Transcriptional Systems Vaccinology Approaches for Vaccine Adjuvant Profiling by Diogo Pellegrina, Heather L. Wilson, George K. Mutwiri, Mohamed Helmy

“…However, the detailed mechanisms of how adjuvants enhance immune responses remain poorly understood and may be a barrier that reduces the rational selection of vaccine components. Previous studies on mechanisms of action of adjuvants have focused on how they activate innate immune responses, including the regulation of cell recruitment and activation, cytokine/chemokine production, and the regulation of some “immune” genes. …”
Get full text

Inheritance of scald resistance in four barley landraces by G. S. Konovalova, E. E. Radchenko

“…Therefore, the most rational plant breeding strategy should envisage broadening of genetic diversity of cultivated varieties. …”
Get full text

Why is it so difficult to understand why we don’t understand human systemic lupus erythematosus? Contemplating facts, conflicts, and impact of “the causality cascade paradigm”... by Ole Petter Rekvig, Ole Petter Rekvig

“…The focus for the present discussion is basically how we, by critical hypotheses, can re-consider science-based selection of SLE classification criteria in order to delimitate and rationalize SLE. Classification criteria, autoimmunity, DNA structures, and anti-dsDNA antibodies are integrated aspects in this discussion.…”
Get full text

Public security in the pre-classical political and legal thought of ancient Greece by Y. O. Zahumenna

“…It is proved that the ancient political and legal doctrines, which comprehend public safety, have the following main features: its nationalization (elevation of the state and its institutions in guaranteeing this security), personalization (close dependence of personal security on public, sometimes even raising personal security over public), universalization (security as a phenomenon of the space world order, general Hellenic security), rationalization (discursive understanding of public security issues), legalization (transfer of public security issues to the plane of its legal support, which becomes imperative, mandatory compliance with polis laws, a system of severe penalties for offenses in the field of public safety, law and order in society and the state), indefiniteness of the actual state and public security (which was due to the polis nature of the state system), axiologization (security as a high human and social value, as a good, as an integral element of the polis worldview and ensuring the proper organization of polis life), polymorphism (breadth of spectrum of public security and specification of its “images” in philosophy, poetry, historiography, rhetoric, etc.). …”
Get full text

Regarding the improvement of organizational and legal regulation of relations in the sphere of protection and use of the animal world and combating poaching during the period of ma... by I. D. Kazanchuk

“…In particular, these are: the proper organization of state administration in the field of protection and use of the animal world; the strengthening the responsibility of citizens and officials for violating the basic requirements and rules of rational use and reproduction of the animal world; the presence of an effective organizational and legal mechanism for the implementation of the rights and obligations of users of animal world objects; the joint actions of the State Environmental Inspection and the Water Police regarding the protection, reproduction and use of rare and endangered animals; the keeping state records of animals and records of their production; the implementation of state and public control in the field of protection, use and reproduction of the animal world; the introduction of new organizational and legal forms and methods of interaction of authorized state bodies and other subjects of combating offenses in the field of animal protection, increasing control over the quality of their implementation; the development of legal eco-education and a system of crime prevention measures; the introduction of modern mechanisms of analytical and logistical support of law enforcement agencies.…”
Get full text

Does the Harvesting Site Influence the Osteogenic Potential of Mesenchymal Stem Cells? by Van Thi Nguyen, Irene Tessaro, Antonio Marmotti, Camilla Sirtori, Giuseppe M. Peretti, Laura Mangiavini

“…To our knowledge, this is the first study comparing and demonstrating that the progenitor cells obtained from diverse surgical sites in hip replacement procedure share common characteristics of MSC but differ about plasticity and may provide rational for clinical application in cell therapy and bone grafting. …”
Get full text

The Law of Fracture Evolution of Overlying Strata and Gas Emission in Goaf under the Influence of Mining by Cheng Cheng, Xiaoyu Cheng, Rui Yu, Wenping Yue, Chao Liu

“…The simulation results were used to explore the law of distribution of pressure relief gas in goaf. Rational parameters of the high-level directional long borehole for the pressure relief gas extraction in goaf were designed based on experimental results. …”
Get full text

Development of a Small-Working-Volume Plunger Hydraulic Pump with Improved Performance Characteristics by Alexey N. Beskopylny, Denis Medvedev, Vyacheslav Grishchenko, Evgeniy Ivliev

“…The developed pump has more rational characteristics compared to existing alternatives for use in water supply systems for induction superheaters. …”
Get full text

PHILOSOPHICAL IDEAS IN SPIRITUAL CULTURE OF THE INDIGENOUS PEOPLES OF NORTH AMERICA by S. V. Rudenko, Y. A. Sobolievskyi

“…The philosophical tradition is characterized by rational argumentation and formulation of philosophical questions that differ from the questions of ordinary language. …”
Get full text

THE RISK-ORIENTED APPROACH TO THE DEVELOPMENT OF CONTROL METHOD by P. S. Serenkov, V. L. Hurevich, M. R. Movlamov, A. S. Yetumya

“…The analysis is carried out on the basis of both theoretical and experimental statistical studies on a number of construction projects.According to the results of the analysis of all particular risks of control unreliability, rational ways of their minimization in the form of technical or organizational and technical measures, which are refl in the developed project of the control method, are proposed. …”
Get full text

Investigation of Fe-Doped Graphitic Carbon Nitride-Silver Tungstate as a Ternary Visible Light Active Photocatalyst by Eid H. Alosaimi, Nadia Azeem, Noor Tahir, Asim Jilani, Muhammad Zahid, Salman. S. Alharthi, Javed Iqbal, Muhammad Yaseen, Zulfiqar Ahmad Rehan, Imran Shahid

“…Graphitic carbon nitride alone or in combination with various other semiconductor metal oxide materials acts as a competent visible light active photocatalyst for the removal of recalcitrant organic pollutants from wastewater. Rational designing of an environment-friendly photocatalyst through a facile synthetic approach encounters various challenges in photocatalytic technologies dealing with semiconductor metal oxides. …”
Get full text

Assessment of the stocks and forecast of the catches of bream (Abramis brama Linnaeus, 1758), common carp (Cyprinus carpio Linnaeus, 1758), roach (Rutilus rutilus Linnaeus, 1758),... by O. Marenkov, O. Nesterenko, I. Borovyk, M. Shmahailo, A. Hamolin

“…The study showed changes in the structure of populations and fish productivity of the reservoir, which allowed us to offer recommendations for the rational use of aquatic biological resources and ensuring the stability of the exploitation of ichthyofauna. …”
Get full text

Plasma brain-related biomarkers and potential therapeutic targets in pediatric ECMO by Sue J. Hong, Bradley J. De Souza, Kristen K. Penberthy, Lisa Hwang, David E. Procaccini, John N. Kheir, Melania M. Bembea

“…Components of the neurovascular unit have been rational targets for this inquiry in ECMO. Central nervous system (CNS) neuronal and astroglial cellular-derived neuron-specific enolase (NSE), tau, glial fibrillary acidic protein (GFAP) and S100β elevations have been detected in ABI and are associated with poorer outcomes. …”
Get full text

Application of the weighted histogram method for calculating the thermodynamic parameters of the formation of oligodeoxyribonucleotide duplexes by I. I. Yushin, V. M. Golyshev, D. V. Pyshnyi, A. A. Lomzov

“…This work opens up new horizons for a rational design of constructs based on NAs for solving problems in biomedicine and biotechnology.…”
Get full text

Alkaloids of narrow-leaved lupine as a factor determining alternative ways of the crop’s utilization and breeding by M. A. Vishnyakova, A. V. Kushnareva, T. V. Shelenga, G. P. Egorova

“…At the same time, it is rational to create highly alkaloid (bitter) varieties for green manure, while food and feed varieties should not lose their adaptive potential, in particular, resistance to pathogens, due to the elimination of alkaloids. …”
Get full text

The position of Lithuanian parties towards Poland in 1920-1926: from modus vivendi to permanent confrontation by Andrius Grodis

“…However, the attitude of the Christian Democrats that it was possible to launch economic relationships with Poland, and the Social Democrats' belief that it was even crucial to do so, which were regarded as a first step in resuming Vilnius, in fact reflected that the leaders of the parties had enough rational reasoning as well as a mature attitude to international relations. …”
Get full text

Comparison of the factors that influence the pattern of procurement and usage of antithrombotic drugs by Mohamed Mansor Manan, Aswani Yanti Baharudin, Qi Ying Lean, Jagjit Singh Dhaliwal, Sachinjeet Kaur Sodhi Dhaliwal, Muhammad Junaid Farrukh, Ching Siang Tan, Long Chiau Ming

“…It is a tool to update the changing or even new pattern of drug usage, which will assist in the justification of rational use of drugs. The mean difference in terms of DDDs of the studied antithrombotic drugs impacts patient demographic characteristics, smoking history, presence of atherosclerotic diseases and peripheral artery diseases, comorbidity, patient compliance, and bleeding history. …”
Get full text

Pathogenetic therapeutic approaches for endocrine diseases based on antisense oligonucleotides and RNA-interference by Olga Golounina, Ildar Minniakhmetov, Ramil Salakhov, Rita Khusainova, Ekaterina Zakharova, Igor Bychkov, Natalia Mokrysheva

“…RNA-targeted therapy can precisely modulate the function of target RNA with minimal off-target effects and can be rationally designed based on sequence data. ASOs and siRNA-based drugs have unique capabilities for using in target groups of patients or can be tailored as patient-customized N-of-1 therapeutic approach. …”
Get full text

Assessment of the Efficiency of Thermal Waste Regeneration in the Blown Impassable Channels of Heating Mains by V. A. Sednin, T. V. Bubyr

“…To solve the problem of increasing the energy efficiency of thermal networks with heat pipelines located in impassable channels, a schematic and structural solution for the rational utilization of thermal waste generated during the transport of thermal energy has been developed. …”
Get full text

Study on Key Influencing Factors of Carbon Emissions from Farmland Resource Utilization in Northeast China Under the Background of Energy Conservation and Emission Reduction by Mulin Sun, Yuhao Fu, Mingyao Sun, Run Huang, Yun Teng

“…Under the background of energy conservation and emission reduction, how to rationally and scientifically utilize the non-renewable resources of northeastern farmland is particularly important. …”
Get full text