Sequestering sequestosome 1 via S-acylation in autophagy, Huntington disease, and beyond by Y Alshehabi, F Abrar, D.D.O Martin

“…We identified S-acylation, a reversible lipid modification of proteins, as an important regulator in protein trafficking and autophagy. SQSTM1 (sequestosome 1/p62) is an essential selective autophagy receptor for the sequestration of ubiquitinated cargoes within autophagosomes and subsequent delivery into lysosomes for degradation. …”
Get full text

Aspartyl protease inhibition interferes with Plasmodium falciparum asexual blood-stage and early gametocyte development by Gamolthip Niramolyanun, Chonnipa Praikongkatham, Rachaneeporn Jenwithisuk, Wanlapa Roobsoong, Jetsumon Sattabongkot, Viriya Pankao, Niwat Kangwanrangsan

“…Within a human host, the parasite possesses many activities for its survival, such as invasion, egress, haemoglobin degradation, and protein trafficking, many of which are related to aspartyl protease, revealing the potential for antimalarial drug targets. …”
Get full text