Knockdown of PTEN promotes colon cancer progression and induces M2 macrophage polarization in the colon cancer cell environment by Xu Han, Ting Yan, Lina Wang, Bin He, Huaxu Yu

“…The expressions of phosphate (p)-p38, c-Jun N-terminal kinase (JNK), activator protein 1 (AP-1), B-cell lymphoma-2 (Bcl-2) protein in colon cancer tissues and cells were significantly higher than in precancerous tissues or CCD-18Co cells (P-values < 0.05). …”
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An unbiased cell morphology-based screen for new, biologically active small molecules. by Masahiro Tanaka, Raynard Bateman, Daniel Rauh, Eugeni Vaisberg, Shyam Ramachandani, Chao Zhang, Kirk C Hansen, Alma L Burlingame, Jay K Trautman, Kevan M Shokat, Cynthia L Adams

“…Principal component analysis was used to identify inhibitors of cellular components not targeted by known protein kinase inhibitors. Here we focus on a hydroxyl-substituted analog (hydroxy-PP) of the known Src-family kinase inhibitor PP2 because it induced cell-specific morphological features distinct from all known kinase inhibitors in the collection. …”
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Andrographolide prevents acute hyperammonemia-induced motor dysfunction in rats. Evidences for its mechanism of action by Arghya Mukherjee, Santosh Singh

“…Malondialdehyde (MDA), reduced glutathione (GSH), protein carbonylation levels and activity of superoxide dismutase (SOD), catalase, glutathione peroxidase (GPx), glutathione reductase (GR) were studied as oxidative stress markers. …”
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Identification of an inter-cysteine loop potentially involved in the activity of Opisthorchis viverrini-granulin-1 by Rozita Takjoo, David T. Wilson, Paramjit S. Bansal, Alex Loukas, Michael J. Smout, Norelle L. Daly

“…Aim: Identification of small bioactive regions in proteins and peptides can be useful information in drug design studies. …”
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Comparative Analysis of Biomarkers in Type 2 Diabetes Patients With and Without Comorbidities: Insights Into the Role of Hypertension and Cardiovascular Disease by Symeon Savvopoulos, Haralampos Hatzikirou, Herbert F Jelinek

“…Methods: Linear discriminant analysis is used for classification method and feature importance, This study examined the relationship between Humanin and mitochondrial protein (MOTSc), mitochondrial peptides associated with oxidative stress, diabetes progression, and associated complications. …”
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Increased nuclear expression of DNA damage inducible transcript 4 can serve as a potential prognostic biomarker in patients with gliomas: a study based on data mining and experimen... by Alireza Sadeghipour, Fahimeh Fattahi, Zahra Madjd, Fatemeh Tajik, Farnoosh Sedaghati, Leili Saeednejad Zanjani

“…To validate these findings, DDIT4 protein expression levels and their prognostic significance were examined in tissue microarrays from glioma patients using immunohistochemistry in clinical samples. …”
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Analysis of somatic piRNAs in the malaria mosquito Anopheles coluzzii reveals atypical classes of genic small RNAs by Sergei Funikov, Alexander Rezvykh, Natalia Akulenko, Jiangtao Liang, Igor V. Sharakhov, Alla Kalmykova

“…By contrast, majority of protein-coding gene-derived 24-32 nt small RNAs lack the hallmarks of piRNAs and have signatures of nontemplated 3’ end tailing. …”
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Correlation between Exclusive Breastfeeding, Complementary Feeding, Infectious Disease with Wasting among Toddlers: a Cross-Sectional Study by Ani Intiyati, Rany Dwi Yuliana Putri, Imam Sarwo Edi, Taufiqurrahman Taufiqurrahman, Inne Soesanti, Nuning Marina Pengge, Dian Shofiya

“…Conclusions: While exclusive breastfeeding tends to reduce wasting, appropriate CF and adequate intake of energy, protein, fat, and carbohydrates are associated with a lower prevalence of wasting. …”
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A Nonsynonymous Single-nucleotide Polymorphism in SLC24A5 Regulates Feather Pigment Deposition in Chinese Yellow Quail by Xiaohui Zhang, Fanghu Wu, Yanxia Qi, Yuanyuan Shang, Lingyun Fan, Yifei Wang

“…The mutant residue was predicted to be located inside the eighth transmembrane helix of the SLC24A5 protein, which is primarily responsible for recognizing Na+/Ca2+ ions. …”
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A comprehensive review on nutritional composition, health benefits, and industrial applications of Jackfruit Seeds by Simran Dhani, Hamid, Nomali Ziphorah Ngobese, Sunny Sharma, Amit K. Jaiswal

“…Seeds of jackfruit are usually considered as waste (15 %) but are rich in protein, starch as well as various bioactive compounds. …”
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Edible portions of precooked blue swimming crab: Chemical composition and effect of chitooligosaccharide conjugate and high-pressure processing on microbial inactivation by Khaettareeya Pimsannil, Suriya Palamae, Xinru Fan, Qiancheng Zhao, Bin Zhang, Soottawat Benjakul

“…Myosin heavy chain and actin constituted as key proteins in meat, but the protein pattern of roe was completely different. …”
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A ribosome-associating chaperone mediates GTP-driven vectorial folding of nascent eEF1A by Ibrahim M. Sabbarini, Dvir Reif, Kibum Park, Alexander J. McQuown, Anjali R. Nelliat, Charlotte Trejtnar, Volker Dötsch, Eugene I. Shakhnovich, Andrew W. Murray, Vladimir Denic

“…Our work shows that an ATP-independent chaperone can drive vectorial folding of nascent chains by co-opting G protein nucleotide binding.…”
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Increasing the concentration of plasma molecules improves the biological activity of platelet-rich plasma for tissue regeneration by Mikel Sánchez, Jon Mercader Ruiz, Daniel Marijuán Pinel, Pello Sánchez, Nicolás Fiz, Jorge Guadilla, Juan Azofra, Maider Beitia, Diego Delgado

“…The present work studies the effectiveness of a novel type of PRP named ‘balanced protein-concentrate plasma’ (BPCP). Different growth factor (GF) levels were measured using Enzyme Linked Immunosorbent Assay (ELISA), and in addition to the increase in intra-platelet GFs found in standard PRP (sPRP), BPCP also showed a higher concentration of plasmatic protein. …”
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Molecular investigation on active compounds in papaya leaves (Carica papaya Linn) as anti-malaria using network pharmacology, molecular docking, clustering-based analysis and molec... by Arwansyah Arwansyah, Sitti Rahmawati, Siti Nuryanti, Yenni Yusuf, Hartono, Abdur Rahman Arif

“…Hence, we investigate the active compounds in Carica papaya Linn as potential drugs against malaria using pharmacology combined with several in silico methods. A total of 23 proteins linked to the active compounds and malaria-related targets in human proteins were identified using network analysis. …”
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Functional-proteomics-based investigation of the cellular response to farnesyltransferase inhibition in lung cancer by Yanbo Pan, Olena Berkovska, Soumitra Marathe, Georgios Mermelekas, Greta Gudoityte, Amare D. Wolide, Taner Arslan, Brinton Seashore-Ludlow, Janne Lehtiö, Lukas M. Orre

“…Summary: Farnesylation is a lipid post-translational modification of proteins crucial for protein membrane anchoring and cellular signaling. …”
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Pureed Foods: Lentil Desserts by Wendy J Dahl, Alison O'Donoughue

“… A pureed diet may be recommended for individuals with swallowing problems; however, it can be challenging for those with a puréed diet to receive adequate protein, fiber, vitamins, and minerals. This 4-page document provides recipes made with puréed lentils, offering desserts that are both tasty and nutrient-dense. …”
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Pureed Foods: Lentil Desserts by Wendy J Dahl, Alison O'Donoughue

“… A pureed diet may be recommended for individuals with swallowing problems; however, it can be challenging for those with a puréed diet to receive adequate protein, fiber, vitamins, and minerals. This 4-page document provides recipes made with puréed lentils, offering desserts that are both tasty and nutrient-dense. …”
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Fish Fillet: White Versus Red, Structure and Nutritional Composition by Rose Omidvar, Michael Sipos, Razieh Farzad

“… Fish is one of the primary sources of protein and other nutrients globally. There are thousands of food fish species with different chemical compositions and nutritional characteristics of fillets. …”
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Potential for Gossypol Toxicity When Feeding Whole Cottonseed to Beef Cattle by Robert O. Myer, Lee R. McDowell

“…Whole cottonseed is a good source of both protein and energy for beef cattle rations. However, one should be aware of potential gossypol toxicity when feeding cottonseed. …”
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Impaired cognitive function and decreased monoamine neurotransmitters in the DNAJC12 gene knockout mouse model by Shunan Wang, Ming Shen, Bo Pang, Bo Zhou, Yuan Yuan, Mei Lu, Xiangling Deng, Min Yang, Shufang Liu, Qiong Wang, Mei Xue, Qisheng Xia, Zhixin Zhang

“…To assess the impact of these mutations on DNAJC12 expression, we used quantitative real-time PCR and Western blotting techniques to measure mRNA and protein levels, respectively. The Morris water maze test was administered to evaluate the cognitive functions of the mice. …”
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