Two faces of the same coin non alcoholic fatty liver disease; with and without diabetes: Comparative clinico pathological analysis: A cross sectional observational study by Syed Mushfiq, Ghulam Nabi Yatoo, Bilal Ahmad Mir, Zubaida Rasool

“…Data on the impact of diabetes on NASH phenotype is sparse from northern India. We studied and compared the clinical profile of NALFD in the presence and absence of DM and the effect of diabetes on NASH. …”
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Exploratory study on the efficacy of topical pan-JAK inhibitor in ocular and skin GVHD in a sclerodermatous GVHD mouse model by Shinri Sato, Yoko Ogawa, Kazuki Asai, Eisuke Shimizu, Shota Shimizu, Hiroko Taniguchi, Takahiro Okazaki, Shigeto Shimmura, Kazuno Negishi, Masatoshi Hirayama

“…In summary, our data suggested that topical delgocitinib administration had the potential to attenuate cGVHD phenotype severity in the skin and eyes of sclerodermatous GVHD mice.…”
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The first cases of collagenous sprue successfully treated with thioguanine by Chris J J Mulder, Gerd Bouma, Tom van Gils, Tine van de Donk, Foke van Delft, E Andra Neefjes-Borst

“…Based on the lack of typical HLA phenotyping and the absence of coeliac-specific antibodies, there seems to be no relation with coeliac disease in these 4 cases. …”
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Role of autophagy defects and significance of adherent-invasive <i>Escherichia coli</i> in Crohn's disease development by I. V. Mayev, D. N. Andreev, D. V. Rakitina, Yu. P. Baykova

“…Besides that intestinal dysbiotic disorders associated with elevation of quantity of microorganisms, possessing pathogenic potential, in particular AIEC is characteristic for CD. This phenotype of microorganisms has capacity of adhesion to mucosal epithelial cells, invasion, and active replication inside macrophages. …”
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Unique North American isolates of severe metastatic hypervirulent Klebsiella pneumoniae strain infections with hepatic abscesses seen in young patients within Texas. by Junaid M Alam, Eric N Riha, Haris Ahmed, Hong M Thai, Kevin Garnepudi, Ramesh B Kesavan, Gnananandh Jayaraman, Anna Sangster, Dylan Curry, Heidi A Butz, Lori Smith, Maureen Vowles, Kelly F Oakeson, Erin L Young, Siva T Sarva

“…Both isolates had yersiniabactin, colibactin, aerobactin and salmochelin producing loci which likely confer these isolates hvKp phenotype. 2020CK-00441 and 2021CK-00720 had a unique pK2044 like plasmid.…”
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Prevalence and molecular characterization of Beta-lactamase resistance gene in multidrug resistance bacteria, Proteus spp. by Sabiha S. Salih, Shno J. Mohammed, Imad M Noori, Lana MA Mohammed, Taib A. Hama Soor

“…The multidrug resistance was found in all isolates and the most common drug resistance phenotype were against tetracycline, rifampin, and doxycycline, while the imepenem, tobramycin, and meropenem remain more effective against the bacteria. …”
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Matrix metalloproteinase-3 is a potent prognostic factor associated with cell proliferation and migration in prostate cancer by Ai Sato, Kiyoshi Takagi, Mio Yamaguchi-Tanaka, Jotaro Okushima, Yuto Yamazaki, Akihiro Ito, Takashi Suzuki

“…However, the clinical and biological significance of MMP3 has not been well elucidated.We therefore immunolocalized MMP3 in prostate cancer tissues (n = 117) and demonstrated that MMP3 immunoreactivity was correlated with aggressive phenotype of prostate cancer, including higher proliferation/invasion ability, and shorter disease-free survival. …”
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Prevalence and predictors of severe Crohn’s disease at a tertiary hospital in South Africa by C Gounden, V Naidoo, Y Moodley

“…CD with a penetrating phenotype at diagnosis is a good predictor for the devleopment of SCD and should be further investigated.  …”
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Pooled screening for CAR function identifies novel IL-13Rα2-targeted CARs for treatment of glioblastoma by Douglas A Lauffenburger, Khloe S Gordon, Caleb R Perez, Andrea Garmilla, Maxine S Y Lam, Joey J Y Aw, Anisha Datta, Andrea Pavesi, Michael E Birnbaum

“…Selections were performed for cytotoxicity, proliferation, memory formation, and persistence on repeated antigen challenge.Results Each enriched CAR robustly produced the phenotype for which it was selected, and one enriched CAR triggered potent cytotoxicity and long-term proliferation on in vitro tumor rechallenge. …”
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Cluster analysis of post-COVID-19 physical and mental health outcomes 3–6 months after SARS-CoV-2 infection: results of the French Prospective ALCOVID Cohort Study by Philippe Halfon, Laurent Chiche, Hervé Pegliasco, Stanislas Rebaudet, Thomas Escoda, Hervé Faralli, Frédéric Cohen

“…Multiple component analysis was used to identify clinical phenotypic clusters of PCC patients, as well as their initial comorbidity groups. …”
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Correlation of ferritin and glutathione peroxidase 4 (GPX4) level as a marker of ferroptosis process in endometrioma by Rina Nulianti, Hartanto Bayuaji, Mulyanusa Amarullah Ritonga, Tono Djuwantono, Dian Tjahyadi, Anita Rachmawati, Sri Ratna Dwiningsih, Aisyah Shofiatun Nisa, Putri Nadhira Adinda Adriansyah

“…This disruption can trigger oxidative injury and an inflammatory response, leading to ferroptosis, particularly in the endometrioma phenotype. This research utilized an observational analytical method with a cross-sectional design to examine the relationship between ferritin and GPx4 levels by assessing them simultaneously. …”
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Nano-XRF of lung fibrotic tissue reveals unexplored Ca, Zn, S and Fe metabolism: a novel approach to chronic lung diseases by Bryan Falcones, Maik Kahnt, Ulf Johansson, Barbora Svobodová, Karin A. von Wachenfelt, Charlott Brunmark, Göran Dellgren, Linda Elowsson, Karina Thånell, Gunilla Westergren-Thorsson

“…In contrast, a bleomycin-induced fibrosis rodent model exhibits a different elemental phenotype with low Fe and increased S, Zn, and Ca. …”
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Wnt/β-catenin signalling underpins juvenile Fasciola hepatica growth and development. by Rebecca Armstrong, Nikki J Marks, Timothy G Geary, John Harrington, Paul M Selzer, Aaron G Maule

“…Notably, silencing FhCTNNB1, the key effector of the Wnt/β-catenin signal cascade led to aberrant development of the neuromuscular system which ultimately proved lethal - the first report of a lethal RNAi-induced phenotype in F. hepatica. The absence of any discernible phenotypes following the silencing of the inhibitory Wnt/β-catenin destruction complex components is consistent with low destruction complex activity in rapidly developing juvenile worms, corroborates transcriptomic expression profiles and underscores the importance of Wnt signalling as a key molecular driver of growth and development in early-stage juvenile fluke. …”
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Case report: A novel 11-bp deletion in exon 11 causing a frameshift in the C-terminal of the ALAS2 gene leading to X-linked sideroblastic anemia—a family study by Salam Al kindi, Salam Al kindi, Altaf Al-Mamari, Shoaib Al-Zadjali, Mohamed Al-Rawahi, Ali Al Madhani, Anil V. Pathare

“…Herein, we report a novel 11-bp deletion in exon 11 leading to a frameshift in the C-terminal region of the ALAS2 gene with a non-functional longer polypeptide of 614 amino acids leading to a loss-of-function mutation manifested as an X-linked sideroblastic anemia phenotype. The proband was a 29-year-old man with moderately severe microcytic hypochromic anemia with splenomegaly and increased ring sideroblasts in the bone marrow with considerable iron overload. …”
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Metabolic reprogramming of naïve regulatory T cells by IL-7 and IL-15 promotes their persistence and performance upon adoptive transfer by Jessica Filoni, Arianna Ferrari, Tatiana Jofra, Anna Rita Putignano, Lorenzo Da Dalt, Susanna Cesarano, Carla Di Dedda, Fabrizia Bonacina, Federica Marchesi, Danilo Norata, Chiara Bonini, Lorenzo Piemonti, Paolo Monti

“…The final Treg product was enriched with cells displaying an immature CD45RA+CD62L+CD95+ phenotype, reminiscent of conventional memory stem T cells. …”
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Endoplasmic reticulum stress-related super enhancer promotes epithelial-mesenchymal transformation in hepatocellular carcinoma through CREB5 mediated activation of TNC by Anqi Wang, Sitong Yan, Jiatao Liu, Xiang Chen, Mengyao Hu, Xiao Du, Weijia Jiang, Zhipeng Pan, Lulu Fan, Guoping Sun

“…In addition, overexpression of CREB5 was associated with poor prognosis and an aggressive phenotype in patients with HCC. We also found that activation of ERS enhanced the expression of CREB5, and upregulation of CREB5 significantly increased cell proliferation, migration, and invasion, and promoted EMT, but inhibited apoptosis. …”
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Heterogeneity analysis provides evidence for a genetically homogeneous subtype of bipolar-disorder. by Caroline C McGrouther, Aaditya V Rangan, Arianna Di Florio, Jeremy A Elman, Nicholas J Schork, John Kelsoe, Bipolar Disorder Working Group of the Psychiatric Genomics Consortium

“…It is heterogeneous, both at the phenotypic and genetic level, although the extent and impact of this heterogeneity is not fully understood. …”
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African animal trypanocide resistance: A systematic review and meta-analysis by Keneth, Iceland Kasozi, Ewan, Thomas MacLeod, Susan, Christina Welburn

“…African animals resistance ( AATr) continues to undermine global efforts to eliminate the transmission of africa intrypanosomiasis in endemic communities. the continued lack of new trypanocides has participated drug misuse and over use, thus contributing to the devlopment of the AADr phenotype. in this study, we investigated the threate associated with AAtr by using the major globally available chemotherapeutic agents. …”
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Megoura crassicauda promote the ability of Vicia faba L. to remediate cadmium pollution of water and soil by Sijing Wan, Shasha Wang, Yan Li, Yexin Xie, Qimei Li, Yinjie Fang, Zhenjuan Yin, Shigui Wang, Yifan Zhai, Bin Tang

“…However, there were no significant changes in germination rate and phenotype. We also found that prolonged Cd treatment increased the activities of stress-related antioxidant enzymes in fava beans, including superoxide dismutase, peroxidase, and malondialdehyde. …”
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Clinical characteristics and outcomes in Asian patients with heart failure with mildly reduced ejection fraction by Julian Cheong Kiat Tay, Shaw Yang Chia, Siew Hui Michelle Koh, David Kheng Leng Sim, Ping Chai, Seet Yoong Loh, Fazlur Rehman Jaufeerally, Sheldon Shao Guang Lee, Patrick Zhan Yun Lim, Jonathan Yap

“…HFmrEF represents a distinct HF phenotype with high atherosclerotic burden and clinical outcomes saddled in between those of HFrEF and HFpEF. …”
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