Genotype-driven sensitivity of mice to tick-borne encephalitis virus correlates with differential host responses in peripheral macrophages and brain by Michaela Berankova, Jiri Holoubek, Vaclav Hönig, Zuzana Matusova, Martin Palus, Jiri Salat, Imtissal Krayem, Jarmila Vojtiskova, Pavel Svoboda, Veronika Pranclova, Lukas Valihrach, Peter Demant, Marie Lipoldova, Daniel Ruzek

“…In the present study, we employed these genetically distinct mouse models to investigate the host response to TBEV infection in both peripheral macrophages, one of the initial target cell populations, and the brain, the terminal target organ of the virus. …”
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Are there Risks from Nanocomposite Restoration Grinding for Dentists? by Daniela Pelclova, Pavel Bradna, Lucie Lischkova, Vladimir Zdimal, Ludmila Maskova, Pavlina Klusackova, Viktoriia Kolesnikova, Jakub Ondracek, Jaroslav Schwarz, Miroslav Pohanka, Tomas Navratil, Stepanka Vlckova, Zdenka Fenclova, Jana Duskova, Andrea Rossnerova, Adela Roubickova

“…However, further studies are needed to evaluate oxidative stress in long-term exposure of both stomatologists and patients and diverse populations with varying health statuses.…”
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Can oral caffeine decrease postoperative opioid consumption following posterior spinal fusion in adolescent idiopathic scoliosis? A randomized placebo-controlled trial by Anne Stuedemann, MSN, RN, CPNP, Richard M Schwend, MD FAAP FAOA, Kenneth A. Shaw, MD, Nicolette Saddler, MSN, APRN, FNP-C, Michon Huston, PA-C, Michael Benvenuti, MD, Julia Leamon, MSN, RN, CPN, Ashley K. Sherman, MA, John Anderson, MD

“…ABSTRACT: Background: Current studies have examined the efficacy of opioid-sparing analgesics primarily in adult surgical populations, while fewer guide pediatric postoperative pain treatment. …”
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TYRO3 blockade enhances anti-PD-1 therapy response by modulating expression of CCN1 in tumor microenvironment by Miso Park, Da-Sol Kuen, Keon Wook Kang, Yeonseok Chung, Jaewoo Park, Munkyung Choi, Yeonji Kim, Eun Chae Roh, Yong June Choi, Yoon Gyoon Kim, Sung Yun Cho

“…Flow cytometry was used for the quantification of cell populations and immunophenotyping of macrophages and T cells. …”
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Intervening to eliminate the centre-effect variation in home dialysis use: protocol for Inter-CEPt—a sequential mixed-methods study designing an intervention bundle by Sarah Damery, Kerry Allen, Lisa Dikomitis, Harry Hill, David Coyle, Maatla Tshimologo, Mark Lambie, Simon J Davies, Iestyn Williams, James Fotheringham, Louise Phillips-Darby, Ivonne Solis-Trapala

“…Survey results, linked to patient-level data from the UK Renal Registry, will populate a causal graph describing patient and centre-level factors, leading to uptake of home dialysis and multistate models incorporating patient-level treatment modality history and mortality. …”
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Seroprevalence of Asymptomatic Leishmania donovani among Laborers and Associated Risk Factors in Agricultural Camps of West Armachiho District, Northwest Ethiopia: A Cross-Sectiona... by Animen Ayehu, Yibeltal Aschale, Wossenseged Lemma, Animut Alebel, Ligabaw Worku, Ayalew Jejaw, Abebe Genetu Bayih

“…Visceral leishmaniasis (VL, also called kala-azar) is a public health problem in Ethiopia, especially in sesame and sorghum growing areas. Compared to other populations, labor migrants are the most exposed. Knowing the seroprevalence of Leishmania donovani and associated risk factors is essential to design appropriate control measures. …”
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LRRK2 Mutations and Asian Disease-Associated Variants in the First Parkinson’s Disease Cohort from Kazakhstan by Rauan Kaiyrzhanov, Akbota Aitkulova, Chingiz Shashkin, Nazira Zharkinbekova, Mie Rizig, Elena Zholdybayeva, Zharkyn Jarmukhanov, Vadim Akhmetzhanov, Gulnaz Kaishibayeva, Talgat Khaibullin, Altynay Karimova, Serik Akshulakov, Askhat Bralov, Nurlan Kissamedenov, Zhanar Seidinova, Anjela Taskinbayeva, Aliya Muratbaikyzy, Henry Houlden

“…We showed that East Asian LRRK variants could be found in Central Asian populations but their pathogenicity remains to be elucidated in larger PD cohorts.…”
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Characterization of the Beekeeping Value Chain: Challenges, Perceptions, Limitations, and Opportunities for Beekeepers in Kayonza District, Rwanda by Borden Mushonga, Landouard Hategekimana, Gervais Habarugira, Erick Kandiwa, Alaster Samkange, Basiamisi Victor Ernest Segwagwe

“…However, the potential for developing beekeeping enterprise (opportunities) is immense given the abundance of wild bee populations, possibility of women participation, abundance of honey collection centres (market), and availability of technical support from Government and development agencies. …”
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Association of HIV infection and hospitalization among mpox cases: a systematic review and meta-analysis by Muhammed Shabil, Shilpa Gaidhane, R. Roopashree, Mandeep Kaur, Manish Srivastava, Amit Barwal, G. V. Siva Prasad, Pranchal Rajput, Rukshar Syed, Anoop Dev, Danish Kundra, Ambanna Yappalparvi, Prakasini Satapathy, Quazi Syed Zahiruddin, Harish Kumar, Renu Sah, Ganesh Bushi

“…There is a critical need for integrated care and enhanced surveillance, especially in populations with high HIV prevalence. Our findings emphasize the importance of ongoing research to better understand HIV and mpox co-infection and to refine management strategies for this vulnerable group. …”
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Deep-learning-based canopy height model generation from sub-meter resolution panchromatic satellite imagery by Charles J Abolt, Javier E Santos, Adam L Atchley, Lucas Wells, Daithi Martin, Russell A Parsons, Rodman R Linn

“…We furthermore demonstrate the workflow’s applicability to fire modeling by conducting simulations in forests populated by trees measured using both this approach and airborne lidar surveying. …”
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Disparities in anxiety and related factors among Chinese older adults across different aged-care models: a comparison of two cross-sectional studies by Xin Zheng, Ziwen Xu, Jiajie Zhao, Sanyuan Hao, Fuqin Xu, Shuo Ding, Guoqing Liu, Shufan Yang, Benjamin Otsen, Wen Zhu, Zhongliang Bai, Jie Yang, Ren Chen

“…Targeted interventions are, therefore emphasized to address the negative impact of anxiety for populations at higher risk.…”
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Determinant of unmet need for family planning among adolescent and young women in Kenya: multilevel analysis using recent Kenyan demographic health survey by Beyene Sisay Damtew, Hinsermu Bayu Abdi, Beker Ahemed Hussien, Getahun Tiruye, Nafyad Tolossa Urgie, Beniam worku Yigezu, Sifan Ahmed Mohammed, Bezawit Melak Fente

“…Addressing this issue requires a comprehensive approach that considers the specific circumstances of these vulnerable populations.…”
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Deletion of sphingosine 1-phosphate receptor 1 in myeloid cells reduces hepatic inflammatory macrophages and attenuates MASH by Gopanandan Parthasarathy, Nanditha Venkatesan, Guneet Singh Sidhu, Myeong Jun Song, Chieh-Yu Liao, Fanta Barrow, Amy Mauer, Tejasav Sehrawat, Yasuhiko Nakao, P. Vineeth Daniel, Debanjali Dasgupta, Kevin Pavelko, Xavier S. Revelo, Harmeet Malhi

“…Intrahepatic leukocyte populations were analyzed by mass cytometry and immunohistochemistry. …”
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CD4 CAR-T cells targeting CD19 play a key role in exacerbating cytokine release syndrome, while maintaining long-term responses by Alice Bergamini, Barbara Camisa, Attilio Bondanza, Fabio Ciceri, Chiara Bonini, Monica Casucci, Beatrice Greco, Camilla Bove, Silvia Arcangeli, Laura Falcone, Rita El Khoury, Anna De Lucia

“…Therefore, the development of cell products with improved therapeutic indexes is highly demanded.Methods In this project, we investigated how CD4 and CD8 populations cooperate during CD19 CAR-T cell responses and what is their specific role in CRS development. …”
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Defects at the Posttranscriptional Level Account for the Low TCRζ Chain Expression Detected in Gastric Cancer Independently of Caspase-3 Activity by Ana Aguinaga-Barrilero, Patricia Castro-Sánchez, Ignacio Juárez, Alberto Gutiérrez-Calvo, Noelia Rodríguez-Pérez, Adela Lopez, Remedios Gómez, José M. Martin-Villa

“…Methods. T cell-enriched populations of blood or tissue (tumoral and nontumoral) origin from 44 patients with gastric adenocarcinoma and 33 healthy subjects were obtained. …”
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Sidewalk thermal comfort in street canyon and role of pavements under perpendicular sun rays during summer by D. Jareemit, M. Srivanit

“…This finding carries significant importance in densely populated areas with limited natural shade, where even slight improvements in thermal comfort can have a positive effect on public health and well-being.CONCLUSION: Albedo reduction alone may not significantly enhance outdoor comfort within the street canyons. …”
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Molecular-genetic bases of plumage coloring in chicken by A. V. Makarova, O. V. Mitrofanova, A. B. Vakhrameev, N. V. Dementeva

“…In poultry including chickens, the color of the plumage can be treated as a genetic marker, useful for identifying breeds, populations and breeding groups with their specific traits. …”
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Low dose DNA methyltransferase inhibitors potentiate PARP inhibitors in homologous recombination repair deficient tumors by Romain Pacaud, Scott Thomas, Sibapriya Chaudhuri, Ann Lazar, Luika A. Timmerman, Pamela N. Munster

“…In contrast, the parental MDA-MB-231 cells and other HRR proficient cell lines produced smaller cell populations with short term treatment, but with much less cumulative DNA damage, and minimal cell death. …”
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The effects of active play interventions on children’s fundamental movement skills: a systematic review by Xinmiao Zhang, Changhao Tang, Miao Geng, Kai Li, Cong Liu, Yujun Cai

“…To better understand the potential of AP in developing FMS in children, high-quality AP interventions and more in-depth studies across diverse populations, settings, and timeframes are needed. Additionally, greater clarity is needed regarding the components of AP interventions and their quantitative relationships with FMS efficacy.…”
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Factors Influencing Informed Consent Preferences in Digital Health Research: Survey Study of Prospective Participants by Brian J McInnis, Ramona Pindus, Daniah Kareem, Daniela G Vital, Eric B Hekler, Camille Nebeker

“…ConclusionsThe findings point toward new ways of evaluating informed consent communication: (1) for responsiveness to specific prospective participant populations, and (2) effectiveness at eliciting informed questions from people considering participation. …”
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