RECQL4 affects MHC class II‐mediated signalling and favours an immune‐evasive signature that limits response to immune checkpoint inhibitor therapy in patients with malignant melan... by Sara Egea‐Rodriguez, Renáta Váraljai, Thierry M. Nordmann, Restuan Lubis, Manuel Philip, Florian Rambow, Alexander Roesch, Michael Flaig, Susanne Horn, Raphael Stoll, Fang Zhao, Annette Paschen, Bert Klebl, Ian D. Hickson, Dirk Schadendorf, Matthias Mann, Iris Helfrich

“…Methods We analysed whole exome and bulk RNA sequencing data from a pan‐cancer cohort of 25 775 patients and cutaneous melanoma cohorts (untreated: n = 471, anti‐progressive disease [PD]‐1 treated: n = 212). RECQL4 copy number variations and expression levels were assessed for patient outcomes. …”
Get full text

Development and interpretation of a pathomics-driven ensemble model for predicting the response to immunotherapy in gastric cancer by Jing Wang, Zhe Li, Wei Wang, Md Tauhidul Islam, Xiaoyan Wang, Zhen Han, Zihan Li, Guoxin Li, Yuming Jiang, Taojun Zhang, Wenjun Xiong, Zepang Sun, Lequan Yu, Zhicheng Zhang, Xianqi Yang, Shengtian Sang, Alyssa A Guo

“…The univariate Cox regression analysis revealed that the prediction signature of pathomics-driven ensemble model was a prognostic factor for progression-free survival in patients with gastric cancer who underwent immunotherapy (p<0.001, HR 0.35 (95% CI 0.24 to 0.50)), and remained an independent predictor after multivariable Cox regression adjusted for clinicopathological variables, (including sex, age, carcinoembryonic antigen, carbohydrate antigen 19-9, therapy regime, line of therapy, differentiation, location and programmed death ligand 1 (PD-L1) expression in all patients (p<0.001, HR 0.34 (95% CI 0.24 to 0.50)). …”
Get full text

Durvalumab and tremelimumab in patients with advanced rare cancer: a multi-centre, non-blinded, open-label phase II basket trialResearch in context by Abha A. Gupta, Anna Tinker, Derek Jonker, Rahma Jamal, Hal Hirte, Eric W. Winquist, Quincy Chu, Christian Kollmannsberger, Ralph Wong, Thierry Alcindor, Torsten O. Nielsen, Ming Tsao, Tricia R. Cottrell, Diane Provencher, John Hilton, Monika K. Krzyżanowska, Christine Elser, Sebastien Hotte, Joana Sederias, Siwei Zhang, Wei Tu, Janet Dancey

“…Patients received D (1500 mg IV) + TM (75 mg IV) on Day 1 q4 weeks for 4 cycles followed by D q4 weeks until disease progression. This trial is registered with ClinicalTrials.gov, NCT02879162. …”
Get full text

New Sources and Old Methods. Reconstructing and Applying the Music-Theoretical Paratext of Johann Sebastian Bach’s Compositional Pedagogy by Derek Remeš

“…In contrast to many modern harmonic perspectives, chordal roots and root progressions played little to no role in the pre-Rameau thoroughbass tradition. …”
Get full text

Efficacy and safety of first-line PD-1/PD-L1 inhibitor in combination with CTLA-4 inhibitor in the treatment of patients with advanced non-small cell lung cancer: a systemic review... by Huimin Zhao, Shanshan Huang, Jianyu Wu, Yanlan Lu, Yue Zou, Haijian Zeng, Chunlan Li, Jin Wang, Xiaochen Zhang, Xiaochen Zhang, Siliang Duan, Siliang Duan, Weiming Liang

“…This meta-analysis aimed to assess the efficacy and safety of first-line PD-1/PD-L1 inhibitor in combination with CTLA-4 inhibitor (CP) in the treatment of patients with advanced NSCLC.MethodsA systemic search was conducted in four databases (PubMed, Cochrane library, Embase, and Web of Science) from their establishment until January 17, 2024, for randomized controlled trials that investigated the use of the first-line PD-1/PD-L1 inhibitor plus CTLA-4 inhibitor in patients with advanced NSCLC. Progression-free survival (PFS), overall survival (OS), objective response rate (ORR), disease control rate (DCR), and adverse events (AEs) were subjected to meta-analyses.ResultsTotally 7 eligible randomized controlled trials including 4682 people were included. …”
Get full text

Relationship between changes in the triglyceride glucose-body mass index and frail development trajectory and incidence in middle-aged and elderly individuals: a national cohort st... by Kai Guo, Qi Wang, Lin Zhang, Rui Qiao, Yujia Huo, Lipeng Jing, Xiaowan Wang, Zixuan Song, Siyu Li, Jinming Zhang, Yanfang Yang, Jinli Mahe, Zhengran Liu

“…Participants with persistently second-lowest to the highest TyG-BMI changes (β = 0.15, 0.38 and 0.76 respectively) and those experiencing the third to fourth cumulative TyG-BMI (β = 0.25 and 0.56, respectively) demonstrated accelerated FI progression. A U-shaped association was observed between TyG-BMI levels and both rapid FI trajectory and higher frail risk, with BMI being the primary factor. …”
Get full text

The HFA‐PEFF score identifies ‘early‐HFpEF’ phenogroups associated with distinct biomarker profiles by Michiel T.H.M. Henkens, Anne‐Mar vanOmmen, Sharon Remmelzwaal, Gideon B. Valstar, Ping Wang, Job A.J. Verdonschot, Mark R. Hazebroek, Leonard Hofstra, Vanessa P.M. vanEmpel, Joline W.J. Beulens, Hester M. denRuijter, Stephane R.B. Heymans

“…Recognizing early‐HFpEF phenogroups is essential to better understand progression towards overt HFpEF and pave the way for early intervention and treatment. …”
Get full text

Automated Synthesis and Initial Evaluation of (4′-Amino-5′,8′-difluoro-1′H-spiro[piperidine-4,2′-quinazolin]-1-yl)(4-[18F]fluorophenyl)methanone for PET/MR Imaging of Inducible Nit... by Skye Hsin-Hsien Yeh, Wen-Sheng Huang, Chuang-Hsin Chiu, Chuan-Lin Chen, Hui-Ting Chen, Dae Yoon Chi, Zhengxing Ge, Tsung-Hsun Yu, Pao-Yeh Wang, Yu-Yeh Kuo, Chun-Tse Hung, Geng-Ying Li, Chi-Wei Chang

“…In vitro, [18F]FBAT rapidly and progressively accumulated in murine microglial BV2 cells exposed to LPS; however, [18F]FBAT accumulation was inhibited by aminoguanidine, a selective iNOS inhibitor. …”
Get full text

Survey on first-line therapeutic management of relapsing–remitting multiple sclerosis in clinical practice in Spain by M. Llaneza, G. Fontes, L. Benedito-Palos, E. Moral

“…Introduction: Current therapies for relapsing–remitting multiple sclerosis (RRMS) help reduce morbidity and delay disease progression. However, the available information on factors influencing decision-making regarding first-line treatment remain poorly understood. …”
Get full text

Evaluation of Learners’ Satisfaction with Open Flexible and Distance Learning Services at the University of Lagos Distance Learning Institute by Adenike Oladipo, Esther O. Oladele, Oladipupo Ajeyalemi, Folashade Afolabi, Peter O. Olayiwola, Johnson A. Adewara, Andrew Akala, Uchenna Udeani

“…Les résultats de cette étude ont révélé que la DLI a moins de marge de progression pour satisfaire les apprenants aux stades de la préinscription, du processus et du produit, avec des réponses moyennes de 7,27, 5,63 et 6,87 respectivement. …”
Get full text

An exploratory study of INPP4B, a biomarker of gemcitabine chemoresistance in pancreatic cancer by REN Jiaqiang, WU Shuai, SU Tong, LI Jie, HAN Liang, WU Zheng

“…Kaplan-Meier curves demonstrated that patients with low INPP4B expression had significantly better progression-free survival (PFS) than those with high expression (HR=2.874, 95% CI: 1.262-6.544, P=0.013). …”
Get full text

Gut bacteria Prevotellaceae related lithocholic acid metabolism promotes colonic inflammation by Liping Chen, Zhenghao Ye, Junhua Li, Lijia Wang, Yu Chen, Meiping Yu, Jian Han, Jiangeng Huang, Dongyan Li, Yongling Lv, Kai Xiong, De’an Tian, Jiazhi Liao, Ursula Seidler, Fang Xiao

“…Subsequent experiments confirmed that LCA supplementation effectively mitigated the inhibitory effects of gut microbiota on colitis progression in mice, primarily through the activation of the sphingosine-1-phosphate receptor 2 (S1PR2)/NF-κB p65 signaling pathway. …”
Get full text

Multiplex immunohistochemistry to explore the tumor immune microenvironment in HCC patients with different GPC3 expression by Mingzhen Zhou, Ziyan Zhou, Lina Hu, Sidong Chen, Fanyan Meng, Jun Chen, Jie Shen

“…This methodology provides valuable insights into the complex interactions and spatial organization of immune cells in the context of hepatocellular carcinoma progression. Low GPC3 expression in HCC patients indicates potential benefits from combined targeted and immunotherapy. …”
Get full text

Global, regional, and national burdens of heart failure in adolescents and young adults aged 10–24 years from 1990 to 2021: an analysis of data from the Global Burden of Disease St... by Chengzhi Yang, Yuhe Jia, Changlin Zhang, Zening Jin, Yue Ma, Xuanye Bi, Aiju Tian

“…Summary: Background: Prior studies suggest prevalence of heart failure (HF) has remained steady or progressively decreased over past 30 years in the general population. …”
Get full text

Inter-pregnancy interval and uterine rupture during a trial of labour after one previous caesarean delivery and no previous vaginal births: a retrospective population-based cohort... by Pejman Adily, Travis Bettison, Mark Lauer, Rajit Narayan, Adam Mackie, Hala Phipps, Vincenzo Berghella, Marjan M. Haghighi, Katelyn Perren, George Johnson, Bradley de Vries

“…Interpretation: The risk of uterine rupture progressively decreases as IPI increases until about 21 months and then stabilises. …”
Get full text

Association of depression in multiple sclerosis with fatigue, sleep disturbances, disability, and health-related quality of life: Outcomes of a cross-sectional study by E. Aparicio-Castro, A. Candeliere-Merlicco, C.M. Santa, R. Villaverde-González

“…It can worsen the symptoms of MS, influence disability progression, and significantly reduce the quality of life (QoL). …”
Get full text

Features of expression of immunohistochemical markers in local and generalized clear cell kidney cancer by E. M. Frantsiyants, A. N. Shevchenko, E. A. Dzhenkova, N. S. Karnaukhov, T. A. Gudtskova, A. A. Breus, E. V. Filatova, D. A. Shvyrev

“…One of the main markers of extracellular matrix degradation MMP‑9 was approximately at the same level at both stages: at local‑50±6% and 49.6±7.2% at generalized, the difference in indicators is not reliable (P<0.05).Conclusion. Progression of clear cell kidney cancer from local to generalized forms is accompanied by hyperexpression of cyclin D1, a decreased e‑cadherin expression while increasing vimentin expression (increasing signs of epithelial-mesenchymal transformation), an increase in CD44 and VEGF expression.…”
Get full text

Diagnostics and treatment of gastroesophageal reflux disease: clinical guidelines of the Russian gastroenterological association by V. T. Ivashkin, I. V. Mayev, I. . A.s. Trukhmanov, Ye. K. Baranskaya, O. B. Dronova, O. V. Zayratyants, R. G. Sayfutdinov, A. A. Sheptulin, T. L. Lapina, S. S. Pirogov, Yu. A. Kucheryavy, O. A. Storonova, D. N. Andreyev

“…The goal of treatment is symptom relief, at erosive esophagitis - healing of erosions and complication prevention, at Barret's esophagus - prophylaxis of disease progression and dysplasia and adenocarcinoma development. …”
Get full text

Impact of Ketogenic and Mediterranean Diets on Gut Microbiota Profile and Clinical Outcomes in Drug-Naïve Patients with Diabesity: A 12-Month Pilot Study by Vanessa Palmas, Andrea Deledda, Vitor Heidrich, Giuseppina Sanna, Giulia Cambarau, Michele Fosci, Lorenzo Puglia, Enrico Antonio Cappai, Alessio Lai, Andrea Loviselli, Aldo Manzin, Fernanda Velluzzi

“…A substantial positive modulatory effect was observed especially up to the sixth month of the NI in KETO due to the progressive increase in bacterial markers of human health. …”
Get full text

Le Proyecto Mono Tocon : recherche, éducation et conservation, au Pérou by Audrey Gaultier, Rosario Huashuayo‑Llamocca, Antonio Boveda‑Penalba, Jan Vermeer

“…Les conséquences de cela sont bien sûr la disparition progressive de nombreuses espèces endémiques, mais également la destruction ou pollution des sources d’eau présentes dans les forêts et l’appauvrissement des communautés humaines. …”
Get full text