Synergistic anticancer effects of cisplatin and phenolic aglycones of the aerial part of Rumex dentatus L. in tongue squamous cell carcinoma: insights from network pharmacology and... by Amany E. Ragab, Ghada M. Al-Ashmawy, Sherin R. El Afify, Ola A. El-Feky, Amera O. Ibrahim

“…KEGG analysis indicated that the drug combination might work through pathways like PI3K-Akt signaling, microRNAs in cancer, and EGFR tyrosine kinase inhibitor resistance. …”
Get full text

Herbal Mouthwash Containing Extracts of Baccharis dracunculifolia as Agent for the Control of Biofilm: Clinical Evaluation in Humans by Vinícius Pedrazzi, Mateus Freire Leite, Reisla Cristina Tavares, Sandra Sato, Glauce Crivelaro do Nascimento, João Paulo Mardegan Issa

“…In measuring the time after use of mouthwash (t=1), there was no difference between products (P=0.602); that is, subjects in the study had a similar PI after the first use. After one week (t=2), there was no difference between the four products evaluated (P=0.674), so, all research individuals completed the study with a similar reduction in dental biofilm between themselves but it was different from initial state (Friedman test). …”
Get full text

Source apportionment, ecological and health risks of potentially toxic elements in street dusts across different land uses in city of Kermanshah, Iran by Ali Asgari, Soheil Sobhanardakani, Mehrdad Cheraghi, Bahareh Lorestani, Maryam Kiani Sadr

“…The computed mean values for the geo-accumulation index (I-geo) and the pollution index (PI) ranged from − 6.07 to 2.67 and from 0.023 to 9.58, respectively, indicating ‘unpolluted’ to ‘moderately to heavily polluted’, and ‘slight to very high polluted’ pollution levels, respectively. …”
Get full text

Hepatoprotective effects of propolis ethanol extract on D-galactose-induced aging mice: A metabolomics and transcriptomics analysis focusing on insulin resistance pathways by Jinjia Liu, Songhao Tian, Jixiang Wang, Qing Sang, Wenting Su, Jinqiang Wu, Fenglei Zai

“…Mechanistically, PEE appeared to exert hepatoprotective effects by modulating the insulin resistance pathway, particularly through the PI3K-AKT/PP1 signaling axis, thereby enhancing glycogen synthesis in the damaged liver. …”
Get full text

Anti-Inflammatory Effects of Aster incisus through the Inhibition of NF-κB, MAPK, and Akt Pathways in LPS-Stimulated RAW 264.7 Macrophages by Daniel Ngabire, Yeong-Ae Seong, Maheshkumar Prakash Patil, Irvine Niyonizigiye, Yong Bae Seo, Gun-Do Kim

“…Additionally, further Western blot results indicated that Aster incisus inhibited the expression of p-PI3K, p-IκBα, p-p65 NF-κB, p-ERK1/2, p-SAPK/JNK, and p-Akt. …”
Get full text

Erythropoietin Activates Autophagy to Regulate Apoptosis and Angiogenesis of Periodontal Ligament Stem Cells via the Akt/ERK1/2/BAD Signaling Pathway under Inflammatory Microenviro... by Denghao Huang, Jie Lei, Xingrui Li, Zhonghao Jiang, Maoxuan Luo, Yao Xiao

“…Cell Counting Kit-8 was used for cell proliferation assay. Annexin V-PI-FITC was used for cell apoptosis through flow cytometry. …”
Get full text

Structure elucidation, immunomodulatory activity, antitumor activity and its molecular mechanism of a novel polysaccharide from Boletus reticulatus Schaeff by Siyuan Su, Xiang Ding, Yiling Hou, Binbin Liu, Zhouhe Du, Junfeng Liu

“…The results of transcriptome sequencing analysis illustrated that total 46 genes enriched in MAPK and total 34 genes enriched in PI3K/Akt signaling pathways in BRS-X group. The protein VEGF and VEGFR expression were significantly reduced under the treatment with BRS-X. …”
Get full text

Applying reproductive technologies and genome resource banking to laboratory animals by S. Ya. Amstislavsky, E. Yu. Brusentsev, T. O. Abramova, D. S. Ragaeva, I. N. Rozhkova, T. N. Igonina, E. A. Kizilova, V. A. Naprimerov, N. Yu. Feoktistoiva

“…Double staining by SYBR Green/PI and subsequent confocal microscopy demonstrated that more than 40 % of amur cat semen retained viability after cryopreservation. …”
Get full text

A Multi-Resonant based reference feedforward adaptive voltage control for Grid-Forming inverter in island mode to compensate system uncertain and harmonic distortions by Renzhi Huang, Zaijun Wu, Xueyong Xu, Xiangjun Quan, Mingfei Li, Zichen Wang, Mengnan Liu

“…Compared with classical PI/PR methods or other adaptive ones, this newly proposed adaptive control method synthesizes high robustness, excellent voltage regulation performance, and low total harmonic distortion under nonlinear loads in island mode. …”
Get full text

Neutrinoless double beta decay from scalar leptoquarks: interplay with neutrino mass and flavor physics by P. S. Bhupal Dev, Srubabati Goswami, Chayan Majumdar, Debashis Pachhar

“…We find that the most stringent constraint on the parameter space comes from μ → e conversion in nuclei and K + → π + ν ν ¯ $$ {K}^{+}\to {\pi}^{+}\nu \overline{\nu} $$ decay. We also point out a tension between the muon and electron (g – 2) anomalies in this context. …”
Get full text

Genome-wide identification and expression analysis of GRAS transcription factors under cold stress in diploid and triploid Eucalyptus by Jiannan Liu, Hao Chen, Chenhe Li, Kang Du, Jun Yang

“…The physical and chemical properties of the proteins encoded by EgrGRAS genes vary, but the ranges of amino acid numbers, molecular weights, and isoelectric points (pI) are similar to those of GRAS proteins from other species. …”
Get full text

Is human-like decision making explainable? Towards an explainable artificial intelligence for autonomous vehicles by Jiming Xie, Yan Zhang, Yaqin Qin, Bijun Wang, Shuai Dong, Ke Li, Yulan Xia

“…In the second stage, we draw inspiration from the field of brain-like trusted AI to construct a robust, in-depth, and unbiased evaluation and interpretability framework involving three dimensions: Permutation Importance (PI) analysis, Partial Dependence Plot (PDP) analysis, and model complexity analysis. …”
Get full text

Intelligent Controller Design and Fault Prediction Using Machine Learning Model by Kailash Kumar, Suyog Vinayak Pande, T. Ch. Anil Kumar, Parvesh Saini, Abhay Chaturvedi, Pundru Chandra Shaker Reddy, Krishna Bikram Shah

“…The optimization of a controller model is proposed by modifying a PI controller taken from a commercial one. With the use of IEEE 39 standard buses, the proposed controller is tested. …”
Get full text

Modeling Soil Behavior with Machine Learning: Static and Cyclic Properties of High Plasticity Clays Treated with Lime and Fly Ash by Gebrail Bekdaş, Yaren Aydın, Sinan Melih Nigdeli, İnci Süt Ünver, Wook-Won Kim, Zong Woo Geem

“…There are 14 inputs, including specific gravity (Gs), void ratio (eo), sieve analysis (+No.4, −No.200), clay size, LL, plastic limit (PL), plasticity index (PI), linear shrinkage (Ls), shrinkage limit (SL), cure day, agent, clay type, and agent percentage. …”
Get full text

Adaptation of Anopheles Vectors to Anthropogenic Malaria-Associated Rubber Plantations and Indoor Residual Spraying: Establishing Population Dynamics and Insecticide Susceptibility by Suntorn Pimnon, Adisak Bhumiratana

“…The study MRP ecotope elicited the population ratio (pi) of Anopheles vectors: An. campestris (0.747), An. dirus (0.168), An. minimus (0.037), An. barbirostris (0.027), and An. pseudowillmori (0.002), and of An. jamesii nonvector (0.019). …”
Get full text

Diagnosing and Treating ANCA-Associated Vasculitis within the COVID-19 Era: A Challenging Case Report by Erjola Likaj, Larisa Shehaj, Deniona Nunci, Lordian Nunci, Irda Rrugeja, Merita Rroji, Saimir Seferi, Nertila Gjonaj, Alma Idrizi, Arjana Strakosha

“…Renal manifestations often present as pauci-immune focal and segmental necrotizing crescentic glomerulonephritis (PI-NCGN), which can progress to acute or chronic kidney failure and multiorgan involvement. …”
Get full text

EDITORIAL by Rafael dos Reis Ferreira, João Antonio de Moraes, Pedro Bravo de Souza, Marcelo Marconato Magalhães, Camila da Cruz Silva, Matheus Barreto Pazos de Oliveira, Felipe Eleutério Pereira, Ricardo Pereira Tassinari

Get full text

The Burden of NAFLD and Its Characteristics in a Nationwide Population with Type 2 Diabetes by Gabriele Forlani, Carlo Giorda, Roberta Manti, Natalia Mazzella, Salvatore De Cosmo, Maria Chiara Rossi, Antonio Nicolucci, Paolo Di Bartolo, Antonio Ceriello, Pietro Guida, AMD-Annals Study Group

Get full text

Cytotoxicity and genotoxicity of orthodontic bands after aging: an in-vitro study by Maryam Karandish, Bahar Khademi, Golnaz Ziaei, Nasrollah Erfani, Leila Moezi, Zahra Faghih

“…Abstract Background This investigation sought to evaluate cytotoxic and genotoxic effects of two different types of orthodontic bands after aging in acidic and neutral artificial saliva using human gingival fibroblast-like (HGF1-PI 1) cell lines. Methods Two commercial brands of orthodontic molar bands (American orthodontic (AO) and 3 S-dental bands), commonly used by orthodontists, were tested. …”
Get full text

Cytotoxic Constituents from the Rhizomes of Curcuma zedoaria by Omer Abdalla Ahmed Hamdi, Syarifah Nur Syed Abdul Rahman, Khalijah Awang, Norhanom Abdul Wahab, Chung Yeng Looi, Noel Francis Thomas, Sri Nurestri Abd Malek

“…Curcumenone (3) and curcumenol (5) displayed strong antiproliferative activity (IC50=8.3±1.0 and 9.3±0.3 μg/mL, resp.) and were found to induce apoptotic cell death on MCF-7 cells using phase contrast and Hoechst 33342/PI double-staining assay. Thus, the present study provides basis for the ethnomedical application of Curcuma zedoaria in the treatment of breast cancer.…”
Get full text