Treatments for partial remission of major depressive disorder: a systematic review and meta-analysis by Marlies E Brouwer, Gert J Geurtsen, Damiaan A J P Denys, Joost Gülpen, Eva A M van Dis, Claudi L Bockting

“…Included were randomised controlled trials (RCTs) examining any treatment in patients with partially remitted MDD aged 13–65 years, reporting data on severity, remission or relapse.Findings Seven RCTs examining psychotherapy including 1024 patients were eligible. …”
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Cumulative Dispensing of Oral Corticosteroids Over 12 Months in People with COPD by Burge AT, Cox NS, Dal Corso S, Jones AW, Faqih FM, Holland AE

“…The aim of this study was to examine cumulative OCS dispensed to people with COPD over 12 months.Patients and Methods: This was a secondary analysis of data from two randomised controlled trials involving people with COPD followed up for 12 months following pulmonary rehabilitation. …”
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A journey into a Mediterranean diet and type 2 diabetes: a systematic review with meta-analyses by Demosthenes Panagiotakos, Katherine Esposito, Paolo Chiodini, Maria Ida Maiorino, Giuseppe Bellastella, Dario Giugliano

“…Objectives To summarise the evidence about the efficacy of a Mediterranean diet on the management of type 2 diabetes and prediabetic states.Design A systematic review of all meta-analyses and randomised controlled trials (RCTs) that compared the Mediterranean diet with a control diet on the treatment of type 2 diabetes and prediabetic states was conducted. …”
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Effect of Yoga on Blood Pressure in Prehypertension: A Systematic Review and Meta-Analysis by Janhavi Sandeep Khandekar, Vanamala Lakshmi Vasavi, Vijay Pratap Singh, Stephen Rajan Samuel, S. G. Sudhan, Bidita Khandelwal

“…Databases such as PubMed, Embase, Scopus, and Web of Science were searched for randomised control trials only in the time duration of 2010–2021. …”
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Extrapolating evidence for molecularly targeted therapies from common to rare cancers: a scoping review of methodological guidance by Sarah J Lord, Saskia Cheyne, John Simes, Doah Cho, Chee Khoon Lee

“…In rare biomarker-defined cancers, randomised controlled trials to adequately assess targeted therapies may be infeasible. …”
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Bariatric surgery and LDL cholesterol (BASALTO) trial study protocol: randomised controlled study evaluating the effect of gastric bypass versus sleeve gastrectomy on high LDL chol... by David Benaiges, Albert Goday, Juana A Flores-Le Roux, Montserrat Fitó, Oscar Pozo, Jose Rodríguez-Morató, Carme Serra, Manuel Pera, Gemma Llauradó, Elisenda Climent, Olga Castañer, Jose M Ramon, Juan Pedro-Botet

“…If these results are confirmed in randomised controlled trials, presurgical LDL cholesterol status could be a relevant factor in surgical procedure election. …”
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The Role of SGLT2 Inhibitors in Heart Failure: A Systematic Review and Meta-Analysis by Vasiliki Tsampasian, Ranu Baral, Rahul Chattopadhyay, Maciej Debski, Shruti S Joshi, Johannes Reinhold, Marc R Dweck, Pankaj Garg, Vassilios S Vassiliou

“…Aims. Recent randomised controlled trials (RCTs) have shown a significant prognostic benefit of sodium-glucose cotransporter 2 (SGLT2) inhibitors in the cardiovascular (CV) profile of patients with diabetes. …”
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Individual participant data meta-analysis of trials comparing frozen versus fresh embryo transfer strategy (INFORM): a protocol by Lan N Vuong, Rui Wang, Ben W Mol, Rong Li, Karin Hammarberg, Kate Brian, Yun Sun, Pollyanna Hardy, Anja Pinborg, Siladitya Bhattacharya, Sacha Stormlund, David J McLernon, Zi-Jiang Chen, Richard S Legro, Carlos Simon, Shimona Lai, Marian G Showell, Daimin Wei, Ze Wang, Keliang Wu, Xavier Santamaría, Christophe Blockeel, Femke Mol, Anna P Ferraretti, Bruce S Shapiro, Forest C Garner, Christos A Venetis, Abha Maheshwari, Gwenda Burns

“…Introduction Existing randomised controlled trials (RCTs) comparing a freeze-all embryo transfer strategy and a fresh embryo transfer strategy have shown conflicting results. …”
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Evidence to practice – lessons learnt in developing an implementation strategy for an online digital health intervention (Eczema Care Online) by Laura Howells, Kim S. Thomas, Miriam Santer, Ingrid Muller, Kate Greenwell, Amanda Roberts, Hywel C. Williams, Jane Harvey, Stephanie J. Lax, Natasha K. Rogers, Tracey H. Sach, Sandra Lawton, Mary Steele, Katy Sivyer, Julie Hooper, Amina Ahmed, Sylvia Wilczynska, Sinead Langan, Paul Leighton

“…Testing in two randomised controlled trials has shown that it is easy to use, cost effective and offers a sustained improvement in eczema symptoms. …”
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Efficacy of brief intervention for drug misuse in primary care facilities: systematic review and meta-analysis protocol by Toshi A Furukawa, Yan Luo, Norio Watanabe, Ethan Sahker, Masatsugu Sakata, Rie Toyomoto, Chiyoung Hwang, Kazufumi Yoshida

“…The aim of this systematic review and meta-analysis is to determine the efficacy of BI for drug misuse in primary care settings.Methods and analysis We will include all randomised controlled trials comparing primary care-delivered BI for drug misuse with no intervention or minimal screening/assessment and usual care. …”
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Non-pharmacological interventions for the reduction and maintenance of blood pressure in people with prehypertension: a systematic review protocol by Paul Rutter, Andrew Clegg, Valerio Benedetto, Caroline Watkins, Nefyn Williams, Joseph Spencer, Lucy Hives, Emma P Bray, Cath Harris, Rachel F Georgiou, Nafisa Iqbal

“…The databases/trial registries that will be searched to identify relevant randomised controlled trials (RCTs) and economic evaluations include Medline, EMBASE, CINAHL, PsycINFO, CENTRAL, the WHO International Clinical Trials Registry Platform, ClinicalTrials.gov, Cochrane Library, Scopus and the International HTA Database. …”
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Comparative efficacy and safety of first-line neoadjuvant therapy for early-stage non-small cell lung cancer based on immune checkpoint inhibitor therapy: a systematic review and n... by Linfeng Wang, Guangda Zheng, Yue Hu, Ayidana Maolan, Yue Luo, Yue Li, Rui Liu

“…Methods We searched PubMed, EMBASE, Cochrane Library, ClinicalTrials.go and randomised controlled trials (RCTs) from major international conferences for literature related to neoadjuvant immunotherapy combinations published as first-line treatment options for non-small cell lung cancer from the start of the library to 20 February 2024, and performed a systematic review and network meta-analysis. …”
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Acupuncture for patients with type 2 diabetes mellitus with dry eye: protocol for a systematic review and meta-analysis by Ting Li, Xin Xu, Juan Wei, Qingbo Wei, Zhouyu Xie, Xiangyu Bian, Yunchuan Wu

“…However, systematic reviews on the effectiveness and safety of acupuncture are lacking, therefore this systematic review aims to evaluate the effectiveness and safety of acupuncture for T2DM with dry eye.Methods and analysis Four English databases (PubMed, Cochrane Library, Embase and Ovid), three Chinese databases (China National Knowledge Infrastructure, Wanfang, Chonqing VIP Information), three Japanese databases (Japan Science, Technology Agency and Japan Medical Abstracts Society) and three Korean databases (Korean Medical database, Oriental Medicine Advanced Searching Integrated System and Research Information Service System) will be searched for reports published between 1 January 2007 and 1 October 2021. Only randomised controlled trials will be included, and language or publication dates will not be restricted. …”
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Evidence mapping and overview of systematic reviews of the effects of acupuncture therapies by Yuqing Zhang, Gordon Guyatt, Lin Wang, Hao Wen, Liming Lu, Gabriel Rada, Lai Wang, Shuqi Ge, Yu Dong, Camila Ávila, Xiaorong Tang, Neng-Gui Xu, Zhao Zeng, Camilo Vergara, Rouhao Chen, Xiaojing Wei, Wen Luo, Jing chun Zeng, Chun-Zhi Tang

“…Objective To provide a route map regarding systematic reviews (SRs) of acupuncture therapies that will meet two goals: (1) to identify areas in which more or better evidence is required and (2) to identify acupuncture applications that, although proven effective, remain underused in practice, and thus warrant more effective knowledge dissemination.Eligibility criteria We included SRs that conducted meta-analyses (MAs) of randomised controlled trials (RCTs) for this overview.Information sources We searched for SRs without language restrictions from January 2015 to November 2020 in four Chinese electronic databases and Epistemonikos database. …”
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Psychological interventions for inflammatory bowel disease: a systematic review and component network meta-analysis protocol by Antje Timmer, Gerta Rücker, Natalia Tiles-Sar, Johanna Neuser, Dominik de Sordi, Anne Baltes, Jan Preiss, Gabriele Moser

“…This is the study protocol.Methods and analysis We will consider randomised, quasi-randomised and non-randomised controlled trials, including cluster randomised and cross-over trials with 2 months of minimum follow-up. …”
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Comparative effectiveness of buprenorphine-naloxone versus methadone for treatment of opioid use disorder: a population-based observational study protocol in British Columbia, Cana... by Lawrence C McCandless, Malcolm Maclure, M Eugenia Socías, Evan Wood, Paul Gustafson, Robert W Platt, Bohdan Nosyk, Sander Greenland, Micah Piske, Trevor Thomson, Emanuel Krebs, Natt Hongdilokkul, Julie Bruneau, M Ehsan Karim, Judith I Tsui

“…Introduction Despite a recent meta-analysis including 31 randomised controlled trials comparing methadone and buprenorphine for the treatment of opioid use disorder, important knowledge gaps remain regarding the long-term effectiveness of different treatment modalities across individuals, including rigorously collected data on retention rates and other treatment outcomes. …”
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Effectiveness of educational interventions to promote safe handling of pesticides: protocol for a systematic review and meta-analysis by Anne Cockcroft, Neil Andersson, Sergio Paredes-Solís, José Legorreta-Soberanis, Belén Madeline Sánchez-Gervacio, Víctor Manuel Alvarado-Castro, Miguel Flores-Moreno, Claudia Erika Rios-Rivera, Janet Saldaña-Almazán

“…We will consider randomised and non-randomised controlled trials that evaluated the impact of educational interventions among farmers about the safe use of pesticides. …”
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Is it feasible to treat polycystic ovarian syndrome with or without insulin resistance using glucokinase activators as novel hypoglycaemic medications? A protocol for a systematic... by Xiaojing Liu, Lei Zeng, Shuo Yuan, Genping Zeng, Xijing Lu, Peiyin Li, Tan Zeng, Zitong Lin, Yuxi Miao

“…The meta-analysis protocol aims to address this knowledge gap, furnish evidence-based data to support potential revisions in PCOS treatment guidelines and promote the utilisation of GKAs in clinical settings.Methods and analysis A comprehensive search will be conducted across the Cochrane Central Register of Controlled Trials, PubMed, Web of Science, Embase, Medline, Scopus, CNKI, Wanfang and VIP databases to identify randomised controlled trials investigating the use of GKAs in the treatment of PCOS, irrespective of the presence of IR. …”
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Web-based interventions for pregnant women with gestational diabetes mellitus: a systematic review and meta-analysis protocol by Ping Xu, Wei Zhang, Xiaojuan Wang, Dan Dan Chen, Pingping Guo, Yin Jin, Zhenzhen Xiang, Minna Mao, Qiong Zheng, Suwen Feng

“…Six electronic databases (PubMed, Web of Science, Cochrane Central Register of Controlled Trials, Embase, CINAHL and PsycINFO) will be comprehensively searched from their inception to 26 January 2022 to identify randomised controlled trials and controlled clinical trials regarding the efficacy of web-based interventions for pregnant women with GDM on glycaemic control, behavioural outcomes, cognitive and attitudinal outcomes, mental health, maternal and neonatal clinical outcomes, and medical service utilisation and costs. …”
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Intrauterine metformin exposure and adiposity outcomes in children: a systematic review and meta-analysis by George Tomlinson, Jill Hamilton, Kellie E Murphy, Jennifer Fu, Najla Tabbara, Denice S Feig

“…Objective The study aims to assess the effect of intrauterine metformin exposure on offspring adiposity measures in childhood.Design Systematic review and meta-analysis.Data sources Medline, Embase and Cochrane Central were searched from inception to 4 October 2024.Eligibility criteria for selecting studies Follow-up studies of randomised-controlled trials and observational studies involving metformin use in pregnancy for any insulin-resistant maternal condition were included.Data extraction and synthesis Two reviewers independently extracted data and completed risk-of-bias assessments using either Cochrane Risk-Of-Bias tool V.2 or Risk of Bias in Non-Randomised Studies of Exposure depending on study design. …”
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