An empowerment programme to improve diet quality during pregnancy – the Power 4 a Healthy Pregnancy cluster randomised controlled trial by Renske M. van Lonkhuijzen, Jeanne H. M. de Vries, Elske Brouwer-Brolsma, Susanne Cremers, Janine P. M. Faessen, Edith J. M. Feskens, Annemarie Wagemakers

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Randomised controlled trial of topical kanuka honey for the treatment of rosacea by James Fingleton, Mark Weatherall, Richard Beasley, Irene Braithwaite, Janwillem Kocks, Mark Holliday, Andrew Corin, Colin Helm, Davitt Sheahan, Barney Montgomery, Judith Riley, Anna Hunt, Christopher Tofield

“…Objective To investigate the efficacy of topical 90% medical-grade kanuka honey and 10% glycerine (Honevo) as a treatment for rosacea.Design Randomised controlled trial with blinded assessment of primary outcome variable.Setting Outpatient primary healthcare population from 5 New Zealand sites.Participants 138 adults aged ≥16, with a diagnosis of rosacea, and a baseline blinded Investigator Global Assessment of Rosacea Severity Score (IGA-RSS) of ≥2. 69 participants were randomised to each treatment arm. 1 participant was excluded from the Honevo group, and 7 and 15 participants withdrew from the Honevo and control groups, respectively.Interventions Participants were randomly allocated 1:1 to Honevo or control cream (Cetomacrogol), applied twice daily for 8 weeks.Main outcome measures The primary outcome measure was the proportion of participants who had a ≥2 improvement in the 7-point IGA-RSS at week 8 compared to baseline. …”
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Tibial tubercle transfer SurgeRy and physiothErapy Versus physIotherapy only for chronic paTellofemorAL paIn: study protocol for a randomiSed controllEd trial (REVITALISE) by Myrthe P. F. van de Ven, Martin Ophey, Victor van de Graaf, Sebastiaan A. W. van de Groes, Marijn Sinkeldam, Charlotte H. W. Wijers, Sander Koëter

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International REACH forgiveness intervention: a multisite randomised controlled trial by Tyler J Vanderweele, Nicole Rodriguez, Richard G Cowden, Man Yee Ho, Everett L Worthington, Andrea Ortega Bechara, Zhuo Job Chen, Elly Yuliandari Gunatirin, Shaun Joynt, Viacheslav V Khalanskyi, Hennadii Korzhov, Ni Made Taganing Kurniati, Anastasiya Anastasiya Salnykova, Liudmyla Shtanko, Sergiy Tymchenko, Vitaliy L Voytenko, Anita Zulkaida, Maya B Mathur

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A randomised controlled implementation trial of the feasibility and effectiveness of school staff delivery of a selective substance use and mental health program during the COVID-1... by Lucinda Grummitt, Kirsty Rowlinson, Joanne Cassar, Chloe Conroy, Louise Birrell, Lexine Stapinski, Emma Louise Barrett, Julia Macauley, Maree Teesson, Nicola C. Newton, Erin V. Kelly

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Deciphering the effect of exercise timing on glucose metabolism: a randomised controlled trial by Fabienne Bruggisser, Denis Infanger, Henner Hanssen, Raphael Knaier

“…Methods Thirty-nine (34% female) non-diabetic adults (mean [standard deviation] age 68 [5] years) and body mass index 24.0 [2.6] kg/m2) participated in this double-blind, randomised controlled trial. Participants were allocated to one of five groups: control group (Con) or exercise at either 8:00, 12:00, 16:00 or 20:00 o'clock (i.e. …”
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Goal attainment scaling as an outcome measure for randomised controlled trials: a scoping review by Elaine Pascoe, Andrea Viecelli, Ruth Hubbard, Benignus Logan, Dev Jegatheesan

“…Objectives (1) Identify the healthcare settings in which goal attainment scaling (GAS) has been used as an outcome measure in randomised controlled trials. (2) Describe how GAS has been implemented by researchers in those trials.Design Scoping review using the Preferred Reporting Items for Systematic Reviews and Meta-Analyses extension for scoping reviews approach.Data sources PubMed, CENTRAL, EMBASE and PsycINFO were searched through 28 February 2022.Eligibility criteria English-language publications reporting on research where adults in healthcare settings were recruited to a randomised controlled trial where GAS was an outcome measure.Data extraction and synthesis Two independent reviewers completed data extraction. …”
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Mental Health Services for Serious Mental Illness: Scoping Review of Randomised Controlled Trials by Pablo Roson Rodriguez, Xiao Chen, Marcelo Arancibia, Eva Madrid, Farhad Shokraneh, Clive E. Adams, Juan Víctor Ariel Franco

“…ABSTRACT Aims This review aims to classify the evidence from randomised controlled trials (RCTs) on mental health services (MHS) for people with serious mental illness (SMI) available in the Cochrane Schizophrenia Group's (CSzG) specialised register. …”
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Systematic comparison of Mendelian randomisation studies and randomised controlled trials using electronic databases by Jie Zheng, George Davey Smith, Tom R Gaunt, Maria K Sobczyk

“…Objective To scope the potential for (semi)-automated triangulation of Mendelian randomisation (MR) and randomised controlled trials (RCTs) evidence since the two methods have distinct assumptions that make comparisons between their results invaluable.Methods We mined ClinicalTrials.Gov, PubMed and EpigraphDB databases and carried out a series of 26 manual literature comparisons among 54 MR and 77 RCT publications.Results We found that only 13% of completed RCTs identified in ClinicalTrials.Gov submitted their results to the database. …”
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The haemodynamic effects of umbilical cord milking in term infants: a randomised controlled trial by Mehmet Tekin, Mahmut Gokdemir, Erzat Toprak, Musa Silahli, Hasan Energin, Zeynel Gokmen

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The Eczema Bathing Study: Weekly versus daily bathing for people with eczema? Protocol of an online, randomised controlled trial [version 2; peer review: 1 approved, 2 approved with reservations] by Paul Leighton, Wei Chern Gavin Fong, Ingrid Muller, Laura Howells, Arabella Baker, Eleanor J Mitchell, Eleanor Harrison, Leila Thuma, Yimin Jiang, Lucy Bradshaw, Alan Montgomery, Fiona Cowdel, Matthew J Ridd, Jane Ravenscroft, Reiko J Tanaka, Miriam Santer, Richard Swinden, Nicholas Hilken, Carron Layfield, Richard Dooley, Sophia Collins, Clare Upton, Tracy Owen, Firoza Davies, Devin Patel, Mars Eddis-Finbow, Hywel C Williams, Goldie Putrym, Kim S Thomas, Amanda Roberts

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60-month follow-up of Long Limb vs. Standard Limb Roux-en-Y gastric bypass for type 2 diabetes and obesity: the LONG LIMB RCT by Saleem Ansari, Anna Kamocka, Tina Mazaheri, Ibiyemi Ilesanmi, Lara Jimenez-Pacheco, Kleopatra Alexiadou, Joanna Tan, Harvinder Chahal, Krishna Moorthy, Sanjay Purkayastha, Anne Margot Umpleby, Stephen Robert Bloom, Francesco Rubino, Alexander Dimitri Miras, Ahmed Rashid Ahmed, Tricia Tan

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The effect of the APOE4 genotype on physiological and cognitive health in randomised controlled trials with an exercise intervention: a systematic review and meta-analysis by Felicity S. E. Spencer, Richard J. Elsworthy, Leigh Breen, Jon R. B. Bishop, Connor Dunleavy, Sarah Aldred

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Optimising patient engagement for assessing total joint arthroplasty outcomes – a randomised controlled trial by Wyatt Tyndall, Nebojsa Kuljic, Michael Thatcher, Michaela Nickol, Johannes M. van der Merwe

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What can qualitative research do for randomised controlled trials? A systematic mapping review by J Hewison, A O'Cathain, A Rudolph, K J THOMAS, S J Drabble

“…Objective To develop an empirically based framework of the aspects of randomised controlled trials addressed by qualitative research.Design Systematic mapping review of qualitative research undertaken with randomised controlled trials and published in peer-reviewed journals.Data sources MEDLINE, PreMEDLINE, EMBASE, the Cochrane Library, Health Technology Assessment, PsycINFO, CINAHL, British Nursing Index, Social Sciences Citation Index and ASSIA.Eligibility criteria Articles reporting qualitative research undertaken with trials published between 2008 and September 2010; health research, reported in English.Results 296 articles met the inclusion criteria. …”
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Efficacy of contralateral acupuncture in women with migraine without aura: protocol for a randomised controlled trial by Ling Zhao, Qifu Li, Yanan Wang, Jialei Feng, Xinghe Zhang, Siwen Zhao, Chonghui Xing, Yongli Song, Xuanxiang Zeng, Meng Kong, Yunqiu Zheng, Taipin Guo

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Lidocaine Infusion for the Management of Postoperative Pain and Delirium (LIMPP): protocol for a randomised control trial by Matthias Behrends, Marc Alan Buren, Alekos Theologis, Ariadne Zuraek, Aaron J Clark, Jacqueline M Leung

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Promoting physical activity in vulnerable adults ‘at risk’ of homelessness: a randomised controlled trial protocol by Sarah E Jackson, Lee Smith, Charlotte Stringer, Mike Loosemore, Eloise Moller, Guillermo Felipe López-Sánchez, Joseph Firth, James Johnstone, Brendon Stubbs, Davy Vancampfort

“…The secondary aim is to evaluate the impact of the intervention on mental and physical health outcomes.Method and analysis A 2-arm, individually randomised controlled trial in people who are homeless and those vulnerable and at risk of homelessness in central London, UK. …”
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Comparative Evaluation of the Effectiveness of Manual and Electric Toothbrushes in Blind Children: A Randomised Controlled Trial by PS Thanalakshme, R Ramesh

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A multi-institution longitudinal randomised control trial of speaking up: Implications for theory and practice by Efrem Violato, Jennifer Stefura, Meredith Patey, Brian Witschen

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