Real-World Experience with CDK4/6 Inhibitors in the First-Line Palliative Setting for HR+/HER2− Advanced Breast Cancer by Ram Patel, John Mathews, Caroline Hamm, Swati Kulkarni, Rasna Gupta, Tarquin Opperman, John Dean Chiong, Abdullah Nasser

“…Landmark trials have demonstrated a comparable progression-free survival (PFS) across CDK4/6 inhibitors, but the overall survival (OS) outcomes have varied. …”
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Correlations of Cancer-Related Fatigue with Clinicopathological Features and Quality of Life in Gastric Cancer by Dong Liu, A-Dong Xia, Yue-Long Xing, Kai Zhang, Dan Chen

“…After chemotherapy, the average CRF BFI scores of the partial remission (PR), disease stability (SD), and disease progression (PD) groups all reduced than those before chemotherapy (all P<0.05). …”
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Predictive role of SLC1A5 in neuroblastoma prognosis and immunotherapy by Jian Cheng, Miaomiao Sun, Xiao Dong, Yang Yang, Xiaohan Qin, Xing Zhou, Yongcheng Fu, Yuanyuan Wang, Jingyue Wang, Da Zhang

“…Conclusion SLC1A5 plays a pivotal role in neuroblastoma by promoting tumor progression and shaping an immunosuppressive microenvironment. …”
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Détermination du statut du Chimpanzé, Pan troglodytes verus, dans une zone non protégée de savane boisée à Bagnomba, Sénégal : Implication pour sa conservation by Papa Ibnou Ndiaye, Landing Badji, Stacy Marie Lindshield, Cheikh Tidiane Bâ, Jill Pruetz

“…Actuellement, la dégradation des habitats du chimpanzé au Sénégal ne cesse de progresser en raison d’effets anthropiques et de changements climatiques. …”
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Association between the composite dietary antioxidant index and non-alcoholic fatty liver disease: evidence from National Health and Nutrition Examination Survey 2005–2016 by Yidian Fu, Yidian Fu, Chao Jiang, Zonglin Li, Xiangyun Shi, Peiyuan Lv, Peiyuan Lv, Jingbo Zhang

“…ImportanceOxidative stress contributes to the progression of non-alcoholic fatty liver disease (NAFLD). …”
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Long-Term Treatment Outcomes of Micropulse Transscleral Cyclophotocoagulation in Primary and Secondary Glaucoma: A 5-Year Analysis by Ronald M. P. C. de Crom, Stefani Kujovic-Aleksov, Carroll A. B. Webers, Tos T. J. M. Berendschot, Henny J. M. Beckers

“…In patients with a preoperative Central Distance Visual Acuity (CDVA) > 0.05 on the Snellen chart, more than two lines of visual acuity (VA) loss were attributed to cataract (n = 10), retinal disease (n = 5), glaucoma progression (n = 3), corneal decompensation (n = 2), or other factors (n = 11). …”
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Fine particulate matter concentrations forecasting using long short-term memory network and meteorological inputs by T. Istiana, B. Kurniawan, S. Soekirno, A. Wihono, D.E. Nuryanto, B.A. Pertala, A. Sopaheluwakan

“…It has effectively surpassed the constraint of collecting observable data, attaining minimal error values on both sensors and satellite data, signifying a noteworthy progression compared to previous studies. Therefore, it might benefit areas lacking sufficient data, providing a valuable tool for air pollution mitigation.…”
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Myofibrillogenesis Regulator-1 in Smooth Muscle Cells Modulates Inflammation Signaling Pathways via Regulating ROCK1 Ubiquitination and Degradation to Impact Aortic Dissection by Yin H, Li X, Lu D, Zhao X, Yang Z, Wang Z, Xu F, Chen Y, Li C

“…Inflammation is a critical mechanism in the development of AD, and identifying specific molecular targets to regulate inflammation is crucial for stopping its progression. This study aimed to investigate the role of MR-1 and ROCK1 in the regulation of inflammation in AD and their potentialities as therapeutic targets.Methods: Researchers performed protein immunoblotting on aortic wall tissue from 10 patients who underwent aortic arch replacement and 10 patients who underwent coronary artery bypass grafting to examine the expression levels of MR-1, ROCK1, and inflammatory pathways in the aortas. …”
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Four weeks of slow-paced breathing: a longitudinal, randomized, placebo-controlled study of the autonomic nervous system by Nicolas Bourdillon, Arnaud Rochat, Vanessa Hoop, Grégoire P. Millet

“…The amplitude of RSA is modified by the respiratory frequency, i.e. an increase in respiratory frequency leads to a progressive decline in RSA as vagal effectors become less able to follow variations at higher frequencies. …”
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Whether Detection of Gene Mutations Could Identify Low- or High-Risk Papillary Thyroid Microcarcinoma? Data from 393 Cases Using the Next-Generation Sequencing by Lei Jin, Liang Zhou, Jian-Biao Wang, Li Tao, Xiao-Xiao Lu, Na Yan, Qian-Ming Chen, Li-Ping Cao, Lei Xie

“…In clinical practice, BRAFV600E mutation does not consistently serve as an effective biomarker to distinguish high-risk PTMC or predict tumor progression. The size of the tumor has a significant correlation with its aggressive characteristics. …”
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The Prognostic Significance of Sleep and Circadian Rhythm for Myocardial Infarction Outcomes: Case-Control Study by Wei-Chih Chin, Pao-Hsien Chu, Lung-Sheng Wu, Kuang-Tso Lee, Chen Lin, Chien-Te Ho, Wei-Sheng Yang, I-Hang Chung, Yu-Shu Huang

“…The use of actigraphy with different algorithms to evaluate sleep and circadian rhythm after acute MI has the potential for predicting outcomes and preventing future disease progression. ObjectiveWe aimed to evaluate how sleep patterns and disrupted circadian rhythm affect the prognosis of MI, using actigraphy and heart rate variability (HRV). …”
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Development of an artificial intelligence-based application for the diagnosis of sarcopenia: a retrospective cohort study using the health examination dataset by Chang-Won Jeong, Dong-Wook Lim, Si-Hyeong Noh, Sung Hyun Lee, Chul Park

“…The values for men gradually decreased after their 20s, and that for women gradually decreased after their 40s, which progressed to a more dramatic decline in the 70s for both sexes. …”
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Engagement With an Internet-Administered, Guided, Low-Intensity Cognitive Behavioral Therapy Intervention for Parents of Children Treated for Cancer: Analysis of Log-Data From the... by Christina Reuther, Louise von Essen, Mudassir Imran Mustafa, Markus Saarijärvi, Joanne Woodford

“…However, intervention adherence rates were marginally under progression criteria. ObjectiveThis study aimed to (1) describe user engagement with the EJDeR intervention and examine whether (2) sociodemographic characteristics differed between adherers and nonadherers, (3) depression and anxiety scores differed between adherers and nonadherers at baseline, (4) user engagement differed between adherers and nonadherers, and (5) user engagement differed between fathers and mothers. …”
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Deep learning-based CT radiomics predicts prognosis of unresectable hepatocellular carcinoma treated with TACE-HAIC combined with PD-1 inhibitors and tyrosine kinase inhibitors by Linan Yin, Ruibao Liu, Wei Li, Shijie Li, Xunbo Hou

“…Abstract Objective To develop and validate a computed tomography (CT)-based deep learning radiomics model to predict treatment response and progression-free survival (PFS) in patients with unresectable hepatocellular carcinoma (uHCC) treated with transarterial chemoembolization (TACE)-hepatic arterial infusion chemotherapy (HAIC) combined with PD-1 inhibitors and tyrosine kinase inhibitors (TKIs). …”
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Distribution of Major HLA-A, -B, -DR, and -DQ Loci Potentially Associated with Multiple Sclerosis in a Healthy Population from Southern Morocco by Abir Fguirouche, Fatimazahra Ouahmani, Ikram Brahim, Raja Hazime, Nissrine Louhab, Najib Kissani, Mohamed Chraa, Brahim Admou

“…<b>Background:</b> Many factors contribute to the development and the progression of Multiple Sclerosis (MS), including Human Leukocyte Antigen (HLA) molecules. …”
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Clinical and molecular analysis of JCPyV and BKPyV infection and associated risk of urothelial carcinoma development in the upper tract by Chun-Nun Chao, Chi-Feng Hung, Wei‑Hong Lai, Chun-Liang Tung, Wan-Yun Yeh, Kai-Wu Yang, Meilin Wang, Ya-Yan Lai, Pei-Lain Chen, Cheng-Huang Shen

“…This study aimed to investigate the prevalence of JCPyV and BKPyV in UTUC and their correlation with cancer progression among the southwest Taiwanese population from 2020 to 2022. …”
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Hubungan Umur dan Lamanya Hemodialisis dengan Status Gizi pada Penderita Penyakit Ginjal Kronik yang menjalani Hemodialisis di RS. Dr. M. Djamil Padang by Hannie Qalbina Syaiful, Fadil Oenzil, Rudy Afriant

“…Tidak terdapat hubungan antara status gizi dengan umur dan lamanya menjalani hemodialisis<br />Kata kunci: PGK, malnutrisi, umur</p><p>Abstract<br />Chronic Kidney Disease (CKD) is still a global health problem due to its increasing prevalence Its irreversible and progressive state. Malnutrition is more common in CKD patients. …”
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Imagined Libya: geopolitics of the margins by Luca Raineri

“…Yet they both contributed to the abusive manipulation of domestic ethnic cleavages, the weaponization of (the research into) the country’s history, and the progressive de-legitimation of the regime. Today, Libya has acquired a prominent role in Turkey’s geopolitical imaginary. …”
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Large-scale screening of HIV-1 T-cell epitopes restricted by 12 prevalent HLA-A allotypes in Northeast Asia and universal detection of HIV-1-specific CD8+ T cells by Yan Ding, Jialai Yan, Ling Huang, Jinhong Yu, Yandan Wu, Chuanlai Shen, Anning Fang

“…BackgroundAlthough the immune response of host T cells to human immunodeficiency virus (HIV) significantly influences the progression of the infection, the development of T-cell-based vaccines and therapies, as well as the clinical evaluation of specific T-cell functions, is currently markedly hindered by the absence of broad-spectrum, functionally validated HIV T-cell epitopes that account for the polymorphisms of the human leukocyte antigen (HLA) within an indicated geographic population. …”
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Durable responders in advanced NSCLC with elevated TMB and treated with 1L immune checkpoint inhibitor: a real-world outcomes analysis by David P Carbone, David Spigel, Jeffrey S Ross, Karthikeyan Murugesan, Gerald Li, Richard S P Huang, Ryon P Graf, Geoffrey R Oxnard, Alexa Schrock, Liangliang Zhang, Khaled Tolba, Jacob Sands

“…Comparing low TMB (&lt;10 muts/Mb), high TMB (10–19 muts/Mb), and very high TMB (≥20 muts/Mb) receiving ICPI alone, we observed a stepwise increase in median rwPFS (real world-progression free survival) (6.5, 7.5, 17.2 months) and rwOS (real world-overall survival) (10.1, 11.8, 26.9 months) as TMB increased. …”
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