A qualitative study exploring depressed participants’ experiences of receiving Augmented Depression Therapy (ADepT) by Rebecca Watson, Kim A Wright, Nigel Reed, Barney Dunn, Emily Widnall, Kalliopi Demetriou, Laura Warbrick, Katie Marchant, Nicole Geschwind, Isabella Magner-Parsons, Rachel Barter

“…Objectives The current study aimed to explore participants’ views on the acceptability, impact and mechanisms of change of Augmented Depression Therapy (ADepT), a novel wellbeing-focused and recovery-oriented psychological therapy for depression.Design A semi-structured qualitative interview design was used, with data analysed using the framework approach.Participants 20 participants with anhedonic depression who had received up to 20 sessions of ADepT, sampled from a pilot randomised controlled trial of ADepT versus Cognitive Behavioural Therapy (CBT).Setting A primary care psychological therapy clinic in Devon, UK, with interviews occurring between May 2018 and February 2020.Results Participants found the wellbeing focus of ADepT acceptable. …”
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Mental health and socio-cognitive predictors of adherence to COVID-19 social distancing rules in adolescents in England by Giacomo Bignardi, Saz P. Ahmed, Marc Bennett, Darren Dunning, Kirsty Griffiths, Jovita T. Leung, Ashok Sakhardande, Blanca Piera Pi-Sunyer, Willem Kuyken, Tim Dalgleish, Sarah-Jayne Blakemore

“…The current study aimed to identify individual-level influences on adherence to social distancing in a longitudinal sample of adolescents aged 11–20 years in England, who took part in a randomised controlled trial. At baseline, 460 participants completed detailed pre-pandemic assessments, including mental health and well-being, altruism, delayed reward discounting, rejection sensitivity, prosociality and susceptibility to prosocial and anti-social influence. …”
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Misuse of Statistical Methods in 10 Leading Chinese Medical Journals in 1998 and 2008 by Shunquan Wu, Zhichao Jin, Xin Wei, Qingbin Gao, Jian Lu, Xiuqiang Ma, Cheng Wu, Qian He, Meijing Wu, Rui Wang, Jinfang Xu, Jia He

“…Many mistakes were found in the randomised controlled trial (56.3% in 1998; 67.9% in 2008), non- randomised clinical trial (57.3%; 58.6%), basic science study (72.9%; 65.5%), case study or case series study (48.4%; 47.2%), and cross-sectional study (57.1%; 44.2%). …”
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Economic evaluation of Maternal Depression Treatment in HIV (M-DEPTH) for perinatal depression among women living with HIV in Uganda: a cost-effectiveness analysis by Ryan McBain, Adeyemi Okunogbe, Rhoda K Wanyenze, Violet Gwokyalya, Glenn Wagner

“…Objective We conducted a cost-effectiveness analysis of an evidence-based collaborative care model for treatment of perinatal depression among women living with HIV in Uganda.Design Maternal Depression Treatment in HIV (M-DEPTH) is a cluster randomised controlled trial implemented from July 2019 to August 2023, during which 391 pregnant women with mild-to-severe depressive symptoms were randomised to receive stepped care for depression (M-DEPTH: behavioural and pharmacological treatments) or care as usual (CAU: hospital referral for severe cases), at one of eight public health facilities in Uganda.Methods We implemented time-driven, activity-based costing to determine the economic cost of M-DEPTH from a societal perspective, compared with CAU. …”
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Adapting and Implementing a Blended Collaborative Care Intervention for Older Adults with Multimorbidity: Quantitative and Qualitative Results from the ESCAPE Pilot Study by Josefine Schulze, Dagmar Lühmann, Jonas Nagel, Cornelia Regner, Christine Zelenak, Kristina Bersch, Christoph Herrmann-Lingen, Matthew M. Burg, Birgit Herbeck-Belnap

“…Next steps include launching the ESCAPE trial, a large randomised-controlled trial across different European healthcare systems and developing strategies to facilitate PCP involvement.…”
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The PainSMART project: Protocol for a research program on effectiveness, mechanisms of effect and patient-practitioner experiences of the PainSMART-strategy as an adjunct to usual... by Richard Thompson, Maria Fors, Ann-Sofi Kammerlind, Pia Tingström, Allan Abbott, Kajsa Johansson

“…<h4>Methods</h4>The PainSMART-project is a research program with a collective suite of studies utilising mixed methods, centred around a randomised controlled trial (ClinicalTrials.gov NCT06187428). …”
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Retention in the Bukhali trial in Soweto, South Africa: a qualitative analysis using self-determination theory by Shane A Norris, Stephen Lye, Catherine E Draper, Nosibusiso Tshetu, Nokuthula Nkosi

“…To address this gap, this study aimed to qualitatively examine retention in the Bukhali randomised controlled trial, from the perspective of trial participants and staff, through the lens of self-determination theory (SDT). …”
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Online cognitive–behavioural therapy for traumatically bereaved people: study protocol for a randomised waitlist-controlled trial by Jos de Keijser, Lonneke Lenferink, Maarten Eisma, Geert Smid, Paul Boelen

“…Moreover, the effect of the quality of the therapeutic alliance on treatment effects and drop-out rates will be explored.Methods and analysis A two-arm (online CBT vs waiting list) open-label parallel randomised controlled trial will be conducted. Participants will complete questionnaires at pretreatment and 12 and 20 weeks after study enrolment. …”
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Challenges of Assessing Maltreated Children Coming into Foster Care by Rachel Pritchett, Harriet Hockaday, Beatrice Anderson, Claire Davidson, Christopher Gillberg, Helen Minnis

“…An ongoing randomised controlled trial in Glasgow, Scotland, recruiting infants entering foster care, provides a unique opportunity to explore some of the issues which need to be considered when assessing these children. …”
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Protocol for a feasibility study evaluating a supported self-management intervention for stroke survivors with aphasia (StarStep study) by Faye Wray, Madeline Cruice, Ian Kellar, Anne Forster

“…Feasibility data will inform decision-making regarding progression to a future definitive cluster randomised controlled trial to evaluate the effectiveness of the intervention. …”
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Implementing injury prevention training in youth handball (I-PROTECT) in Sweden: study protocol for a cluster randomised trial by Per Nilsen, Alex Donaldson, Eva Ageberg, Sofia Bunke, Jennie Linnéll, Karin Moesch, Karolina Lucander, Axel Ström, Robert Wedberg, Per Ekberg

“…Within the I-PROTECT research project, the specific aim of this study is to investigate the implementation of the end-user-targeted I-PROTECT programme.Methods and analysis This pragmatic two-armed cluster randomised controlled trial is conducted collaboratively with the Swedish Handball Federation that has overall responsibility for handball in Sweden. …”
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The impact of universal mental health screening on stigma in primary schools by Annabel Songco, Deanna A. Francis, Emma A. McDermott, Chloe Y. S. Lim, Abigail Allsop, Joseph Croguennec, Gemma Sicouri, Andrew Mackinnon, Jennifer L. Hudson

“…Methods Across 6 primary schools, a cluster randomised controlled trial allocated schools to one of two conditions. …”
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Comparison of two skin protection regimes for the Prevention of Incontinence-associated Dermatitis in geriatric care (PID): a study protocol for an exploratory randomised controlle... by Jan Kottner, Monira El Genedy-Kalyoncu, Alexandra Fastner, Bettina Völzer, Kathrin Raeder, Konrad Neumann, Nils Axel Lahmann

“…IAD incidence of the control and intervention groups will be compared to estimate effect sizes, and the procedural feasibility of the intervention will be tested to plan a possible subsequent confirmatory randomised controlled trial.Ethics and dissemination The study received the approval of the ethics committee of Charité–Universitätsmedizin Berlin (EA4/043/22). …”
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Move to improve - Prescribing physical activity and deprescribing paracetamol for low back pain: Protocol for a hybrid type III feasibility study by David Roberts, Paulo H Ferreira, Josielli Comachio, Paula R Beckenkamp, Thomas Patterson, Mark Halliday, Emma Kwan-Yee Ho

“…Qualitative (open-ended questions) will be integrated with the feasibility trial outcomes to inform the design of a full-scale randomised controlled trial.Ethics and dissemination This study has ethical approval from the Sydney Local Health District Human Research Ethics Committee (2023/ETH02683). …”
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Development and validation of the Multimorbidity Treatment Burden Questionnaire (MTBQ) by Daisy Gaunt, Chris Salisbury, Mei-See Man, Katherine Chaplin, Polly Duncan, Mairead Murphy

“…The scale was piloted and the final version was tested in 1546 adults with multimorbidity (mean age 71 years) who took part in the 3D Study, a cluster randomised controlled trial. For each question, we examined the proportion of missing data and the distribution of responses. …”
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Evaluating an implementation programme for medication review with follow-up in community pharmacy using a hybrid effectiveness study design: translating evidence into practice by Fernando Martínez-Martínez, Shalom I Benrimoj, Victoria Garcia-Cardenas, Raquel Varas-Doval, Miguel A Gastelurrutia, Maria Jose Zarzuelo, Beatriz Perez-Escamilla

“…Objectives To evaluate an implementation programme of a community pharmacy medication review with follow-up (MRF) service using a hybrid effectiveness-implementation study design, and to compare the clinical and humanistic outcomes with those in a previously conducted cluster randomised controlled trial (cRCT).Setting Community pharmacies in Spain.Participants 135 community pharmacies and 222 pharmacists providing MRF to polymedicated patients aged 65 or over.Intervention The intervention was an implementation programme for the MRF service. …”
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Attitudes and adherence to changes in nutrition and physical activity following surgery for prostate cancer: a qualitative study by Richard M Martin, Raj Persad, J Athene Lane, Ellie Shingler, Luke A Robles, Edward Rowe, Anthony Koupparis, Amit Bahl, Constance Shiridzinomwa, Lucy McGeagh

“…We aimed to explore these factors in men following prostatectomy for prostate cancer (PCa).Design, setting and participants A qualitative study using semistructured interviews with men, who made changes to their diet and/or PA as part of a factorial randomised controlled trial conducted at a single hospital in South West England. …”
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Clinically SUspected ScaPhoid fracturE: treatment with supportive bandage or CasT? ‘Study protocol of a multicenter randomized controlled trial’ (SUSPECT study) by Max Reijman, Jan A N Verhaar, Abigael Cohen, Gerald A Kraan, Nina M C Mathijssen, Marc A Koopmanschap, Sander Mol, Joost W Colaris

“…We hypothesise that the functional outcome after 3 months is not inferior in patients treated with supportive bandage compared to patients treated with below-elbow cast, but with lower costs in the supportive bandage group.Methods and analysis The SUSPECT study is an open-labelled multicentre randomised controlled trial with non-inferiority design. A total of 180 adult patients with a clinically suspected scaphoid fracture and normal initial radiographs are randomised between two groups: 3 days of supportive bandage or 2 weeks of below-elbow cast. …”
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Effects of active video games on mental health among college students: a systematic review by Yue Zhao, Kim Geok Soh, Hazizi bin Abu Saad, Wenchao Rong, Cong Liu, Xinzhi Wang

“…A systematic review was conducted following the PRISMA guidelines, and compliant studies using randomised controlled trial design (RCT) were included. The methodological quality of the included studies was evaluated using the PEDro scale. …”
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Melatonin supplementation for the treatment of infantile spasms: protocol for a randomised placebo-controlled triple-blind trial by Jing Wang, Tao Xu, Miao Liu, Jian Chen, Guang Yang, Weiwei Feng, Yulin Sun, Xiuyu Shi, Liping Zou

“…This study aims to analyse the therapeutic effect of melatonin supplementation for the treatment of IS.Methods and analysis This is a triple-blinded (trial participant, outcome assessor and the data analyst), prospective, randomised controlled trial to be conducted in the Department of Paediatrics, The First Medical Center of Chinese PLA General Hospital, Beijing, China from November 2020. …”
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