Lipid-mediated hydrophobic gating in the BK potassium channel by Lucia Coronel, Giovanni Di Muccio, Brad S. Rothberg, Alberto Giacomello, Vincenzo Carnevale

“…Abstract Structures of the large-conductance, calcium-activated potassium (BK) channel in the Ca2+ −bound and Ca2+ −free states have suggested that K+ conduction is not gated via a steric closure of the pore-lining helices of the channel, in contrast to the gating mechanism of other 6TM channels. …”
Get full text

Mefloquine-induced conformational shift in Cx36 N-terminal helix leading to channel closure mediated by lipid bilayer by Hwa-Jin Cho, Dong Kyu Chung, Hyung Ho Lee

“…Notably, these inhibitors competitively bind to the binding pocket of the N-terminal helices (NTH), inducing a conformational shift from the pore-lining NTH (PLN) state to the flexible NTH (FN) state. …”
Get full text

PoreWalker: a novel tool for the identification and characterization of channels in transmembrane proteins from their three-dimensional structure. by Marialuisa Pellegrini-Calace, Tim Maiwald, Janet M Thornton

“…Finally, pore features, including diameter profiles, pore-lining residues, size, shape and regularity of the pore are calculated, providing a quantitative and visual characterization of the channel. …”
Get full text

Spatial Characteristics and Genesis of Tight Clastic Reservoirs in Yingcheng Formation of Changling Fault Depression in the Southern Songliao Basin by Hansheng Mu, Ruilei Li, Jianfeng Zhu, Wen Xu, Xiyu Qu

“…The research results show that (1) the tight clastic reservoir space types of Yingcheng Formation in the Longfengshan subsag of the Changling fault depression in the southern Songliao Basin include residual primary pores, secondary dissolved pores, and microfractures, with mainly secondary dissolved pores; (2) pore lining chlorite is an important mechanism for the preservation of primary pores; (3) water-rock simulation experiments have confirmed that volcanic rock cuttings are easy to dissolve and are the main contributor to the secondary dissolution pores in the study area; and (4) the Raman displacement technique of methane inclusions has confirmed the existence of overpressure, which is the cause of hydrocarbon generation and pressurization and is the main motivation for a microcrack formation.…”
Get full text

Cryo-EM structures of a pentameric ligand-gated ion channel in liposomes by Vikram Dalal, Brandon K Tan, Hanrui Xu, Wayland WL Cheng

“…In the desensitized structure, the ion conduction pore has a constriction at the 9’ leucine of the pore-lining M2 helix, indicating that 9’ is the desensitization gate in ELIC. …”
Get full text

Influence of Laumontite and Chlorite Mineral Characteristics on Reservoir Physical Properties in Junggar Basin by Fei Liang, Jun Niu, Jin He, Cong Wang

“…The results indicate that the chlorite minerals exhibit a trioctahedral crystal structure and are found in four distinct forms: as pore linings, grain coatings, pore fillings and chlorite pseudomorph. …”
Get full text