Rehabilitation using virtual gaming for Hospital and hOMe-Based training for the Upper limb post Stroke (RHOMBUS II): protocol of a feasibility randomised controlled trial by Cherry Kilbride, Tom Butcher, Meriel Norris, Nana Anokye, Alyson Warland, Karen Baker, Dimitrios A Athanasiou, Guillem Singla-Buxarrais, Jennifer Ryan, Francesca Gowing, Carole Pound, Victoria Stewart, Basaam Aweid, Arul Samiyappan

“…The aim of the Rehabilitation using virtual gaming for Hospital and hOMe-Based training for the Upper limb post Stroke study is to determine the safety, feasibility and acceptability of the NeuroBall as a rehabilitation intervention for the UL in subacute stroke.Methods and analysis A feasibility randomised controlled trial (RCT) will compare the NeuroBall plus usual care with usual care only, in supporting UL rehabilitation over 7 weeks. …”
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Person-centred eHealth intervention for patients on sick leave due to common mental disorders: study protocol of a randomised controlled trial and process evaluation (PROMISE) by Ingibjörg H Jonsdottir, Hanna Gyllensten, Lilas Ali, Andreas Fors, Karl Swedberg, Inger Ekman, Matilda Cederberg, Kristina Glise

“…Person-centred care (PCC) has previously shown positive effects on self-efficacy however this needs to be further investigated in relation to patients with CMDs and in an eHealth context.Methods and analysis This study is an open randomised controlled trial comparing a control group receiving standard care with an intervention group receiving standard care plus PCC by telephone and a digital platform. …”
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Allogenic faecal microbiota transplantation for antibiotic-associated diarrhoea in critically ill patients (FEBATRICE)-Study protocol for a multi-centre randomised controlled trial (phase II). by Ivana Cibulkova, Veronika Rehorova, Hana Soukupova, Petr Waldauf, Monika Cahova, Jan Manak, Martin Matejovic, Frantisek Duska

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A workplace organisational intervention to improve hospital nurses’ and physicians’ mental health: study protocol for the Magnet4Europe wait list cluster randomised controlled trial by Peter Griffiths, Jonathan Drennan, Jackie Bridges, Luk Bruyneel, Jane Ball, Linda H Aiken, Douglas M Sloane, Anners Lerdal, Matthew McHugh, Herbert Smith, Anne Marie Rafferty, Reinhard Busse, Walter Sermeus, Julia Köppen, Lars E Eriksson, Kaat Siebens, Matthew D McHugh, Anne Scott, Ingeborg Strømseng Sjetne, Sydney Anstee, Peter Van Bogaert, Rikard Lindqvist, Linda Aiken, Douglas Sloane, Hans De Witte, Wilmar B Schaufeli, Hans De Witte, Simon Dello, Dorothea Kohnen, Claudia Bettina Maier, Lisa Smeds Alenius, Mary Del Guidice, Timothy Cheney, Claudia Maier, Joan Kleine, Elaine Lehane Vera McCarthy, Noeleen Brady, Monica Bukkøy Kjetland, Paul Van Aken, Danny Van Heusden

“…Magnet hospitals, a model shown to attract and retain staff in US research, creates positive work environments that aim to support the well-being of healthcare professionals.Methods and analysis Magnet4Europe is a cluster randomised controlled trial, with wait list controls, designed to evaluate the effects of organisational redesign, based on the Magnet model, on nurses’ and physicians’ well-being in general acute care hospitals, using a multicomponent implementation strategy. …”
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Healthy food prescription incentive programme for adults with type 2 diabetes who are experiencing food insecurity: protocol for a randomised controlled trial, modelling and implementation studies by Colleen Norris, Tyler Williamson, Richard Oster, Dana Lee Olstad, Laura White, David J T Campbell, Sharlette Dunn, Kim D Raine, Mary L'Abbé, Richard Lewanczuk, Lorraine L Lipscombe, Eldon Spackman, Reed Beall, Kienan Williams, Sara Scott, Gabrielle L Zimmermann, Kerry A McBrien, Kieran J D Steer, Catherine B Chan, Sheila Tyminski, Seth Berkowitz, Alun L Edwards, Terry Saunders-Smith, Saania Tariq, Naomi Popeski, Sara Nejatinamini, Aruba Naser, Carlota Basualdo-Hammond, Petra O’Connell, Judy Seidel, Jason Cabaj

“…We will use a type 2 hybrid-effectiveness design to examine the reach, effectiveness, adoption, implementation and maintenance (RE-AIM) of a healthy food prescription incentive programme for adults experiencing food insecurity and persistent hyperglycaemia. A randomised controlled trial (RCT) will investigate programme effectiveness via impact on glycosylated haemoglobin (primary outcome), food insecurity, diet quality and other clinical and patient-reported outcomes. …”
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Comparison of the Journey II bicruciate stabilised (JII-BCS) and GENESIS II total knee arthroplasty for functional ability and motor impairment: the CAPAbility, blinded, randomised controlled trial by Allan B Clark, Toby O Smith, J Wells, Iain McNamara, Juliet High, Ann Marie Swart, Valerie Pomeroy, Graham Creelman, Celia Whitehouse, B Harry, Celia Clarke

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Costs of community-wide mass drug administration and school-based deworming for soil-transmitted helminths: evidence from a randomised controlled trial in Benin, India and Malawi by Judd Walson, ROBIN BAILEY, Katya Galactionova, Maitreyi Sahu, Samuel Paul Gideon, Saravanakumar Puthupalayam Kaliappan, Chloe Morozoff, Sitara Swarna Rao Ajjampur, Khumbo Kalua, Euripide Avokpaho, Moudachirou Ibikounle, Arianna Rubin Means, James Simwanza, Wongani Lungu, Parfait Houngbegnon, Adrian J F Luty, Rachel Pullan

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Micronutrient dose response (MiNDR) study among women of reproductive age and pregnant women in rural Bangladesh: study protocol for double-blind, randomised, controlled trials by Tahmeed Ahmed, Hasmot Ali, Michael Rosenblum, Daniel J Erchick, Towfida Jahan Siddiqua, Rezwanul Haque, Parul Christian, Sarah Baker, Eleonor Zavala, Kerry J Schulze, SM Tafsir Hasan, Khalid Bin Ahsan, Sulagna Bandyopadhyay, Hasan Mahmud Sujan, Md. Hafizur Rahman, Katherine K Stephenson, Ximing Ge, Ethan K Gough, Brooke Langevin, Lee Shu Fune Wu, Brian Dyer, Anjan Kumar Roy, Mohammad Jubair, Amena Al Nishan, Mathangi Gopalakrishnan, Klaus Kraemer

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Effects of perioperative oxycodone as the sole opioid on immunity within a multi-modal analgesia framework in patients undergoing cervical cancer surgery: A randomised controlled trial by Jingjing Liu, Sumeng Chen, Jianxiao Chen, Hailian Liu, Weiyi Li, Haomin Chi, Xiaowei Ding, Shaoqiang Huang

“…Methods: In this randomised controlled trial (RCT), patients scheduled for laparoscopic radical hysterectomy for cervical cancer were randomised to receive either oxycodone (Group O) or conventional opioid regimens (Group C). …”
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Value of ctDNA in surveillance of adjuvant chemosensitivity and regimen adjustment in stage III colon cancer: a protocol for phase II multicentre randomised controlled trial (REVISE trial) by Jun Huang, Rui Fan, Ziqiang Wang, Meng Qiu, Jiahao Zhou, Zikai Zhou, Xiangbing Deng, Qingbin Wu

“…The potential benefit of intensified adjuvant chemotherapy, oxaliplatin, irinotecan, leucovorin and fluoropyrimidine (FOLFOXIRI), for ctDNA-positive patients remains to be elucidated.Methods and analysis This multicentre phase II randomised controlled trial aims to investigate the utility of ctDNA in monitoring chemosensitivity and to preliminarily assess whether intensified chemotherapy with FOLFOXIRI can increase ctDNA clearance and improve survival outcomes. …”
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Comment On ‘Comparative analysis of LMA Blockbuster® clinical performance: Blind versus Miller laryngoscope-guided insertion in paediatric general anaesthesia – A double-blinded, randomised controlled trial’ by Mamta Rana, Neeti Dogra

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Treatment of e-cigarette use among hospitalised adolescents and young adults: a protocol for intervention development and evaluation of preliminary efficacy and implementation outcomes in a randomised controlled trial by Delwyn Catley, Kimber P Richter, Karen Wilson, Shelbie Wooten, Melissa K Miller, Abbey Masonbrink

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Study protocol for a randomised controlled trial on the use of intraoperative ultrasound-guided laparoscopic ovarian cystectomy (UGLOC) as a method of fertility preservation in the management of benign ovarian cysts by Srdjan Saso, Sadaf Ghaem-Maghami, Jan Yvan Jos Verbakel, Benjamin P Jones, Joseph Yazbek, Mona El-Bahrawy, Lorraine S Kasaven

“…This study will evaluate the effect on ovarian reserve following two different surgical interventions for the management of benign ovarian cysts.Methods and analysis We will conduct a two-armed randomised controlled trial comparing laparoscopic ovarian cystectomy, considered gold standard treatment as per the Royal College of Obstetricians and Gynaecologists (RCOG) Green Top guidelines for the management of benign ovarian cysts, with ultrasound-guided laparoscopic ovarian cystectomy (UGLOC), a novel method of FPS. …”
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Correction : ‘Protocol for the impact of machine learning-based clinician decision support algorithims in perioperative care (IMAGINATE) in Singapore general hospital: a large prospective randomised controlled trial’

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Effect of Zhan Zhuang Qigong on upper limb static tremor and aerobic exercise capacity in patients with mild-to-moderate Parkinson’s disease: study protocol for a randomised controlled trial by Hang Su, Xiaoyu Jiang, Limin Wang, Linlin Zhang, Qing Wang, Xihua Liu, Xiaoming Xi, Yuxiao Chen, Xinjie Qu, Haihao Cao, Wenyu Sun, Guoming Chen, Huifen Liu, Jiahui Jiang, Hongyan Bi

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Comparing physiological and psychological effects of virtual reality vs. traditional high-intensity interval training in healthy individuals: results from a preliminary pilot randomised controlled trial by Jonathan Robinson, Mohammad Haziq Bin Abdul Razak

“…Methods Using a parallel-design pilot randomised controlled trial, 10 participants completed the study and were randomly allocated to either the VR group (n = 5) or non-VR group (n = 5). …”
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C-reactive protein testing in primary care and antibiotic use in children with acute respiratory tract infections in Kyrgyzstan: an open-label, individually randomised, controlled trialResearch in context by Elvira Isaeva, Joakim Bloch, Azamat Akylbekov, Robert L. Skov, Anja Poulsen, Jørgen A.L. Kurtzhals, Susanne Reventlow, Nandini Sreenivasan, Maamed Mademilov, Volkert D. Siersma, Talant Sooronbaev, Jesper Kjærgaard, Rune M. Aabenhus

“…Methods: In this open label individually randomised controlled trial, children aged 6 months to 12 years with ARTI in primary care settings were assigned to receive either standard care or standard care plus CRP testing. …”
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Comparing acceptance of smoking cessation and smoke-free home intervention offers and associated factors among people with low income in the USA: baseline results of a randomised controlled trial by Matthew W Kreuter, Michelle C Kegler, Jennifer Wolff, Amy McQueen, Lauren Grimes, Enguday Teshome, Rachel Garg, Tess Thompson, Kelly Carpenter

“…Expanding quitline services may increase the total number of people engaged in tobacco control efforts and the number who eventually quit. In this randomised controlled trial, we offered both arms a tobacco quitline intervention. …”
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Effectiveness of nicotine salt vapes, cytisine, and a combination of these products, for smoking cessation in New Zealand: protocol for a three-arm, pragmatic, community-based randomised controlled trial by Natalie Walker, Amanda Calder, Joanne Barnes, George Laking, Varsha Parag, Chris Bullen

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Improving coverage of antenatal iron and folic acid supplementation and malaria prophylaxis through targeted information and home deliveries in Côte d’Ivoire: a cluster randomised controlled trial by Günther Fink, Nicole Probst-Hensch, Jürg Utzinger, Siaka Koné, Daouda Dao

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