Absent in melanoma 2: a potent suppressor of retinal pigment epithelial-mesenchymal transition and experimental proliferative vitreoretinopathy by Yu Chen, Mingyuan Jiang, Liping Li, Shanshan Yang, Zuimeng Liu, Shiwen Lin, Wanxiao Wang, Jinyang Li, Feng Chen, Qiang Hou, Xiaoyin Ma, Ling Hou

“…These findings provide new insights into the complex mechanisms underlying RPE-EMT and PVR pathogenesis, with implications for rational strategies for potential therapeutic applications in PVR by targeting RPE-EMT.…”
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Recommendations of the Russian Gastroenterological Association in Diagnosis and Treatment of Gastroesophageal Reflux Disease by V. T. Ivashkin, I. V. Maev, A. S. Trukhmanov, T. L. Lapina, O. A. Storonova, O. V. Zayratyants, O. B. Dronova, Yu. A. Kucheryavyy, S. S. Pirogov, R. G. Sayfutdinov, Yu. P. Uspenskiy, A. A. Sheptulin, D. N. Andreev, D. E. Rumyantseva

“…Current recommendations of the Russian Gastroenterological Association are developed to acquaint medical practitioners with modern diagnostics, treatment and trends in rational drug therapy for gastroesophageal reflux disease (GERD).General provisions. …”
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Predicting Multi-Scenario Land Use Changes and Soil Erosion in the Huaihe River Basin Based on Coupled PLUS-CSLE Model by GUO Weiling, XU Liuyang, JIA Jiang, GAO Chang, XIA Xiaolin, WANG Bangwen, ZHANG Jingyu, CHEN Lei, CHEN Yingjian

“…[Objective] Understanding the future temporal and spatial evolution of land use and soil erosion in the Huaihe River Basin is of significant importance for rational and coordinated use of land resources, formulating future soil and water conservation strategies, and promoting sustainable development strategies. …”
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Integrative analysis of metabolite and transcriptome reveals the biosynthetic pathway and candidate genes for iridoid glycoside biosynthesis in Neopicrorhiza scrophulariiflora (Pen... by Ke Rao, Ke Rao, Siyu Liu, Siyu Liu, Xiaohui Tang, Guofu Jia, Shaohua Yang, Chaoxiang Ren, Chaoxiang Ren, Jin Pei, Jin Pei

“…Due to overharvesting, N. scrophulariiflora resources are facing the risk of depletion, urgently requiring resource protection and rational utilization. However, the biosynthetic pathways and related genes of active compounds in N. scrophulariiflora have not been fully investigated. …”
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Epidemiologic characteristics of infectious disease-related public health emergencies in Guangdong province, 2014 – 2023: a surveillance data analysis by Weiyi CHEN, Runing GUO, Yun HUANG, Jianhua HUANG, Meiling YANG, Jiya DAI, Fengxiang SHI, Wenjia LIANG

“…ObjectiveTo analyze the epidemiological characteristics of infectious disease-related public health emergencies in Guangdong Province from 2014 to 2023, for the development of effective infectious disease prevention and control strategies and rational allocation of health resources. MethodsData on infectious disease public health emergencies reported in Guangdong province from 2014 to 2023 were obtained from the Public Health Emergency Management Information System of the Chinese Center for Disease Control and Prevention. …”
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Integrative genomic analyses combined with molecular dynamics simulations reveal the impact of deleterious mutations of Bcl-2 gene on the apoptotic machinery and implications in ca... by Ghazi Elamin, Ghazi Elamin, Zhichao Zhang, Depika Dwarka, Kabange Kasumbwe, John Mellem, Nompumelelo P. Mkhwanazi, Paradise Madlala, Paradise Madlala, Mahmoud E. S. Soliman

“…Following 500 ns, MD simulations showed that these mutations caused a significant distortion in the protein conformational, protein-protein interactions (PPIs), and drug binding landscape compared to Bcl-2WT.ConclusionDespite being a predictive study, the findings presented in this report would offer a perspective insight for further experimental investigation, rational drug design, and cancer gene therapy.…”
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Overexpression of miR-124 enhances the therapeutic benefit of TMZ treatment in the orthotopic GBM mice model by inhibition of DNA damage repair by Yuchen Wei, Peng Wang, Jianhui Zhao, Xin Fan, Jun Jiang, Xiuli Mu, Yuzhou Wang, Angang Yang, Rui Zhang, Shijie Hu, Zhangyan Guo

“…Taken together, we rationally explained a novel and important mechanism of the miR-124-mediated high sensitivity to TMZ-induced cell death in GBM and provided evidence to support that miR-124-RAD51 regulatory axis could be a promising candidate in the comprehensive treatment with TMZ in GBM.…”
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CADD-based discovery of novel oligomeric modulators of PKM2 with antitumor activity in aggressive human glioblastoma models by Maia Cabrera, Romina Armando, Ian Czarnowski, Patricio Chinestrad, Ramiro Blanco, Alejandra Zinni, Daniel Gómez, Diego L. Mengual Gómez, Pablo Lorenzano Menna

“…These effects were directly linked to their inhibition of PKM2 enzymatic activity, validating the proposed mechanism of action in their rational design. ADMET studies further highlighted their strong potential as lead PKM2 inhibitors for GBM treatment.Molecular dynamics (MD) simulations and post-MD analyses, including Dynamic Cross-Correlation Maps (DCCM), Probability Density Function (PDF), and Free Energy Landscape (FEL), confirmed the stability of the protein-ligand interactions and highlighted critical residues at the dimer-dimer interface. …”
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Isolation, purification, structural characteristic and antioxidative property of polysaccharides from A. cepa L. var. agrogatum Don by Hongcheng Liu, Hongxiu Fan, Jing Zhang, Shanshan Zhang, Wenting Zhao, Tingting Liu, Dawei Wang

“…These results provide a reference for further research and rational development of ALAP polysaccharides. Keywords: Polysaccharides, Allium cepa L. var. agrogatum Don, Structural characterization, Antioxidative property…”
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Exploring the effects of Tianma Gouteng granules on L-NAME-induced hypertensive rats based on 16S rDNA gene sequencing and metabolomics by Li Cheng, Zhenyang Huang, Jiawei He, Xinyi Zhang, Jiangxue Di, Hanmei Jiang, Yi Liu

“…Conclusions: TG can treat hypertension by affecting differential strains and differential metabolites, providing a scientific basis for guiding the rational use of TG.…”
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Evaluating the Accessibility of Urban Public Open Spaces Based on an Improved 2SFCA Model: A Case Study Within Chengdu’s Second Ring Road by Ling Jian, Xiaojiang Xia, Yinbing Zhao, Yang Zhang, Yuanqiao Wang, Yi Tang, Jie Chang, Changliu Wang

“…The rational allocation of urban public open spaces (UPOS) is critical for creating a livable urban environment. …”
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Integrating biodiversity assessments into local conservation planning: the importance of assessing suitable data sources by Ferraille, Thibaut, Kerbiriou, Christian, Bigard, Charlotte, Claireau, Fabien, Thompson, John D.

“…Finally, we propose a workflow to guide SEA stakeholders through the process of data rationalization and use in conservation planning. …”
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Structure of Spatial Correlation Network and Influencing Factors of Urban-Rural Integration in China by Wang Kai, Liu Meilun, Tan Jiaxin, Gan Chang

“…In practice, optimizing interprovincial urban-rural interaction and promoting cross-regional urban-rural integration development in a scientific and rational way are highly significant.…”
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Opportunities for Prevention of Complications in Intestinal Stoma Surgery by V. S. Groshilin, V. D. Kuznetsov, D. V. Kuznetsov, A. A. Pogosyan

“…In group 1 (n = 25) the developed therapeutic and diagnostic algorithm was applied, which included a rational choice of the colostomy localization site, taking into account individual features of the anterior abdominal wall structure, the quality of vascularity of the ostomy intestine, the terminal portion of its mesentery, the length and topography of the end section. …”
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Identification and characterization of the functional tetrameric UDP-glucose pyrophosphorylase from Klebsiella pneumoniae by Isabel Ramón Roth, Pavel Kats, Timm Fiebig, Françoise Routier, Roman Fedorov, Larissa Dirr, Jana I. Führing

“…UGPs have, therefore, gained attention as anti-bacterial drug target candidates, prompting us to study their structure-function relationships to provide a basis for the rational development of specific inhibitors. UGP function is tied to its oligomeric state, and the majority of bacterial homologs have been described as tetramers encoded by the galU gene. …”
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An Integrated Stacking Ensemble Model for Natural Gas Purchase Prediction Incorporating Multiple Features by Junjie Wang, Lei Jiang, Le Zhang, Yaqi Liu, Qihong Yu, Yuheng Bu

“…It not only facilitates the rational allocation of resources for companies but also helps to reduce operational costs. …”
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Frequencies and ethnic distribution of ABO and RhD blood groups in China: a population-based cross-sectional study by Min Liu, Jue Liu, Shikun Zhang, Qiaomei Wang, Haiping Shen, Yiping Zhang

“…The diversity in the distribution of the ABO and RhD blood groups in different ethnic groups should be considered when developing rational and evidence-based strategies for blood collection and management.…”
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Share Capital Management in the Context of Ensuring Competitive Advantages of the Retail Business Entity by A. S. Dyadin, N. V. Bobro

“…It has been demonstrated that it is possible to determine the most rational ratio of capital indicators calculated on the basis of factors of influence, risks and practical experience that brings the target capital structure as close as possible to its optimal value. …”
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Effects of yeast culture on growth performance, antioxidant capacity, immune function, and intestinal microbiota structure in Simmental beef cattle by Xueqiang Li, Xueqiang Li, Nan An, Nan An, Hui Chen, Hui Chen, Dacheng Liu, Dacheng Liu

“…This paper aimed to evaluate the effects of yeast culture (YC) on the growth performance, antioxidant capacity, immune function, and intestinal microbiota structure in beef cattle.MethodsForty Simmental bulls were randomly divided into two groups, including the control group fed with Total mixed ration (TMR) and YC group fed with TMR supplemented with 2% YC, for 60 days. …”
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A high fraction of inspired oxygen does not mitigate atelectasis-induced lung tissue hypoxia or injury in experimental acute respiratory distress syndrome by Kentaro Tojo, Takuya Yazawa

“…Our results indicate that raising FIO2 levels to attenuate atelectasis-induced lung injury cannot be rationalized.…”
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