Decision impact studies, evidence of clinical utility for genomic assays in cancer: A scoping review. by Gillian Parker, Sarah Hunter, Samer Ghazi, Robin Z Hayeems, Francois Rousseau, Fiona A Miller

“…All studies were published in the last 12 years with the majority for breast cancer (72%); followed by other cancers (28%) (lung, prostate, colon). Studies reported on the impact of 19 different proprietary (18) and generic (1) assays. …”
Get full text

The Impact of Metastatic Bone Cancers on Serum Calcium Levels: A Focused Analysis of Patient Outcomes by Muhammad Khizar Memon, Syed Uzair Mahmood, Sidra Memon, Azhar Rashid, Muhammad Ali Memon, Shahzad Ali Jiskani

“…The corrected calcium level of the patients with breast cancer was statistically lower compared with the prostate cancer patients - 8.3 ± 0.5 mg/dl (p = 0.01) compared with 9.0 ± 0.6 mg/dl. …”
Get full text

Towards Personalized Radiotherapy in Pelvic Cancer: Patient-Related Risk Factors for Late Radiation Toxicity by Anna C. Nuijens, Arlene L. Oei, Nicolaas A. P. Franken, Coen R. N. Rasch, Lukas J. A. Stalpers

“…This narrative review examines patient-related determinants of late toxicity following external beam radiotherapy for pelvic tumors, with a focus on prostate and cervical cancer patients. In Part I, we address various methods for quantifying radiation toxicity, providing context for interpreting toxicity data. …”
Get full text

Travel Burden and the Direct Medical Costs of Urologic Surgery by Daniel J. Olson, John L. Gore, Kenn B. Daratha, Kenneth P. Roberts

“…**Methods:** This was a retrospective observational cohort study of 12 106 patients over 50 years of age undergoing transurethral resection of the prostate (TURP), radical prostatectomy (RP) or radical cystectomy (RC) in Washington State hospitals between 2009 and 2013. …”
Get full text

Frequency of BK virus genotypes in patients with colorectal cancer by Mahsa Javadi, Gholamabbas Kaydani, Roya Pirmoradi, Abdolhassan Talaiezadeh, Azadeh Haghi Navand, Mohammad Karimi Baba Ahmadi, Manoochehr Makvandi

“…Furthermore, its involvement in a tumorigenic family necessitates consideration in various malignancies such as urogenital tumors, prostate cancer, colorectal cancer (CRC), and brain cancer. …”
Get full text

Exosomes as Mediators of Cell-to-Cell Communication in Thyroid Disease by Yi Wang, Feng Xu, Jia-Yu Zhong, Xiao Lin, Su-Kang Shan, Bei Guo, Ming-Hui Zheng, Ling-Qing Yuan

“…To date, several studies have demonstrated that exosomes play crucial roles in disease pathogenesis and development, such as breast and prostate cancer. However, studies investigating connections between exosomes and thyroid disease are limited. …”
Get full text

Personalized medicine: An alternative for cancer treatment by Devendra Singh, Vinay Kumar Dhiman, Minakshi Pandey, Vivek Kumar Dhiman, Avinash Sharma, Himanshu Pandey, Sunil Kumar Verma, Rajeev Pandey

“…Cancer is projected to be responsible for approximately 10 million deaths in 2020, accounting for one in six deaths globally. Prostate, colon, lung, and breast cancers are the most common types of cancer. …”
Get full text

Calculated Tumor Volume Is an Independent Predictor of Biochemical Recurrence in Patients Who Underwent Retropubic Radical Prostatectomy by Nobumichi Tanaka, Kiyohide Fujimoto, Akihide Hirayama, Yasushi Nakai, Yoshitomo Chihara, Satoshi Anai, Atsushi Tomioka, Keiji Shimada, Noboru Konishi, Yoshihiko Hirao

“…Between January 1997 and March 2006, 255 patients with clinically localized adenocarcinoma of the prostate (clinical T1-3N0M0) who had undergone retropubic radical prostatectomy were enrolled in this study. …”
Get full text

Neurovascular bundle sparing in hypofractionated radiotherapy maintained with realistic treatment uncertainties by Roel C. Kwakernaak, Victor J. Brand, Jesús Rojo-Santiago, Femke E. Froklage, Mischa S. Hoogeman, Steven J.M. Habraken, Maaike T.W. Milder

“…Background and purpose: Erectile dysfunction is a common side effect of radiotherapy for prostate cancer. To mitigate this toxicity, it has been suggested to limit the dose to critical nerves and vessels. …”
Get full text

Implementation of a sexual health clinic in an oncology setting: patient and provider perspectives by Andrew G. Matthew, Taylor Incze, Elisa Stragapede, Steven Guirguis, Sarah E. Neil-Sztramko, Dean S. Elterman

“…Healthcare providers and patients representing selected cancer types (prostate, cervical, ovarian, testicular, bladder, kidney, and head and neck cancer) participated in semi-structured interviews. …”
Get full text

Concurrent Viewing of H&E and Multiplex Immunohistochemistry in Clinical Specimens by Larry E. Morrison, Tania M. Larrinaga, Brian D. Kelly, Mark R. Lefever, Rachel C. Beck, Daniel R. Bauer

“…<b>Results:</b> Application is made to several clinically relevant specimens, including breast cancer (HER2, ER, and PR), prostate cancer (PSMA, P504S, basal cell, and CD8), Hodgkin’s lymphoma (CD15 and CD30), and melanoma (LAG3). …”
Get full text

Multi-stage structure-based virtual screening approach combining 3D pharmacophore, docking and molecular dynamic simulation towards the identification of potential selective PARP-1... by Mahmoud A. El Hassab, Wagdy M. Eldehna, Ghaneya S. Hassan, Sahar M. Abou-Seri

“…Elevated levels of PARP-1 were observed in many types of tumor cells, such as breast, lung, ovarian, prostate, and melanomas. In an attempt to provide a future guide for developing selective inhibitors for PARP-1 over PARP-2 to minimize the resulting side effects from PARP-2 inhibitors, we constructed a structure-based virtual screening approach (SBVS). …”
Get full text

Association of whole grain food consumption with lung cancer risk: a prospective cohort study by Kanran Wang, Junhan Zhao, Dingyi Yang, Mao Sun, Yongzhong Wu, Wei Zhou

“…Therefore we aim to investigate the relationship between whole grain food consumption and lung cancer in the Prostate, Lung, Colorectal, and Ovarian Cancer Screening Trial (PLCO) cohort. …”
Get full text

Correlation between oxygen reserve index monitoring and blood gas oxygen values during anesthesia in robotic total prostatectomy surgery by Hilal Zengin

“…Materials and methods The study was carried out with adult male patients over the age of 18 who underwent RARP with the diagnosis of prostate cancer. An ORI pulse oximeter was additionally attached to their index fingers for ORI monitoring. …”
Get full text

Human Immune System Increases Breast Cancer-Induced Osteoblastic Bone Growth in a Humanized Mouse Model without Affecting Normal Bone by Tiina E. Kähkönen, Mari I. Suominen, Jenni H. E. Mäki-Jouppila, Jussi M. Halleen, Azusa Tanaka, Michael Seiler, Jenni Bernoulli

“…Bone metastases are prevalent in many common cancers such as breast, prostate, and lung cancers, and novel therapies for treating bone metastases are needed. …”
Get full text

Qualitative analysis of patients’ feedback from a PROMs survey of cancer patients in England by Richard Wagland, Jessica Corner, Adam Glaser, Sir Mike Richards

“…Objective This study examined how free-text comments from cancer survivors could complement formal patient-reported outcome measures (PROMs), as part of the England PROMs survey programme for cancer.Design A qualitative content analysis was conducted of responses to a single open-ended free-text question placed at the end of the cross-sectional population-based postal questionnaire.Setting Individuals were identified through three UK Cancer Registries and questionnaires were posted to their home addresses.Participants A random sample of individuals (n=4992) diagnosed with breast, colorectal, non-Hodgkins lymphoma or prostate cancer at 1, 2, 3 and 5 years earlier.Results 3300 participants completed the survey (68% response rate). …”
Get full text

Are deprivation-specific cancer survival patterns similar according to individual-based and area-based measures? A cohort study of patients diagnosed with five malignancies in Engl... by Lucy Elliss-Brookes, Aurélien Belot, Matthew Baker, Fiona C Ingleby, Laura M Woods, Iain M Atherton

“…Objective To investigate if measured inequalities in cancer survival differ when using individual-based (‘person’) compared with area-based (‘place’) measures of deprivation for three socioeconomic dimensions: income, deprivation and occupation.Design Cohort study.Setting Data from the Office for National Statistics Longitudinal Study of England and Wales, UK, linked to the National Cancer Registration Database.Participants Patients diagnosed with cancers of the colorectum, breast, prostate, bladder or with non-Hodgkin’s lymphoma during the period 2008–2016.Primary and secondary outcome measures Differentials in net survival between groups defined by individual wage, occupation and education compared with those obtained from corresponding area-level metrics using the English and Welsh Indices of Multiple Deprivation.Results Survival was negatively associated with area-based deprivation irrespective of the type analysed, although a trend from least to most deprived was not always observed. …”
Get full text

ENDOPROSTHESIS OF THE SHOULDER JOINT IN METASTATIC LESIONS OF THE PROXIMAL HUMERUS DURING IMMUNOSUPPRESSIVE THERAPY by M. V. Ivanova, V. Yu. Karpenko, A. V. Bukharov, V. A. Derzhavin

“…Metastatic lesions of long bones occurs 2-4 times more common than primary tumors and often are diagnosed with breast cancer in 65–73%, of prostate cancer in 56–68% and lung cancer in 30–36% of patients. …”
Get full text

PSMA PET/CT Identifies Intrapatient Variation in Salivary Gland Toxicity From Iodine-131 Therapy by Vineet Mohan MSc, Wouter V. Vogel MD, PhD, Gerlof D. Valk MD, PhD, Jan P. de Boer MD, PhD, Marnix G. E. H. Lam MD, PhD, Bart de Keizer MD, PhD

“…It is currently insufficiently understood how the dose and biodistribution of 131 I relates to salivary gland toxicity, and whether this is consistent for all salivary glands within a single patient. Prostate-specific membrane antigen (PSMA) positron emission tomography/computed tomography (PET/CT) was recently introduced as a new tool to evaluate the relative loss of vital acinar cells in individual salivary glands. …”
Get full text

<i>shp-2</i> gene knockout upregulates CAR-driven cytotoxicity of YT NK cells by V. G. Subrakova, S. V. Kulemzin, T. N. Belovezhets, A. N. Chikaev, N. A. Chikaev, O. A. Koval, A. A. Gorchakov, A. V. Taranin

“…We demonstrate that the combination of shp-2 gene knockout and CAR expression increases the cytotoxicity of effector NK-like YT cells against human prostate cancer cell line Du-145 with ectopic expression of PSMA protein, which is specifically targeted by the CAR.…”
Get full text