Molecular docking of ferulic acid, bakuchiol and niazirin on peroxisome proliferator-activated receptor gamma (PPAR-γ) as anti-diabetic agents by Anjar Hermadi Saputro, Riri Fauziyya, Sarmoko, Iwan Syahjoko Saputra

“… Background: Diabetes mellitus remains one of the most dangerous illnesses worldwide. The PPAR-gamma protein plays a crucial role in lipid and carbohydrate metabolism, making it a key target for diabetes therapy. …”
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InceptionDTA: Predicting drug-target binding affinity with biological context features and inception networks by Mahmood Kalemati, Mojtaba Zamani Emani, Somayyeh Koohi

“…In this paper, we introduce InceptionDTA, a novel drug-target binding affinity prediction model that leverages CharVec, an enhanced variant of Prot2Vec, to incorporate both biological context and categorical features into protein sequence encoding. InceptionDTA utilizes a multi-scale convolutional architecture based on the Inception network to capture features at various spatial resolutions, enabling the extraction of both local and global features from protein sequences and drug SMILES. …”
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Computational and In silico study of novel fungicides against combating root rot, gray mold, fusarium wilt, and cereal rust. by Mollah Naimuzzaman, Md Mahabub Hasan, Ajoy Kumer, Abu Yousuf Hossin, Mohammad Harun-Ur-Rashid, Swapan Kumar Roy, Abu Noman Faruq Ahmmed, Jamal Uddin

“…The exploration of potential candidates for fungicides against four fungal proteins that cause some vital plant diseases, namely Phytophthora capsici, Botrytis cinerea, Fusarium oxysporum f. sp. lycopersici, and Puccinia graminis f. sp. tritici, was conducted using in silico, molecular docking simulations, and molecular dynamic (MD) simulation for selecting the nature of binding affinity with actives sites of proteins. …”
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Development of sugar- and fat-reduced pulse cookies with improved predicted glycemic behavior by Xinying Suo, Marianna Tagliasco, Matteo Bonfini, Laura Bonfili, Oscar Moreno Araiza, Anna Baggio, Anna Maria Eleuteri, Nicoletta Pellegrini, Elena Vittadini

“…Developed cookies had higher protein and fiber contents, reduced sugar (∼45 - 50 % reduction), and saturated fats (∼77 - 80 % reduction) and also had a lower predicted glycemic index compared to traditional cookies. …”
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Data-independent LC-MS/MS analysis of ME/CFS plasma reveals a dysregulated coagulation system, endothelial dysfunction, downregulation of complement machinery by Massimo Nunes, Mare Vlok, Amy Proal, Douglas B. Kell, Etheresia Pretorius

“…We identified 24 proteins that are significantly increased in the ME/CFS group compared to the controls, and 21 proteins that are significantly downregulated. …”
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FNDC5/irisin mitigates the cardiotoxic impacts of cancer chemotherapeutics by modulating ROS-dependent and -independent mechanisms by Manish Kumar, Abhishek Singh Sengar, Anushree Lye, Pranesh Kumar, Sukhes Mukherjee, Dinesh Kumar, Priyadip Das, Suvro Chatterjee, Adele Stewart, Biswanath Maity

“…Here, we demonstrate that fibronectin type III domain-containing protein 5 (FNDC5), the precursor protein for myokine irisin, is depleted in the hearts of human cancer patients or mice exposed to chemotherapeutics. …”
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Tissue shear as a cue for aligning planar polarity in the developing Drosophila wing by Su Ee Tan, David Strutt

“…This promotes core protein turnover at cell-cell contacts parallel to the flow direction, possibly via dissociation of transmembrane complexes by shear forces. …”
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Low concentrations of Lactobacillus rhamnosus GG ( Yoba®) are safe in male Drosophila melanogaster by Keneth Iceland, Kasozi, Aisha, Bukenya, Ejike, Daniel Eze, Josephine, Kasolo, Dickson Stuart, Tayebwa, Fred, Ssempijja, Joy, Suubo, Andrew, Tamale, Isaac, Echoru, Ibrahim, Ntulume, Sarah Kemuma, Onkoba, Lisa Nkatha, Micheni, Emmanuel Tiyo, Ayikobua, Oscar Hilary, Asiimwe, Muhamudu, Kalange

“…The study assessed male w1118 Drosophila melanogaster which were provided food supplemented with Yoba ® at 1%, 3%, 6%, and 12% on motor function, total protein, catalase activity, and hydrogen peroxide scavenging activity and lifespan. …”
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Long-term Conservative Follow-up in Children with High-grade Vesicoureteral Reflux and an Abnormal Dimercaptosuccinic Acid Scan by Pankaj V Deshpande

“…All children have normal growth, kidney function, urine protein/creatinine ratio, and blood pressure at present. (15 years follow-up in 17 children). …”
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Relationship between dietary intake and atherogenic index of plasma in cardiometabolic phenotypes: a cross-sectional study from the Azar cohort population by Shirin Soheilifard, Elnaz Faramarzi, Reza Mahdavi

“…There was a statistically significant difference in the mean energy intake and the percentage of energy intake from protein among the cardiometabolic phenotypes (p < 0.001). …”
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Design and evaluation of bromelain-encapsulated alginate beads reinforced with gum Arabic: Formulation, characterization, and stability in simulated gastrointestinal conditions by Methavee Peanparkdee, Phornphimon Janchai, Tanwarat Aksornsri, Pilanee Vaithanomsat

“…Crude bromelain extract-loaded beads exhibited optimal protein release across pH 3–7 at 25 °C, with enhanced release following thermal treatment. …”
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REDD1 expression in podocytes facilitates renal inflammation and pyroptosis in streptozotocin-induced diabetic nephropathy by Siddharth Sunilkumar, Sandeep M. Subrahmanian, Esma I. Yerlikaya, Allyson L. Toro, Edward W. Harhaj, Scot R. Kimball, Michael D. Dennis

“…In support of the hypothesis, streptozotocin (STZ)-induced diabetes increased REDD1 protein abundance in the kidney concomitant with renal immune cell infiltration. …”
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Perspectives on the adoption of black-soldier fly larvae for animal feed among livestock farmers in Sub-Saharan Africa by Dieu-Merci Akonkwa Nyamuhirwa, Shiferaw Feleke, Paul-Martin Dontsop Nguezet, Dioukou Sissoko, Bokar Moussa, Abel-Gautier Kouakou, Seydou Zakari, Tahirou Abdoulaye, Victor Manyong

“…IntroductionBlack soldier fly larvae (BSFL) are increasingly promoted as cost-effective, and environmentally friendly source of protein in animal nutrition. However, there is limited information about farmers' adoption rates and the factors influencing their adoption decisions in Sub-Saharan Africa (SSA). …”
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Do wolframin, P-glycoprotein, and GRP78/BiP cooperate to alter the response of L1210 cells to endoplasmic reticulum stress or drug sensitivity? by Simona Kurekova, Lucia Pavlikova, Mario Seres, Viera Bohacova, Jana Spaldova, Albert Breier, Zdena Sulova

“…This was associated with increased GRP78/BiP expression and modulation of the expression of several other proteins active in the cellular response to ERS (like CHOP, spliced XBP1, 50-kDa ATF6 protein fragment and others) in P-gp positive cells. …”
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Improved growth performance, food efficiency, and lysine availability in growing rats fed with lysine-biofortified rice by Qing-Qing Yang, Pui Kit Suen, Chang-Quan Zhang, Wan Sheung Mak, Ming-Hong Gu, Qiao-Quan Liu, Samuel Sai-Ming Sun

“…Abstract Rice is an excellent source of protein, and has an adequate balance of amino acids with the exception of the essential amino acid lysine. …”
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Mechanism of warmed malate ringer’s solution in fluid resuscitation in improving the lethal triad of severe trauma by WU Yinyu, SHE Han, SHE Han, DU Yunxia, DU Yunxia

“…MR solution resuscitation shortened tail bleeding time (P<0.05), increased core body temperature (P<0.05), elevated plasma vWF level (P<0.05), increased protein levels of VE-cadherin, PGC1α and Mfn2 (P<0.05), and decreased that of p-Drp1 protein expression (P<0.05) when compared with the rats at 180 min after severe traumatic injury. …”
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Bioremediation of Soil Microcosms from Auto-Mechanic Workshops by AT Ajao, AO Oluwajobi, VS Olatayo

“…Bioremediation of the soil microcosms was designed for 2months using mixed culture of the isolates. TVC, Protein, Dehydrogenase and lipase activities were used as bioindicators for the bioremediation processes. …”
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Isolation of Intact Mitochondria From Drosophila melanogaster and Assessment of Mitochondrial Respiratory Capacity Using Seahorse Analyzer by Christopher Groen, Anthony Windebank

“…Isolation of intact mitochondria for protein analysis or respiration measurements has been previously reported in numerous model organisms. …”
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Microwave-assisted extraction enhances Aquafaba functionality: A high value-added egg white replacer in vegan meringue production by Zahra Kargar, Abdollah Hematian Sourki

“…X-ray diffraction revealed a reduction in protein crystal size, and FT-IR analysis confirmed the absence of harmful compounds in MAEA. …”
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