Development and Validation of a Nomogram for Predicting Long-Term Net Adverse Clinical Events in High Bleeding Risk Patients Undergoing Percutaneous Coronary Intervention by Junyan Zhang, Zhongxiu Chen, Ran Liu, Yuxiao Li, Hongsen Zhao, Yanning Li, Minggang Zhou, Hua Wang, Chen Li, Li Rao, Yong He

“…Methods: We prospectively enrolled PCI-HBR patients from May 2022 to April 2024 at West China Hospital of Sichuan University. The cohort was randomly divided into training and internal validation sets in a ratio of 7:3. …”
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Knowledge, attitudes and practices of healthcare workers towards COVID-19 in three states of Nigeria in 2022 by Alash’le Abimiku, Nifarta Andrew, Elima Jedy-Agba, Rita Okonkwo, Olumide Okunoye, Oyewole Oyedele, Martin Edun, Ugochi Ezenwelu, Asmau Aminu-Alhaji, Aondoakura Kombu, Timothy Attah, Jibreel Jumare, Kenneth Enwerem, Sophia Osawe, Victor Ejeh, Michaela Udioh, Okame Okah-Avae, Elonna Obak, Olusola Anuoluwapo Akanbi, Mary Okoli, Nnaemeka C Iriemenam, McPaul Okoye

“…HCWs were selected using a stratified random sampling technique. A structured questionnaire including sociodemographic and health information, and KAP sections was administered to participants. …”
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LcProt: Proteomics‐based identification of plasma biomarkers for lung cancer multievent, a multicentre study by Hengrui Liang, Runchen Wang, Ran Cheng, Zhiming Ye, Na Zhao, Xiaohong Zhao, Ying Huang, Zhanpeng Jiang, Wangzhong Li, Jianqi Zheng, Hongsheng Deng, Yu Jiang, Yuechun Lin, Yun Yan, Lei Song, Jie Li, Xin Xu, Wenhua Liang, Jun Liu, Jianxing He

“…Feature selection was performed using differential expressed protein analysis, area under curve (AUC) evaluation and least absolute shrinkage and selection operator (LASSO) regression. Random forest was used for multitask model construction based on the key proteins. …”
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The effects of ultra-selective beta1-antagonism on the metabolic and cytokine profile in septic shock patients receiving noradrenaline: a sub-investigation from the STRESS-L Random... by Jarrod L. Thomas, Kirsty C. McGee, Anower Hossain, Gavin D. Perkins, Anthony C. Gordon, Duncan Young, Danny McAuley, Mervyn Singer, Ranjit Lall, Tina Kramaric, Janet M. Lord, Tony Whitehouse, Luis A. J. Mur, for the STRESS-L. collaborators

“…The individual-level models were adjusted for confounders, such as age, sex, noradrenaline dosage and patient (random effect). Results Analysis was undertaken at cluster- and individual-level. …”
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Effectiveness of using implementation frameworks to facilitate the implementation of a stroke management guideline in the traditional Chinese medicine hospitals in China: protocol... by Zhuo Chen, Yefeng Cai, Wenjun He, Yiyuan Cai, Lingrui Liu, Qing Zhao, Sensen lv, Dong (Roman) Xu, Chun Hao, Lanping Zhang, Pengfei Guo, Yuning Shi

“…This study aims to evaluate the effectiveness of three popular frameworks—Consolidated Framework for Implementation Research (CFIR), Theoretical Domains Framework (TDF) and Normalization Process Theory (NPT)—in improving implementation outcomes for the integrated TCM and Western medicine clinical practice guideline for stroke management.Methods and analysis This study employs a hybrid type III design with a factorial randomised controlled trial, where 45 TCM hospitals will be randomly assigned to one of eight experimental conditions based on the use or non-use of each framework (CFIR, TDF, NPT). …”
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Investigating the impact of microbiome-changing interventions on food decision-making: MIFOOD study protocol by Meghedi Vartanian, Konrad Jakob Endres, Yee Teng Lee, Silke Friedrich, Marie-Theres Meemken, Imke Schamarek, Kerstin Rohde-Zimmermann, Robin Schürfeld, Lina Eisenberg, Anja Hilbert, Frauke Beyer, Michael Stumvoll, Julia Sacher, Arno Villringer, Julia F. Christensen, A. Veronica Witte

“…We therefore aim to examine the effects of prebiotic and neurocognitive behavioral interventions on food decision-making and to assay the underlying mechanisms in a Randomized Controlled Trial (RCT). Method This study uses a parallel arm RCT design with a 26-week intervention period. …”
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Factors associated with attention-deficit/hyperactivity disorder among Tunisian children by Asma Guedria, Asma Guedria, Asma Guedria, Mohamed Guedria, Manel Ben Fredj, Manel Ben Fredj, Randaline Ayoub, Randaline Ayoub, Randaline Ayoub, Hela Ben Abid, Hela Ben Abid, Hela Ben Abid, Ahmed Mhalla, Ahmed Mhalla, Ahmed Mhalla, Hela Slama, Hela Slama

“…The second group included 80 healthy control children. They were randomly selected and matched for age and gender. A literature-based questionnaire assessing the socio-demographic data, biological and environmental factors associated with ADHD was administered to the parents. …”
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Lung function and onset of cardiometabolic diseases in the longitudinal Burden of Obstructive Lung Disease study by Andre F S Amaral, Andrzej Pająk, Thorarinn Gislason, Syed Masud Ahmed, Rain Jogi, Abdul Rashid, Christine Jenkins, Fiona McLean, James Potts, Tobias Welte, Dali Wang, Eric Bateman, Wen Wang, Zafar Fatmi, Kevin Mortimer, Christer Janson, Nanshan Zhong, João Cardoso, Parvaiz A Koul, Rune Nielsen, Nazrul Islam, Graham Devereux, Andrei Malinovschi, Sanjay Juvekar, Talant Sooronbaev, Berik Emilov, Bertrand Mbatchou, Ayola Akim Adegnika, Padukudru Anand Mahesh, Kate Hardaker, EFM Wouters, Imed Harrabi, Amund Gulsvik, Sundeep Salvi, Muhammad Irfan, Bill Brashier, Inga Sif Ólafsdóttir, Zouhair Tabka, Peter G J Burney, Jaymini Patel, Filip Mejza, David M Mannino, Meriam Denguezli, Michael Studnicka, Althea Aquart-Stewart, Parvaiz Koul, Herve Lawin, Asaad Ahmed Nafees, Olayemi Awopeju, Gregory E Erhabor, Louisa Gnatiuc, Ali Kocabas, Cristina Barbara, Hasan Hafizi, Anila Aliko, Donika Bardhi, Holta Tafa, Natasha Thanasi, Arian Mezini, Alma Teferici, Dafina Todri, Jolanda Nikolla, Rezarta Kazasi, Hamid Hacene Cherkaski, Amira Bengrait, Tabarek Haddad, Ibtissem Zgaoula, Maamar Ghit, Abdelhamid Roubhia, Soumaya Boudra, Feryal Atoui, Randa Yakoubi, Rachid Benali, Abdelghani Bencheikh, Nadia Ait-Khaled, Guy Marks, Tessa Bird, Paola Espinel, Brett Toelle, Torkil Dawes, Bernd Lamprecht, Lea Schirhofer, Akramul Islam, Shayla Islam, Qazi Shafayetul Islam, Mesbah Ul-Haque, Tridib Roy Chowdhury, Sukantha Kumar Chatterjee, Dulal Mia, Shyamal Chandra Das, Mizanur Rahman, Shahaz Uddin, Nurul Islam, Luiza Khatun, Monira Parvin, Abdul Awal Khan, Maidul Islam, Arsene Kpangon, Karl Kpossou, Gildas Agodokpessi, Paul Ayelo, Benjamin Fayomi, Atongno Humphrey Ashu, Wan C Tan, Shengming Liu, Jiachun Lu, Pixin Ran, Yumin Zhou, Hendrik Laja, Katrin Ulst, Vappu Zobel, Toomas-Julius Lill, Isabelle Bodemann, Henning Geldmacher, Bryndis Benedikdtsdottir, Kristin Jörundsdottir, Lovisa Gudmundsdottir, Sigrun Gudmundsdottir, Mahesh Rao, Sajjad Malik, Nissar A Hakim, Umar Hafiz Khan, Rohini Chowgule, Vasant Shetye, Jonelle Raphael, Rosel Almeda, Mahesh Tawde, Rafiq Tadvi, Sunil Katkar, Milind Kadam, Rupesh Dhanawade, Umesh Ghurup, Siddhi Hirve, Somnath Sambhudas, Bharat Chaidhary, Meera Tambe, Savita Pingale, Arati Umap, Archana Umap, Nitin Shelar, Sampada Devchakke, Sharda Chaudhary, Suvarna Bondre, Savita Walke, Ashleshsa Gawhane, Anil Sapkal, Rupali Argade, Vijay Gaikwad, Jyoti Londhe, Sapna Madas, Akosua Francia Aikman, Meerim Akmatalieva, Saadat Usenbaeva, Jypara Kydyrova, Eliza Bostonova, Ulan Sheraliev, Nuridin Marajapov, Nurgul Toktogulova, Toktogul Azilova, Gulnara Beishekeeva, Nasyikat Dononbaeva, Aijamal Tabyshova, Wezzie Nyapigoti, Ernest Mwangoka, Mayamiko Kambwili, Martha Chipeta, Gloria Banda, Suzgo Mkandawire, Justice Banda, Li-Cher Loh, Siti Sholehah, Mohamed C Benjelloun, Chakib Nejjari, Mohamed Elbiaze, Karima El Rhazi, Daniel Obaseki, Gregory Erhabor, Olufemi Adewole, Tina Endresen, Lene Svendsen, Asaad A Nafees, Aysha Zahidie, Natasha Shaukat, Meesha Iqbal, Luisito F Idolor, Norberto A Francisco, Camilo C Roa, Fernando G Ayuyao, Cecil Z Tady, Daniel T Tan, Sylvia Banal-Yang, Vincent M Balanag, Renato B Dantes, Lourdes Amarillo, Lakan U Berratio, Lenora C Fernandez, Gerard S Garcia, Teresita S de Guia, Thessa Reyes, Leander P Simpao, Jakub Frey, Rafal Harat, Pawel Nastalek, Wojciech Skucha, Andrzej Szczeklik, Magda Twardowska, Fátima Rodrigues, Hermínia Dias, João Almeida, Maria João Matos, Paula Simão, Moutinho Santos, Reis Ferreira, H Alorainy, E El-Hamad, A Hashi, R Dela, R Fanuncio, E Doloriel, I Marciano, Anamika Jithoo, Desiree Adams, Edward Barnes, Jasper Freeman, Anton Hayes, Sipho Hlengwa, Christine Johannisen, Mariana Koopman, Innocentia Louw, Ina Ludick, Alta Olckers, Johanna Ryck, Janita Storbeck, Kirthi Gunasekera, Rajitha Wickremasinghe, Asma Elsony, Hana A Elsadig, Nada Bakery Osman, Bandar Salah Noory, Monjda Awad Mohamed, Suhaiba Khalifa, Mahmoud Elhadi, Mohand Hassan, Dalia Abdelmonam, Katarina Nisser, Gunilla Hägg, Terence Seemungal, Fallon Lutchmansingh, Liane Conyette, Myriam Denguezli, Hager Daldoul, Zaki Boukheroufa, Firas Chouikha, Wahbi Belhaj Khalifa, Attila Hancioglu, Ismail Hanta, Sedat Kuleci, Ahmet Sinan Turkyilmaz, Sema Umut, Turgay Unalan, Peter GJ Burney, Hadia Azar, Caron Amor, Michael Tumilty, Risha Dudhaiya, A Sonia Buist, Mary Ann McBurnie, William M Vollmer, Suzanne Gillespie, Sean Sullivan, Todd A Lee, Kevin B Weiss, Robert L Jensen, Robert Crapo, Paul Enright, John Cain, Rebecca Copeland, Dana Hazen, Jennifer Methvin, Rana Ahmed, Ewa Niżankowska-mogilnicka, Sullian S Naval, Jin-Ping Zheng, Gunnar Gudmundsson, Ben Knox-Brown, Dhiraj Agarwal, M Al Hajjaj, L Safia, Namarig Mohamed Elhassan, Marwa Mohamed Mohamaden, Sanjay K Juvekar, Stefanni Nonna M Paraguas, Anders Ørskov Rotevatn, Alexandra SchwedaLinow, Talant M. Sooronbaev, Bermet M. Estebesova, GJ Wesseling, MariaTeresita N Reyes, Flordeliza Sanchez, MAl Ghobain, Hasab Alrasoul Akasha Ahmed Osman, Abdel Mu’is El Zain, Ulrike SpetzNystrom, GunMarie Lund

“…The association between lung function and the onset of participant-reported cardiometabolic diseases was assessed in each site using regression models, and estimates were combined using random effects meta-analysis. Models were adjusted for sex, age, smoking, body mass index and educational level.Results Participants with greater per cent predicted FVC were less likely to have new-onset diabetes (OR per 10%=0.91, 95% CI 0.84 to 0.99), heart disease (OR per 10%=0.86, 95% CI 0.80 to 0.92) and stroke (OR per 10%=0.81, 95% CI 0.73 to 0.89) during the follow-up period (mean±SD 9.5±3.6 years). …”
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Exploring the synergistic effect of rose distillation waste and biostimulant beside other organic amendments onRosa damascena seedlings’ growth by Soumia El Malahi, Lahcen Irahoui, Wafaa Mokhtari, Mounia Ennami, Houda Taimourya, Jamaa Zim, Abdallah Zayani, Bahija Zakeri, Khalid Dhassi, Mimoun Mokhtari, Lalla Mina Idrissi Hassani

“…Method: The data was collected experimentally in a controlled greenhouse condition.  A complete randomized block design with three replicates was applied to conduct the experimental units. …”
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Knowledge towards health impacts of climate change among Amhara Sayint community, Northeastern Ethiopia by Genanew Mulugeta Kassaw, Asmamaw Malede, Adinew Gizeyatu, Metadel Adane, Asha Embrandiri, Awoke Keleb, Gete Berihun, Abebe Kassa Geto, Belachew Tekleyohannes Wogayehu, Gebremeskel Kibret Abebe, Tibebu Habtie Zewde, Sisay Abebe Debela, Solomon Seyoum, Amana Ogeto Luke, Gashaw Wondaya, Atitegeb Abera Kide, Mekonnen Moges, Denise Metoyer, Mesfin Gebrehiwot

“…Design/methodology/approach – A community-based cross-sectional study was conducted from 20 July to 5 September 2022, involving 605 randomly selected households in Amhara Sayint district, Northeastern Ethiopia. …”
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The mechanism of tea tree oil regulating the damage of hydrogen sulfide to spleen and intestine of chicken by Yachao Wang, Yilei Liang, Yan Huang, Wei wang, Xiaoyan Long, Li Jiang, Tingting Cheng, Jinfeng Du, Xuegang Luo

“…A total of 240 one-day-old Lohmann Brown chicks were randomly divided into three groups: the control group (CON), the H2S exposure group (AVG), and the TTO treatment group (TTG), with four replicates, each consisting of 20 chicks. …”
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Immunomodulatory and anti-inflammatory potential of botanicals bioactive product (PHYTO AX'CELL™) for an improvement of the well-being of laying hens at the peak of production by Alessandro Guerrini, Roberta Salaroli, Augusta Zannoni, Giancarlo Avallone, Francesca Leone, Valentina Serra, Giulia Quaglia, Francesca del Zozzo, Thibaut Chabrillat, Claire Carlu, Caterina Lupini, Doriana Eurosia Angela Tedesco

“…In this study, 764 Lohmann LSL-White hens on the first day (d) of the 26th wk of age (T0), were randomly assigned to 2 replicated experimental groups, control and treated (n=382 each). …”
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Efficacy and cost-effectiveness of an ACT and compassion-based intervention for women with breast cancer: study protocol of two randomised controlled trials {1} by Inês A. Trindade, Andreia Soares, David Skvarc, Diogo Carreiras, Joana Pereira, Óscar Lourenço, Filipa Sampaio, Bruno de Sousa, Teresa C. Martins, Paula Boaventura, Joana Marta-Simões, Mind Project Team, Helena Moreira

“…Methods Participants will be women diagnosed with breast cancer randomly assigned to the Mind programme or a support group intervention (active control) in a 1:1 ratio for study 1, while study 2 includes one more arm (treatment as usual; inactive control) and a 2:2:1 ratio. …”
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Shi-Zhen-An-Shen Decoction, a Herbal Medicine That Reverses Cuprizone-Induced Demyelination and Behavioral Deficits in Mice Independent of the Neuregulin-1 Pathway by Chao Ma, Yan Wu, Xinyao Liu, Yi He, Yuan Jia, Pei Chen, Dongqing Yin, Yanzhe Ning, Guoqiang Xing, Zuoli Sun, Hongxiao Jia

“…Sixty male C57BL/6 mice were randomly divided into six groups (n=10 per group): (1) control group, (2) cuprizone (CPZ, a copper chelator that induced demyelination, 0.2% w/w)+saline, (3) CPZ+low-dose SZASD (8.65 g·kg-1·d-1), (4) CPZ+medium-dose SZASD (17.29 g·kg-1·d-1), (5) CPZ+high-dose SZASD (25.94 g·kg-1·d-1), and (6) CPZ+quetiapine (QTP, an atypical antipsychotic that served as a positive treatment control, 10 mg·kg-1·d-1). …”
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Effects of different monochromatic light on growth performance and liver circadian rhythm of Yangzhou geese by Yingqing Xu, Yi Tang, Yiyi Cheng, Wen Yang, Jie Liu, Binbin Guo, Gang Luo, Huanxi Zhu

“…A total of 144 male Yangzhou geese were randomly assigned to four groups based on light color, with each group consisting of 36 geese. …”
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Mechanism of salvianolic phenolic acids and hawthorn triterpenic acids combination in intervening atherosclerosis: network pharmacology, molecular docking, and experimental validat... by Qu Zhai, Shixi Shang, Zihan Zhang, Lihua Sun, Ying Huang, Shuyi Feng, Qian Wu, Haifeng Cui, Xiaolu Shi

“…The predictions were subsequently validated through the implementation of animal in vivo experiments. ApoE−/− mice were randomly assigned to three experimental groups, namely, a model group, an atorvastatin group, and an SHC group. …”
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Methodological challenges using routine clinical care data for real-world evidence: a rapid review utilizing a systematic literature search and focus group discussion by Michelle Pfaffenlehner, Max Behrens, Daniela Zöller, Kathrin Ungethüm, Kai Günther, Viktoria Rücker, Jens-Peter Reese, Peter Heuschmann, Miriam Kesselmeier, Flavia Remo, André Scherag, Harald Binder, Nadine Binder, for the EVA4MII project

“…Limitations of this type of data cited in the discussion sections were extracted and classified according to different bias types: main bias categories in non-randomized studies (information bias, reporting bias, selection bias, confounding) and additional routine data-specific challenges (i.e., operationalization, coding, follow-up, missing data, validation, and data quality). …”
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Viral load suppression rate of third-line antiretroviral therapy and its association with gender among HIV patients after second-line treatment failure in Africa: a systematic revi... by Tilahun Degu Tsega, Sintayehu Simie Tsega, Asaye Alamneh Gebeyehu, Getaneh Atikilt Yemata, Rahel Mulatie Anteneh, Almaw Genet Yeshiwas, Getasew Yirdaw, Chalachew Yenew, Anley Shiferaw Enawgaw, Amare Genetu Ejigu, Ahmed Fentaw Ahmed, Zeamanuel Anteneh Yigzaw, Berhanu Abebaw Mekonnen, Meron Asmamaw Alemayehu, Abathun Temesgen, Abebaw Molla, Habitamu Mekonen, Assefa Andargie Kassa, Gashaw Melkie Bayeh

“…Publication bias was checked using a funnel plot, Begg’s and Egger’s test, followed by the DerSimonian and Laird random effects model. Meta-regression, subgroup and sensitivity analyses were also performed. …”
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Risk factors for ocular biological parameters in Chinese preschool children: a cohort study from the Beijing whole childhood eye study by Xi Qin, Yunyun Sun, Yunyun Sun, Shana Wang, Xiaolan Xie, Lei Gao, Huijian Li, Huijian Li, Ruihua Wei, Jing Fu, Jing Fu, Bidan Zhu

“…Therefore, this study aimed to investigate the effects of these factors on the AL, CR, and AL/CR ratio in children aged 3–6 years in Beijing.MethodsIn this 3-month study, initiated in November 2021, children aged 3–6 years from nine kindergartens in Beijing were randomly selected for ocular biological parameter measurements. …”
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Vegetation disturbance and regrowth dynamics in shifting cultivation landscapes by Yamini Bhat, Subrata Nandy, Krishna Das, Muna Tamang, Hitendra Padalia, Arun Jyoti Nath, Koushik Majumdar, Rocky Pebam, Pynkhlainbor Thongni, Bandana Kurmi, Ashesh Kumar Das, S. P.S. Kushwaha, R. P. Singh

“…., forests and trees outside forests, rubber plantation, shifting cultivation, water bodies, agriculture, and settlements, were mapped with an accuracy of 83.08% using a random forest classifier. This classification enabled the identification of the effective study area, which included forest areas with shifting cultivation patches. …”
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