Repression of CADM1 transcription by HPV type 18 is mediated by three-dimensional rearrangement of promoter-enhancer interactions. by Karen Campos-León, Jack Ferguson, Thomas Günther, C David Wood, Steven W Wingett, Selin Pekel, Christy S Varghese, Leanne S Jones, Joanne D Stockton, Csilla Várnai, Michelle J West, Andrew Beggs, Adam Grundhoff, Boris Noyvert, Sally Roberts, Joanna L Parish

“…We have previously shown that HPV18 recruits the host protein CTCF to viral episomes to control the differentiation-dependent viral transcriptional programme. …”
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NT5E (CD73) as a prognostic biomarker and therapeutic target associated with immune infiltration in lung adenocarcinoma by Leyan Chen, Tuoya Qi, Bishu Zhang, Xuelong Wang, Mingfeng Zheng

“…We found that NT5E was significantly overexpressed at both the mRNA and protein levels in LUAD tissues. Elevated NT5E expression was significantly linked to multiple clinicopathological factors, including metastasis and pathological stage, and served as a strong predictor of poor prognosis in LUAD patients. …”
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Establishment and characterization of ovarian clear cell carcinoma patient-derived xenografts by Joseph J. Caumanns, Shang Li, Gert J. Meersma, Evelien W. Duiker, Ate G. J. van der Zee, G. Bea A. Wisman, Steven de Jong

“…ARID1A, PTEN, ATM, BRCA1 and PIK3CA mutations were found in matched tumors and PDXs. ARID1A protein loss was further verified by immunohistochemical staining. …”
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Effect of a Yogic Breathing Technique on Immune Parameters among Healthcare Workers: A Randomized Controlled Pilot Study by Archana Balasubramanian, Priyathersini Nagarajan, Mathangi Damal Chandrasekar, Kaviraja Udupa, Emmanuel Bhaskar, Divya Kanchibotla, Saumya Subramanian

“…Pro-inflammatory markers such as erythrocyte sedimentation rate, C-reactive protein and neutrophil-to-lymphocyte ratio showed a decrease in mean values after 12 weeks in both groups, which was not statistically significant. …”
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Determinants of Adverse Perinatal Outcomes in Ibadan, Nigeria: The influence of maternal lifestyle. by Ikeola A Adeoye, Chioma O Unogu, Kofoworola Adediran, Babatunde M Gbadebo

“…Of the lifestyle factors examined, only a high protein diet with a non-alcoholic beverage dietary pattern had a statistically significant association with preterm birth [AOR: 0.50, 95%CI (1.08-3.52)]. …”
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Engineering a phi15-based expression system for stringent gene expression in Pseudomonas putida by Eveline-Marie Lammens, Daniel C. Volke, Alison Kerremans, Yannick Aerts, Maarten Boon, Pablo I. Nikel, Rob Lavigne

“…Moreover, by successfully decoupling cell growth and protein production using phi15 gp16, a host RNAP inhibitor, expression levels could be enhanced further (20%). …”
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Anti-allergic potentials of Ceriops decandra leaves in TDI-induced allergic mice: Comprehensive in-vivo and in-silico studies by Aishwarja Dey, Subarna Rani, Rabindra Nath Acharyya, Apurba Kumar Barman, Khondoker Shahin Ahmed, Nripendra Nath Biswas, Shrabanti Dev, Asish Kumar Das

“…Among those Rutin hydrate, exhibited the best docking scores at all the targeted protein molecules and the highest binding affinity was (-9.8 kcal/mol) against Interleukin-5. …”
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Targeted therapy and immunotherapy for gastric cancer: rational strategies, novel advancements, challenges, and future perspectives by Dong Luo, Yunmei Liu, Zhengmao Lu, Lei Huang

“…Programmed cell death protein 1 (PD-1) and programmed cell death-ligand 1 (PD-L1) antibodies are the most commonly used immunotherapeutic agents and have been used with some success in GC treatment. …”
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Artesunate, EDTA, and colistin work synergistically against MCR-negative and -positive colistin-resistant Salmonella by Yajun Zhai, Peiyi Liu, Xueqin Hu, Changjian Fan, Xiaodie Cui, Qibiao He, Dandan He, Xiaoyuan Ma, Gongzheng Hu

“…Additionally, we also demonstrated that the CheA of chemosensory system and virulence-related protein SpvD were critical for the bacteriostatic synergistic effects of the triple combination. …”
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A study looking at how missed somatropin injections affect growth in children with growth hormone deficiency: a plain language summary of publication by Jane Loftus, Bradley S. Miller, Craig S. Parzynski, Jose Alvir, Yong Chen, Priti Jhingran, Anu Gupta, Mitch DeKoven, Victoria Divino, Jenny Tse, Jing He, Michael Wajnrajch

“…Glossary of commonly used terms Adherence – in this study, adherence refers to whether the children had enough medication ( somatropin ) to have daily injections as prescribed by their doctor. Growth hormone - a protein made in the pituitary gland that helps the body grow properly. …”
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Optimalisasi Kandungan Gizi dan Aktivitas Antioksidan Bubur Instan berbasis Beras Pratanak dan Tepung Mocaf yang Difortifikasi Bayam Merah by Zulfa Nur Hanifa, Esi Emilia

“…Analisis proksimat untuk menentukan kadar air, abu, protein, lemak, dan karbohidrat menggunakan metode sesuai dengan metode AOAC 1995. …”
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Structural basis for the ligand-dependent activation of heterodimeric AHR-ARNT complex by Xiaotong Diao, Qinghong Shang, Mengqi Guo, Yubin Huang, Meina Zhang, Xiaoyu Chen, Yinping Liang, Xiangnan Sun, Fan Zhou, Jingjing Zhuang, Shuang-Jiang Liu, Christoph F. A. Vogel, Fraydoon Rastinejad, Dalei Wu

“…Our findings further reveal the structural underpinnings of a ligand-driven activation mechanism, whereby a segment of the AHR protein undergoes a structural transition from chaperone engagement to ARNT heterodimer stabilization, to generate the transcriptionally competent assembly. …”
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Escherichia coli in septic arthritis: prevalence and antibiotics susceptibility patterns by Masroora Ali Khan, Muhammad Kamran Taj, Zahid Khan, Imran Taj, Muhammad Naeem, Saima Azam

“…Suspected patients showed a significant increase in the levels of white blood cells (WBC), C-reactive protein (CRP), and erythrocyte sedimentation rate (ESR), notably, these levels were further elevated in E. coli-positive patients. …”
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CircSPG21 ameliorates oxidative stress-induced senescence in nucleus pulposus-derived mesenchymal stem cells and mitigates intervertebral disc degeneration through the miR-217/SIRT... by Yongbo Zhang, Sheng Yang, Xuan You, Zhengguang Li, Liuyang chen, Rui Dai, Hua Sun, Liang Zhang

“…Interactions among circSPG21, miR-217, and the NAD-dependent protein deacetylase sirtuin-1 (SIRT1) were validated through dual-luciferase assays, RNA fluorescence in situ hybridization and RNA immune precipitation. β-Gal staining, EdU staining, Western blotting, JC-1 assays, cell cycle analysis, and quantitative reverse transcription PCR (RT‒qPCR) were used to examine the functions of these molecules in TBHP-induced senescent NPMSCs. …”
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Bee Venom—A Potential Complementary Medicine Candidate for SARS-CoV-2 Infections by Keneth Iceland, Kasozi, Simon Peter, Musinguzi

“…Melittin is associated with the underexpression of proinflammatory cytokines, including nuclear factor-kappa B (NF-kB), extracellular signal-regulated kinases (ERK1/2), and protein kinase Akt. BV therapy also involves group III secretory phospholipase A2 in the management of respiratory and neurological diseases. …”
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Causal links between obesity, lipids, adipokines, and cognition: a bidirectional Mendelian-randomization analysis by Meng Gong, Haichao Liu, Zhixiang Liu, Yongshen Wang, Shiyi Qi, Hong Guo, Song Jin

“…BackgroundThe aim of this study was to explore the genetic level association between obesity, lipids, adipokines, and cognitive ability using bidirectional Mendelian randomization (MR) strategies.MethodsSummary data for three obesity indicators [body mass index (BMI), body fat percentage (BFP) and waist-hip ratio (WHR)], three lipid indicators [HDL cholesterol (HDL), LDL cholesterol (LDL) and triglycerides (TG)], three adipokines [circulating leptin (LEP), Agouti-related protein (AgRP) and Adiponectin (APDN)], and four cognitive ability indicators [cognitive function (CF), cognitive performance (CP), simple reaction time (SRT) and fluid intelligence score (FIS)] were collected. …”
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Characterization of food wastes from the hotel industry as a potential feedstock for energy production by Emily Machuma Muchele, Booker Osodo, Isaiah Omosa, Emmanuel Yeri Kombe

“…The average feedstock characteristics were observed to be moisture content (6.0%, p < .001, R2 = 90.70 %), total solid (93.7%, p < .001, R2 = 99.97 %), volatile solid (84.3%, p < .001, R2 = 99.80 %), ash content (4.2%, p = .005, R2= 48.54 %), fixed carbon (5.4%, p < .001, R2 = 88.61%), nitrogen (3.6%, p = .04, R2 = 36.81 %), carbon to nitrogen ratio C/N (4.0), crude protein (22.4%, p = .004, R2 = 49.36 % ), crude lipids (12.1%, p < .001, R2 = 89.06 %), total organic carbon (44%, p < . 001, R2 = 94.70%), potassium (0.6%), sodium (1.2%), calcium (0.2%), and phosphorus (0.4%). …”
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A report on the physicochemical and antioxidant properties of three Indonesian forest honeys produced by Apis dorsata by Mahani, Pamungkas Rizki Ferdian, Habil Muhammad Ghibran, Amirah Fathia Herlina, Siti Nurhasanah, Nunung Nurjanah, Rizki Rabeca Elfirta, Avry Pribadi, Raden Lia Rahadian Amalia, I Made Samudra

“…Key physicochemical parameters include moisture, color, electrical conductivity (EC), total dissolved solids (TDS), total suspended solids (TSS), density, diastase number (DN), hydroxymethylfurfural (HMF), pH, total acidity, ash content, protein content, and reducing sugars. Antioxidant properties, assessed through total phenolic content (TPC), total flavonoid content (TFC), DPPH radical scavenging activity, ascorbic acid equivalent antioxidant capacity (AEAC), and ferric reducing power (FRP), revealed significant regional variability. …”
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Designing and evaluating alternative livelihoods for shark conservation: a case study on thresher sharks in Alor Island, Indonesia by Rafid A. Shidqi, Dewi R. Sari, Jeheskiel Alopen, Yodhikson M. Bang, Igo Arianto, Primiaty N. S. Kopong, Vivekananda Gitandjali TD, Etoile Smulders, Hollie Booth

“…Indonesia is the world's largest shark fishing nation, and in Alor Island, thresher sharks have been a primary target for small-scale fishing communities for decades, sustaining subsistence livelihoods and serving as a protein source. With thresher shark populations continuously declining, there is a need for conservation measures to reduce shark mortality from fishing, while also securing the well-being of coastal communities. …”
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Skin autofluorescence as part of the comprehensive assessment of clinical and metabolic status of patients with end-stage chronic kidney disease by Darya Yu. Konovalova, Peter A. Lebedev, Olga V. Ushakova, Elena E. Potyakina, Dmitriy V. Kornilin, Vladimir N. Grishanov, Marina V. Komarova

“…SAF was associated with malnutrition stages (by NRI; r=−0.39; p 0.001), the Charlson comorbidity index (r=0.60, p 0.0001), and inflammatory activity based on C-reactive protein in the PHD group (r=0.32, p 0.01). CONCLUSION: Models of SAF determinants in each studied group were proposed. …”
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