5-HT7R enhances neuroimmune resilience and alleviates meningitis by promoting CCR5 ubiquitination by Zhenfang Gao, Yang Gao, Yuxiang Li, Jie Zhou, Ge Li, Shun Xie, Ruiyan Jia, Lanying Wang, Ziying Jiang, Meng Liang, Chunxiao Du, Yaqiong Chen, Yinji Liu, Lin Du, Cong Wang, Shuaijie Dou, Zhonglin Lv, Lubin Wang, Renxi Wang, Beifen Shen, Zhiding Wang, Yunfeng Li, Gencheng Han

“…Methods: By FACS and histopathology analysis of brain Streptococcus pneumonia meningitis infection model and behavioral testing. …”
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Role of Chest X-Ray in Coronavirus Disease and Correlation of Radiological Features with Clinical Outcomes in Indian Patients by Satyanand Sathi, Richa Tiwari, Savita Verma, Anil Kumar Garg, Virendra Singh Saini, Manoj Kumar Singh, Amit Mittal, Devinder Vohra

“…Baseline chest X-ray showed a sensitivity of 63.3% in diagnosing typical findings of SARS-CoV-2 pneumonia. The maximum RALE score was 2.13 ± 1.9 in hospitalized patients and 0.57 ± 0.77 in discharged patients (p value <0.0001). …”
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General immunologic reactivity of patients with COVID-19 and its relation to gene polymorphism, severity of clinical course of the disease and combination with comorbidities by M.O. Sokolenko, L.P. Sydorchuk, L.S. Sokolenko, A.A. Sokolenko

“…A cohort study was conducted involving 204 patients with COVID-19 diagnosed with community-acquired pneumonia of mild, moderate, and severe degrees who also had comorbidities: endocrinopathies (46 patients), cardiovascular diseases (82 patients), and comorbidities of the ENT organs, connective tissue, gastrointestinal tract, chronic kidney disease (CKD), which were grouped into the group "other comorbidities (76 patients). …”
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Epidemiology of notifiable outbreaks in different hospital units in Saudi Arabia: A national descriptive study by Nawal M. Alanazi, Nasser H. Alshanbari, Hala M. Roushdy, Yahya I. Alnshbah, Eman Ali Barnawi, Nawaf M. Almatrafi, Rula Felemban, Zainah M. Al Shahrani, Nadeen Burhan, Aiman El-Saed, Khalid H. Alanazi

“…The main device-associated infections were central line-associated bloodstream infection (38.5 %) and ventilator-associated pneumonia (39.0 %). The main pathogens were Candida auris (29.9 %), Klebsiella spp. (24.5 %), Acinetobacter baumanni (19.6 %) and Pseudomonas spp. (7.7 %). …”
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Ceftazidime-Avibactam Versus Colistin for the Treatment of Multidrug-Resistant <i>Pseudomonas aeruginosa</i> Infections: A Multicenter Cohort Study by Thamer A. Almangour, Zakiyah Alkherb, Leen Ghonem, Mohammed Al Musawa, Abdullah Almohaizeie, Sara Almuhisen, Aminah Alharbi, Nader Damfu, Doaa Aljefri, Jeelan Alghaith, Awaly Alfozan, Ahlam Alghamdi, Ahmad Aljabri, Abdullah A. Alhifany, Mohammed Alessa, Yazed Saleh Alsowaida

“…A total of 57% presented with pneumonia, 21% with bacteremia, and 61% were in the intensive care unit. …”
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Adverse events associated with the delivery of telerehabilitation across rehabilitation populations: A scoping review. by Thomas Yau, Josh Chan, McKyla McIntyre, Damanveer Bhogal, Angie Andreoli, Carl Froilan D Leochico, Mark Bayley, Ailene Kua, Meiqi Guo, Sarah Munce

“…Understanding adverse events, such as falls during physiotherapy or aspiration pneumonia during speech therapy, is crucial for identifying limitations and optimizing delivery through risk mitigation and quality indicators. …”
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Influenza Immunization in Very-Low-Birth-Weight Infants: Epidemiology and Long-Term Outcomes by Marie-Theres Dammann, Hannah Kraft, Guido Stichtenoth, Kathrin Hanke, Michael Zemlin, Janina Soler Wenglein, Isabell Ricklefs, Alexander Herz, Alexander Humberg, Dorothee Viemann, Geraldine Engels, Matthias Volkmar Kopp, Folke Brinkmann, Carsten Fortmann-Grote, Wolfgang Göpel, Egbert Herting, Christoph Härtel, Ingmar Fortmann, on behalf of the German Neonatal Network

“…Background: Very-low-birth-weight infants (VLBWIs; birth weight < 1500 g) are at an increased risk of complicated influenza infection, which frequently includes pneumonia, encephalitis or even death. Data on influenza immunization and its outcome in VLBWIs are scarce. …”
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Comparison of demographic, clinical and laboratory characteristics between first and second COVID-19 waves in a secondary care hospital in Qatar: a retrospective study by Prem Chandra, Vamanjore A Naushad, Nishan K Purayil, Abazar Ahmad M Saeed, Pradeep Radhakrishnan, Irfan Varikkodan, Joe V Mathew, Jaseem Sirajudeen, Riyadh A Hammamy, Ahmad M Badi, Aasir M Suliman, Mohamed N Badawi, Saket Arya, Maryam AlMotawa, Aisha Al-Baker, Rania Alatom, Anand Kartha

“…Objective To compare the patient profile and outcomes in Qatar during the first and second waves of the COVID-19 pandemic.Setting A retrospective observational study was conducted comparing the demographic, clinical and laboratory characteristics of patients with COVID-19 infection admitted to a secondary care hospital, during the first and second waves of the pandemic.Participants 1039 patients from the first wave and 991 from the second wave who had pneumonia on chest X-ray and had a confirmed SARS-CoV-2 infection by a real-time PCR test of a nasopharyngeal swab were included. …”
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UPDATE ON CYTOMEGALOVIRUS INFECTION MANAGEMENT IN ALLOGENEIC HEMATOPOIETIC STEM CELL TRANSPLANT RECIPIENTS by José Luis Piñana, Estela Giménez, Lourdes Vázquez, María Ángeles Marcos, Manuel Guerreiro, Rafael Duarte, Ariadna Pérez, Carlos de Miguel, Ildefonso Espigado, Marta González-Vicent, María Suarez-Lledó, Irene García-Cadenas, Rodrigo Martino, Angel Cedillo, Monserrat Rovira, Rafael de la Cámara, David Navarro, Carlos Solano

“…We evaluated the role of CMV DNA load quantification in diagnosing CMV disease, particularly pneumonia and gastrointestinal involvement, along with the utility of specific CMV immune monitoring in identifying at-risk patients. …”
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Ultrasound‐Activated Precise Sono‐Immunotherapy for Breast Cancer with Reduced Pulmonary Fibrosis by Xiang Li, Gao He, Hui Jin, Xinyu Xiang, Dong Li, Renmiao Peng, Jing Tao, Xinping Li, Kaiyang Wang, Yu Luo, Xiaoan Liu

“…However, immune‐related adverse events (irAEs) pose a significant challenge in immunotherapy, particularly the associated pneumonia as the primary adverse reaction, which can lead to irreversible pulmonary fibrosis. …”
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New Insights on Continuous Renal Replacement Therapy for Acute Respiratory Distress Syndrome: A Systematic Review and Meta‐Analysis by Siyao Zeng, Shanpeng Cui, Yue Li, Zhipeng Yao, Yunlong Li, Yang Cao, Lianghe Wen, Ming Li, Junbo Zheng, Hongliang Wang

“…Secondary outcome indicators include incidence of ventilator‐associated pneumonia (VAP), ICU length of stay, mechanical ventilation time, oxygenation index (OI) at 24 h (h), OI at 48 h, OI at 72 h, OI at 7 days (d), partial pressure of oxygen (PaO2) at 72 h, Acute Physiology and Chronic Health Evaluation II (APACHE II) score at 24 h, APACHE II score at 48 h, APACHE II score at 72 h, APACHE II score at 7 d, extravascular lung water indexes (EVLWI) at 72 h, TNF‐α at 24 h, TNF‐α at 7 d, IL‐6 at 24 h, IL‐6 at 48 h, IL‐6 at 72 h, and IL‐6 at 7 d. …”
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A multicenter analysis to identify the risk factors for stroke recurrence and mortality within 1 year by Eman A. Alraddadi, Eman A. Alraddadi, Hashim F. Alotaibi, Hashim F. Alotaibi, Yasser Alatawi, Ahmed Aljabri, Ahmed A. Alghamdi, Ahmed A. Alghamdi, Fahad Alturki, Fahad Alturki, Faisal F. Alamri, Faisal F. Alamri

“…Additional risk factors for the composite outcome included older age of patients (HR = 1.02, 95% CI:1.01–1.03, p = 0.0009), admission to the intensive care unit (ICU) (HR = 3.70, 95% CI:2.63–5.22, p = 0.0105), pneumonia (HR = 1.47, 95% CI:1.05–2.05, p = 0.0249), and brain edema (HR = 2.36, 95% CI:1.58–3.46, p = 0.0001).ConclusionKey findings include a stroke recurrence rate of 9.96% and a combined death/stroke recurrence rate of 21.83% within 365 days. …”
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Screening and identification of host signaling pathways for alleviating influenza-induced production of pro-inflammatory cytokines, IP-10, IL-8, and MCP-1, using a U937 cell-based... by Si Chen, Si Chen, Yang Yu, Yue Su, Xiaoqin Lian, Lefang Jiang, Zhuogang Li, Mingxin Zhang, Yarou Gao, Haonan Zhang, Xingjian Zhu, Jiaxin Ke, Xulin Chen

“…Moreover, our results suggest that TKIs present promising opportunities as novel therapeutic agents against influenza-induced pneumonia.…”
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Can invasive interventions be avoided with a holistic swallowing therapy program in older patients in intensive care units: percutaneous endoscopic gastrostomy tubes or oral intake... by Çağla Eliküçük, Fatma Esen Aydinli, Nazan Has Selmi, Cansu Uzunoğlu, Murathan Köksal, Volkan Öter, Belgin Akan, Erdal Birol Bostanci, Güldeniz Argun

“…IntroductionThe use of percutaneous endoscopic gastrostomy (PEG) tubes in older patients did not show any benefits in terms of survival, improvement in quality of life, or reduction in aspiration pneumonia. Significant gaps exist regarding the evidence for the evaluation and management of dysphagia in older patients. …”
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Survey of Legionella Species Found in Thai Soil by Tatiana C. Travis, Ellen W. Brown, Leonard F. Peruski, Duangkamon Siludjai, Possawat Jorakate, Prasert Salika, Genyan Yang, Natalia A. Kozak, Maja Kodani, Agnes K. Warner, Claressa E. Lucas, Kathleen A. Thurman, Jonas M. Winchell, Somsak Thamthitiwat, Barry S. Fields

“…When contaminated aerosols are inhaled, legionellosis may result, typically as either the more serious pneumonia Legionnaires’ disease or the less severe flu-like illness Pontiac fever. …”
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AI-Driven Innovations for Early Sepsis Detection by Combining Predictive Accuracy With Blood Count Analysis in an Emergency Setting: Retrospective Study by Tai-Han Lin, Hsing-Yi Chung, Ming-Jr Jian, Chih-Kai Chang, Hung-Hsin Lin, Chiung-Tzu Yen, Sheng-Hui Tang, Pin-Ching Pan, Cherng-Lih Perng, Feng-Yee Chang, Chien-Wen Chen, Hung-Sheng Shang

“…MethodsThis retrospective study at Tri-Service General Hospital (September to December 2023) analyzed 746 ICU patients with suspected pneumonia-induced sepsis (supported by radiographic evidence and a SOFA score increase of ≥2 points), alongside 746 stable outpatients as controls. …”
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Adoptive cell transfer of piezo-activated macrophage rescues immunosuppressed rodents from life-threating bacterial infections by Xiaoyi Liu, Wenxiu Xu, Junkun Feng, Ying Wang, Kai Li, Yi Chen, Wenjun Wang, Weiwei Zhao, Shaohua Ge, Jianhua Li

“…Moreover, we test the use of these piezo-activated macrophages (piezoMϕ) as adoptive cell therapy (ACT) for treating various immunosuppressive bacterial infections, including sepsis, pneumonia and peritonitis. Our study thus highlights the potential application of catalytic nanoparticles as a promising alternative to conventional infection treatment to effectively modulate the innate immune responses and to engineer macrophages for immunotherapy purposes.…”
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Impact of Sex on Infection Risk in Patients with Systemic Lupus Erythematosus by R. Borrelli, S. Nicola, F. Corradi, I. Badiu, L. Lo Sardo, N. Rashidy, A. Quinternetto, M. Mazzola, F. Meli, E. Saracco, I. Vitali, S. Negrini, L. Brussino

“…The differences in the distribution of infections, such as the higher prevalence of pneumonia in males and urinary tract infections in females, suggest that sex-specific factors, including immunological and hormonal differences, may influence infection susceptibility. …”
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Protocol for a phase IV double-blind randomised controlled trial to investigate the effect of the 13-valent pneumococcal conjugate vaccine and the 23-valent pneumococcal polysaccha... by Tao Chen, Duolao Wang, Konstantinos Liatsikos, Stephen B Gordon, Hassan Burhan, Ben Morton, Tinashe K Nyazika, Bradford D Gessner, Helen Hill, Andrea Collins, Josh Hamilton, Kelly Davies, Fred Fyles, Phoebe Hazenberg, Elizabeth Begier, Angela Hyder-Wright, Sherin Pojar, Christopher Myerscough, Jesus Reine, Ryan E Robinson, Britta Urban, Elena Mitsi, Carla Solorzano, Angela Quinn, Kaijie Pan, Annaliesa S Anderson, Christian Theilacker, Daniela M Ferreira, Kelly Convey, James Court, Madlen Farrar, Lisa Hitchins, Ashleigh Howard, Lauren Kerruish, Samuel Latham, Annabel Murphy, Elissavet Nikolaou, Angelina Peterson

“…Introduction Despite widely available vaccinations, Streptococcus pneumoniae (SPN) remains a major cause of morbidity and mortality worldwide, causing community-acquired pneumonia, meningitis, otitis media, sinusitis and bacteraemia. …”
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Fusion protein-based COVID-19 vaccines exemplified by a chimeric vaccine based on a single fusion protein (W-PreS-O) by Pia Gattinger, Luibov I. Kozlovskaya, Alexander S. Lunin, Olga S. Gancharova, Dina I. Sirazova, Dina I. Sirazova, Vasiliy D. Apolokhov, Egor S. Chekina, Ilya V. Gordeychuk, Ilya V. Gordeychuk, Alexander V. Karaulov, Alexander V. Karaulov, Rudolf Valenta, Rudolf Valenta, Rudolf Valenta, Rudolf Valenta, Aydar A. Ishmukhametov, Aydar A. Ishmukhametov

“…We found that W-PreS-O-vaccinated hamsters developed robust nABs against Omicron BA.1, showed almost no development of pneumonia, and had significantly reduced infectious virus titers in the lungs. …”
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