Antioxidant Activity, Enzyme Inhibition Potentials, and Phytochemical Profiling of Premna serratifolia L. Leaf Extracts by Adelina Simamora, Adit W. Santoso, Kris H. Timotius, Ika Rahayu

“…The inhibition potentials of both extracts against several enzymes related to metabolic diseases (α-glucosidase, α-amylase, xanthine oxidase, and protease) were evaluated. The phytochemical analysis was conducted by an LC-QTOF-MS/MS technique. …”
Get full text

Identification of potent TMPRSS4 inhibitors through structural modeling and molecular dynamics simulations by Ismail Hdoufane, Mehdi Oubahmane, Youssef Habibi, Christelle Delaite, Mohammed M. Alanazi, Driss Cherqaoui

“…Abstract TMPRSS4, a transmembrane serine protease type II, is associated with various pathological illnesses. …”
Get full text

The presence of elafin, SLPI, IL1-RA and STNFα RI in head and neck squamous cell carcinomas and their relation to the degree of tumour differentiation by U. Westin, M. Nyström, I. Ljungcrantz, B. Eriksson, K. Ohlsson

“…SLPI and elafin are serine protease inhibitors produced in the serous cells of the upper respiratory airways and in the keratinocytes, respectively. …”
Get full text

Retargeting Clostridium difficile Toxin B to Neuronal Cells as a Potential Vehicle for Cytosolic Delivery of Therapeutic Biomolecules to Treat Botulism by Greice Krautz-Peterson, Yongrong Zhang, Kevin Chen, George A. Oyler, Hanping Feng, Charles B. Shoemaker

“…Botulinum neurotoxins (BoNTs) deliver a protease to neurons which can cause a flaccid paralysis called botulism. …”
Get full text

Study of Body Composition and Metabolic Parameters in HIV-1 Male Patients by Gurudath Gundurao Sreekantamurthy, N Biplab Singh, Th Bhimo Singh, Th Suraj Singh, Karam Romeo Singh

“…HIV patients on highly active antiretroviral therapy (HAART) containing protease inhibitors (PIs) had been often associated with lipodystrophy. …”
Get full text

Binding and cleavage of pro-urokinase by a tegument extract of Fasciola hepatica newly excysted juveniles activate the host fibrinolytic system by Judit Serrat, María Torres-Valle, Carolina De Marco Verissimo, Mar Siles-Lucas, Javier González-Miguel

“…Abstract Plasmin, the final product of fibrinolysis, is a broad-spectrum serine protease that degrades extracellular matrix (ECM) components, a function exploited by multiple pathogens for dissemination purposes. …”
Get full text

Purification of Angiotensin-I-Converting Enzyme Inhibitory Peptides Derived from Camellia oleifera Abel Seed Meal Hydrolysate by Guang-long Yao, Wei He, You-gen Wu, Jian Chen, Xin-wen Hu, Jing Yu

“…Our manuscript presents an optimized preparation of ACE inhibitory peptides with alkaline protease and enzyme kinetics parameters. Ultrafiltration, gel chromatography, and RP-HPLC purification were conducted for ACE inhibitory peptides, and peptide molecular weight distribution and amino acid composition were analyzed in the enzymolysis liquid. …”
Get full text

Characteristics and bioinformatics of peptides from natural and cultured sandfish (Holothuria scabra) by Pawitporn Daopa, Chakkapat Aenglong, Sittiruk Roytrakul, Teerasak E-kobon, Xue Zhao, Wanwimol Klaypradit

“…Sandfish from both sources were subjected to double enzymatic hydrolysis using neutral protease–alcalase (NA), papain–neutral protease (PN), and papain–alcalase (PA) to obtain protein hydrolysates. …”
Get full text

Chemical reactivity of alliin and its molecular interactions with the M proteasepro of SARS-CoV-2 by López-Orozco Wendolyne, Mendoza-Huizar Humberto Luis, Álvarez-Romero Giaan Arturo, Torres-Valencia Jesús Martín, Sanchez-Zavala Maricruz

“…Last result suggests that this molecule is a potential candidate for further in vitro evaluation as a drug for the treatment of the major protease-based SARS-CoV-2 virus.…”
Get full text

The effect of replacing red algae on histomorphology and enzymes of digestive tract of Nile tilapia, Oreochromis niloticus by Sanaz Kord, Rahim Abdi, Isaac Zamani, Rhima Peyghan

“…Results: Histological examination in the mid-esophagus, anterior, middle, and posterior parts of the intestine showed that the highest number of mucous cells, the highest thickness of the epithelium and muscle layer, as well as the highest height and thickness of the esophageal villi were observed in the group receiving the diet containing 9% red algae. Also, protease, amylase and lipase enzymes in the treatments had a higher level than in the control group, with the exception that the amount of protease was higher than amylase and lipase. …”
Get full text

Effects of dietary Bacillus NP5 and sweet potato extract on growth and digestive enzyme activity of dumbo catfish Clarias sp. by Achmad Noerkhaerin Putra, Yayu Romdhonah

“…Penambahan sinbiotik pada pakan memberikan hasil terbaik pada parameter bobot akhir, laju pertumbuhan harian, FCR, retensi protein, rasio efisiensi protein, dan aktivitas enzim protease dibandingkan dengan perlakuan lainnya.   …”
Get full text

Identifying the potential of ovalbumin and its’ hydrolysates to be used in a liquid food system to develop functional beverages by Maggonage Hasini Udeshika Maggonage, Prabudhdha Manjula, Edirisingha Dewage Nalaka Sandun Abeyrathne, Dewei Shu, Xi Huang, Dong Uk Ahn

“…The beverages were sequentially hydrolyzed using pepsin (pH 2.5, 37°C for 3 h) first, then with protease (pH 6.5, 37°C for 3 h), or protease (pH 6.5, 37°C for 3 h) followed by trypsin (pH 7.8, 37°C for 3 h) combinations. …”
Get full text

Hemoglobin-Derived Antioxidant Peptides from Beef Cattle in Ningxia: Identification Based on Computerized Screening and Molecular Docking by XU Feiran, WANG Yu, WANG Xiaojing, CUI Wei, WANG Yongkun, ZHOU Hui, WANG Zhaoming, CAI Kezhou, ZHANG Bao, XU Baocai

“…In this study, three enzymatic hydrolysis methods, alkaline protease (E1), pepsin + trypsin (E2), and alkaline protease + pepsin + trypsin (E3), were used to prepare hemoglobin hydrolysates from Ningxia beef cattle, which were screened for their antioxidant activity. …”
Get full text

Effects of Dietary Yeast, Saccharomyces cerevisiae, and Costmary, Tanacetum balsamita, Essential Oil on Growth Performance, Digestive Enzymes, Biochemical Parameters, and Disease R... by Hossein Adineh, Morteza Yousefi, Basim S. A. Al Sulivany, Ehsan Ahmadifar, Mohammad Farhangi, Seyyed Morteza Hoseini

“…The highest amylase (P=0.026), lipase (P=0.036), and protease (P=0.009) activities were observed in Sc + Tb treatment. …”
Get full text

On some models for cancer cell migration throughtissue networks by Jan Kelkel, Christina Surulescu

“…We propose some models allowing to account for relevant processes at the various scales of cancer cell migration through tissue, ranging from the receptor dynamics on the cell surface over degradation of tissue fibers by protease and soluble ligand production towards the behavior of the entire cell population.…”
Get full text

Effects of Tannic Acid Supplementation of a High-Carbohydrate Diet on the Growth, Serum Biochemical Parameters, Antioxidant Capacity, Digestive Enzyme Activity, and Liver and Intes... by Yi Wang, Jianjun Wu, Luoxin Li, Yuanfeng Yao, Chiqing Chen, Yucong Hong, Yi Chai, Wei Liu

“…In turn, 800 mg/kg dietary TA significantly inhibited protease activity in the pyloric caecum and intestine (P<0.05). …”
Get full text

Development of Digestive Enzyme of Patin Pangasius hypohthalmus Larvae by I. Effendi, D. Augustine, . Widanarni

“…Dengan memotong waktu pemberian Artemia 2 - 4 hari dan disubstitusi dengan Tubifex, aktifitas enzim protease, lipase dan amilase pada larva ikan patin, memiliki pola yang sama. …”
Get full text

Bidirectional approach of Punica granatum natural compounds: reduction in lung cancer and SARS-CoV-2 propagation by Md. Abul Barkat, Afreen Fatima, Bushra Riaz, Mohd. Zaheen Hassan, Tanveer Ahamad, Abdulkareem A. Alanezi, Harshita Barkat, Afaf F. Almuqati, Yahya I. Asiri, Sahabjada Siddiqui

“…The glide module of Maestro software was used to investigate the molecular-docking interaction of the constituents against main protease (Mpro) and papain-like protease (PLpro) of SARS-CoV-2. …”
Get full text

Prevalence of HIV Drug Resistance Mutations in HIV Type 1 Isolates in Antiretroviral Therapy Naïve Population from Northern India by S. Sinha, H. Ahmad, R. C. Shekhar, N. Kumar, L. Dar, J. C. Samantaray, S. K. Sharma, A. Bhargava, R. M. Pandey, R. L. Mitsuyasu, J. L. Fahey

“…Analysis was performed using Viroseq genotyping system based on sequencing of entire protease and two-thirds of the Reverse Transcriptase (RT) region of pol gene. …”
Get full text

Distal protein-protein interactions contribute to nirmatrelvir resistance by Eric M. Lewandowski, Xiujun Zhang, Haozhou Tan, Aiden Jaskolka-Brown, Navita Kohaal, Aliaksandra Frazier, Jesper J. Madsen, Lian M. C. Jacobs, Jun Wang, Yu Chen

“…Abstract SARS-CoV-2 main protease, Mpro, is responsible for processing the viral polyproteins into individual proteins, including the protease itself. …”
Get full text