WGCNA and integrative network analysis identify CHRNA5 and CTLA4 as potential therapeutic targets against angiosarcoma by Trishla Bhatnagar, Madiha Haider, Mohd Yasir Khan, Mohammad Zahid Ashraf

“…The intersection of true hub genes from MCC analysis of WGCNA modules and high-degree nodes from an unclustered network revealed eight consistently overexpressed genes in all angiosarcoma samples.Among the eight enriched genes, CHRNA5 and CTLA4, are exclusively overexpressed in angiosarcoma and not in other cancers of the same tissue origin, with significant drug-protein interactions suggesting their potential as therapeutic targets.…”
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Prevalence and risk factors of teat end hyperkeratosis in cows from the Urals region of Russia by A.S. Barkova, V.V. Verkhoturov

“…Also, animals with changes in the area of the teat canal opening have changes in the qualitative composition of milk, in particular, increased protein content and a decreased lactose content, which may indicate the development of an inflammatory process in the mammary gland.…”
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Quercetin inhibits the biological activity of endometrial cancer by regulating autophagy: A network pharmacology analysis and cellular experimental validation by Lingchen Yang, Hongwei Ma

“…Cell Counting Kit-8 and flow cytometry assays were used to evaluate cell proliferation and apoptosis; cell invasive and migratory abilities were assessed by Transwell and wound healing assays, respectively; the observation of the cell ultrastructure was performed by transmission electron microscopy; the relative protein expressions were measured by the western blot assay. …”
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Infantile (congenital) anaplastic intracranial solitary fibrous tumor/hemangiopericytoma—A case report with brief literature review by Mohapatra Debahuti, Lenka Anasuya, Deo R. Chandra, Das Prateek

“…The immunohistochemistry showed vimentin, CD 34, STAT6, CD99 positivity whereas Glial fibrillary acidic protein, Epithelial membrane antigen, and S-100 negativity. …”
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Placental Maspin Gene Expression Pattern May Be Used to Distinguish Between Preeclampsia and Intrauterine Growth Restriction by Gogsen Onalan, Yunus Kasim Terzi, Yusuf Aytac Tohma, Erkan Yurtcu, Esra Kuscu, Feride Iffet Sahin, Hulusi Bulent Zeyneloglu

“… Objective: Maspin is one of the members of serin protease inhibitor superfamily, and acts as a tumor suppressor protein. Here we report maspin expression in placental tissues of preeclampsia or intrauterine growth retardation pregnancies. …”
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Enterovirus-like particles encapsidate RNA and exhibit decreased stability due to lack of maturation. by Louis Kuijpers, Evdokia-Anastasia Giannopoulou, Yuzhen Feng, Wouter van den Braak, Abbas Freydoonian, Ramon Ramlal, Hugo Meiring, Belén Solano, Wouter H Roos, Arjen J Jakobi, Leo A van der Pol, Nynke H Dekker

“…In contrast to prior studies and prevailing hypotheses, we show that insect-cell produced enterovirus VLPs include encapsidated RNA fragments with viral protein coding sequences. Our integrated approach reveals that CVA6 VLPs do not undergo viral maturation, in contrast to virions; that they can encapsidate RNA fragments, similarly to virions; and that despite the latter, they are more brittle than virions. …”
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Is Aquaculture a Success? Evidence from Africa by Okoth, Sharon, Hounsounou, Hilda R.B., Turyasingura, Benson, Moenga, Kelvin O., Mwalughali, Thoko B. S., Lubembi, Sharon Indasi

“…Although the contribution of aquaculture is small, sometimes termed insignificant, its growth is steady and it has a promising future as far as its goals (increased protein food production and improved livelihoods of fisher communities) are concerned.…”
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Blood biomarkers to identify patients with different intracranial lesion combinations after traumatic brain injury by Pia Koivikko, Ari J. Katila, Riikka SK. Takala, Iftakher Hossain, Teemu M. Luoto, Rahul Raj, Mari Koivisto, Olli Tenovuo, Kaj Blennow, Peter Hutchinson, Henna-Riikka Maanpää, Mehrbod Mohammadian, Virginia F. Newcombe, Jean-Charles Sanchez, Jussi Tallus, Mark van Gils, Henrik Zetterberg, Jussi P. Posti

“…S100 calcium-binding protein B (S100B), glial fibrillary acidic protein (GFAP), heart fatty-acid binding protein (H-FABP), neurofilament light (NF-L), interleukin-10 (IL-10), total-tau (t-tau), and β-amyloids 1–40 (Aβ40) and 1–42 (Aβ42) were analysed from plasma samples. …”
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Dihydroquercetin attenuated Prevotella copri-caused intestinal injury by modulating gut microbiota and bile acids in weaned piglets by Long Wang, Ruizhi Hu, Siqi Ma, Xizi Yang, Jiatai Gong, Hongkun Xiang, Mingkun Shi, Xupeng Yuan, Liang Chen, Hongfu Zhang, Bie Tan, Xi He, Jianhua He, Shusong Wu

“…Moreover, DHQ increased the expression of tight junction proteins (claudin-2, occludin and tight junction protein zonula occludens protein-1 (ZO-1) and the mRNA expression of glutathione peroxidase 4 (GPX-4) in ileum (P < 0.001). …”
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Chemo-proteomics reveals dihydrocaffeic acid exhibits anti-inflammation effects via Transaldolase 1 mediated PERK-NF-κB pathway by Guanjun Li, Huiying Li, Peili Wang, Xinzhou Zhang, Wenhua Kuang, Ling Huang, Ying Zhang, Wei Xiao, Qingfeng Du, Huan Tang, Jigang Wang

“…Nevertheless, the specific protein targets and potential molecular mechanisms of DA in acute pneumonia are still poorly understood. …”
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In vivo production of engineered ACE2 decoy protects lungs from SARS-CoV-2 infection by Yuta Suzuki, Takayuki Miyazaki, Yoko Ida, Tatsuya Suzuki, Yumi Itoh, Shuto Nakao, Keita Kondo, Kenji Kubara, Keisuke Nishioka, Hiroki Muto, Ryuji Watari, Toshifumi Hirayama, Dai Kakiuchi, Shinya Sato, Satoshi Inoue, Yoshifumi Uemoto, Yohei Mukai, Atsushi Hoshino, Toru Okamoto, Junji Matsui

“…An improved pharmacokinetic profile of the produced protein was compared to injection of the 3N39v4 protein. …”
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A nucleoside-modified mRNA vaccine prevents enterovirus A71 infection in mouse model by Fengyu Chi, Fengyu Chi, Xu Zhang, Xu Zhang, Dong Zhang, Dong Zhang, Airu Zhu, Zhen Zhuang, Zhaoyong Zhang, Zhenjie Zhang, Chuansong Quan, Kaixiao Nie, Juan Li, Chunhong Yin, Jie Tong, Yuming Li, Yuming Li, Yuming Li

“…This study investigates the potential of an mRNA vaccine targeting the EV-A71 VP1 protein.MethodsA nucleoside-modified mRNA vaccine encoding the VP1 protein of EV-A71, encapsulated in lipid nanoparticles (LNPs), was developed. …”
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Effect of electroacupuncture on vascular remodeling in rats with cerebral ischemia by regulating irisin based on VEGF/Akt/eNOS signaling pathway by Lu Cao, Wenchao Ding, Yashuo Feng, Chong Guan, Li Liu, Hongyu Xie, Kewei Yu, Dongyan Xu, Lijuan Zhao, Xuan Sha, Xiaoman Deng, Santian Wu, Yangrui Wang, Yi Wu, Tingting Zhang, Nianhong Wang

“…Type III fibronectin domain protein 5-silenced adeno-associated virus (rAAV-shFNDC5) was injected into the lateral ventricle as a control. …”
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Potential impact and mechanism of aged polyethylene microplastics on nitrogen assimilation of Lactuca sativa L. by Xiaoli Mou, Hedong Zhu, Renrui Dai, Li Lu, Shengqi Qi, Min Zhu, Yuyang Long, Nan Ma, Chao Chen, Jiali Shentu

“…N assimilation in lettuce was significantly inhibited by aged MNPs, which manifested as the soluble protein content in lettuce under AP20 and AP0.1 treatments being significantly reduced by 30.59 and 42.11 %, respectively (P < 0.01). …”
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THE ROLE OF PLATELET-RICH FIBRIN FACILITATES THE HEALING OF GASTROCNEMIUS MUSCLE DEFECT: A PRELIMINARY STUDY ON ANIMAL MODEL by Dwikora Novembri Utomo, Kukuh Dwiputra Hernugrahanto

“…Two and four weeks after surgery, the defect was examined immunohistochemically for the expression of Pax7 protein. Results: The implanted group showed higher IRS score in two and four weeks compared to the control group. …”
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Overlap of Functional Gastrointestinal Disorders: Common Mechanisms of Pathogenesis as a Key to Rational Therapy by S. N. Mekhdiyev, O. A. Mekhdieva, O. M. Berko

“…As a pathogenetically justified pharmacotherapy of overlap syndrome, Kolofort, highly diluted antibodies to TNF-α, histamine and brain-specific protein S-100, is of interest.Conclusion. Kolofort has demonstrated high efficacy and safety including among patients with overlap FGID enabling to consider it as the treatment of choice in these patients.…”
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The emerging roles of aberrant alternative splicing in glioma by Reda Ben Mrid, Sara El Guendouzi, Marco Mineo, Rachid El Fatimy

“…Dysregulation of this process, through variations in spliceosome components, aberrant splicing factors and RNA-binding protein activity, disproportionate regulation of non-coding RNAs, and abnormal mRNA methylation, can contribute to the disruption of AS. …”
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Nutritional and Anti-nutritional Levels of Some Local Vegetables(<i>Vernomia anydalira, Manihot esculenta, Teiferia occidentalis, Talinum triangulare, Amaranthus spinosus</i>) from... by PO Agbaire

“…Analyses were done using standard analytical methods. Crude protein, crude lipid, carbohydrate, moisture, ash, crude fiber and colorific values, had values 4.74%±1.48, 4.78% ± 0.62, 4.98% ± 1.79,80.84% ± 4.69,1.96% ± 0.19,2.00% ± 1.25,78.92 ± 21.94Kcal/100g respectively. …”
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Preventive role of Pastinaca sativa in mitigating metabolic dysfunction-associated steatotic liver disease via modulation of metabolic endotoxemia by Ji-Eun Park, Hye-Bin Lee, Yu Ra Lee, Guijae Yoo, Hee-Kyoung Son, Sang Yoon Choi, Miri Park, Ho-Young Park

“…PRE also lowered hepatic lipogenic protein levels induced by the high-fat diet. Additionally, PRE enhanced gut health by reducing endotoxins, improving intestinal permeability, and upregulating tight junction proteins. …”
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Activating PKC-ε induces HIV expression with improved tolerability. by Alivelu M Irrinki, Jasmine Kaur, Bally Randhawa, Ryan McFadden, Chelsea Snyder, Hoa Truong, Daniel Soohoo, Eric Hu, Helen Yu, Bernard P Murray, Bing Lu, Dmytro Kornyeyev, Ishak Darryl Irwan, Lan Nguyen, Yu-San Yang, Jean-Philippe Belzile, Uli Schmitz, Todd C Appleby, Brian Schultz, Jay Lalezari, Steven Deeks, Tomas Cihlar, Jeffrey P Murry

“…Activation of latent HIV during ART could improve recognition and elimination of infected cells by the immune system. Protein kinase C (PKC) isozymes increase HIV transcription and hence are potential latency reversal agents. …”
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