Presynaptic CRF1 Receptors Mediate the Ethanol Enhancement of GABAergic Transmission in the Mouse Central Amygdala by Zhiguo Nie, Eric P. Zorrilla, Samuel G. Madamba, Kenner C. Rice, Marissa Roberto, George Robert Siggins

“…These data indicate that presynaptic CRF1 receptors play a critical role in permitting or mediating ethanol enhancement of GABAergic synaptic transmission in CeA, via increased vesicular GABA release, and thus may be a rational target for the treatment of alcohol abuse and alcoholism.…”
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Empirical Analysis of the Impact of the Internet on Social Trust in Chinese Provinces during 2016-2020 by Li Zhengrong, Guo Mengyao, Wang Fang

“…This study has significant implications for the scientifically sound and rational utilization of the positive role of the Internet as well as for balancing the development of information technology with social progress. …”
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Combinatorial functionomics identifies HDAC6-dependent molecular vulnerability of radioresistant head and neck cancer by Sharon Pei Yi Chan, Celestia Pei Xuan Yeo, Boon Hao Hong, Evelyn Mui Cheng Tan, Chaw Yee Beh, Eugenia Li Ling Yeo, Dennis Jun Jie Poon, Pek Lim Chu, Khee Chee Soo, Melvin Lee Kiang Chua, Edward Kai-Hua Chow

“…In this study, we utilized a combinatorial functionomics approach, the Quadratic Phenotypic Optimization Platform (QPOP), to rationally design drug pairings that exploit the molecular fingerprint and vulnerability of established in vitro isogenic radioresistant (RR)-HNC models. …”
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Spatial-Temporal Changes and Influencing Factors of Regional Technological Innovation Efficiency in China: A Three Entity Comparative Perspective by Ye Lei, Zhang Ting, Cao Xianzhong, Zeng Gang

“…Our findings provide a basis for the rational allocation of technological innovation resources and the optimization of the regional innovation environment.…”
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Effects of Long-Term Nitrogen Fertilization on Nitrous Oxide Emission and Yield in Acidic Tea (<i>Camellia sinensis</i> L.) Plantation Soils by Fuying Jiang, Yunni Chang, Jiabao Han, Xiangde Yang, Zhidan Wu

“…This study offers a theoretical foundation for developing rational N fertilizer management practices and strategies aimed at reducing N₂O emissions in tea-plantation soils.…”
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Effect of different diets on the fatty acid composition of buffalo bulk milk by Sebastiana Failla, Giuliano Palocci, Michela Contò, Gianluca Renzi, Chiara Evangelista, Loredana Basiricò, Umberto Bernabucci

“…The basic diet of each group was supplemented with different components representing about 3% in dry matter of total ration. The basic diet (B) comprised maize silages, alfalfa hay, corn grain, and soybean as concentrates. …”
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Designing host-associated microbiomes using the consumer/resource model by Germán Plata, Karthik Srinivasan, Madan Krishnamurthy, Lukas Herron, Purushottam Dixit

“…ABSTRACT A key step toward rational microbiome engineering is in silico sampling of realistic microbial communities that correspond to desired host phenotypes, and vice versa. …”
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Guidance for the gastrointestinal evaluation and management of iron deficiency in Sub-Saharan Africa by W M Simmonds, Y Awuku, C Barrett, M Brand, K Davidson, D Epstein, E Fredericks, S Gabriel, S Grobler, C Gounden, L Katsidzira, V J Louw, V Naidoo, C Noel, E Ogutu, N Ramonate, N Seabi, M Setshedi, J Van Zyl, G Watermeyer, C Kassianides

“…Recommendations have been developed to: (i) aid clinicians in the evaluation of suspected gastrointestinal iron loss and iron malabsorption, and often a combination of these; (ii) improve clinical outcomes for patients with gastrointestinal causes of ID; (iii) provide current, evidence-based, context-specific recommendations for use in the management of ID; and (iv) conserve resources by ensuring rational utilisation of blood and blood products. …”
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Effect of different diets on the fatty acid compo- sition of buffalo bulk milk by Sebastiana Failla, Giuliano Palocci, Michela Contò, Gianluca Renzi, Chiara Evangelista, Loredana Basiricò, Umberto Bernabucci

“…They were provided as a total mixed ratio where different components (about 3% in dry matter of total ration) were added to the essential diet for each group: basic diet (B) was composed of maize silages, alfalfa hay, corn grain, and soybean as concentrates, the second diet contained linseed as an additional constituent to B (L), another brewer’s spent grain (T), additional alfalfa and mixed hay (H), additional corn grain (M), grass (G); other farms included in B diet both grass and cottonseed (CG), grass and linseed (GL) or grass and brewer’s spent grain (TG) and at last grass linseed and brewer’s spent grain (LTG). …”
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Perspektywiczne kierunki rozwoju biologii człowieka w Polsce, ze szczególnym uwzględnieniem auksologii by Napoleon Wolański, Anna Siniarska

“…After that the process of rational cognition (theory) takes place, and innovative theories propagate the “science” development. …”
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Temporal changes in plasma and milk lipids in response to an esophageal bolus of rumen-protected fish oil in lactating Holstein dairy cows by J.E. Rico, V. Sáinz de la Maza-Escolà, N.D. Senevirathne, P. Deme, N.J. Haughey, R. Gervais, J.W. McFadden

“…Cows were fed a total mixed ration to meet or exceed nutrient requirements and were milked thrice daily. …”
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Outcome and Management of Sepsis at RozhHalat Emergency Hospital in Erbil –Kurdistan region of Iraq by Samir Qader Ahmad, Shakawan Muhamad Ismaeel, Dara Ahmed Mohammed Ahmed Mohammed, Halgurd Fathulla Ahmed

“…The mean age was 47 with male to female ration of 2:3 (42% male and 58% female). The overall mortality rate was high at 68% with higher rate among female and older age group. …”
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PRACTICAL TRAINING OF OFFICERS OF THE STATE FIRE SERVICE THROUGH GAME-BASED LEARNING by V. V. Bulgakov, A. A. Lazarev, E. P. Konovalenko, T. A. Mochalova

“…The proposed methodological tool has shown promise in more rational redistribution of teaching time and expansion of the base of practical modules for designing business games for the purpose of development of new relevant professional competencies in students.…”
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Effect of Arthrospira platensis (Spirulina) as a dietary supplement during transition period in dairy buffaloes by Giuseppe De Rosa, Vittoria L. Barile, Carmela M.A. Barone, Claudia Lambiase, Francesco Serrapica, Giovanna De Matteis, Emanuela Rossi, Corrado Pacelli

“…The animals were equally divided into two groups (control=C and Spirulina=S) fed with the same total mixed ration. In top dressing mode, the S group additionally received 50 g/head/d of freeze-dried Spirulina for one month before calving and 100 g/head/d for 90 d after calving. …”
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Sustainability assessment of animal feed production from by-products of Sago palm smallholder industry by Allaily ., A.D. Santoso, M.N. Rofiq, N.A. Sasongko, H. Daulay, E.I. Wiloso, E. Widjaja, B.N. Utomo, A.I. Yanuar, S. Suryani, Y.P. Erlambang, U.N. Thiyas, D. Iskandar, A. Anhar, M. Rahmawati, T. Simamora, Y. Yusriani, G. Maghfirah, M. Ammar

“…Furthermore, it is important to increase the use of Sago pulp as animal feed to improve the substitution of commercial rations usage, and facilitate sustainability value of the economic dimension. …”
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Development of a Comprehensive Fall Risk Assessment Tool for Older People in Elderly Care Institutions and Its Test by LUO Yuan, ZHANG Hua, WANG Sanxiang, ZHANG Mengxi, DENG Yuqian, RAN Haiye, LIU Jiaxin, ZHANG Yi, CHEN Xi, WU Yibo, ZHAO Liping

“…The correlation coefficient method, critical ration, internal consistency test and exploratory factor analysis were used for item analysis and screening. …”
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Analisis Asosiasi Untuk Menemukan Pola Pada Terapi Obat Pasien Dengan Menggunakan Metode Apriori by Evi Dewi Sri Mulyani, Teuku Mufizar, Sarmidi Sarmidi, Cepi Rahmat Hidayat, Dede Syahrul Anwar, Rofi Chaeruddin

“…Abstract   Drug Therapy Monitoring (PTO) is a process that includes a process of activities to ensure drug therapy for patients is safe, effective and rational. The dataset was obtained from the Nabila Clinic which contains health services such as checking the patient's condition, giving actions, and administering drugs according to doctor's prescriptions. …”
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Predictors of Unfavorable Outcomes in Patients with Atrial Fibrillation and Concomitant Heart Failure with Different Ejection Fractions: RIF-CHF Register One-Year Follow-Up by Igor Zhirov, Natalia Safronova, Yulia Osmolovskaya, Alina Alshevskaya, Andrey Moskalev, Sergey Tereshchenko

“…AF + HFpEF patients were significantly older than patients in two other groups (40.6% of patients were older than ≥75 years vs. 24.8%, respectively, p<0.001) and had the lowest rate of prior myocardial infarctions (25.3% vs. 46.1%, p<0.001) and the lowest adherence to rational therapy of HF (27.4% vs. 47.1%, p<0.001). …”
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Chemical Synthesis, Efficacy, and Safety of Antimalarial Hybrid Drug Comprising of Sarcosine and Aniline Pharmacophores as Scaffolds by Jean Baptiste Niyibizi, Peter G. Kirira, Francis T. Kimani, Fiona Oyatsi, Joseph K. Ng’ang’a

“…Covalent bitherapy is a rational and logical way of drug design which entails joining a couple of molecules with individual intrinsic action into a unique agent, hence packaging dual activity into one hybrid. …”
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Construction of the mathematical model of the strength of post-consumer wood made blockboard of different designs by Serhiy Gayda, Lyubomyr Medvid

“…It is substantiated that any wood resources should be used rationally and comprehensively, in particular this applies to wood residues from various stages of primary wood processing – from logging to the creation of finished products. …”
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