Prognostic significance of neutrophil extracellular trap-related genes in childhood acute lymphoblastic leukemia: insights from multi-omics and in vitro experiment by Cheng Chen, Yu Ma, Yadai Gao, Huiqing Ge, Xiaochun Zhang

“…Immune cell profiling showed significant differences in cell populations such as aDCs, eosinophils and Th2 cells between risk groups. …”
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Multicentre, 26-week, open-label phase 2 trial of the JAK inhibitor filgotinib in Behçet’s disease, idiopathic inflammatory myopathies and IgG4-related disease: DRIMID study protoc... by Sander W Tas, Joost Raaphorst, Paco M J Welsing, Jacob M van Laar, Rogier M Thurlings, Robbert J Goekoop, César Magro Checa, Jan A M van Laar, Bettina C Geertsema-Hoeve, Nicolle H Rekers, Erik Present

“…Introduction Research into novel therapies for rare, immune-mediated inflammatory diseases (IMIDs) faces significant challenges, including small patient populations, complex clinical trial design and difficulties in patient recruitment. …”
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Single-chain variable fragment affinity tuning can optimize anti-AML CAR-NK cell functionality by Marianna Zahurak, Ravi Varadhan, Ilias Christodoulou, Ruyan Rahnama, Jun Choe, Huilin Yang, Monika Kizerwetter, Christian Guaraca, Natalie Jordan Holl, Stamatia C Vorri, Megan Zinsky, Danielle G Jones, Nikol Garcia Espinoza, Yun-Huai Kuo, Jamie B. Spangler, Challice L. Bonifant

“…Here, we study the functional consequences of CAR binding affinity and targeted epitope on CAR-NK cell activation, cytolytic synapse formation, and antitumor activity.Methods We characterized NK-92 and primary NK cell populations expressing variant affinity AML-specific CARs containing single-chain variable fragments (scFvs, 26292 or 7G3) targeting two epitopes on CD123. 26292 affinity variants were discovered through directed evolution of an error-prone mutagenic library, while 7G3 affinity variants were previously reported. …”
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Private, public, and bottled drinking water: Shared contaminant-mixture exposures and effects challenge by Paul M. Bradley, Kristin M. Romanok, Kelly L. Smalling, Stephanie E. Gordon, Bradley J. Huffman, Katie Paul Friedman, Daniel L. Villeneuve, Brett R. Blackwell, Suzanne C. Fitzpatrick, Michael J. Focazio, Elizabeth Medlock-Kakaley, Shannon M. Meppelink, Ana Navas–Acien, Anne E. Nigra, Molly L. Schreiner

“…Regardless of the supply, increased public engagement in source-water protection and drinking–water treatment is necessary to reduce risks associated with long-term DW–contaminant exposures, especially in vulnerable populations, and to reduce environmental waste and plastics contamination.…”
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Deep immunophenotyping of circulating immune cells in major depressive disorder patients reveals immune correlates of clinical course and treatment response by Fabiola Stolfi, Claudio Brasso, Davide Raineri, Virginia Landra, Camilla Barbero Mazzucca, Ali Ghazanfar, Lorenza Scotti, Riccardo Sinella, Vincenzo Villari, Giuseppe Cappellano, Paola Rocca, Annalisa Chiocchetti

“…This work aimed at immunophenotyping peripheral blood cells in the relapse phase of the disorder, to identify relevant cell populations for clinical monitoring of patients. Multiparametric analysis was performed on the peripheral blood of 60 MDD patients using flow cytometry to identify lymphocytes (naïve/effector, memory, regulatory) and myeloid cells (dendritic cells, monocytes). …”
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Barriers and facilitators to facility-based delivery in rural Zambia: a qualitative study of women’s perceptions after implementation of an improved maternity waiting homes interve... by Peter C Rockers, Godfrey Biemba, Davidson H Hamer, Nancy A Scott, Jeanette L Kaiser, Taryn Vian, Rachel M Fong, Thandiwe Ngoma, Jody R Lori, Michelle Munro-Kramer, Misheck Bwalya, Gertrude Musonda, Eden Ahmed Mdluli, Viviane Rutagwera Sakanga, Kayla J Kuhfeldt

“…MWHs may be useful to address the distance challenge, but no single intervention is likely to address all barriers experienced by rural, low-resourced populations. MWHs should be considered in a broader systems approach to improving access in remote areas.Trial registration number NCT02620436.…”
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Early T-Cell Precursor Leukemia Has a Higher Risk of Induction-Related Infection among T-Cell Acute Lymphoblastic Leukemia in Adult by Kangyu Huang, Min Dai, Qiuli Li, Nannan Liu, Dainan Lin, Qiang Wang, Xuan Zhou, Zhixiang Wang, Ya Gao, Hua Jin, Xiaoli Liu, Qifa Liu, Hongsheng Zhou

“…Our data for the first time demonstrated that ETP-ALL characterized with impaired myelopoiesis were more susceptible to induction-related infection among T-ALL populations.…”
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Protocol for Rhapsody: a longitudinal observational study examining the feasibility of speech phenotyping for remote assessment of neurodegenerative and psychiatric disorders by Allan H Young, Rebecca Strawbridge, Ammar Al-Chalabi, Dag Aarsland, Aleksandra Podlewska, Ray Chaudhuri, Elliot Hampsey, Marton Meszaros, Caroline Skirrow, Rosie H Taylor, Lazarus Chok, Jack Weston, Emil Fristed, Olabisi Awogbemila

“…Introduction Neurodegenerative and psychiatric disorders (NPDs) confer a huge health burden, which is set to increase as populations age. New, remotely delivered diagnostic assessments that can detect early stage NPDs by profiling speech could enable earlier intervention and fewer missed diagnoses. …”
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Effect of Bovine Serum Albumin (BSA) Concentration on Cryopreservation of Booroolong Frog Sperm with Evaluation of Post-Thaw Motility in Caffeine by Zara M. Anastas, Aimee J. Silla, Phillip G. Byrne, Rebecca J. Hobbs, Michael S. McFadden, Jonathan Daly, Justine K. O’Brien

“…Reproductive technologies, including sperm cryopreservation, offer conservationists enhanced capacity to genetically manage populations and improve the outcomes of conservation breeding programs (CBPs). …”
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Evaluating the Effectiveness of mRNA-1273.815 Against COVID-19 Hospitalization Among Adults Aged ≥ 18 Years in the United States by Amanda Wilson, Neloufar Rahai, Ekkehard Beck, Elisha Beebe, Brian Conroy, Daina Esposito, Priya Govil, Hagit Kopel, Tianyi Lu, James Mansi, Morgan A. Marks, Katherine E. Mues, Rohan Shah, Michelle Skornicki, Tianyu Sun, Astra Toyip, Mitra Yousefi, David Martin, Andre B. Araujo

“…Conclusion During the 2023–2024 respiratory season, the mRNA-1273.815 vaccine significantly protected against COVID-19-related hospitalizations and medically attended COVID-19 across diverse adult populations and demonstrated durability of the effect. …”
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Smoking and secondhand smoke exposure and carotid intima-media thickness: Baseline data from the Aidai Cohort Study in Japan by Makoto Saito, Yoshihiro Miyake, Keiko Tanaka, Chisato Nagata, Hidenori Senba, Yasuko Hasebe, Toyohisa Miyata, Takashi Higaki, Eizen Kimura, Bunzo Matsuura, Osamu Yamaguchi, Ryuichi Kawamoto

“…Introduction Epidemiological evidence regarding the relationship between smoking and secondhand smoke (SHS) exposure and carotid intima-media thickness (CIMT) has been limited in Asian populations. Employing baseline data from the Aidai Cohort Study, Japan, we evaluated the evidence in this cross-sectional study. …”
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Gestational weight gain and increased risk of cesarean delivery across body mass index categoriesAJOG Global Reports at a Glance by Pearl A. McElfish, PhD, Britni L. Ayers, PhD, Nicola L. Hawley, PhD, Aaron Caldwell, PhD, Austin Porter, DrPh, Michael D. Macechko, MD, Donya Watson, MD, Jennifer A. Callaghan-Koru, PhD, James P. Selig, PhD, Jennifer A. Andersen, PhD, Nirvana Manning, MD, Lanita White, PharmD, Enrique Gomez-Pomar, MD, Clare C. Brown, PhD

“…CONCLUSION: This study found a strong association between an excessive rate of gestational weight gain and the risk of cesarean delivery, regardless of prepregnancy body mass index, suggesting the need for continued efforts to reduce excessive gestational weight gain across populations.…”
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Luminescence Nanothermometry Based on Pr3+ : LaF3 Single Core and Pr3+ : LaF3/LaF3 Core/Shell Nanoparticles by M. S. Pudovkin, D. A. Koryakovtseva, E. V. Lukinova, S. L. Korableva, R. Sh. Khusnutdinova, A. G. Kiiamov, A. S. Nizamutdinov, V. V. Semashko

“…The FIR sensitivity can be attributed to the fact that 3P1 and 3P0 states share their electronic populations according to the Boltzmann process. The values of Sa for lifetime thermometry for core nanoplates, core/shell nanoplates, core nanospheres, and core/shell nanospheres were (36.4 ± 3.1) · 10−4, (70.7 ± 5.9) · 10−4, (40.7 ± 2.6) · 10−4, and (68.8 ± 2.4) · 10−4 K−1, respectively.…”
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Safety and Immunogenicity of the Tetravalent Recombinant COVID-19 Protein Vaccine SCTV01E in Children and Adolescents Aged 3 to 17 Years: A Randomized, Double-Blind, Placebo-Contro... by Fengcai Zhu, Ting Huang, Pengfei Jin, Linglin Zhang, Zhongqiang Jin, Wenli Zhang, Dongya Yuan, Zhong Wang, Yusong Deng, Jiaxin Li, Xiao Shen, Yongpan Fu, Jian Li, Xinjie Yang, Jing Li, Liangzhi Xie

“…This supports its potential use in younger populations.…”
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Melatonin alleviates high temperature exposure induced fetal growth restriction via the gut-placenta-fetus axis in pregnant mice by Jia-Jin Wu, Xiaoyu Zheng, Caichi Wu, Wen Ma, Yibo Wang, Jun Wang, Yulong Wei, Xiangfang Zeng, Shihai Zhang, Wutai Guan, Fang Chen

“…Conclusion: Melatonin alleviates HS-induced low fetal weight during pregnancy via the gut-placenta-fetus axis, the first time highlighting the gut microbiota as a novel intervention target to mitigate the detrimental impact of global temperature rise on vulnerable populations.…”
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Distinct effects of fine and coarse aerosols on microphysical processes of shallow-precipitation systems in summer over southern China by F. Chen, F. Chen, Y. Yang, L. Yu, Y. Li, W. Liu, Y. Liu, Y. Liu, S. Lolli

“…<p>Densely populated southern China, adjacent to the South China Sea, which is associated with shallow precipitation during summer, is an open-air natural laboratory for studying the impact of aerosol particles on shallow-precipitation events. …”
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Safety and Efficacy of Incorporating Actellic^® 300 CS into Soil Wall Plaster for Control of Malaria Vectors in Rural Northeastern Uganda by Tonny Jimmy Owalla, Emmanuel Okurut, Kenneth Ssaka, Gonsaga Apungia, Barbara Cemeri, Andrew Akileng, Basil Ojakol, Mark J. I. Paine, Hanafy M. Ismail, Thomas G. Egwang

“…We assessed the safety and efficacy of a user-friendly, locally tailored malaria vector control approach dubbed “Hut Decoration for Malaria Control” (HD4MC) based on the incorporation of a WHO-approved insecticide, Actellic^® 300 CS, into a customary hut decoration practice in rural Uganda where millions of the most vulnerable and malaria-prone populations live in mud-walled huts. Three hundred sixty households were randomly assigned to either the HD4MC (120 households), IRS (120 households) or control group without any wall treatment (120 households). …”
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Women’s experiences of gender-based violence supports through an intersectional lens: a global scoping review by Amaya Perez-Brumer, Beverley M Essue, Cyndirela Chadambuka, Isabel Arruda-Caycho, Danielle Tocallino, Rebecca Balasa, Prossy Kiddu Namyalo, Carmina Ravanera, Sarah Kaplan

“…Objective To apply an intersectional lens to explore how the interconnected social identities of women across global settings impact access experiences for gender-based violence (GBV) supports.Design A scoping review.Data sources We systematically searched seven databases to identify studies published in English from the database inception to January 2023.Inclusion criteria We included peer-reviewed studies with a primary objective of examining the access experiences of populations who self-identify as women (aged 15 years or older) who have experienced GBV, have intersecting identities (ie, racialisation, poverty, etc) that can further contribute to marginalisation and utilised or sought support services.Methods Two reviewers independently completed title/abstract, full-text screening and data charting. …”
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Moderate regular physical exercise can help in alleviating the systemic impact of schistosomiasis infection on brain cognitive function by Inssaf Berkiks, Inssaf Berkiks, Nada Abdel Aziz, Nada Abdel Aziz, Nada Abdel Aziz, Blessing Moses, Blessing Moses, Tiroyaone Brombacher, Tiroyaone Brombacher, Frank Brombacher, Frank Brombacher

“…Furthermore, our investigation unearthed profound alterations in the immune and glial cell populations within the CNS. Notably, we observed marked changes in CD4+ T cells and eosinophils in the meninges, as well as alterations in glial cell dynamics within the hippocampus and other brain regions. …”
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The global, regional, and national burden of type 2 diabetes mellitus attributable to low physical activity from 1990 to 2021: a systematic analysis of the global burden of disease... by Jiehua Wei, Luying Fan, Zixuan He, Senmao Zhang, Ying Zhang, Xidi Zhu, Fan Xia, Xinli Song, Lizhang Chen, Zhiyong Zou, Tingting Wang

“…Substantial increases in national action are urgently needed to target elder populations especially in low-middle and middle SDI regions, and special efforts should be made to promote physical activity in young adults with LPA.…”
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