Efeitos do Orforglipron no tratamento da obesidade by Marcelo José da Silva de Magalhães, Pedro Henrique Martins de Souza, Victória Toledo Oliva Ferreira Silva

“…Foi avaliada a perda de peso absoluta por meio do uso do Orforglipron dose de 45 mg diária versus placebo. Resultados: foram selecionados cinco ensaios clínicos randomizados. …”
Get full text

Economic Evaluation of a Novel Treatment of Attention-Deficit/Hyperactivity Disorder in US Motor Vehicle Drivers by Jacie T. Cooper, John E. Schneider, Jim Potenziano, David S. Fam

“…A randomized controlled trial showed that DXR patients were 43% less likely to crash during a driving simulation than individuals taking placebo. Study outcomes suggest a DXR crash rate similar to that of a driver without ADHD, while patients treated with the current standard of care (SOC) have a 52% higher crash risk than non-ADHD drivers. …”
Get full text

NS5A replication complex inhibitor daclatasvir in the basis of chronic hepatitis C interferon-free therapy by M. V. Mayevskaya, M. S. Zharkova, V. T. Ivashkin

“…A safety profile and tolerability of daclatasvir is good, comparable to placebo group. The drug is not registered in Russia yet, its approval in combination to asunaprevir is expected soon.Conclusion. …”
Get full text

Efficacy and safety of new protease inhibitor faldaprevir in treatment of hepatitis C by M. V. Mayevskaya, M. S. Zharkova, V. T. Ivashkin

“…The combination of faldaprevir to interferon and ribavirin has essentially increased efficacy of treatment at previously untreated patients with hepatitis C genotype 1 (according to results of SILEN-C1 study, frequency of SVR achievement was 82% in group receiving faldaprevir in comparison to 56% of patients, who received placebo). Addition of faldaprevir to treatment mode has allowed to increase frequency of SVR (to 50%) in patients with unsuccessful course of standard antiviral therapy. …”
Get full text

Inhaled corticosteroids' effect on COVID-19 patients: A systematic review and meta-analysis of randomized controlled trials by Yasra Badi, Mohamed Hammad, Abdelrahman G. Tawfik, Mona Muhe Eldeen Eshag, Mahmoud M. Elhady, Khaled Mohamed Ragab, Anas Zakarya Nourelden, Mohamed Hesham Gamal, Ahmed Hashem Fathallah

“…Our study showed a significant decrease in the LOS in ICS patients over placebo (MD = -1.52, 95% CI \[-2.77 to -0.28\], *p-value* = 0.02). …”
Get full text

Prophylactic antibiotics in laparoscopic cholecystectomy: Reducing postoperative infection risk–A meta-analysis and trial sequential analysis by Shufeng Wang, Qing Gao, Xiaogang Qi, Lihua Hong, Hai Huang

“…RCTs comparing prophylactic antibiotics versus placebo or no treatment in patients undergoing laparoscopic cholecystectomy were included. …”
Get full text

Issues of diagnostics and treatment of abdominal pain at irritable bowel syndrome at outpatient stage of the healthcare by Yu. A. Kucheryavy, T. L. Lapina, M. A. Livzan, M. F. Osipenko

“…The rate of adverse events and tolerability of hyoscine butylbromide are comparable to that of placebo.Conclusion. Symptomatic treatment by antispasmodic drugs is justified from the moment of referral for medical aid to outpatient department. …”
Get full text

Efficacy of continuous intravenous infusion of lidocaine on postoperative sore throat after laryngeal mask insertion: a randomized controlled trial by Jianxin Jiang, Jimin Wu, Shuqi Shi, Xiaoli Dong, Jiaxiang Yin, Yini Wu

“…Methods In this prospective trial one hundred and sixty general anesthesia surgery patients (20 to 60 years) using laryngeal mask airway were randomly divided into control group (Group C, saline as placebo), lidocaine gel group (Group LG, lidocaine gel applied to the surface of the laryngeal mask), single intravenous lidocaine group (Group SL, intravenous lidocaine 1.5 mg/kg at induction of anesthesia) and continuous infusion of lidocaine group (Group CL, a bolus of 1.5 mg/kg, followed by an infusion of 2 mg/kg/h until the end of the surgical). …”
Get full text

Understanding Cognition, Oxytocin, and Pain in Elders (UCOPE): protocol for a double-blinded cross-over trial in chronic knee osteoarthritis pain by Yenisel Cruz-Almeida, Soamy Montesino-Goicolea, Pedro Valdes-Hernandez, Zhiguang Huo, Roland Staud, Natalie C. Ebner

“…Methods In this article, we describe the rationale and design of the Understanding Cognition, Oxytocin, and Pain in Elders (UCOPE) study, a double-blinded intervention in which 80 participants over 45 years of age with knee osteoarthritis pain will be recruited to participate in a cross-over trial of 4 weeks of intranasal oxytocin or placebo administration. Primary study outcomes include preliminary changes in pain intensity and interference as well as multi-modal assessment batteries including circulating biomarkers and neuroimaging measures. …”
Get full text

Effect of Weight-Loss Diet Combined with Taurine Supplementation on Fasting Levels of Fibroblast Growth Factors19, 21, and 𝛃-klothoCo-Receptor in Obese Women: A Randomized Clinical... by Maryam Asadi, Fatemeh Haidari, Hossein Bavi Behbahani, Maryam J Chitsazi, Javad Mohammadi-asl, Kambiz Ahmadi-Angali

“…Methods: Participants were randomly assigned to two groups: a standard weight-loss group receiving 3 g/day of Tau capsules for 8 weeks (n=20) and a standard weight-loss group receiving placebo capsules for 8 weeks (n=18). The weight loss intervention aimed to reduce 30% of the total energy consumed by the participants.A paired t-test and an independent sample t-test were employed to assess parametric continuous data within and between the groups. …”
Get full text

Total glucosides of paeony for rheumatoid arthritis: a protocol for a systematic review by Jing Luo, Guo-Yan Yang, Di-Er Jin, Ying-Ze Zhang, Jian-Ming Wang, Wei-Ping Kong, Qing-Wen Tao

“…RCTs comparing TGP with placebo, no treatment, or disease-modifying antirheumatic drugs for patients with RA will be retrieved. …”
Get full text

Efficacy and safety of antifibrotic drugs for interstitial lung diseases other than IPF: A systematic review, meta-analysis and trial sequential analysis. by Mei Yang, Yuying Tan, Ting Yang, Dan Xu, Mei Chen, Lei Chen

“…<h4>Methods</h4>We updated a systematic review with meta-analysis and trial sequential analysis (TSA) of randomized controlled trials and prospective studies on antifibrotic drug (nintedanib or pirfenidone) vs other intervention (placebo, no intervention or conventional treatment) in non-IPF ILDs. …”
Get full text

Effect of probiotic and prebiotics supplementation on hemoglobin levels and iron absorption among women of reproductive age and children: a systematic review and meta-analysis by Aditi Apte, Ashwini Parge, Radhika Nimkar, Anju Sinha

“…However, there is low certainty of evidence that the intervention led to improvement in fractional absorption of iron as compared to placebo or iron [8 studies, n = 335, mean increase 0.74%, 95%CI-0.11–1.38, p = 0.02]. …”
Get full text

GWAS of CRP response to statins further supports the role of APOE in statin response: A GIST consortium study by Emma F. Magavern, Harshal Deshmukh, Geraldine Asselin, Elizabeth Theusch, Stella Trompet, Xiaohui Li, Raymond Noordam, Y.-D. Ida Chen, Teresa E. Seeman, Kent D. Taylor, Wendy S. Post, Jean-Claude Tardif, Dirk S. Paul, Emelia J. Benjamin, Nancy L. Heard-Costa, Ramachandran S. Vasan, Jerome I. Rotter, Ronald M. Krauss, J.Wouter Jukema, Paul M. Ridker, Patricia B. Munroe, Mark J. Caulfield, Daniel I. Chasman, Marie-Pierre Dubé, Graham A. Hitman, Helen R. Warren

“…Both loci are also associated with baseline CRP levels, and neither locus achieved a significant (P < 0.05) result from the statin v. placebo interaction meta-analysis using randomized clinical trial data. …”
Get full text

Digital sleep phenotype and wrist actigraphy in individuals at clinical high risk for psychosis and people with schizophrenia spectrum disorders: a systematic review and meta-analy... by Andrea Cipriani, Edoardo Giuseppe Ostinelli, John Torous, Paolo Brambilla, Philip McGuire, Dominic Oliver, Rosario Aronica, Charlotte Austin

“…The risk-of-bias assessment ranged from some concerns to high risk.Conclusions Our analyses identified sleep abnormalities in CHR-P and SSD compared with placebo. However, observed heterogeneity and potential biases across studies may limit the interpretability of findings. …”
Get full text

Exploring the association between statins use or HMG-CoA reductase inhibition and migraine: a systematic review and meta-analysis by Hamdy A. Makhlouf, Amr K. Hassan, Nereen A. Almosilhy, Ahmed S.A. Osman, Shrouk Ramadan, Moaz Elsayed Abouelmagd

“…RCTs supported the efficacy of statins in reducing migraine frequency, days, and intensity compared to placebo. Conclusions Statins, already well-established for cardiovascular benefits, emerge as a promising dual-purpose therapy for many neurological disorders. …”
Get full text

High-intensity statin therapy in patients with chronic kidney disease: a systematic review and meta-analysis by Jing Wang, Ling Wu, Yu-Ling Yan, Bo Qiu, Song-Bai Deng, Xiao-Dong Jing, Jian-Lin Du, Ya-Jie Liu, Qiang She

“…Objective To evaluate the efficacy and safety of high-intensity statin therapy in patients with chronic kidney disease (CKD).Design A systematic review and meta-analysis.Data sources Randomised controlled trials (RCTs) comparing high-intensity statin therapy (atorvastatin 80 mg or rosuvastatin 20/40 mg) with moderate/mild statin treatment or placebo were derived from the databases (PubMed, Embase, Ovid, the Cochrane Central Register of Controlled Trials (CENTRAL) in the Cochrane Library, and ISI Web of Knowledge).Outcome measure Primary end points: clinical events (all-cause mortality, stroke, myocardial infarction and heart failure); secondary end points: serum lipid, renal function changes and adverse events.Results A total of six RCTs with 10 993 adult patients with CKD were included. …”
Get full text

Health-Related Quality-of-Life Utility Values in Adults With Late-Onset Pompe Disease: Analyses of EQ-5D Data From the PROPEL Clinical Trial by Alison Griffiths, Simon Shohet, Neil Johnson, Alasdair MacCulloch

“…PROPEL was a Phase 3, double-blind, randomized controlled trial, which evaluated cipaglucosidase alfa plus miglustat, vs alglucosidase alfa plus placebo in 123 adult patients with LOPD (clinicaltrials.gov: NCT03729362). …”
Get full text

Electroacupuncture for mild-to-moderate dry eye: study protocol for a multicentre, randomised, single-blind, sham-controlled trial by Yue Zhao, Guang Yang, Yun-Qiong Lu, Mei-Yan Li, Jue Hong, Yan-Ting Yang, Xue-Jun Wang, Xie-He Kong, Zhao Ma, Xin-Yun Huang, Yue-Lan Zou, Xing-Tao Zhou, Xiao-Peng Ma

“…Clinical evidence shows that electroacupuncture (EA) can improve DE symptoms, tear secretion and tear film stability, but it remains controversial whether it is just a placebo effect. We aim to provide solid clinical evidence for the EA treatment of DE.Methods and analysis This is a multicentre, randomised, sham-controlled trial. …”
Get full text

The Effectiveness of Add-on Treatment with Nutraceutical by V. T. Ivashkin, M. A. Morozova, E. A. Poluektova, O. S. Shifrin, A. G. Beniashvili, G. E. Rupchev, A. A. Alekseev, Yu. M. Poluektov, Z. A. Mamieva, A. L. Kovaleva, A. I. Ulyanin, E. A. Trush

“…The experimental group received as add-on the nutraceutical “SZ Gastro” (containing a standardized amount of menthol, gingerol and D-limonene); patients in the control group — placebo. The duration of the study was 30 days. The severity of somatic symptoms was assessed with the 7×7 questionnaire. …”
Get full text