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    Development of machine learning models for predicting non-remission in early RA highlights the robust predictive importance of the RAID score-evidence from the ARCTIC study by Gaoyang Li, Shrikant S. Kolan, Franco Grimolizzi, Joseph Sexton, Giulia Malachin, Guro Goll, Tore K. Kvien, Tore K. Kvien, Nina Paulshus Sundlisæter, Manuela Zucknick, Siri Lillegraven, Espen A. Haavardsholm, Espen A. Haavardsholm, Bjørn Steen Skålhegg

    Published 2025-02-01
    “…This study aims to predict 6-month non-remission in 222 disease-modifying anti-rheumatic drug (DMARD)-naïve RA patients initiating methotrexate monotherapy, using baseline patient characteristics from the ARCTIC trial.MethodsMachine learning models were developed utilizing twenty-one baseline demographic, clinical and laboratory features to predict non-remission according to ACR/EULAR Boolean, SDAI and CDAI criteria. …”
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    Modeling and Predicting Time Series with Non-stationarity and Volatility by FENG Qiang, ZHAO Jianguang, YANG Rong, NIU Baoning

    Published 2025-05-01
    Subjects: “…time series prediction; non-stationarity; high volatility; long short-term memory neural network; multi-head self-attention…”
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    Finite family groups for fermionic and leptoquark mixing patterns by Jordan Bernigaud, Ivo de Medeiros Varzielas, Jim Talbert

    Published 2020-01-01
    “…Assuming experimentally interesting CKM and PMNS matrix elements, our algorithm finds an abundance of predictive non-Abelian flavour groups and therefore provides promising directions for future model building in the flavoured leptoquark space, regardless of whether the anomalous R K ∗ $$ {\mathcal{R}}_{K^{\left(\ast \right)}} $$ measurements withstand further experimental scrutiny.…”
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    The Emerging Biomarkers in Chronic Obstructive Pulmonary Disease: A Narrative Review by Kaitlin M. Phillips, Philip F. Lavere, Nicola A. Hanania, Muhammad Adrish

    Published 2025-05-01
    “…The fraction of exhaled nitric oxide (FENO) is increasingly studied in eosinophilic COPD endotypes and can be a diagnostic and predictive non-invasive biomarker. Imaging biomarkers, especially the quantitative computerized tomography (QCT) assessment of airway remolding, functional small airway disease, air trapping, lung function, and volume surrogates, all serve as non-invasive biomarkers for screening, early detection, and disease progression. …”
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    A Novel In Vitro Primary Human Alveolar Model (AlveolAir™) for H1N1 and SARS-CoV-2 Infection and Antiviral Screening by Cindia Ferreira Lopes, Emilie Laurent, Mireille Caul-Futy, Julia Dubois, Chloé Mialon, Caroline Chojnacki, Edouard Sage, Bernadett Boda, Song Huang, Manuel Rosa-Calatrava, Samuel Constant

    Published 2025-03-01
    “…The differences between animal models and humans contribute to inefficiencies in drug development, highlighting the need for more relevant and predictive, non-animal models. In this context, AlveolAir™, a fully primary in vitro 3D human alveolar model, was characterized and demonstrated the sustained presence of alveolar type I (ATI) and type II (ATII) cells. …”
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    Childhood adversity as a predictor of non-adherence to statin therapy in adulthood. by Maarit Jaana Korhonen, Jaana I Halonen, M Alan Brookhart, Ichiro Kawachi, Jaana Pentti, Hasse Karlsson, Mika Kivimäki, Jussi Vahtera

    Published 2015-01-01
    “…<h4>Purpose</h4>To investigate whether adverse experiences in childhood predict non-adherence to statin therapy in adulthood.…”
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    CT radiomics identifying non‐responders to neoadjuvant chemoradiotherapy among patients with locally advanced rectal cancer by Zinan Zhang, Xiaoping Yi, Qian Pei, Yan Fu, Bin Li, Haipeng Liu, Zaide Han, Changyong Chen, Peipei Pang, Huashan Lin, Guanghui Gong, Hongling Yin, Hongyan Zai, Bihong T. Chen

    Published 2023-02-01
    “…Conclusion Pretreatment CT radiomics achieved satisfying performance in predicting non‐response to nCRT and could be helpful to assist in treatment planning for patients with LARC.…”
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    Enzyme promiscuity shapes adaptation to novel growth substrates by Gabriela I Guzmán, Troy E Sandberg, Ryan A LaCroix, Ákos Nyerges, Henrietta Papp, Markus de Raad, Zachary A King, Ying Hefner, Trent R Northen, Richard A Notebaart, Csaba Pál, Bernhard O Palsson, Balázs Papp, Adam M Feist

    Published 2019-04-01
    “…After as few as approximately 20 generations, evolved populations repeatedly acquired the capacity to grow on five predicted non‐native substrates—D‐lyxose, D‐2‐deoxyribose, D‐arabinose, m‐tartrate, and monomethyl succinate. …”
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