Chondroitin Sulphate-Chitosan Based Nanogels Loaded with Naringenin-β-Cyclodextrin Complex as Potential Tool for the Treatment of Diabetic Retinopathy: A Formulation Study by Zucca G, Vigani B, Valentino C, Ruggeri M, Marchesi N, Pascale A, Giovilli G, Malavasi L, Sandri G, Rossi S

“…N3@NAR/β-CD capability to sustain in vitro NAR release, radical scavenging activity and in vitro biocompatibility were finally demonstrated.Conclusion: The physico-chemical properties of N3@NAR/β-CD were responsible for their cell uptake, suggesting their potential to target retinal endothelial cells. The high NAR/β-CD complexation efficiency and the sustained NAR release over 72 hours could guarantee the maintenance of an effective drug concentration at the damage site while reducing the injection number. …”
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Clinical Review of Ocular Traumas Resulting in Enucleation or Evisceration in a Tertiary Eye Care Center in Hungary by Gábor Tóth, Milán Tamás Pluzsik, Béla Csákány, Gábor László Sándor, Olga Lukáts, Zoltán Zsolt Nagy, Nóra Szentmáry

“…The main clinical diagnoses after ocular trauma were open globe injury (n = 96; 77.4%), ocular burns (n = 6; 4.8%), traumatic optic neuropathy (n = 4; 3.2%), bulbar avulsion (n = 3; 2.4%), traumatic cataract (n = 2; 1.6%), retinal ablation (n = 1; 0.8%), and traumatic carotid-cavernous fistula (n = 1; 0.8%). …”
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Correlation Between the Ratio of Uric Acid to High-Density Lipoprotein Cholesterol (UHR) and Diabetic Retinopathy in Patients with Type 2 Diabetes Mellitus:A Cross-Sectional Study by Wang L, Liu L, Luo H, Wu Y, Zhu L

“…Leran Wang,1 Lei Liu,2 Huilan Luo,3– 5 Yiling Wu,3– 5 Lingyan Zhu3– 5 1Queen Mary School, Jiangxi Medical College, Nanchang University, Nanchang City, People’s Republic of China; 2Department of Endocrinology, Lu’an Hospital of Anhui Medical University, Lu’an City, Anhui Province, People’s Republic of China; 3Department of Endocrinology and Metabolism, the First Affiliated Hospital, Jiangxi Medical College, Nanchang University, Nanchang City, People’s Republic of China; 4Jiangxi Clinical Research Center for Endocrine and Metabolic Disease, the First Affiliated Hospital of Nanchang University, Nanchang City, People’s Republic of China; 5Jiangxi Branch of National Clinical Research Center for Metabolic Disease, Nanchang City, People’s Republic of ChinaCorrespondence: Lingyan Zhu, Jiangxi Branch of National Clinical Research Center for Metabolic Disease, No. 17, Yongwaizheng Street, Nanchang City, Jiangxi Province, People’s Republic of China, Tel +86-13870690788, Email zly982387@126.comBackground/Objective: Considering the uncertain relationship between high-density lipoprotein cholesterol (HDL-C) and uric acid (UA) with diabetic retinopathy (DR),this study investigates the link between Uric Acid to High-Density Lipoprotein Cholesterol (UHR) and DR in T2DM patients, evaluating its potential for DR diagnosis and early prediction.Study Design and Data Collection: This retrospective study analyzed 1450 type 2 diabetes patients, divided into NDR and DR groups by retinal exams. We gathered demographic and clinical data, calculated UHR, and explored its correlation with DR development.Outcomes: Individuals diagnosed with diabetic retinopathy (DR) exhibited a markedly elevated uric acid to high-density lipoprotein cholesterol (UHR) ratio when contrasted with those without DR (NDR), achieving statistical significance with a P-value below 0.001. …”
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Retrospective Analysis of the Prevalence and Risk Factors of Retinopathy of Prematurity in a Single-Center Cohort in Romania and Comparison with National and European Data by Zsuzsánna Simon-Szabó, Sándor Pál, Aliz Pándi, Zsuzsanna Gáll, Hajnal Finta, Zsuzsánna Incze-Bartha, Cristina Maki, Manuela Cucerea

“…In those found to have stage 2 and 3 ROP in zone II with plus disease (n = 6), intravitreal anti-VEGF injections and/or retinal laser treatments were performed. Notably, no cases of ROP-related blindness were recorded. …”
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Evaluating choroidal vascular changes in young adults with high myopia utilizing swept source optical coherence tomography angiography by Qing wang, Lin-Bo He, Sha Li, Hong-Ling Liu, Yong Liu

“…Conclusion: Age primarily influenced retinal vessel density, whereas axial length significantly affected Sattler's and Haller's layers. …”
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Automated multidimensional deep learning platform for referable diabetic retinopathy detection: a multicentre, retrospective study by Chi Pui Pang, Weiqi Chen, Mingzhi Zhang, Tsz Kin Ng, Yi Zheng, Guihua Zhang, Jian-Wei Lin, Ji Wang, Jie Ji, Ling-Ping Cen, Peiwen Xie, Yongqun Xiong, Hanfu Wu, Dongjie Li

“…According to the UK DR screening guideline, a DL model based on colour retinal images with five-dimensional classifiers, namely image quality, retinopathy, maculopathy gradability, maculopathy and photocoagulation, was developed. …”
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Co-isolation of human donor eye cells and development of oncogene-mutated melanocytes to study uveal melanoma by Yunxi Chen, Eva Jin, Mohamed Abdouh, Éric Bonneil, Daniel Alexander Jimenez Cruz, Thupten Tsering, Qianqian Zhou, Aurélie Fuentes-Rodriguez, Alexandra Bartolomucci, Alicia Goyeneche, Solange Landreville, Miguel N. Burnier, Julia V. Burnier

“…Results Given the precious value of human donor eyes for studying multiple ocular cell types, we validated a co-isolation protocol of both human NCMs and retinal pigment epithelial (RPE) cells from a single eye. …”
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Response to Aflibercept Therapy in Three Types of Choroidal Neovascular Membrane in Neovascular Age-Related Macular Degeneration: Real-Life Evidence in the Czech Republic by Jan Nemcansky, Alexandr Stepanov, Michal Koubek, Miroslav Veith, Yun Min Klimesova, Jan Studnicka

“…Best-corrected visual acuity (BCVA) and central retinal thickness (CRT) were measured using Early Treatment Diabetic Retinopathy Study (ETDRS) charts and spectral-domain optical coherence tomography (OCT). …”
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Risk factors for ocular biological parameters in Chinese preschool children: a cohort study from the Beijing whole childhood eye study by Xi Qin, Yunyun Sun, Yunyun Sun, Shana Wang, Xiaolan Xie, Lei Gao, Huijian Li, Huijian Li, Ruihua Wei, Jing Fu, Jing Fu, Bidan Zhu

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Neuroprotective Actions of Cannabinoids in the Bovine Isolated Retina: Role of Hydrogen Sulfide by Leah Bush, Anthonia Okolie, Jenaye Robinson, Fatima Muili, Catherine A. Opere, Sunny E. Ohia, Ya Fatou Njie Mbye

“…Enzyme immunoassay measurement of 8-epi PGF2α (8-isoprostane) levels was performed to assess lipid peroxidation in retinal tissues. <b>Results:</b> In the presence of H₂O₂ (100 µM), methanandamide (1 nM–100 µM) and 2-AG (1–10 µM) significantly (<i>p</i> < 0.001) blocked the H₂O₂-induced elevation in 8-isoprostane levels in the isolated bovine retina. …”
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Disturbances of visual perception in non-demented patients with Parkinson’s disease by R. Timofejavaitė, V. Vilda, A. Liveikienė, R. Kaladytė-Lokominienė

“…Patients underwent ophthalmological examination which provided data on colour discrimination, contrast sensitivity, eye pressure, and retinal ganglion cell layer thickness (RGCL). The relations between minor hallucinations and clinical factors were investigated by comparison of PD and control groups, and PD group. …”
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