Effects of high-pressure homogenization on phenolics profile, antioxidant activity, α-glucosidase inhibitory activity, and insulin resistance of peach juice during simulated gastro... by Yijin Peng, Shenke Bie, Shengbao Cai, Linyan Zhou, Chaofan Guo

“…Molecular docking analysis further revealed that key phenolic compounds, including phlorizin and quercetin, interacted effectively with IRS1/PI3K/AKT pathway proteins, contributing to the alleviation of insulin resistance. …”
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Blue light promotes conjunctival epithelial-mesenchymal transition and collagen deposition through ITGB4 by Qianjie Yang, Kuangqi Chen, Siyi Chen, Yinhao Wang, Yutong Xia, Jinbo Chen, Ye Shen

“…BL disrupted cell conjunction and regulated EMT-related proteins. RNA sequencing analysis revealed upregulation of ITGB4 and enrichment of cell migration and adhesion pathways. …”
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Analysis of differential metabolites in Liuyang douchi at different fermentation stages based on untargeted metabolomics approach by Liwen Jiang, Yi Chen, Tiantian Zhao, Pao Li, Luyan Liao, Yang Liu

“…Obvious hydrolysis of carbohydrates, proteins and slight lipids degradation were observed. …”
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Probiotics, metabolism and the functional condition of cardio-vascular system by Ye. A. Kashukh, V. T. Ivashkin

“…According to recent studies human gastrointestinal microbiome may increase cardiovascular risk due to bacterial production of proinflammatory proteins that both promote development of atherosclerosis and directly affect the heart and vessels. …”
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In-situ formation mechanism of endogenous fluorescent carbon dots during the roasting process of small yellow croaker (Larimichthys polyactis) by Yutong Qu, Shuyi Zhao, Jilong Ni, Long Jiao, Xiaoye Zhang, Soottawat Benjakul, Zhiyu Liu, Xiang Chen, Bin Zhang

“…This was due to the thermal aggregation of biological macromolecules such as proteins and fats, leading to thermal decomposition and disintegration, resulting in the formation of FCDs (∼5 nm). …”
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Natural biopolymers in edible coatings: Applications in food preservation by Arun Karnwal, Gaurav Kumar, Rattandeep Singh, Manickam Selvaraj, Tabarak Malik, Abdel Rahman Mohammad Al Tawaha

“…Made from natural biopolymers such as proteins, polysaccharides, and lipids, these coatings form a thin, edible layer on food surfaces. …”
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Live Visualization of Calcified Bones in Zebrafish and Medaka Larvae and Juveniles Using Calcein and Alizarin Red S by Rina Koita, Sae Oikawa, Taisei Tani, Masaru Matsuda, Akinori Kawamura

“…A prevalent technique for investigating calcified bone development in these species involves using transgenic fish that express fluorescent proteins labeling calcified bones; however, acquiring these fish and isolating appropriate crosses can be time-consuming. …”
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Innovative bean sprouts basket (iBSB): A conceptual paper on a new dimension of low-cost bean sprout cultivation among agro-community by Yusuf Munifah Siti Amira, Takrim Aiman, Lazim Siti Saripa Rabiah Mat

“…The sprouts are composed of proteins, carbohydrates, and biochemical compounds with a significant amount of the recommended daily requirement for ascorbic acid and riboflavin, as well as a variety of minerals obtained through the consumption of sprouts. …”
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Gen inhibiting the Wnt/Ca2+ signaling pathway alleviates cerebral ischemia/reperfusion injury by Li Li, Saisai Liu, Mengzhe Wang, Mengjia Li, Yi Liu, Haili Chen, Jie Chen, Weiting Tao, Li Huang, Shidi Zhao

“…Further analysis revealed that Gen regulates key proteins in the Wnt/Ca2+ signaling pathway, including Wnt5a and Frizzled-2, effectively preventing intracellular calcium accumulation and subsequent damage. …”
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Intestinal Barrier, Permeability and Nonspecific Inflammation in Functional Gastrointestinal Disorders by A. L. Kovaleva, E. A. Poluektova, O. S. Shifrin

“…For instance, FD patients exhibit variant expression of cell junction proteins (claudin-1, zonula occludens, occludin, E-cadherin, β-catenin and desmoglein-2), and IBS patients — overexpression of claudin-2. …”
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Endothelial AGGF1 promotes retinal angiogenesis by coordinating TNFSF12/FN14 signalling by Ying Cheng, Man Zhang, Chenguang Li, Long Su, Lingli Fu, Shi Wu, Chaofei Xu, Bei Sun, Liming Chen

“…AGGF1 upregulates the expression of cell cycle proteins by increasing the binding of tumour necrosis factor ligand superfamily member 12 (TNFSF12) to fibroblast -growth -factor-inducible 14 (FN14, TNFRSF12A). …”
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A mathematical model of mechanotransduction by Bradley J. Roth

“… This article reviews the mechanical bidomain model, a mathematical description of how the extracellular matrix and intracellular cytoskeleton of cardiac tissue are coupled by integrin membrane proteins. The fundamental hypothesis is that the difference between the intracellular and extracellular displacements drives mechanotransduction. …”
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Respiratory pathology in the mdx/utrn -/- mouse: A murine model for Duchenne Muscular Dystrophy (DMD). by Marán Y Hernández Rodríguez, Debolina D Biswas, Aoife D Slyne, Jane Lee, Evelyn Scarrow, Sarra M Abdelbarr, Heather Daniels, Ken D O'Halloran, Leonardo F Ferreira, Charles A Gersbach, Mai K ElMallah

“…The most studied DMD mouse model- the mdx mouse- has a milder respiratory phenotype compared to humans, likely due to compensatory overexpression of utrophin. mdx/utrn-/- mice lack both dystrophin and utrophin proteins. These mice have an early onset of muscular dystrophy, severe muscle weakness, and premature death, but the respiratory pathophysiology is unclear. …”
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Bioprinting of bespoke islet-specific niches to promote maturation of stem cell-derived islets by Myungji Kim, Seungyeon Cho, Dong Gyu Hwang, In Kyong Shim, Song Cheol Kim, Jiwon Jang, Jinah Jang

“…Here, we bioengineer the in vivo-like pancreatic niches by optimizing the combination of pancreatic tissue-specific extracellular matrix and basement membrane proteins and utilizing bioprinting-based geometrical guidance to recreate the spatial pattern of islet peripheries. …”
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Treatment of irritable bowel syndrome: the past, present and future by V. T. Ivashkin, Ye. A. Poluektova, O. S. Lyashenko, D. V. Reykhart

“…Considering new data on IBS pathogenesis (disorder of intestinal microbiome, functional and structural remodeling of proteins of cell membrane at the level of synapses of spinal cord posterior horns), prescription of probiotics and peripheral opioid receptors agonists is proven as well. …”
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Research Progress of ROS-Mitochondrial Pathway on Cardiovascular Protection of Tea Polyphenols by Tingting DENG, Jinchan PI, Xiaoping PENG, Yufei YAO, Yiquan LI, Wenjuan LI

“…From the perspective of ROS-mitochondrial pathway, the article elucidates how tea polyphenols behaved the beneficial effects against cardiovascular diseases by modulating the expression of mitochondrial fusion and fission proteins, reducing the opening of mitochondrial membrane permeability transition pore, maintaining cellular calcium homeostasis, mitigating mitochondrial DNA damage and regulating mitochondrial apoptosis signaling pathways. …”
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An Improved Yolov10n for Detection of Bronchoalveolar Lavage Cells by Peihe Jiang, Shaoqi Li, Yanfen Lu, Xiaogang Song

“…Bronchoalveolar lavage fluid (BALF) is a liquid sample that reflects the biological status of lung tissues, containing a wealth of components such as cells and proteins. These components provide a non-invasive method to obtain pathological information about the lungs, serving as a powerful complement to traditional lung biopsies. …”
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Critical functions for STAT5 tetramers in the maturation and survival of natural killer cells by Jian-Xin Lin, Ning Du, Peng Li, Majid Kazemian, Tesfay Gebregiorgis, Rosanne Spolski, Warren J. Leonard

“…IL-15 activates STAT5 proteins, which can form dimers or tetramers. We previously found that NK cell numbers are decreased in Stat5a−Stat5b tetramer-deficient double knockin (DKI) mice, but the mechanism was not investigated. …”
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Paracrine activity of Smurf1-silenced mesenchymal stem cells enhances bone regeneration and reduces bone loss in postmenopausal osteoporosis by Alberto González-González, Itziar Álvarez-Iglesias, Daniel García-Sánchez, Monica Dotta, Ricardo Reyes, Ana Alfonso-Fernández, Alfonso Bolado-Carrancio, Patricia Díaz-Rodríguez, María Isabel Pérez-Núñez, José Carlos Rodríguez-Rey, Jesús Delgado-Calle, Flor M. Pérez-Campo

“…Proteomic analysis of the soluble and vesicular CM fractions identified key proteins involved in bone regeneration. Results CM from Smurf1-silenced MSCs significantly enhanced mineralization in vitro and bone formation in vivo. …”
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Nanomédicaments pour le traitement de maladies graves et recherches duales by Couvreur, Patrick

“…This review aims to describe and discuss the characteristics and functionalities of the different generations of nanocarriers, from their inception to the present day, discussing the prospects they offer for the production of therapeutic proteins, for facilitating gene editing (CRISPR/Cas9), and for enabling immune checkpoint blockade in oncology. …”
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