang Cao, Luoan Xiong, Hongying Deng, Kangkang Ma, Ning Liu, Yanding Qin, Shen-Bo Chen, Jun-Hu Chen, Yao Li, Yijin Liu, Zhongbo Yu

“…Among them, hammerhead is the smallest and best characterized ribozyme. However, the structure and biochemical data of ribozymes have been disagreed on, making the understanding of its catalysis mechanism a longstanding issue. …”
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A comparative survey of the influence of small self-cleaving ribozymes on gene expression in human cell culture by Dennis Kläge, Elisabeth Müller, Jörg S. Hartig

Subjects: “…Ribozyme…”
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Minimal twister sister-like self-cleaving ribozymes in the human genome revealed by deep mutational scanning by Zhe Zhang, Xu Hong, Peng Xiong, Junfeng Wang, Yaoqi Zhou, Jian Zhan

Subjects: “…self-cleaving ribozyme…”
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A novel ribozyme-based prophylaxis inhibits influenza A virus replication and protects from severe disease. by Julie Motard, Ronan Rouxel, Alexandra Paun, Veronika von Messling, Martin Bisaillon, Jean-Pierre Perreault

“…The most promising ribozymes were chosen based on an initial in silico screening, and their efficacy was assessed using in vitro cleavage assays. …”
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An Engineered RNase P Ribozyme Effectively Reduces Human Coronavirus 229E Gene Expression and Growth in Human Cells by Yujun Liu, Bin Yan, Hao Gong, Fenyong Liu

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The RNA-DNA world and the emergence of DNA-encoded heritable traits by Suvam Roy, Supratim Sengupta

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Temperature-sensing riboceptors by Savani Anbalagan

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Exploring the Potential and Advancements of Circular RNA Therapeutics by Lei Wang, Lianqing Wang, Chunbo Dong, Jialong Liu, Guoxin Cui, Shan Gao, Zhida Liu

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Biology and utilization of R2 retrotransposons by Shengqiu Luo, Qicheng Chen, Yangcan Chen, Wei Li

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Antisense technology as a potential strategy for the treatment of coronaviruses infection: With focus on COVID‐19 by Seyedeh Hoda Alavizadeh, Maham Doagooyan, Fatemeh Zahedipour, Shima Yahoo Torghabe, Bahare Baharieh, Firooze Soleymani, Fatemeh Gheybi

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Opening new frontiers with catalytic nucleic acids in miRNA inhibition by Olga Patutina, Svetlana Miroshnichenko, Daria Chiglintseva, Marina Zenkova

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RNase P cleavage of pseudoknot substrates reveals differences in active site architecture that depend on residue N-1 in the 5’ leader by David M. Kosek, J. Luis Leal, Ema Kikovska-Stojanovska, Guanzhong Mao, Shiying Wu, Samuel C. Flores, Leif A. Kirsebom

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Origin & influence of autocatalytic reaction networks at the advent of the RNA world by Stephen A. Zorc, Raktim N. Roy

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Expression of the <i>Nicotiana benthamiana</i> Retrozyme 1 (NbRZ1) Genomic Locus by Alexander A. Lezzhov, Anastasia K. Atabekova, Denis A. Chergintsev, Andrey G. Solovyev, Sergey Y. Morozov

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Synthesis of electrophile-tethered preQ1 analogs for covalent attachment to preQ1 RNA by Laurin Flemmich, Ronald Micura

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