An ingestible bioimpedance sensing device for wireless monitoring of epithelial barriers by Brian M. Holt, Justin M. Stine, Luke A. Beardslee, Hammed Ayansola, Younggeon Jin, Pankaj J. Pasricha, Reza Ghodssi

“…In the GI tract, local inflammatory processes induce alterations in tight junction proteins, enhancing paracellular ion permeability. …”
Get full text

Untargeted metabolomic and proteomic analysis implicates SIRT2 as a novel therapeutic target for diabetic nephropathy by Ruijing Zhang, Runze Chang, Heng Wang, Jinshan Chen, Chuanlong Lu, Keyi Fan, Yuhang Zhang, Lizheng Li, Sheng Yan, Honglin Dong

“…Correlation analysis of major differentially abundant metabolites and differentially expressed proteins revealed that SIRT2 might be a key hub linking energy metabolism and innate immune responses. …”
Get full text

D-2-hydroxyglutarate impairs DNA repair through epigenetic reprogramming by Fengchao Lang, Karambir Kaur, Haiqing Fu, Javeria Zaheer, Diego Luis Ribeiro, Mirit I. Aladjem, Chunzhang Yang

“…CTCF depletion leads to the disruption of chromatin organization around the DNA damage sites, which abolishes the recruitment of essential DNA damage repair proteins BRCA2 and RAD51, as well as impairs homologous repair in the IDH mutant cancer cells. …”
Get full text

The Importance of Breakfast in Enhancing Students' Focus at School by Nurul Widad Fitri Muhammad, Nur Aina Mardhiah Che Rahim, Amrina Rasyada Kamaruzaman, Noor Fatimah Mujahid, Khairulnazrin Nasir

“…The results demonstrate that eating a healthy breakfast, a combination of carbohydrates, proteins and vegetables, does help students focus better in class. …”
Get full text

Effects of pollen enriched diet on hypopharyngeal glands’ morphology and morphometry and vitellogenin transcription levels in honey bees by Claudia D’Emilio, Viviana Valenzano, Paola Maiolino, Karen Power, Manuela Martano, Gennaro Di Prisco

“…Pollen proteins are necessary for the development of the hypopharyngeal glands (HPGs), and for Vitellogenin (VG) synthesis, responsible for producing royal jelly, essential for larval development and queen feeding. …”
Get full text

Synthetic peptides as valuable and versatile tools for research: our 20 year journey in Chile by Constanza Cárdenas, Paula Santana, Claudio Álvarez, Luis Mercado, Sergio Marshall, Fernando Albericio, Fanny Guzmán

“…According to the International Union of Pure and Applied Chemistry (IUPAC), peptides are small proteins with a size between 2 and 50 amino acids residues. …”
Get full text

Andrographolide suppresses cervical cancer progression by targeting angiogenesis and inducing apoptosis in a CAM-PDX model by Wanwan Zou, Jun Lou, Yun Yi, Yiming Cui, Xiaoyan Chu

“…Immunohistochemical analysis revealed that AND downregulated key proteins associated with cancer cell proliferation and survival, including Ki67, B-cell lymphoma 2 (BCL-2), and Erythroblast transformation-specific-related gene (ERG). …”
Get full text

Prediction of inhibitory peptides against E.coli with desired MIC value by Nisha Bajiya, Nishant Kumar, Gajendra P. S. Raghava

“…Additionally, we screened anti-E. coli proteins in the proteomes of three probiotic bacterial strains and created a web-based platform, “EIPpred”, enabling users to design peptides with desired MIC values ( https://webs.iiitd.edu.in/raghava/eippred ).…”
Get full text

In silico identification of switching nodes in metabolic networks by Mairet, Francis

“…Additionally, switch metabolites are deeply involved in post-translational modification of proteins, showing their importance in cellular regulation. …”
Get full text

Factors associated with iron deficiency aneamia among pregnant women at Chuk hospital in Kigali, Rwanda by Mercy Nwankwo, Chinenye, Hashim Abdullahi, Fardosa

“…A balanced diet, rich in proteins, iron and vitamins from good sources like liver, meat, eggs, green peas, figs, beans, whole wheat and green bananas remains very critical in tackling iron deficiency anaemia problem among the pregnant women. …”
Get full text

Structural basis for RNA-guided DNA degradation by Cas5-HNH/Cascade complex by Yanan Liu, Lin Wang, Qian Zhang, Pengyu Fu, Lingling Zhang, Ying Yu, Heng Zhang, Hongtao Zhu

“…Abstract Type I-E CRISPR (clustered regularly interspaced short palindromic repeats)–Cas (CRISPR-associated proteins) system is one of the most extensively studied RNA-guided adaptive immune systems in prokaryotes, providing defense against foreign genetic elements. …”
Get full text

Assessment of Herpes Simplex Virus Type 1 and 2 by IHC in Association with CD14 Antigen in Placental Tissues from Women with Miscarriage by Zainab A. Hamid, Solaf J. Ali, Ali Hattem Hussain

“…The IHC- expressions of HSV-1, HSV-2, and CD14 proteins were detected in 4(10%), 15(37.5%), 15(37.5%) in placental tissues from miscarriage women, respectively. …”
Get full text

Engineered Bacillus subtilis WB600/ZD prevents Salmonella Infantis-induced intestinal inflammation and alters the colon microbiota in a mouse model by Wei Li, Xue Wang, Keyuan Chen, Yaohong Zhu, Guiyan Yang, Yipeng Jin, Jiufeng Wang

“…Infantis infection and increased expression of antioxidant and tight junction proteins, thus alleviating the severity of intestinal inflammation in both the jejunum and ileum (P < 0.01). …”
Get full text

Cloned airway basal progenitor cells to repair fibrotic lung through re-epithelialization by Yu Zhao, Yueqing Zhou, Weipan Zhang, Mingzhe Liu, Jun Duan, Xiaopeng Zhang, Qiwang Ma, Yujia Wang, Yuzhen Zhang, Zhongliang Guo, Ting Zhang, Wei Zuo

“…Mechanistically, the engrafted human progenitor cells do not function by differentiating into mature alveolar cells in mouse lung; instead, they differentiate into saccular cells expressing multiple tight junction proteins such as CLDN4, which help the lung to re-establish epithelial barriers. …”
Get full text

Exosome-based targeted delivery of NF-κB ameliorates age-related neuroinflammation in the aged mouse brain by Chae-Jeong Lee, Seung Hyun Jang, Jiwoo Lim, Hyunju Park, So-Hee Ahn, Seon Young Park, Hyangmi Seo, Soo-Jin Song, Jung-A Shin, Chulhee Choi, Heon Yung Gee, Youn-Hee Choi

“…Exosomes are potent therapeutics or drug delivery vehicles for various materials, including proteins and regulatory genes, to target cells. In the present study, we evaluated the therapeutic efficacy of exosomes loaded with a nondegradable form of IκB (Exo-srIκB), which inhibits the nuclear translocation of NF-κB to suppress age-related neuroinflammation. …”
Get full text

Folate alleviated skin inflammation and fibrosis resulting from impaired homocysteine metabolism by Jiefeng Huang, Wuyan Lu, Shenli Zhao, Zixin Cai, Linxiao Li, Zihao Hu, Yu Jiang, Jinyi Deng, Yiming Tang, Chenzhang Shi, Chen Wang, Guangpeng Liu, Shuaijun Li

“…Skin fibrosis, characterized by uncontrolled secretion of extracellular matrix (ECM) proteins such as collagen, can lead to excessive scarring and compromised tissue function. …”
Get full text

Cytokine-armed oncolytic herpes simplex viruses: a game-changer in cancer immunotherapy? by Howard L Kaufman, Hongbin Wang, Dipongkor Saha, Samuel D Rabkin, Mia Borlongan, Uyen Le, Hans J Nauwynck

“…Cytokines are small proteins that regulate the growth and functional activity of immune cells, and several have been approved for cancer therapy. …”
Get full text

High-resolution mass spectrometry measurement of N-terminal carbamylated hemoglobin as a potential marker for chronic diseases with elevated blood urea levels by Fangjun Chen, Priscilla S.-W. Yeung, Carolyn V. Wong, Ruben Y. Luo

“…Beyond CarHb, the use of other carbamylated proteins as clinical diagnostic and prognostic markers can be explored.…”
Get full text

Immune-endocrine crossroads: the impact of nuclear receptors in Tuberculosis and Chagas disease by Ana R. Pérez, Ana R. Pérez, Oscar A. Bottasso, Oscar A. Bottasso, Oscar A. Bottasso, Natalia E. Santucci, Natalia E. Santucci

“…Nuclear Receptors (NRs) comprise a superfamily of proteins with essential roles in cell signaling, survival, proliferation, and metabolism. …”
Get full text

Understanding integrative approach of translational bioinformatics on cardiovascular disease: Myocardial Ischemia by Yeswanth Ranganathan, Saayaa Nazar, Ravi Shankar Krishnan, Yuvaraj Dinakarkumar, Vijayalakshmi Varadarajan, Lenita Sebastian, Brindha Rethinam

“…It covers the discovery of novel biomarkers (miRNA, lncRNA, and tsRNA), analysis of genes and proteins, and integrated bioinformatics to identify differentially expressed genes. …”
Get full text