Cost-effectiveness of Triple Therapy with Telaprevir for Chronic Hepatitis C Virus Patients in Germany by Jona T. Stahmeyer, Svenja Schauer, Siegbert Rossol, Hans Heinrich Wedemeyer, Daniel Wirth, Florence Bianic, Christian Krauth

“…The introduction of first generation protease inhibitors has significantly improved the treatment of hepatitis C genotype 1 patients. …”
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Optimizing mycelial growth of Trametes versicolor HBB 7328 for enzyme production and green energy by Nikita Goyat, Rajeev Kumar Kapoor, Baljeet Singh Saharan, Prexha Kapoor, Deepika Dhanda

“…Enzymatic activity screening showed that T. versicolor HBB 7328 was positive for laccase, cellulase, protease, and xylanase activities. Notably, it exhibited substantial laccase activity (50.167 U/mL). …”
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Identification of Mutations that Encode Drug Resistance in the Polymerase Gene of the Human Immunodeficiency Virus by Zhengxian Gu, Hengsheng Fang, Horacio Salomon, Qing Gao, Mark A Wainberg

“…The complete reverse transcriptase open reading frames of these viruses, and portions of flanking protease and integrase within the pol gene, were cloned and sequenced by polymerase chain reaction (PCR) techniques. …”
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FOXG1 promotes osteogenesis of bone marrow-derived mesenchymal stem cells by activating autophagy through regulating USP14 by Yiqi Zhang, Long Zhou, Qin Fu, Ziyun Liu

“…Mechanically, FOXG1 transcriptionally represses ubiquitin-specific protease14 (USP14) via binding to the USP14 promoter. …”
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A phase 1 clinical trial of SP16, a first-in-class anti-inflammatory LRP1 agonist, in healthy volunteers. by George F Wohlford, Leo F Buckley, Dinesh Kadariya, Taeshik Park, Juan Guido Chiabrando, Salvatore Carbone, Virginia Mihalick, Matthew S Halquist, Adam Pearcy, Dana Austin, Cohava Gelber, Antonio Abbate, Benjamin Van Tassell

“…<h4>Background</h4>Endogenous serine protease inhibitors are associated with anti-inflammatory and pro-survival signaling mediated via Low-density lipoprotein receptor-related protein 1 (LRP1) signaling. …”
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Plant Growth Promoting Rhizobacteria for Biocontrol of Tomato Bacterial Wilt Caused by Ralstonia solanacearum by Habtamu Mekonnen, Mulugeta Kibret, Fassil Assefa

“…All isolates produced cellulase and lipase, and only BDUA1 and BDUA3 produced protease and amylase. Besides, BDUA1 and BDUA2 showed phosphate solubilization and production of indole-3-acetic acid, HCN, and siderophore, while BDUA3 solubilized phosphate and produced HCN and siderophore. …”
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Sustainable Protein Sources: Functional Analysis of <i>Tenebrio molitor</i> Hydrolysates and Attitudes of Consumers in Poland and Spain Toward Insect-Based Foods by Marcelina Maciejewska, Anna Dąbrowska, Marina Cano-Lamadrid

“…The study optimized the process of enzyme hydrolysis using serine protease from <i>Cucurbita ficifolia</i>, thereby enhancing DPPH scavenging capacity increased from 3.15 ± 0.53 to 8.17 ± 0.62 µM Trolox/mL and ABTS decolorization capacity increased from 4.29 ± 0.01 to 10.29 ± 0.01 µM Trolox/mL after 5 h of hydrolysis. …”
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Computational design of drug candidates for influenza A virus subtype H1N1 by inhibiting the viral neuraminidase-1 enzyme by Tambunan Usman Sumo Friend, Parikesit Arli Aditya, Dephinto Yonaniko, Sipahutar Feimmy Ruth Pratiwi

“…In order to increase peptide stability, cyclization is necessary to prevent its digestion by protease enzyme. Cyclization of peptide ligands by formation of disulfide bridges is preferable for designing inhibitors of neuraminidase-1 because of their high activity and specificity. …”
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Budd-Chiari Syndrome with Multiple Thrombi due to a Familial Arg42Ser Mutation in the Protein C Gene by Jun Muratsu, Atsuyuki Morishima, Kazuhiro Mizoguchi, Keiji Ataka, Hiroshi Yamamoto, Xinping Fan, Toshiyuki Miyata, Katsuhiko Sakaguchi

“…Genetic analysis showed the presence of a c.125C>A (Arg42Ser) substitution in the protein C gene (PROC) of the proband, which generates an Arg42Ser mutation that replaces the scissile bond Arg42-Ala43 normally cleaved by a furin-like processing protease. Her father and younger brother also carried this mutation, although they had no evidence of thrombosis.…”
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In vitro efficacy of plant growth-promoting rhizobacteria isolated from ginger (Zingiber officinale) rhizosphere for biological control of plant pathogens by Ruth Meike Jayanti, Sabrina Ayu Kristianingrum, Andree Wijaya Setiawan

“…Among them, isolate 235A2 demonstrated the highest potential as a biological control agent, with capabilities including phosphate solubilization, nitrogen fixation, protease enzyme production, and significant inhibition rates of F. oxysporum (13.79%), Colletotrichum sp. (55.56%), and Alternaria sp. (35.61%) in vitro. …”
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Proteomic Analysis of Hippocampus and Cortex in Streptozotocin-Induced Diabetic Model Mice Showing Dementia by Kenji Matsuura, Mieko Otani, Masaoki Takano, Keiichi Kadoyama, Shogo Matsuyama

“…These identified proteins and phosphoproteins could be functionally classified as cytoskeletal protein, oxidoreductase, protein deubiquitination, energy metabolism, GTPase activation, heme binding, hydrolase, iron storage, neurotransmitter release, protease inhibitor, transcription, glycolysis, antiapoptosis, calcium ion binding, heme metabolic process, protein degradation, vesicular transport, and unknown in the hippocampus or cortex. …”
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Comprehensive Assessment of Biomolecular Interactions of Morpholine-Based Mixed Ligand Cu(II) and Zn(II) Complexes of 2,2′-Bipyridine as Potential Anticancer and SARS-CoV-2 Agents:... by Karunganathan Sakthikumar, Rui Werner Maçedo Krause, Bienfait Kabuyaya Isamura

“…Density FunctionalTheory (DFT) and molecular docking calculations were relied on to unveil the electronic structure, reactivity, and interacting capability of all substances with DNA, BSA, and SARS-CoV-2 main protease (Mpro). These observed binding energies fell within the following ranges: −7.7 to −8.6, −7.2 to −10.2, and −6.7 to −8.2 kcal/mol, respectively. …”
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Increased Yield and Improved Transplantation Outcome of Mouse Islets with Bovine Serum Albumin by Suzanne Bertera, A. N. Balamurugan, Rita Bottino, Jing He, Massimo Trucco

“…Bovine serum albumin (BSA) is recognized as a protease inhibitor possibly protecting function and viability in islets. …”
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Functionalized oligonucleotides, synthetic catalysts as enzyme mimics by Chardet, Crystalle, Serres, Sandra, Payrastre, Corinne, Escudier, Jean-Marc, Gerland, Béatrice

“…We will exemplify the development of FuON either presenting RNA-cleaving activity or acting as peroxidase or protease mimics and discuss the impact of the introduced modifications.…”
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A CDFT-Based Computational Peptidology (CDFT-CP) Study of the Chemical Reactivity and Bioactivity of the Marine-Derived Alternaramide Cyclopentadepsipeptide by Norma Flores-Holguín, Juan Frau, Daniel Glossman-Mitnik

“…The computational pharmacokinetics study revealed the potential ability of alternaramide as a therapeutic drug by interacting with GPCR ligands and protease inhibitors. The ADMET indices confirm this assertion through the absence of toxicity and good absorption and distribution properties.…”
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VETOZIM MULTI - AN INNOVATIVE SOLUTION FOR THE POULTRY INDUSTRY by O. Khodakivskyi, Ye. Baranovskyi

“…The composition of the multienzyme preparation Vetozym Multi from the company "Vetsintez" is characterized, which contains a complex of enzymatic activities: glucanase, xylanase, cellulase, protease, amylase, mannanase, phytase. The practical results of using the multienzyme preparation Vetozym Multi as part of compound feeds for broilers are presented. …”
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BACH2 in TRegs Limits the Number of Adipose Tissue Regulatory T Cells and Restrains Type 2 Immunity to Fungal Allergens by Amanda Contreras, Darin L. Wiesner, Brock Kingstad-Bakke, Woojong Lee, John P. Svaren, Bruce S. Klein, M. Suresh

“…Most strikingly, Treg-specific Bach2 deficiency resulted in enhanced fungal protease-induced Type 2 allergic inflammation in the lungs, with no detectable effects on Type 1 responses to systemic or respiratory viral infections. …”
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BPI-ANCA Provides Additional Clinical Information to Anti-Pseudomonas Serology: Results from a Cohort of 117 Swedish Cystic Fibrosis Patients by Ulrika Lindberg, Malin Carlsson, Thomas Hellmark, Mårten Segelmark

“…IgA BPI-ANCA was compared with assays for antibodies against alkaline protease (AP), Elastase (ELA), and Exotoxin A (ExoA). …”
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Vascular Pathology in Alpha 1 Antitrypsin Deficient Chronic Obstructive Pulmonary Disease and Emphysema Patients: Case Reports by Gordon M, Gangemi AJ, Sandwith EL, Kumaran M, Kueppers F

“…In addition to pulmonary manifestations, AATD has also been associated with vascular pathology due to excessive protease activity, tissue degradation, and vessel stiffening. …”
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IL-1β-Induced Matrix Metalloprotease-1 Promotes Mesenchymal Stem Cell Migration via PAR1 and G-Protein-Coupled Signaling Pathway by Ming-Siou Chen, Cheng-Yu Lin, Yun-Hsuan Chiu, Chie-Pein Chen, Pei-Jiun Tsai, Hwai-Shi Wang

“…MMP-1 siRNA transfected MSCs, and MSC pretreatment with IL-1β inhibitor interleukin-1 receptor antagonist (IL-1RA), MMP tissue inhibitor of metalloproteinase 1 (TIMP1), tissue inhibitor of metalloproteinase 2 (TIMP2), MMP-1 inhibitor GM6001, and protease-activated receptor 1 (PAR1) inhibitor SCH79797 confirms that PAR1 protein signaling pathway leads to IL-1β-induced cell migration. …”
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