Immunoinformatic strategy for developing multi-epitope subunit vaccine against Helicobacter pylori. by Md Nahian, Md Rasel Khan, Fabiha Rahman, Hossain Mohammed Reza, Imren Bayil, Tanjum Ahmed Nodee, Tabassum Basher, Mostafizur Rahaman Sany, Rabeya Najnin Munmun, S M Ariful Habib, Lincon Mazumder, Mrityunjoy Acharjee

“…In this study, we employed an immunoinformatic strategy to design a set of candidate multi-epitope subunit vaccines by combining the most potent B and T cell epitopes from three targeted antigenic proteins (BabA, CagA, and VacA). Out of the 12 hypothetical vaccines generated, two (HP_VaX_V1 and HP_VaX_V2) were found to be strongly immunogenic, non-allergenic, and structurally stable. …”
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Cytogenetic impact of gamma radiation and its effects on growth, yield and drought tolerance of maize (Zea mays L.) by Walaa M. Al-Sayed, Hanaa H. El-Shazly, Awatif I. El-Nahas, Ahmed A. A. Omran

“…The study also investigates the sodium dodecyl sulfate–polyacrylamide gel electrophoresis (SDS-PAGE) banding patterns of proteins in grains yielded under the influence of gamma radiation and drought treatments. …”
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Organic Glass-Forming Liquids and the Concept of Fragility by Alba-Simionesco, Christiane

“…An important category of glass-forming materials is organic; it includes molecular liquids, polymers, solutions, proteins that can be vitrified by cooling the liquid under standard conditions or after special thermal treatments. …”
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Using the Sleeping Beauty Transposon System for Doxycycline-inducible Gene Expression in RAW264.7 Macrophage Cells to Study Phagocytosis by Parsa Kamali, Gregory Fairn

“…Finally, using the doxycycline-promoter allows for low near endogenous expression of proteins or robust overexpression.…”
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Development of an mPBPK machine learning framework for early target pharmacology assessment of biotherapeutics by Krutika Patidar, Nikhil Pillai, Saroj Dhakal, Lindsay B. Avery, Panteleimon D. Mavroudis

“…By unraveling new design rules for antibody drug properties that are dependent on ML-based TO assessment, we deliver a first-in-class ML-based target pharmacology assessment framework toward better understanding of the biology-specific PK and ADME processes of antibody drug candidate proteins and reduce the overall time for drug development.…”
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Exosomes derived from liver failure patients’ plasma stimulated mesenchymal stem cells alleviate acute liver failure by Zhuoran Wang, Jun Ling, Shaoli You, Bing Zhu

“…The levels of signaling pathway proteins were determined by western blotting. Results Stimulation with plasma from patients with liver failure significantly altered the morphology of MSCs and reduced their proliferative activity. …”
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Diversity of harmful and beneficial insects on faba bean, Vicia faba L. in Assiut Governorate, Northern Upper Egypt by Hend O. Mohamed, Hassan F. Dahi, Asmaa H. Mahmoud

“…Their seeds are rich sources of proteins, carbohydrates, minerals, and vitamins for human food and animal consumption. …”
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Biomarker discovery and phytochemical interventions in Alzheimer's disease: A path to therapeutic advances by Mithila Debnath, Mahir Azmal, Rashid Taqui, Moshiul Alam Mishu, Ajit Ghosh

“…This research provides a promising viewpoint on treatments for AD by focusing on proteins that are increased in certain parts of the brain, such as the EC and PC, which play a crucial role in the pathways leading to neurodegeneration.…”
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Nanomechanical characterization of soft nanomaterial using atomic force microscopy by Chi-Dat Lam, Soyeun Park

“…Atomic force microscopy (AFM) is a promising method for generating high-spatial-resolution images, providing insightful perspectives on the nanomechanical attributes of soft matter, including cells, bacteria, viruses, proteins, and nanoparticles. AFM is widely used in biological and pharmaceutical sciences because it can scrutinize mechanical properties under physiological conditions. …”
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Acute hepatitis of non-specified etiology by Ye. V. Tsyganova, O. O. Znoyko, N. D. Yushchuk, K. R. Dudina, M. G. Isagulyants, N. V. Petrakova, T. V. Petrova, M. I. Mikhaylov

“…Investigation of patients with acute hepatitis of non-specified etiology included clinical, epidemiologic, routine laboratory, serological methods; molecular biological method (RNA of hepatitis A, C, Е, G viruses; DNA of hepatitis B virus, TTV, CMV, EBV, HHV of 1, 2, 6 and 8 types, PV B-19, NV-f – qualitative analysis); method of immunofluorescence (assessment of antimitochondrial and antinuclear antibodies); immunologic methods (laboratory diagnostic methods) – independent assessment of specific antibodies for individual HCV antigens spectrum, including structural and unstructural proteins and compound peptides, representing the whole HCV polyprotein (overall 38 antigens: 34 HCV antigens and 4 control antigens) in blood serum by EIA method; investigation of Т-cellular immune response to HCV antigens by blast-cell lymphocytes transformation method under stimulation by HCV antigens with quantitative evaluation of cytokine secretion; instrumental method – ultrasound investigation of abdominal organs.Conclusions. …”
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Efficiency comparison of natural coagulants (Cactus pads and Moringa seeds) for treating textile wastewater (in the case of Kombolcha textile industry) by Getahun Demeke Worku, Shimeles Nigussie Abate

“…Moringa seeds and cactus pad consist of proteins (cationic and dimeric) which help in neutralizing and absorbing colloidal charges in water containing suspended solids. …”
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The helper strategy in vector-transmission of plant viruses by Di Mattia, Jérémy, Zeddam, Jean-Louis, Uzest, Marilyne, Blanc, Stéphane

“…HCs are virus-encoded non-structural proteins produced in infected plant cells that are mandatory for the transmission success. …”
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Studying the impact of chitosan salicylaldehyde/schiff base/CuFe2O4 in PC3 cells via theoretical studies and inhibition of PI3K/AKT/mTOR signalling by Ghada H. Elsayed, Asmaa M. Fahim

“…Furthermore, the docking stimulation of the chitosan derivatives with different proteins showed the presence of CuFe2O4 particles effect on the interaction inside their pockets and increased the activities, and it’s related to biological evaluation. …”
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The epididymal microenvironment in Akodon cursor (Muridae, Sigmodontinae, Akodontini): The lifetime of spermatozoa from production to maturation by Tatiana Prata Menezes, Fernanda Carolina Ribeiro Dias, Nara Clara Lazaroni e Merchid, Camila Folly Batista, Camilo Jose Ramirez-Lopez, Arabela Guedes de Azevedo Viana, Renner Philipe Rodrigues Carvalho, Adrielli Ribeiro Araújo, José Lino-Neto, Gisele Lessa, Arlindo A. Moura, Mariana Machado-Neves

“…Proteomic analysis identified 56 proteins in the proximal epididymal regions of A. cursor related to crucial processes, including cellular homeostasis, flagellar elongation, and the elimination of defective sperm during epididymal transit. …”
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TMEM45A enhances palbociclib resistance and cellular glycolysis by activating AKT/mTOR signaling pathway in HR+ breast cancer by Cui Chen, Zehong Chen, Jinze Zhao, Xinyun Wen, Hanming Yao, Zijin Weng, Huiping Xiong, Zongheng Zheng, Juekun Wu

“…Moreover, attenuation of TMEM45A expression reduces cancer aggressiveness by decreasing the expression of EMT and glycolysis-related proteins. Subsequent gene set enrichment analysis (GSEA) confirms that TMEM45A activates the AKT/mTOR signaling pathway, which is integral to cell cycle progression and glycolysis. …”
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Identification of HPV16 E1 and E2-specific T cells in the oropharyngeal cancer tumor microenvironment by Christine McInnis, Lakshmi Srinivasan, Anthony J Coyle, Shilpa Bhatia, Glenn J Hanna, Ann Marie Egloff, Brinda Vijaykumar, Qiaomu Tian, Yanbo Sun, Del Leistritz-Edwards, Charles T Quinn, Ravi Uppaluri, Daniel C Pregibon

“…We used single-cell analysis with encoded peptide-human leukocyte antigen (HLA) tetramers to analyze HPV16+ and HPV33+ OPSCC tumors, characterizing the ex vivo cellular responses to HPV-derived antigens presented in major Class I and Class II HLA alleles.Results We identified robust cytotoxic T-cell responses to HPV16 proteins E1 and E2 that were shared across multiple patients, particularly in HLA-A*01:01 and HLA-B*08:01. …”
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Three local plants adapt to ecological restoration of abandoned lead-zinc mines through assembly of rhizosphere bacterial communities by Wei Gao, Shuyi Chen, Xin Yu, Sumin Chen, Caijing Wan, Ying Wang, Peng Wu, Qiang Li

“…In addition, different plants have been found to have different functions in the lead-zinc ecological restoration process, including iron complex transport system-permitting proteins and ATP binding cassettes.DiscussionThis study confirms for the first time that plants adapt to the remediation process of abandoned lead-zinc mines by non-randomly assembling rhizosphere bacterial communities and functions, providing a reference for screening microbial remediation bacterial resources and plant microbe joint bioremediation strategies for lead-zinc mines.…”
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Serum Zinc Levels in Women with Polycystic Ovarian Syndrome are Lower as Compared to Those without Polycystic Ovarian Syndrome: A Cohort Study by Swati Dhar, Reena Yadav, Akash Tomar

“…Background: Zinc is an essential micronutrient, a vital stabiliser and a cofactor in many enzymes such as superoxide dismutase and phospholipase C and also acts as an antioxidant by protecting the sulfhydryl groups of different proteins and enzymes against free radicals. It is unclear if serum zinc levels are correlated with polycystic ovary syndrome (PCOS) and its pathophysiology, although relation between diabetes and insulin resistance has been established. …”
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Electroacupuncture combined with trigonelline inhibits pyroptosis in cerebral ischemia-reperfusion by suppressing autophagy via the PI3K/AKT/mTOR signaling pathway by Zhengguo Qiu, Jianbing Ma, Xiaqing Zhang, Mingna Jiao, Liqiang Zhi

“…The expression of various proteins was measured using IF assay and western blot. …”
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A genome-wide association study identified SNP markers and candidate genes associated with morphometric fruit quality traits in mangoes by Shamseldeen Eltaher, Jin Li, Barbie Freeman, Sukhwinder Singh, Gul Shad Ali

“…Gene annotation of the significant markers revealed candidate genes coding for important proteins, enzymes, and transcription factors associated with fruit development traits.…”
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