Study of vascular endothelial dysfunction in children with beta-thalassemia major before and after quercetin therapy by Fatma Al Zahraa Sherai, Maaly Mabrouk, Ibrahim Badraia, Adel Hagag, Eman Elaskary

“…They were categorized into two equal groups: group I: received 12 weeks of quercetin therapy and group II: served as control group and received 12 weeks of placebo. Results Serum ferritin, C-reactive protein, and lactate dehydrogenase levels showed significantly lower values among patients after 12 weeks of quercetin therapy compared with controls. …”
Get full text

Clinical Effect of Teucrium polium Extract Ointment on Post Pilonidal Sinus Excision Wound Healing: A Randomized Controlled Trial by Reza Hosseinpour, Nuruddin Hosseini, Seyedeh Fatemeh Hekmatzadeh, Saadat Mehrabi, Hossein Sadeghi Mansourkhani, Marita Mohamadshahi

“…A total of 132 participants admitted to public hospitals in Yasuj with pilonidal sinus disease were randomized into three groups: T. polium ointment, serum, and placebo. The primary outcomes were changes in wound size and wound recovery time after surgery, while secondary outcomes included changes in wound edema and wound exudate. …”
Get full text

Vitamin D associates with improved quality of life in participants with irritable bowel syndrome: outcomes from a pilot trial by Sue F Plummer, Iveta Garaiova, Elizabeth A Williams, Bernard M Corfe, Simon Tazzyman, Nicholas Richards, Andrew R Trueman, Amy L Evans, Vicky A Grant

“…We undertook a pilot trial to provide data to support a power calculation and to justify a full trial.Methods This was a randomised, double blinded, three-arm parallel design trial of vitamin D, placebo or a combination of vitamin D and probiotics. …”
Get full text

Efficacy and safety of pharmacotherapy for cancer cachexia: A systematic review and network meta‐analysis by Hao Chen, Masashi Ishihara, Hiroki Kazahari, Ryusuke Ochiai, Shigeru Tanzawa, Takeshi Honda, Yasuko Ichikawa, Nobuyuki Horita, Hisashi Nagai, Kiyotaka Watanabe, Nobuhiko Seki

“…The netmeta package in R software was used to calculate the pooled effect, employing a random effects model. Results Seven placebo‐controlled randomized trials involving 1421 patients were analyzed. …”
Get full text

Plasma Metabolite Profiles of Healthy Volunteers after Administration of a Thai Herbal Formula for Dizziness by Ranida Boonrak, Kajee Pilakasiri, Suksalin Boonranasubkajorn, Natchagorn Lumlerdkij, Pravit Akarasereenont

“…These participants were randomized into three groups: YHF20 (n=30), Lorazepam (n=30), and Placebo (n=30). Principal Component Analysis (PCA) and Orthogonal Partial Least Squares Discriminant Analysis (OPLS-DA) were then conducted to identify differential metabolites and pathways. …”
Get full text

Clinical and molecular response to alpha1‐oleate treatment in patients with bladder cancer by Farhan Haq, Samudra Sabari, Jaromir Háček, Antonín Brisuda, Ines Ambite, Michele Cavalera, Parisa Esmaeili, Murphy Lam Yim Wan, Shahram Ahmadi, Marek Babjuk, Catharina Svanborg

“…Clinical effects of alpha1‐oleate were recently observed in patients with non‐muscle invasive bladder cancer (NMIBC), using a randomized, placebo‐controlled study protocol. Aims To investigate if there are dose‐dependent effects of alpha1‐oleate. …”
Get full text

Antisecretory treatment efficacy by proton pump inhibitors at gastroduodenal ulcer bleedings by M. A. Evseyev, I. M. Klishin

“…Parenteral forms of Н2-blockers as conservative hemostasis components showed efficacy which statistically does not differ from that of placebo. Metaanalysis of 18 studies revealed, that continuous intravenous infusion of omeprazole significantly reduces frequency of recurrent hemorrhage. …”
Get full text

Modern Possibilities of Using Acotiamide in the Treatment of Functional Dyspepsia by A. A. Sheptulin, Yu. S. Rabotyagova

“…The conducted studies have confirmed the higher efficacy of acotiamide compared to placebo in reducing the severity of such symptoms of functional dyspepsia as a feeling of epigastric postprandial fullness and bloating, early satiation. …”
Get full text

Comparative Efficacy of NAFLD Therapies and Biomarker Associations: A Meta-Analysis Based on Liver Fat Content by Haoxiang Zhu, Ling Xu, Yinhua Lv, Juan Yang, Jihan Huang, Qingshan Zheng, Guang Ji, Lujin Li

“…Methods: We performed a systematic search of public databases for placebo-controlled randomized trials on NAFLD up to September 29, 2023. …”
Get full text

Effect of biannual azithromycin on respiratory pathogens among symptomatic children: results from the randomised Macrolides Oraux pour Réduire les Décès avec un Oeil sur la Résista... by Jie Liu, Thomas M Lietman, Jeremy D Keenan, Kieran S O'Brien, Elodie Lebas, Amza Abdou, Benjamin F Arnold, James A Platts-Mills, Eric R Houpt, Stephanie A Brennhofer, Elizabeth T Rogawski McQuade, Ramatou Maliki, Jixian Zhang, Suzanne Stroup, Suporn Pholwat, Ahmed M Arzika

“…Swabs were tested by quantitative PCR using a customised TaqMan Array Card that included assays for 19 respiratory pathogens.Results Nasopharyngeal detection of Haemophilus influenzae, Moraxella catarrhalis and Streptococcus pneumoniae was common in both azithromycin and placebo communities. The prevalence was reduced in children from azithromycin communities for just two pathogens: Bordetella pertussis and H. influenzae type b (Hib). …”
Get full text

TO COMPARE THE EFFECTS OF SUSTAINED NATURAL APOPHYSEAL GLIDESON PAINAND CERVICAL MOBILITY IN TENSION HEADACHES AMONG STUDENTS by Bushra Ovais

“…Results: Sustained Natural Apophyseal Glidesgroup showed a significant outcomein just two weeks sessions while placebo group does not show good outcomein pain and cervical mobility.In our study we weretried to aware people about the Tension headache due to study pressure. …”
Get full text

Phenolic acids from Anisopus mannii modulates phosphofructokinase 1 to improve glycemic control in patients with type 2 diabetes: A double-blind, randomized, clinical trial by Peter U. Amadi, Justice O. Osuoha, Chidi N. Ekweogu, Suha J. Jarad, Esienanwan E. Efiong, Prince C. Odika, Chioma Ejiofor, Oluchi Aloy-Amadi, Govind S. Gill, Chiamaka W. Adumekwe, Ailun Gaowa, Dawei Zhang, Barbora de Courten, Emmanuel N. Agomuo

“…Patients were randomized into a placebo group or either of the following two treatment groups: oral administration of 12 mg or 20 mg/kg body weight of PhAM once every 48 h for 6 months. …”
Get full text

Can anticytokine therapy prevent unfavourable course of ulcerative colitis? by A. Yu. Baranovsky, E. A. Kondrashina, A. G. Kharitonov

“…Data of investigation prove, that so-called «top down» therapy with application of Remicade improves quality of life scores of patients in comparison to placebo (in 1 year) for over 18%, for 25,4% (in 2 years) and for 27,8% (in 3 years). …”
Get full text

Viloxazine, a Non-stimulant Norepinephrine Reuptake Inhibitor, for the Treatment of Attention Deficit Hyperactivity Disorder: A 3 Year Update by Hannah W Haddad, Paul B. Hankey, Jimin Ko, Zahaan Eswani, Pravjit Bhatti, Amber N. Edinoff, Adam M. Kaye, Alan D. Kaye

“…Phase 2 and 3 randomized control trials have demonstrated significant efficacy of viloxazine in improving ADHD symptoms versus placebo. Related to its long-standing use as an antidepressant, the safety profile and pharmacokinetics of viloxazine are well understood. …”
Get full text

Promising role of voxelotor in managing sickle cell disease in children: a narrative review by Amit Agrawal, Gaurav Jadon, Japna Singh, Dalwinder Janjua

“…In a phase III trial, voxelotor-treated patients showed significantly elevated hemoglobin levels (>1 g/dL from baseline) compared to placebo-treated patients. The group that received voxelotor also showed a greater decrease in hemolytic markers but a comparable incidence of side effects. …”
Get full text

New Possibilities for the Treatment of Crohn’s Disease by Z. A. Mamieva, E. A. Poluektova, O. S. Shifrin

“…The drug interrupts the cascade of humoral and cellular reactions leading to transmural inflammation of the intestinal wall by blocking the interaction of the p40 subunit with the IL-12Rβ1 chain on the surface of T-lymphocytes and NK cells. A number of placebo-controlled studies have demonstrated the effectiveness of Ustekinumab in the induction and the maintenance of remission in those patients with Crohn’s disease who showed no response to conventional therapy (glucocorticosteroids and immunosuppressants) and therapy with TNF-α antagonists. …”
Get full text

A clinical study of the immunogenicity and protective potency of a live recombinant GamLPV vaccine for intranasal use for the prevention of whooping cough in adult volunteers by Alevtina A. Lidzhieva, Alisa Yu. Medkova, Sergey V. Kulikov, Ludmila N. Sinyashina, Rezida A. Sioundioukova, Andrey P. Markov, Aleksey B. Verveda, Natalia E. Abaeva, Irina N. Chernyshova, Marina V. Gavrilova, Kristina K. Bushkova, Ilya N. Dyakov, Gennady I. Karataev

“…In this multicenter, clinical, randomized, placebo-controlled, double-blind study 260 healthy adults aged 18–65 years were divided into 2 groups: G1 — 210 volunteers (GamLPV) and G2 — 50 volunteers (placebo). 0.25 ml GamLPV delivered to each nostril (5 × 109 CFU) 60 days apart. …”
Get full text

Testosterone Replacement Therapy in the Treatment of Depression by Danyon J. Anderson, Parsia Vazirnia, Catherine Loehr, Whitney Sternfels, Jamal Hasoon, Omar Viswanath, Alan D. Kaye, Ivan Urits

“…Conversely, some studies have found no difference in depressive symptoms after treatment with testosterone when compared with placebo. It was also noted that over administration of testosterone is associated with multiple adverse effects and complications…”
Get full text

Vitamin D and Selenium: Review of Clinical Trials of Synergistic Effects on Thyroid Antibody Levels and Disease Progression in Hashimoto’s Thyroiditis by Agnieszka Starzyk, Piotr Charzewski

“…Adverse events were rare and comparable to placebo. Vitamin D deficiency correlated with elevated TSH, anti-TPO, and anti-TG levels, with HT patients showing significantly lower vitamin D levels than healthy controls or hypothyroid patients. …”
Get full text

A toolkit for quantifying individual response to herbal extracts in metabolic and inflammatory stress by Soo-yeon Park, Oran Kwon, Tim van den Broek, Jildau Bouwman, Ji Yeon Kim

“…Two randomized, double-blind, placebo-controlled crossover trials were conducted involving participants with PhenFlex challenge after overnight fasting. …”
Get full text