Protocol for a multicentre, prospective cohort study of clinical, proteomic and genomic patterns associated with osteoporosis to develop a multidimensional fracture assessment tool... by Noushin Fahimfar, Bagher Larijani, Afshin Ostovar, Iraj Nabipour, Patricia Khashayar, Hans Peter Dimai, Nahid Moradi, Safoora Gharibzadeh

“…The fracture risk model is intended to be developed in two different populations, namely a European and a Middle Eastern one; (2) to develop a medical device, which would measure and/or quantify proteomic as well as genomic factors as present in whole blood samples collected through finger prick; (3) to test the clinical applicability and the validity of prototypes of the to be developed point of care device at both clinical centres.Methods and analysis This article presents the protocol of this prospective cohort that will be carried out independently at two different centres (Division of Endocrinology and Diabetology at the Medical University of Graz (MUG) as a clinic-based cohort, and Endocrinology and Metabolism Research Institute (EMRI) at the Tehran University of Medical Sciences (TUMS) as a population-based cohort). …”
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Investigating the Electron-capture Supernova Candidate AT 2019abn with JWST Spectroscopy by Sam Rose, Ryan M. Lau, Jacob E. Jencson, Mansi M. Kasliwal, Kishalay De, Michael E. Ressler, Ori D. Fox, Matthew J. Hankins

“…ILRTs represent a mysterious class of transients that exhibit peak luminosities between those of classical novae and supernovae and that are known to be highly dust obscured. Similar to the prototypical examples of this class of objects, NGC 300 2008-OT and SN 2008S, AT 2019abn has an extremely red and dusty progenitor detected only in pre-explosion Spitzer/IRAC imaging at 3.6 and 4.5 μ m and not in deep optical or near-infrared Hubble Space Telescope images. …”
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Linking The Cancer Imaging Archive and GenBank to the National Clinical Cohort Collaborative by Ahmad Baghal, Joel Saltz, Tahsin Kurc, Prateek Prasanna, Samantha Baghal, Janos Hajagos, Erich Bremer, Shaymaa Al‐Shukri, Joshua L. Kennedy, Michael Rutherford, Tracy Nolan, Kirk Smith, Christopher G. Chute, Fred Prior

“…Conclusion Linking across clinical data sources at the patient level provides opportunities to gain insights from data that may not be known otherwise. The PPRL prototype and the pilot serve as a model to link disparate and diverse data repositories to enhance clinical research.…”
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Comparative analysis of brushless DC and switched reluctance motors for optimizing off-grid water pumping by Avinash Kumar, Sanjay Marwaha, Manpreet Singh Manna, Anupma Marwaha, Rajat Kumar, Mohammad Amir, Mohit Bajaj, Ievgen Zaitsev

“…The simulation results of converter topologies used for respective motors have been further validated using experimentation on respective prototype motors.…”
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Self-Examination Low-Cost Full-Field Optical Coherence Tomography (SELFF-OCT) for neovascular age-related macular degeneration: a cross-sectional diagnostic accuracy study by Peter Koch, Inke König, Johann Roider, Jan Tode, Konstantine Purtskhvanidze, Claus von der Burchard, Helge Sudkamp, Cristoph Ehlken, Moritz Moltmann, Britta Heimes, Michael Münst, Malte vom Endt, Timo Kepp, Dirk Theisen-Kunde, Gereon Hüttmann

“…This trial investigates an improved prototype for patients with AMD and focusses on device operability and diagnostic accuracy compared with established spectral-domain OCT (SD-OCT).Design Prospective single-arm diagnostic accuracy study.Setting Tertiary care centre (University Eye Clinic).Participants 46 patients with age-related macular degeneration.Interventions Patients received short training in device handling and then performed multiple self-scans with the SELFF-OCT according to a predefined protocol. …”
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The 0ν2β-decay CROSS experiment: preliminary results and prospects by The CROSS collaboration, I. C. Bandac, A. S. Barabash, L. Bergé, M. Brière, C. Bourgeois, P. Carniti, M. Chapellier, M. de Combarieu, I. Dafinei, F. A. Danevich, N. Dosme, D. Doullet, L. Dumoulin, F. Ferri, A. Giuliani, C. Gotti, P. Gras, E. Guerard, A. Ianni, H. Khalife, S. I. Konovalov, E. Legay, P. Loaiza, P. de Marcillac, S. Marnieros, C. A. Marrache-Kikuchi, C. Nones, V. Novati, E. Olivieri, C. Oriol, G. Pessina, D. V. Poda, T. Redon, V. I. Tretyak, V. I. Umatov, M. M. Zarytsky, A. S. Zolotarova

“…Rejection factors higher than 99.9% of α surface radioactivity have been demonstrated in a series of prototypes based on crystals of Li2MoO4 and TeO2. We have also shown that point-like energy depositions can be identified up to a distance of ∼ 1 mm from the coated surface. …”
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Type I IFN induces long-chain acyl-CoA synthetase 1 to generate a phosphatidic acid reservoir for lipotoxic saturated fatty acids by Shelley Barnhart, Masami Shimizu-Albergine, Eyal Kedar, Vishal Kothari, Baohai Shao, Melissa Krueger, Cheng-Chieh Hsu, Jingjing Tang, Jenny E. Kanter, Farah Kramer, Danijel Djukovic, Vadim Pascua, Yueh-Ming Loo, Lucrezia Colonna, Sadie J. Van den Bogaerde, Jie An, Michael Gale, Jr., Karen Reue, Edward A. Fisher, Sina A. Gharib, Keith B. Elkon, Karin E. Bornfeldt

“…Conversely, ACSL1 induction is not needed for IFN-I’s ability to induce the prototypical IFN-stimulated protein signature or to suppress proliferation or macrophage metabolism. …”
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Experimental study on modal analysis and vibration response of tunnel structures under different damage conditions due to subway train loads by Rui Hou, Tao Li, Zhongyu Zhang, Lingfeng Li, Bo Liu, Dongwei Ren

“…Abstract Based on a prototype of the Beijing subway tunnel, this research conducts large-scale model experiments to systematically investigate the vibration response patterns of tunnels with different damage levels under the influence of measured train loads. …”
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mRNA vaccines with RBD mutations have broad-spectrum activity against SARS-CoV-2 variants in mice by Xiaoming Liang, Yuxia Yuan, Junbin Wang, Cong Tang, Yun Yang, Yanan Zhou, Hao Yang, Qing Huang, Wenhai Yu, Haixuan Wang, Yuhuan Yan, Dongdong Lin, Yanwen Li, Xuena Du, Longhai Yuan, Wenqi Quan, Daoju Wu, Shuaiyao Lu

“…Moreover, all three vaccines induced neutralizing antibodies against the prototype viral strain and relevant variants, including the Alpha and Beta strains and the Omicron variants BA.1, BA.2, BA.5, XBB.1.5, XBB.1.16, EG.5.1, and EG.5.1.1, with BSCoV06 demonstrating broader neutralizing antibody activity. …”
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Tailoring lipid management interventions to reduce inequalities in cardiovascular disease risk management in primary care for deprived communities in Northern England: a mixed-meth... by Julia L Newton, Yu Fu, Sarah Sowden, Paula Whitty, Eugene YH Tang

“…Health professionals involved in the organisation and delivery of routine lipid management to deprived populations will be interviewed to understand the implementation and delivery of current lipid management and associated challenges. The prototype intervention will be informed by the evidence generated from workpackages 1–3, which will be reviewed and assessed using the nominal group technique to reach consensus. …”
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Dual-Polarized Wideband Filtering Antenna Array Based on Stacked-PCB Structure by Matti Kuosmanen, Sten E. Gunnarsson, Johan Malmstrom, Juha Ala-Laurinaho, Jari Holopainen, Ville Viikari

“…The operation of the proposed antenna array is confirmed by measurements of an <inline-formula> <tex-math notation="LaTeX">$11\times 12$ </tex-math></inline-formula> antenna array prototype, which show that the gain suppression level in the stopband is more than 30 dB up to 37 GHz, and more than 20 dB up to 40 GHz.…”
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Proximal tubule-on-chip as a model for predicting cation transport and drug transporter dynamics by Isy Petit, Quentin Faucher, Jean-Sébastien Bernard, Perrine Giunchi, Antoine Humeau, François-Ludovic Sauvage, Pierre Marquet, Nicolas Védrenne, Florent Di Meo

“…We assessed transporters mRNA expression, cellular polarization and protein expression via immunofluorescence, and monitored the transcellular transport of prototypic xenobiotics by determining their efflux ratios. …”
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A Five-Year Retrospective Study of Foot-and-Mouth Disease Outbreaks in Southern Africa, 2014 to 2018 by Elliot Mpolokang Fana, Sununguko Wata Mpoloka, Melvin Leteane, LaToya Seoke, Kelebogile Masoba, Mokganedi Mokopasetso, Aobakwe Rapharing, Tshephang Kabelo, Patricia Made, Joseph Hyera

“…The genetic diversity of the identified Southern African Type (SAT)-FMD viruses was determined by comparing sequences from outbreaks and historical prototype sequences. Of the 453 samples investigated, 176 were positive for four FMDv serotypes. …”
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On the Fractional Dynamics of Kinks in Sine-Gordon Models by Tassos Bountis, Julia Cantisán, Jesús Cuevas-Maraver, Jorge Eduardo Macías-Díaz, Panayotis G. Kevrekidis

“…In the present work, we explored the dynamics of single kinks, kink–anti-kink pairs and bound states in the prototypical fractional Klein–Gordon example of the sine-Gordon equation. …”
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Sub-terahertz transmissive reconfigurable intelligent surface for integrated beam steering and self-OOK-modulation by Dongfang Shen, Feng Lan, Luyang Wang, Tianyang Song, Munan Yang, Tianyu Hu, Yueting Li, Xiaolei Nie, Jiayao Yang, Shixiong Liang, Hongxin Zeng, Hui-Fang Zhang, Pinaki Mazumder, Ziqiang Yang, Yaxin Zhang, Tie Jun Cui

“…An experimental retrieved equivalent lumped-element circuit model is implemented in joint field-circuit simulations and is validated by experiments. A fabricated prototype demonstrates excellent performance of TRIS with the minimum insertion loss of 2.8 dB for operational states, large bandwidth nearly covering the entire W-band for 1-bit phase shift, deep OOK amplitude modulation of 12 dB, and wide scanning range of ±60° with low specular transmission. …”
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Autonomous Behavior Intelligence Control of Self-Evolution Mobile Robot for High-Voltage Transmission Line in Complex Smart Grid by Wei Jiang, Gan Zuo, De Hua Zou, Hongjun Li, Jiu Jiang Yan, Gao Cheng Ye

“…Based on this, the robot autonomous operation control system has been designed and the robot physical prototype has been developed for three maintenance tasks of insulators, drainage plates, and dampers. …”
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User-centred design of ChestCare: mHealth app for pulmonary rehabilitation for patients with COPD; a mixed-methods sequential approach by Suad J. Ghaben, Arimi Fitri Mat Ludin, Nazlena Mohamad Ali, Devinder Kaur Ajit Singh

“…Methods In this mixed-methods sequential research, we deployed the UCD iterative design through the prototype app design and development sequence. The first phase was built based on the results of a previous needs assessment study and an analysis of related apps. …”
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Molecular Epidemiology of Human Norovirus Variants from Outbreaks in Zhejiang Province, China, during 2021 by Yi Sun, Yongjuan Yuan, Haiyan Mao, Lingxuan Su, Qiong Ge, Jian Gao, Changping Xu, Liming Gong

“…Capsid microvariation of GII.2 displayed histo-blood group antigen binding patterns compared to the GII.2 prototype, although VP1 sequences were considered to have a minimal impact on antigenicity. …”
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Four-color single-molecule imaging system for tracking GPCR dynamics with fluorescent HiBiT peptide by Toshiki Yoda, Yasushi Sako, Asuka Inoue, Masataka Yanagawa

“…G-protein-coupled receptors (GPCRs), a major class of drug targets, are prototypical membrane receptors that have been studied using single-molecule imaging techniques. …”
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Research on power plant security issues monitoring and fault detection using attention based LSTM model by Shengda Wang, Zeng Dou, Danni Liu, Han Xu, Ji Du

“…Wind power is well distributed around the world, making it suitable to be exploited in human activities for the general welfare of society. Objectives A prototype security situational awareness system applicable to the power data communication network service and traffic model should be developed. …”
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