Hepatoprotective Effects of Nasturtium Officinale and Allium Polyanthum Extracts on CCL4- Induced Hepatic Damage In Albino Rats by Shkar Rzgar K.Rostam, Zana Hassan Ibrahim, Rebaz Rebwar Mala, Soran Qadir Abdul

“…Aspartate aminotransferase (AST), Alanine aminotransferase (ALT), Alkaline phosphatase (ALP), Total serum bilirubin (TSB), Total protein (TP), Albumin (ALB) and malondialdehyde (MDA) were measured in serum at the end of the study. …”
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Soluble fibres modulate dough rheology and gluten structure via hydrogen bond density and Flory-Huggins water interaction parameter by Stefano Renzetti, Lisa Lambertini, Helene C.M. Mocking-Bode, Ruud G.M. van der Sman

“…Image analysis of the gluten network revealed that fibre structure and physico-chemical properties influenced the gluten network by altering branching rate, lacunarity, and protein strand width. Comparing inulins and polydextrose of similar molecular weights (Mw) indicated that interactions with gluten were influenced more by NOH,s than Mw. …”
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Compound lactic acid bacteria enhance the aerobic stability of Sesbania cannabina and corn mixed silage by Muhammad Tahir, Tianwei Wang, Jiaqi Zhang, Tianqi Xia, Xian Deng, Xiaofeng Cao, Jin Zhong

“…Abstract Background The strategic delay of aerobic deterioration in Sesbania cannabina and corn (SC) mixed silage, coupled with effective fermentation, could increase the protein-rich silage utilization by ruminants. Thus, we sought to investigate the role of a compound lactic acid bacteria (LAB) inoculant (Lactobacillus plantarum + Lactobacillus farciminis + Lactobacillus buchneri + Lactobacillus hilgardii; at a level of 106 CFU/g fresh weight) in enhancing the aerobic stability of SC mixed silage. …”
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MatE transporter affects methane metabolism in Methermicoccus shengliensis and is modulated by methoxylated aromatic compounds by Huan Leng, Dong Wang, Qing Yang, Shuxin Wang, Leizhou Guo, Pengyan Zhao, Yi Chen, Lirong Dai, Guihong Cha, Liping Bai, Frank Delvigne

“…Specifically, the MATE family transporters (MatE) and transduction-like protein (Tlp) were hypothesized to play a crucial role in substrate transport. …”
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RECQL4 requires PARP1 for recruitment to DNA damage, and PARG dePARylation facilitates its associated role in end joining by Mansoor Hussain, Prabhat Khadka, Komal Pekhale, Tomasz Kulikowicz, Samuel Gray, Alfred May, Deborah L. Croteau, Vilhelm A. Bohr

“…Abstract RecQ helicases, highly conserved proteins with pivotal roles in DNA replication, DNA repair and homologous recombination, are crucial for maintaining genomic integrity. …”
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Alzheimer-mutant γ-secretase complexes stall amyloid β-peptide production by Parnian Arafi, Sujan Devkota, Emily Williams, Masato Maesako, Michael S Wolfe

“…Missense mutations in the amyloid precursor protein (APP) and presenilin-1 (PSEN1) cause early-onset familial Alzheimer’s disease (FAD) and alter proteolytic production of secreted 38-to-43-residue amyloid β-peptides (Aβ) by the PSEN1-containing γ-secretase complex, ostensibly supporting the amyloid hypothesis of pathogenesis. …”
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Current molecular understanding of central nervous system schwannomas by Takahiro Tsuchiya, Satoru Miyawaki, Yu Teranishi, Kenta Ohara, Yudai Hirano, Shotaro Ogawa, Seiei Torazawa, Yu Sakai, Hiroki Hongo, Hideaki Ono, Nobuhito Saito

“…The development of these tumors is primarily linked to mutations in the NF2 gene. Merlin, the protein encoded by NF2, is integral to several signaling pathways, including Ras/Raf/MEK/ERK, PI3K/Akt/mTORC1, Wnt/β-catenin, and the Hippo pathway. …”
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Regulation of ER stress-induced apoptotic and inflammatory responses via YAP/TAZ-mediated control of the TRAIL-R2/DR5 signaling pathway by Y. El Yousfi, F. J. Fernández-Farrán, F. J. Oliver, A. López-Rivas, R. Yerbes

“…Mechanical signals emerging from extracellular matrix (ECM) rigidity and cell shape regulate the activity of transcriptional co-activators Yes-associated protein (YAP) and its paralog Transcriptional Coactivator with PDZ-binding motif (TAZ). …”
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Analysis of expression and transport activity of sugar transporter gene HpSWEET7 from red pitaya by ZHENG Qianming, YAN Shuang, XIE Pu, WANG Honglin, MA Yuhua

“…Gene expression was analyzed by qRT-PCR, and the subcellular localization was detected by fusing fluorescent protein. Sugar transport activity was investigated by the yeast growth complementation and acidification assay. …”
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Transcriptome-wide identification and characterization of WUSCHEL-related homeobox (WOX) gene family in Pinus yunnanensis by Junfei Xu, Zhaoliu Hu, Sili Chen, Junrong Tang, Lin Chen, Peizhen Chen, Nianhui Cai, Yulan Xu

“…To address this gap, we investigated the presence, expression profiles and protein characteristics of WOX gene in P. yunnanensis. …”
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Risk of first venous thrombosis by comparing different thrombin generation assay conditions: results from the MEGA case-control study. by Kristien Winckers, Eugenia Biguzzi, Stella Thomassen, Alexandra Heinzmann, Frits R. Rosendaal, Tilman Mathias Hackeng, Astrid van Hylckama Vlieg

“…Methods: Basal TG at low tissue factor (TF) concentration and high TF concentration in the presence and absence of activated protein C (APC) were measured in plasma samples from 2,081 patients with first VTE and 2,908 healthy controls from the MEGA study. …”
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Competitive displacement of lipoprotein lipase from heparan sulfate is orchestrated by a disordered acidic cluster in GPIHBP1 by Anamika Biswas, Samina Arshid, Kristian Kølby Kristensen, Thomas J.D. Jørgensen, Michael Ploug

“…Modeling this interface revealed widespread polyelectrolyte interactions spanning both LPL domains, which explains why the acidic tail stabilizes LPL activity and protein conformation. In functional assays, we showed that the acidic cluster at 19–30 also had the greatest impact on preserving LPL activity, mitigating ANGPTL4-catalyzed LPL inactivation, preventing PSCK3-mediated LPL cleavage, and, importantly, displacing LPL from HSPGs. …”
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Comparing parboiling and milling for selenium-enriched rice (Oryza sativa L.): Differences in selenium speciation, texture, microstructure, and sensory by Kun Zhuang, Zihan Zhang, Shuyou Shang, Kai Zheng, Xiaolong Zhou, Wenjing Huang, Yuehui Wang, Wenping Ding

“…The results regarding cooking quality and microstructure indicated that parboiling restricts starch dissolution during cooking, while the protein remains distributed within starch cell gaps. …”
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Unveiling the new chapter in nanobody engineering: advances in traditional construction and AI-driven optimization by Jiwei Liu, Lei Wu, Anqi Xie, Weici Liu, Zhao He, Yuan Wan, Wenjun Mao

“…AI’s exceptional performance in protein structure prediction and molecular interaction simulation has introduced novel perspectives and tools for Nb design and optimization. …”
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Features of Crohn's Disease Depending on the Age of Disease Onset by E. G. Ganich, O. B. Shchukina

“…The visits included: the collection of complaints, medical history, objective examination, clinical blood testing; biochemical blood testing (C-reactive protein); fecal calprotectin; ileocolonoscopy. Statistical processing of the obtained data was carried out using Excel, RStudio and the R language; for categorical data, the Pearson chi-square test or Fisher's exact test was used (for 2 × 2 tables with small samples). …”
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Case report: A novel 11-bp deletion in exon 11 causing a frameshift in the C-terminal of the ALAS2 gene leading to X-linked sideroblastic anemia—a family study by Salam Al kindi, Salam Al kindi, Altaf Al-Mamari, Shoaib Al-Zadjali, Mohamed Al-Rawahi, Ali Al Madhani, Anil V. Pathare

“…Sanger sequencing documented a missense mutation leading to a frameshift with an elongated polypeptide of 614 AA instead of the normal 587 AA protein c.1743_1753 del (p.Gln581Hisfs*35). This mutation affected the interaction with cofactor pyridoxal 5′-phosphate since the patient’s hemoglobin improved with oral administration of pyridoxine tablets. …”
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Oncogenic RIT1 mutations confer ferroptosis vulnerability in lung adenocarcinoma by Ruilan Ma, Dian Yang, Peng Wang, Ziyi Zhang, Xuehong Zhang, Jialiang Song, Han Liu, Shuyan Liu, Yingqiu Zhang, Lijuan Zou

“…Through biochemical characterization of RIT1 hotspot mutations, we propose that RIT1 alterations were associated with increased protein abundance that promoted cell growth. Transcriptomic profiling indicated that oncogenic RIT1 mutant expression influenced common tumorigenic RAS/MAPK, PI3K/AKT, and E2F1 pathways, in addition to altered NFE2L2 target expression. …”
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Development of Predictive Models for Progression from Diabetic Kidney Disease to End-Stage Renal Disease in Type 2 Diabetes Mellitus: A Retrospective Cohort Study by Hu H, Mu X, Zhao S, Yang M, Zhou H

“…Time-dependent receiver operating characteristic (ROC) was used to evaluate prediction performance, and the area under the curve (AUC) was calculated to assess the model’s accuracy.Results: The Cox regression model developed for the 555 patients clinically diagnosed with DKD identified 5 predictors (body mass index (BMI), estimated glomerular filtration rate (eGFR), 24-hour urinary total protein (UTP), systemic immune-inflammatory index (SII), and controlling nutritional status (CONUT), whereas the Competing risks model included 4 predictors (BMI, eGFR, UTP, CONUT). …”
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Plasma from hypertensive pregnancy patients induce endothelial dysfunction even under atheroprotective shear stress by Sarah Viana-Mattioli, Miriam Helena Fonseca-Alaniz, Iguaracy Pinheiro-de-Sousa, Ricardo Rosa Junior, Moises Henrique Mastella, Ricardo de Carvalho Cavalli, Valeria Cristina Sandrim

“…Abstract Preeclampsia (PE) is a challenge in maternal healthcare due to its complex nature, characterized by high blood pressure, protein in the urine, and damage to various organs. …”
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Optimized gene transduction in human lung organoids: A high-efficiency method for advanced research applications by Jasmin Khateeb, Jady Liang, Yuchong Li, Thenuka Thanabalasingam, Julie Khang, Mirjana Jerkic, Giovanna Pellecchia, Bhooma Thiruv, Ya-Wen Chen, Ori Rotstein, Arthur S. Slutsky, Haibo Zhang

“…The success of this method was validated at both the gene and protein levels using single-cell RNA sequencing (scRNA-seq) and various cellular and molecular assays. …”
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