Clinical utility of receptor status prediction in breast cancer and misdiagnosis identification using deep learning on hematoxylin and eosin-stained slides by Gil Shamai, Ran Schley, Alexandra Cretu, Tal Neoran, Edmond Sabo, Yoav Binenbaum, Shachar Cohen, Tal Goldman, António Polónia, Keren Drumea, Karin Stoliar, Ron Kimmel

“…Abstract Background Molecular profiling of estrogen receptor (ER), progesterone receptor (PR), and ERBB2 (also known as Her2) is essential for breast cancer diagnosis and treatment planning. …”
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Long-term trends in the incidence of male breast cancer and nomogram for predicting survival in male breast cancer patients: a population-based epidemiologic study by Aimin Huang, Daning Li, Zhe Fan, Jingfang Chen, Weidong Zhang, Wentao Wu

“…A total of 2,057 patients were included in the competing risk analysis, which identified factors like older age, estrogen receptor (ER) negative, progesterone receptor (PR) negative, and advanced AJCC stage as being associated with shorter survival. …”
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The Impact of p53 and Ki67 Expression in Endometrial Cancer and its Effect on Survival by Zekiye Sahin, Burak Bayraktar, Tugba Karadeniz, Muzaffer Sanci

“…RESULTS: The study included 140 patients who met the inclusion criteria, 60% (n=84) of whom had endometrioid type endometrial carcinoma and 40% (n=56) had non-endometrioid type endometrial carcinoma. Estrogen and progesterone receptor positivity was significantly higher in the endometrioid type endometrial carcinoma group (p<0.001 and p<0.001, respectively). …”
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Comparing the efficacy of different methods in assessing cervical stromal invasion in endometrial carcinoma: a retrospective study of 2,020 patients by Ying Yang, Ying Yang, Zhijun Ye, Zhijun Ye, Yifei Zhao, Yifei Zhao, Zhengyu Li, Zhengyu Li

“…CSI was associated with cancer antigen 125, myometrial invasion, adnexal invasion, parametrial invasion, lymph node metastasis, and progesterone receptor.ConclusionsMRI is relatively superior in assessing CSI, although diagnostic authenticity and consistency were unsatisfactory. …”
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Enhanced preoperative prediction of breast lesion pathology, prognostic biomarkers, and molecular subtypes using multiple models diffusion-weighted MR imaging by Litong He, Feng Li, Yanjin Qin, Yuling Li, Qilan Hu, Zhiqiang Liu, Yunfei Zhang, Tao Ai

“…Notably, IVIM-D and DKI-MK values were significantly different between estrogen receptor (ER)-positive and ER-negative tumors. Progesterone receptor (PR)-positive cancers exhibited lower Mono-ADC, IVIM-D, DKI-MD, SEM-DDC, CTRW-Dm, and CTRW-α values, alongside higher DKI-MK value compared to PR-negative cancers (p < 0.05). …”
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The Association between ER, PR, HER2, and ER−/PR+ Expression and Lung Cancer Subsequent in Breast Cancer Patients: A Retrospective Cohort Study Based on SEER Database by Hong Yu Shao, Bao Tan Hao, Feng Xiao Gao

“…The available research on the association between estrogen receptor (ER), progesterone receptor (PR), human epidermal growth factor receptor 2 (HER2), ER−/PR+ status, and the occurrence of lung cancer subsequent to breast cancer in patients (referred to as BC-LuC) had been limited. …”
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Predicting breast cancer prognosis using PR and PIK3CA biomarkers: a comparative analysis of diagnostic groups by Yuting Feng, Qingzhen Song, Lei Yan, Ruoqi Li, Mengqin Yang, Peng Bu, Jing Lian

“…Abstract Purpose To evaluate the prognostic significance of progesterone receptor (PR) expression and the PIK3CA mutation status in HR+/HER2 − breast cancer patients, with the goal of screening patients who may derive the greatest benefit from PI3K-targeted therapy. …”
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Upregulated SAE1 Drives Tumorigenesis and Is Associated with Poor Clinical Outcomes in Breast Cancer by Hong Liu, Jing Wang, Yunhai Li, Feng Luo, Lei Xing

“…The SAE1 overexpression was significantly associated with the tumor size, tumor-node-metastasis stage, estrogen receptor, progesterone receptor, human epidermal growth factor receptor 2, and whether or not it was a triple-negative BC. …”
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(<i>E</i>)-1-(3-(3-Hydroxy-4-Methoxyphenyl)-1-(3,4,5-Trimethoxyphenyl)allyl)-1<i>H</i>-1,2,4-Triazole and Related Compounds: Their Synthesis and Biological Evaluation as Novel Anti... by Gloria Ana, Azizah M. Malebari, Sara Noorani, Darren Fayne, Niamh M. O’Boyle, Daniela M. Zisterer, Elisangela Flavia Pimentel, Denise Coutinho Endringer, Mary J. Meegan

“…<b>Methods</b>: A panel of 29 compounds was synthesized and examined by a preliminary screening in estrogen receptor (ER) and progesterone receptor (PR)-positive MCF-7 breast cancer cells together with cell cycle analysis and tubulin polymerization inhibition. …”
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Evaluating the Effectiveness of Cyclin-Dependent Kinase 4/6 Inhibitors in Early- and Very Early-Onset Metastatic Breast Cancer: A Multicenter Study by Akif Doğan, Nurullah İlhan, Goncagül Akdağ, Sedat Yıldırım, Mustafa Seyyar, Zeynep Yüksel Yaşar, Hande Nur Erölmez, Heves Sürmeli, Buğra Öztosun, Özlem Nuray Sever, Hatice Odabaş, Mahmut Emre Yıldırım, Devrim Çabuk, Nedim Turan, Mahmut Gümüş

“…Additional factors associated with poorer outcomes included liver metastasis, progesterone receptor negativity, high tumor grade, and the concurrent use of fulvestrant with CDK4/6 inhibitors. …”
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An assessment of breast cancer HER2, ER, and PR expressions based on mammography using deep learning with convolutional neural networks by Shun Zeng, Hongyu Chen, Rui Jing, Wenzhuo Yang, Ligong He, Tianle Zou, Peng Liu, Bo Liang, Dan Shi, Wenhao Wu, Qiusheng Lin, Zhenyu Ma, Jinhui Zha, Yonghao Zhong, Xianbin Zhang, Guangrui Shao, Peng Gong

“…Expressions of human epidermal growth factor receptor 2 (HER2), estrogen receptor (ER), and progesterone receptor (PR) are critical to the development of therapeutic strategies for breast cancer. …”
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The Heart as a Site of Metastasis of Benign Metastasizing Leiomyoma: Case Report and Review of the Literature by Mariam Meddeb, Robert D. Chow, Randolph Whipps, Reyaz Haque

“…Immunohistochemical staining was positive for smooth muscle α-actin and desmin, as well as estrogen and progesterone receptors, consistent with the diagnosis of uterine leiomyoma.…”
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Lymphoepithelioma-Like Carcinoma of the Breast: A Case Report Unveiling Several Clinical and Histopathological Challenges by Tarek Aridi, Mohamad Fawwaz, Ahmad Kassab, Marwan Bahmad, Faisal Houcheimi, Mohamad Mshiek, Fouad Boulos, Ali Kanj, Ghassan Ramadan, Hisham F. Bahmad, Najla Fakhruddin

“…The tumor is negative for estrogen and progesterone receptors and did not overexpress HER2/neu. Routine tests for clearance before surgery were performed, and patient was managed by a modified radical mastectomy with axillary lymph node dissection showing no residual tumor. …”
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Immune Aspects and Myometrial Actions of Progesterone and CRH in Labor by Nikolaos Vrachnis, Fotodotis M. Malamas, Stavros Sifakis, Panayiotis Tsikouras, Zoe Iliodromiti

“…In humans, a “functional” progesterone withdrawal occurs with onset of labor through changes in progesterone metabolism, progesterone receptors, and other molecules that either facilitate or antagonize progesterone function. …”
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Aggressive Angiomyxoma in Pregnancy: A Rare Condition, a Common Misdiagnosis by J. Sampaio, I. Sarmento-Gonçalves, D. Ramada, T. Amaro, P. Tiago-Silva

“…Its positivity to estrogen and progesterone receptors can justify enlargement and recurrence during pregnancy, although few cases are reported. …”
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Comparison of Syndecan-1 Immunohistochemical Expression in Lobular and Ductal Breast Carcinoma with Nodal Metastases by Ivana Miše, Majda Vučić

“…Primary IDC showed a negative correlation between epithelial Sdc1 and progesterone receptors (PRs), whereas ILC showed a positive correlation between stromal Sdc1 and histological gradus. …”
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The Immunoexpression of Glucocorticoid Receptors in Breast Carcinomas, Lactational Change, and Normal Breast Epithelium and Its Possible Role in Mammary Carcinogenesis by Raja Alyusuf, Javed Fayyaz Wazir, Urmil Prabha Brahmi, Abdul Rahman Fakhro, Moiz Bakhiet

“…The role of estrogen and progesterone receptors in breast cancer biology is well established. …”
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Prenatal exposure to nitrate alters uterine morphology and gene expression in adult female F1 generation rats by André Gilberto Cassiani, Thiago Pinheiro Arrais Aloia, Érica Kássia Sousa-Vidal, Sérgio Podgaec, Carla de Azevedo Piccinato, Caroline Serrano-Nascimento

“…Additionally, nitrate treatment significantly increased the expression of estrogen receptors and reduced the expression of progesterone receptors in the uterus. Conclusion: Our results strongly suggest that prenatal exposure to nitrate programs gene expression and alters the uterine morphology in female F1 rats, potentially increasing their susceptibility to developing uterine diseases during adulthood.…”
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Lumbar Ureteral Stenosis due to Endometriosis: Our Experience and Review of the Literature by Salvatore Butticè, Antonio Simone Laganà, Valeria Barresi, Antonino Inferrera, Giuseppe Mucciardi, Antonina Di Benedetto, Carmela Emanuela D'Amico, Carlo Magno

“…Immunohistochemical test of the glandular epithelium showed positivity for estrogen and progesterone receptors and moreover stromal cells were positive for CD10. …”
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Canine Mammary Tumors as a Potential Model for Human Breast Cancer in Comparative Oncology by Amirhossein Razavirad, Sanaz Rismanchi, Pejman Mortazavi, Ahad Muhammadnejad

“…In total, 64 canine mammary tumors were selected to study the most common markers, which are applicable for human breast cancer treatment, including estrogen and progesterone receptors (ER and PR), human epidermal growth factor (HER2/neu), Ki67, and cyclooxygenase 2 (Cox2). …”
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