Individual-level brain phenotypes in first-episode mania: normative modelling of brain morphometry and brainAGE by Kevin Yu, Ruiyang Ge, Yuetong Yu, Shalaila Haas, Nicole Sanford, Lakshmi N. Yatham, Sophia Frangou, Trisha Chakrabarty

“…Mean G-brainAGE in FEM was −1.04 (s.d. 3.26) years and negatively correlated with age of onset, while L-brainAGE did not differ significantly between groups. Conclusions Regional morphometry and local brain-ageing metrics in FEM patients aligned with normative ranges, suggesting minimal abnormalities in early bipolar disorder. …”
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