Oxidative stress in viral hepatitis by Huseyin Erdal, Hacer Ozlem Kalayci

“…In viral hepatitis, viral proteins and immune-mediated inflammatory responses contribute to excessive ROS generation, resulting in oxidative damage to hepatocytes. …”
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Case report of familial hypercholesterolemia with internal carotid neck swelling by Sudesh Kumar, Prajna Ray, Ranita Sahana

“…Familial hypercholesterolemia is a multi-gene disorder affecting 1 in 200-500 individual which is characterized by increased level of total cholesterol and low density lipoprotein (LDL) which deposit cholesterol reach protein leading to xanthomas, corneal arcus and prone to develop risk for atherosclerosis and coronary heart disease. 11 year female, born of consanguineous marriage attended with yellowish patches (Xanthelasma) bilaterally present over upper eyelid, buttock since 5-6 years. …”
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Pulmonary fibrosis as the sole manifestation of anti-Ku antibody positivity in the absence of myositis: A case report by Angelo Nigro, Dr.

“…Background: Anti-Ku antibodies are autoantibodies directed against the Ku protein complex involved in DNA repair. They are typically associated with overlap syndromes featuring polymyositis and systemic sclerosis. …”
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Egg Microinjection for the Ladybird Beetle Harmonia axyridis by Taro Nakamura, Yuji Matsuoka, Teruyuki Niimi

“…In this paper, we present a detailed protocol for microinjecting DNA, RNA, or protein solutions into fertilized eggs of the multicolored Asian ladybird beetle, Harmonia axyridis, under a stereomicroscope equipped with an injection apparatus. …”
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Effect of Breed on the Composition of Cow Milk under Traditional Management Practices in Ado-Ekiti, Nigeria by K Adesina

“…Representative samples of milk obtained from four cows of each breed were bulked separately and analysed for proximate, mineral and amino acids composition. The ash, protein and lactose contents of the milk did not differ significantly among the three cow breeds. …”
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Prmt5 is essential for intestinal stem cell maintenance and homeostasis by Li Yang, Xuewen Li, Chenyi Shi, Bing Zhao

“…Abstract Intestinal homeostasis relies on the continuous renewal of intestinal stem cells (ISCs), which could be epigenetically regulated. While protein arginine methyltransferase 5 (Prmt5) is known to play a key role in multiple organs as an epigenetic modifier, its specific function in maintaining intestinal homeostasis remains to be elucidated. …”
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Assessing the product attributes of Iranian localized frozen dumpling dough incorporated with fish paste by M. Shirazy, N. Mooraki, M. Honarvar

“…The pH, total ash, acid insoluble ash, and salt percentage did not significantly differ between the samples (P > 0.05); however, the samples' moisture, crude protein, crude lipid, peroxide, contents did significantly differ (P < 0.05). …”
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Investigation of hemostasis by thromboelastography in the patient with liver cirrhosis (Clinical case) by Ye. L. Bulanova, A. Yu. Bulanov, D. S. Gatsolayeva

“…Estimating the submitted clinical case, it is possible to conclude on necessity of thromboelastography in patients with bleeding, which can develop both due to disorder of hemostasis (at patients with failure of protein-synthetic liver function), and due to invasive intervention. …”
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Exploring the interactions of rapamycin with target receptors in A549 cancer cells: insights from molecular docking analysis by Sanjeev K. Ganesh, C. Subathra Devi

“…Also reports on the binding of rapamycin to cancer cell receptors are limited to the serine/threonine protein kinase mTORC1. Hence, to uncover the exact potential of rapamycin in cancer therapy, a series of cell culture and in silico studies were conducted to identify other receptors capable of binding to rapamycin. …”
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Bio-deterioration of sweet potato (<i>ipomoea batatas lam</i>) in storage, inoculation-induced quality changes, and control by modified atmosphere by Oyeyipo Olutimilehin Olaitan

“…Inoculation of samples with the four prevalent rot fungi significantly (p = 0.05) increased crude protein, lipid and ash content. In contrast, there was a significant decrease in carbohydrate and moisture content when compared with the controls. …”
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Identification of a guanine nucleotide exchange factor for Arf3, the yeast orthologue of mammalian Arf6. by Alison K Gillingham, Sean Munro

“…Small G proteins of the Arf and Rab families are fundamental to the organisation and activity of intracellular membranes. …”
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Phytochemicals, Nutritional and Elemental Composition of different plant parts of Rinorea oblongifolia (C.H Wright) C. Marquand ex Chipp by Adeniyi Ohunayo, Olusola Elekofehinti, Muftau Kolawole Oladunmoye, Anthony Kayode Onifade

“…Proximate analysis showed that the leaves had the highest moisture (9.17%), crude protein (9.91%), and carbohydrate (75.26%) contents, while roots had the highest ash (2.45%) and crude fat (4.61%). …”
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Delta opioid receptors engage multiple signaling cascades to differentially modulate prefrontal GABA release with input and target specificity by Ryan P.D. Alexander, Kevin J. Bender

“…We found that DORs regulate inhibition from these interneuron classes using different G-protein signaling pathways that both converge on presynaptic calcium channels but regulate distinct aspects of calcium channel function. …”
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Antiseizure medications and their differing effects on cardiovascular risk by Aleena Abbasi, Bassil Abbasi, Scott Mintzer, Carla LoPinto-Khoury

“…Other markers of vascular risk, including c-reactive protein, non-high-density lipoprotein and homocysteine, are affected by antiseizure medications, although adults and children may have different responses. …”
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miR124a-3p inhibitor alleviates AFB1-induced hepatoxicity via targeting chicken glucocorticoid receptor mRNA by Mindie Zhao, Liang Chen, Yulan Zhao, Jie Liu, Huimin Chen, Ruqian Zhao

“…Western blot confirmed a significant decrease in GR protein. miRNA PCR revealed upregulation of miR124a-3p. …”
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Effects of prolonged NaHCO3 exposure on the serum immune function, antioxidant capacity, intestinal tight junctions, microbiota, mitochondria, and autophagy in crucian carp (Carass... by Jia Liu, Faye Zhang, Zihao Yan, Zhengyao Guo, Yuqian Lu, Baolan Yao, Yuehong Li, Wenfa Lv

“…The levels of ATG5, ATG7, and Beclin1 mRNA and protein were significantly increased along with the levels of LC3b mRNA and the ratio of protein LC3 II /LC3 I. …”
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Exploring the multi-targeted mechanism of Saikosaponin A in prostate cancer treatment: a network pharmacology and molecular docking approach by Genbao Zhu, Genbao Zhu, Genbao Zhu, Zhiming Jiang, Niuping Zhu, Niuping Zhu, Donghui Wang, Donghui Wang, Tianpeng Guo, Tianpeng Guo, Yiqing Meng, Yiqing Meng, Yi Zhu, Yi Zhu, Kemeng Tan, Mengxue Hu, Heng Tang, Xuannian Wang, Xuannian Wang

“…However, the mechanism underlying the effects of SSA in prostate cancer treatment remains elusive.MethodsIn this study, a network pharmacology approach was applied to identify relevant targets from drug- and disease-related databases, and intersections were analyzed using Venny2.1 to construct a Protein-Protein interaction (PPI) interaction network. …”
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Blood coagulation system in patients with chronic kidney disease: a prospective observational study by Xi Yang, Yang Wang, Ri-bao Wei, Ting-yu Su, Meng-jie Huang, Ping Li, Xiang-mei Chen, Ping Di, Qing-ping Li

“…The platelet count, platelet aggregation, von Willebrand factor antigen (vWF:Ag), vWF ristocetin cofactor activity (vWF:RCo), fibrinogen, factor V (FV), FVII, FVIII, antithrombin III, protein C, protein S, D-dimer, standard coagulation tests and thromboelastography were measured in patients with CKD and controls. …”
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Amyloidogenic immunoglobulin light chains disturb contractile function and calcium transients in a human cardiac spheroid model of light chain (AL) amyloidosis by Mélanie Bézard, Jean-Sébastien Vartanian-Grimaldi, Julien Henri, Denisa Calin, Amira Zaroui, Mounira Kharoubi, Thibaud Damy, Onnik Agbulut, Ekaterini Kordeli

“…LC-treated hiPSC-CM cultures and LC-containing spheroids presented structural and functional defects including: (1) decreased levels and subcellular disorganization of sarcomeric protein alpha-actinin; (2) abnormal accumulation of calcium handling SERCA2a protein; (3) impaired contractility of spheroids and altered calcium transients. …”
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HPGCN: A graph convolutional network-based prediction model for herbal heat/cold properties by Qikai Niu, Jing’ai Wang, Hongtao Li, Lin Tong, Haiyu Xu, Weina Zhang, Ziling Zeng, Sihong Liu, Wenjing Zong, Siqi Zhang, Siwei Tian, Huamin Zhang, Bing Li

“…In this study, we propose an herbal property graph convolutional network (HPGCN) model by combining TCM theory, modern pharmacological mechanisms, prior knowledge of herbal properties, and intelligent algorithms, which can effectively predict herbal heat/cold properties. Based on protein-protein interactions (PPI) and herb-herb networks, 30 target genes were selected as features for herbal heat/cold property prediction. …”
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