The impact of arbuscular mycorrhizal colonization on flooding response of Medicago truncatula by Vajiheh Safavi-Rizi, Vajiheh Safavi-Rizi, Helen Friedlein, Sayedhamid Safavi-Rizi, Franziska Krajinski-Barth

“…In this study, we investigated the effects of mycorrhizal colonization and flooding stress on the growth, physiological and molecular responses of M. truncatula wild-type (WT) and ha1-2 mutant lines. ha1-2 mutant plants are unable to form a functional symbiosis with AM fungi as they are impaired in the proton pump required for phosphate transport from AM fungus to the plant. …”
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Drug-Drug Interactions Between HIV Antivirals and Concomitant Drugs in HIV Patients: What We Know and What We Need to Know by Emanuela De Bellis, Danilo Donnarumma, Adele Zarrella, Salvatore Maria Mazzeo, Annarita Pagano, Valentina Manzo, Ines Mazza, Francesco Sabbatino, Graziamaria Corbi, Pasquale Pagliano, Amelia Filippelli, Valeria Conti

“…Protease inhibitors, followed by nonnucleoside reverse transcriptase inhibitors and integrase inhibitors have been recognized as the main players in DDIs with antivirals used to control co-infection, such as Hepatitis C virus, or with drugs commonly used to treat HIV comorbidities, such as lipid-lowering agents, proton pump inhibitors and anticancer drugs. However, the studies do not seem to be consistent with regard to sample size and follow-up, the drugs involved, or the results obtained. …”
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Subsurface investigation for pre-foundation study utilizing integrated geophysical and geotechnical methods, UNILORIN campus by Gabriel Efomeh Omolaiye, Abdulhameed Kayode Oniyangi, Taofeeq Ayinde ISSA, Sodiq Bamidele Adam

“…The land magnetic survey was acquired at 20 m spacing along seven traverses with the use of Geometrics G857 Proton Precession Magnetometer revealing the presence of concealed basement contact separating the biotite schist in the north from granite gneiss in the south. …”
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Termination-acidity tailoring of molybdenum carbides for alkaline hydrogen evolution reaction by Zhigang Chen, Minghao Yang, Yifan Li, Wenbin Gong, Juan Wang, Tong Liu, Chunyu Zhang, Shuang Hou, Guang Yang, Hao Li, Ye Jin, Chunyan Zhang, Zhongqing Tian, Fancheng Meng, Yi Cui

“…However, the effectiveness of transition-metal carbides catalyzing hydrogen evolution in high-pH electrolyte is severely compromised due to the lowered proton activity and intractable alkaline-leaching issue of transition-metal centers. …”
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V-ATPase in glioma stem cells: a novel metabolic vulnerability by Alessandra Maria Storaci, Irene Bertolini, Cristina Martelli, Giorgia De Turris, Nadia Mansour, Mariacristina Crosti, Maria Rosaria De Filippo, Luisa Ottobrini, Luca Valenti, Elisa Polledri, Silvia Fustinoni, Manuela Caroli, Claudia Fanizzi, Silvano Bosari, Stefano Ferrero, Giorgia Zadra, Valentina Vaira

“…Abstract Background Glioblastoma (GBM) is a lethal brain tumor characterized by the glioma stem cell (GSC) niche. The V-ATPase proton pump has been described as a crucial factor in sustaining GSC viability and tumorigenicity. …”
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Perforated Carcinoma in the Gastric Remnant: A Case of Conservative Treatment Prior to Successful Curative R0 Resection by Ken Yuu, Hiroshi Kawashima, Sho Toyoda, Satoshi Okumura, Kansuke Yamamoto, Naoto Mizumura, Aya Ito, Hiromitsu Maehira, Atsuo Imagawa, Masao Ogawa, Masayasu Kawasaki, Masao Kameyama

“…Conservative medical management was selected, including nasogastric tube insertion, antibiotics, and proton pump inhibitors, because his peritonitis was limited to his epigastrium and his general condition was stable. …”
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Methionine-driven methylation modification overcomes plasmid-mediated high-level tigecycline resistance by Dan Fang, Tianqi Xu, Fulei Li, Yue Sun, Jingyi Sun, Yanqing Yin, Haijie Zhang, Zhiqiang Wang, Yuan Liu

“…Our mechanistic analysis demonstrates that exogenous Met promotes intracellular tigecycline accumulation by upregulating bacterial proton motive force. Moreover, Met accelerates the conversion to S-adenosyl-L-methionine, an essential methyl donor, thereby enhancing 5mC methylation modification in the promoter region of tet(X4) gene and reducing its expression. …”
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Effects of water stably-enriched with oxygen as a novel method of tissue oxygenation on mitochondrial function, and as adjuvant therapy for type 2 diabetes in a randomized placebo-... by Joan Khoo, Christoph E Hagemeyer, Darren C Henstridge, Sumukh Kumble, Ting-Yi Wang, Rong Xu, Linsey Gani, Thomas King, Shui-Boon Soh, Troy Puar, Vanessa Au, Eberta Tan, Tunn-Lin Tay, Carmen Kam, Eng-Kiong Teo

“…The high-glucose environment induced a greater mitochondrial proton leak in cells cultured in ELO water compared to cells cultured in control medium at similar glucose concentration. …”
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Metabolic changes of thalamus assessed by 1H-MRS spectroscopy in patients of cervical spondylotic myelopathy following decompression surgery by Jiangqin Zheng, Yujin Zhang, Baogen Zhao, Ning Wang, Ting Gao, Li Zhang

“…ObjectiveTo assess the changes of thalamic metabolites before and after surgery in patients with Cervical Spondylotic Myelopathy (CSM) using Hydrogen Proton Magnetic Resonance Spectroscopy (1H-MRS) and to investigate its association with improvement in neurological function.MethodsForty-eight CSM patients who underwent cervical decompression surgery from December 2022 to June 2023 were included, and 33 healthy volunteers were recruited. …”
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Diagnostic Accuracy of EndoFaster® and Narrow-Band Imaging Endoscopy in Patients with Impaired Gastric Acid Secretion: A Real-Time Prospective Study by M. Cazzato, G. Esposito, G. Galli, E. Pilozzi, E. Lahner, V. D. Corleto, A. Zullo, E. Di Giulio, B. Annibale

“…Patients in therapy with proton pump inhibitors, previous gastric surgery, and/or known gastric neoplasia were excluded. …”
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Awake brain MRSI reveals anesthetic sensitivity and regional aging effects on [13C]bicarbonate metabolism in mice by Maiko Ono, Rena Kono, Kosei Hirata, Kosei Hirata, Keita Saito, Motonao Nakao, Yoichi Takakusagi, Rikita Araki, Akira Sumiyoshi, Yuhei Takado

“…Abnormalities and alterations in the glycolytic pathway in the pathology of neurodegenerative diseases and brain aging have received much attention, as clinical applications of proton-based magnetic resonance spectroscopy (MRS) have recently illuminated the elevation of lactate concentrations in the brains of patients with neurodegenerative diseases, including Alzheimer’s disease. …”
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Simultaneous Determination of Multiple Acid-Suppressing Drugs by UPLC-MS/MS Method and Application for Pharmacokinetics Study by Li X, Liu S, Yu M, Xi W, Wu X, Liu D, Liu A, Wang H

“…Xiuqi Li,1,* Shupeng Liu,1,* Mengyang Yu,1 Wanlin Xi,1 Xiaofei Wu,1 Dan Liu,2 Aijing Liu,1 Hongyun Wang1 1Clinical Pharmacology Research Center, Peking Union Medical College Hospital, NMPA Key Laboratory for Clinical Research and Evaluation of Drug, Beijing Key Laboratory of Clinical PK & PD Investigation for Innovative Drugs, Chinese Academy of Medical Sciences and Peking Union Medical College, Beijing, 100730, People’s Republic of China; 2School of Life Science and Biopharmaceuticals, Shenyang Pharmaceutical University, Shenyang, Liaoning, 110000, People’s Republic of China*These authors contributed equally to this workCorrespondence: Hongyun Wang, Email wanghy@pumch.cnBackground: Proton pump inhibitors (PPIs) and potassium competitive acid blockers (P-CABs) are widely used to treat acid-related diseases (ARDs). …”
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Dietetic service provision and nutritional interventions provided to patients with head and neck sarcoma: Findings from a national United Kingdom centre five-year audit by Florence Cook, Dimitris Tatsis, Malla Salli, Deepti Sinha, Nicholas Kalavrezos

“…Nutritional interventions were as follows: dietary counselling 100% (n = 66); oral nutritional support 90.9% (n = 60); oral nutritional supplements 75.8% (n = 50); enteral tube-feeding 54.5% (n = 36). 15.2% (n = 10) had a prophylactic gastrostomy; n = 4 pre-surgery and n = 6 pre-radiotherapy/proton-beam therapy±chemotherapy with 100% and 33.3% using the tube for ≥4 weeks respectively. …”
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Advantages of alginate and PPI combination in relief of heartburn and regurgitation during the first days of treatment of gastroesophageal reflux disease by D. S. Bordin, O. B. Yanova, O. I. Berezina, Ye. V. Treyman

“…To estimate advantages of combined intake of proton pump inhibitor (PPI) and alginate in comparison to monotherapy by PPI in terms of symptom relief in the first days of gastroesophageal reflux disease (GERD) treatment.Material and methods. …”
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Recommendations of the Russian Gastroenterological Association in Diagnosis and Treatment of Gastroesophageal Reflux Disease by V. T. Ivashkin, I. V. Maev, A. S. Trukhmanov, T. L. Lapina, O. A. Storonova, O. V. Zayratyants, O. B. Dronova, Yu. A. Kucheryavyy, S. S. Pirogov, R. G. Sayfutdinov, Yu. P. Uspenskiy, A. A. Sheptulin, D. N. Andreev, D. E. Rumyantseva

“…Patients should be conclusively performed esophageal 24-hour pH-metry or pH-impedance monitoring, high-resolution manometry to thoroughly examine functionality of esophagus, esophagogastric junction and assess disease prognosis and therapy outcomes.Treatment of GERD should be personalised accounting for clinical manifestations and severity, as well as aimed at symptom improvement, lesion healing in erosive esophagitis, averting complications, Barrett's esophagus progression, dysplasia and esophageal adenocarcinoma.Proton pump inhibitors (PPIs) are most effective agents in primary (4-8 weeks) and maintenance anti-GERD therapy. …”
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Amplified impact of contact uniformity on the performance of low-catalyst-loading fuel cells by Yuanzhe Ma, Xuanyu Wang, Ziliang Deng, Yongzhen Wang, Nanfeng Zheng, Kai Han, Zipeng Zhao

“…Reducing platinum group metal (PGM) usage in a proton exchange membrane fuel cell (PEMFC) is essential for its broad implementation. …”
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Tracing the change of the volatile compounds of soy sauce at different fermentation times by PTR-TOF-MS, E-nose and GC–MS by Qixin Kan, Longbipei Cao, Liping He, Peipei Wang, Guangdie Deng, Jun Li, Jiangyan Fu, Qingrong Huang, Chi-Tang Ho, Yunqi Li, Chunhui Xie, Yong Cao, Linfeng Wen

“…Proton-transfer reaction time-of-flight mass spectrometry (PTR-TOF-MS), combined with electronic nose (E-nose), was first used to track the change of volatile organic compounds (VOCs) in soy sauce in this study. …”
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Rapid identification of high-temperature Daqu Baijiu with the same aroma type by UV-VIS sensor of HBT combined with Zn2+ by Yanmei Zhu, Yuanyuan Su, Yipeng Cang, Hengye Chen, Wanjun Long, Wei Lan, Xue Jiang, Haiyan Fu

“…The specific mechanism of light signal change was mainly based on the competitive coordination effect of pyrazines and other nitrogen-containing compounds in high-temperature Daqu Baijiu and small molecular probe HBT on Zn2+ and the excited state intramolecular proton transfer (ESIPT) mechanism of HBT itself. Results: The random forest results showed that the prediction set classification accuracy was improved from 62.37% to 100%. …”
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Continuous underground observation of the geomagnetic field in Xuzhou City, North China, and its time-varying characteristics by Mei Han, Mei Han, Lianghui Guo, Lianghui Guo, Lianghui Guo, Yun Wang, Yun Wang, Xiang Wang, Xiang Wang

“…In this experiment, two close-space fluxgate magnetometers were deployed in the underground roadway of the LCMA to observe the variations of geomagnetic three components simultaneously, and a proton magnetometer was installed on its ground to observe the variation of geomagnetic total field. …”
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Trial of alginates in throat symptoms: protocol for a pragmatic, multicentre, placebo controlled, double blind, parallel, randomised controlled trial of liquid alginate (Gaviscon A... by David Hamilton, Ruth Wood, Dawn Teare, Miranda Morton, Rebecca Maier, James O’Hara, Tony Fouweather, Julian McGlashan, Julie Thompson, Richard Joyce, Hesther Smith, Lysbeth Evans

“…Symptoms of PTS and GORD are commonly treated with proton pump inhibitors (PPIs) or alginates are often, incorrectly, advocated. …”
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