Ataxia, Ophthalmoplegia, and Areflexia: What Would You Think? by N. Karsan, P. Fletcher, I. Bodi, B. K. MacDonald

“…There are further five cases described in which an association between cancer and a Miller Fisher phenotype has been shown. Some of these have identified antiganglioside antibodies in the serum and, in one case, also showed antibodies deposited within the primary tumour itself. …”
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Chronic Heart Failure: We Are Fighting the Battle, but Are We Winning the War? by John J. Atherton

“…Heart failure represents an end-stage phenotype of a number of cardiovascular diseases and is generally associated with a poor prognosis. …”
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Tumor-Related Exosomes Contribute to Tumor-Promoting Microenvironment: An Immunological Perspective by Wuzhen Chen, Jingxin Jiang, Wenjie Xia, Jian Huang

“…They can interfere with the maturation of DC cells, impair NK cell activation, induce myeloid-derived suppressor cells, and educate macrophages into protumor phenotype. They can also selectively induce effector T cell apoptosis via Fas/FasL interaction and enhance regulatory T cell proliferation and function by releasing TGF-β. …”
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Child with Deletion 9p Syndrome Presenting with Craniofacial Dysmorphism, Developmental Delay, and Multiple Congenital Malformations by Nirmala D. Sirisena, U. Kalpani S. Wijetunge, Ramya de Silva, Vajira H. W. Dissanayake

“…This finding contributes to the widening of the spectrum of phenotypic features associated with deletion 9p syndrome.…”
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New opinion on the issue of proton pump inhibitor-refractory gastroesophageal reflux disease by Yu. V. Yevsyutina, A. S. Trukhmanov

“…There is a disorder of the immune response as a disbalance between cellular and humoral components of immunity at GERD, that can be determined as phenotype of macrophages (М1 or М2), and other immune and non-immune cells.Conclusion. …”
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Endothelin but Not Angiotensin II May Mediate Hypertension-Induced Coronary Vascular Calcification in Chronic Kidney Disease by Simon W. Rabkin

“…Increased cellular phosphate may induce CAC through increased Ca x phosphate product, transformation of vascular smooth muscle cells into a bone-producing phenotype or cell apoptosis that releases procalcific substances. …”
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The ADF/Cofilin-Pathway and Actin Dynamics in Podocyte Injury by Beina Teng, Alexander Lukasz, Mario Schiffer

“…Since almost all proteinuric diseases result from a similar phenotype with effacement of the foot processes, we propose that cofilin-1 is at the centre stage of the development of proteinuria and thus may be an attractive drug target for antiproteinuric treatment strategies.…”
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Anti- and Protumorigenic Effects of PPARγ in Lung Cancer Progression: A Double-Edged Sword by Howard Li, Mary C. M. Weiser-Evans, Raphael Nemenoff

“…Activation of PPARγ in a variety of cancer cells leads to inhibition of growth, decreased invasiveness, reduced production of proinflammatory cytokines, and promotion of a more differentiated phenotype. However, systemic activation of PPARγ has been reported to be protumorigenic in some in vitro systems and in vivo models. …”
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Biology of extracellular vesicles and the potential of tumor-derived vesicles for subverting immunotherapy of cancer by Theresa L Whiteside

“…This review describes phenotypic and functional attributes of TEX that underline their reprogramming capabilities. …”
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Brooke–Spiegler Syndrome: Familial Cylindromatosis, a Rare Variant of a Rare Familial Syndrome by Harsh Patel, William Naber, Austin Cusick, Craig Oser

“…Excision and pathologic investigation of three large masses from different body sites determined a shared phenotype of cylindromas. Subsequent evaluation of the patient's son separately, after primary patient excision, confirmed cylindroma development as well. …”
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The Roles of Fibroblast Growth Factors in the Testicular Development and Tumor by Xin Jiang, Melissa Skibba, Chi Zhang, Yi Tan, Ying Xin, Yaqin Qu

“…The testis is mainly consisted of germ cells, Sertoli cells and Leydig cells to develop and maintain the male phenotype and reproduction. This review summarizes the structure and fuctions of testis, the roles of FGFs on testicular development and potential involvement in testicular tumor and its regulatory mechanism. …”
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How data science and AI-based technologies impact genomics by Jing Lin, Kee Yuan Ngiam

“…Advancements in high-throughput sequencing have yielded vast amounts of genomic data, which are studied using genome-wide association study (GWAS)/phenome-wide association study (PheWAS) methods to identify associations between the genotype and phenotype. The associated findings have contributed to pharmacogenomics and improved clinical decision support at the point of care in many healthcare systems. …”
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STING modulates HBV-related acute-on-chronic liver failure by mediating autophagy and macrophage polarization by Hao Zhang, Teng Liang, Wanlu Duan, Futing Liu, LiPing Li, Qian Liu, Jianfei Li, Qiyin Zong, Lei Jin, Qin Wang, Qiang Zhou

“…However, in later stages, STING may aggravate liver injury by shifting liver macrophage polarization to the M1 phenotype, thereby enhancing the inflammatory response.…”
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Genetic disruption of Blimp-1 drastically augments the antitumor efficacy of BCMA-targeting CAR T cells by Anthony M. Battram, Joan Mañé-Pujol, David F. Moreno, Aina Oliver-Caldés, Judit Carpio, Oriol Cardus, Luis Gerardo Rodríguez-Lobato, Álvaro Urbano-Ispizua, Carlos Fernández de Larrea

“…Blimp-1 knockout (KO) CAR T cells displayed a memory-like phenotype compared with control (Mock) CAR T cells, but had reduced effector function, with a striking loss of granzyme B. …”
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Dual-release hydrocortisone treatment improves serum and peripheral blood mononuclear cell inflammatory and immune profiles in patients with autoimmune primary adrenal insufficienc... by Laura Tomasello, Antonina Coppola, Giuseppe Pizzolanti, Giuseppe Pizzolanti, Carla Giordano, Giorgio Arnaldi, Valentina Guarnotta

“…ObjectiveThe primary outcome was the evaluation of the T-cell phenotype in autoimmune primary adrenal insufficiency (PAI). …”
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Developmental dysfunction in a preclinical model of Kcnq2 developmental and epileptic encephalopathy by Miaomiao Mao, Nikola Jancovski, Yafit Kushner, Lucas Teasdale, Phan Truong, Kun Zhou, Samuel Reid, Linghan Jia, Ye Htet Aung, Melody Li, Christopher A. Reid, Sean Byars, Ingrid Scheffer, Steven Petrou, Snezana Maljevic

“…Conclusions: Our study reports on a novel Kcnq2 DEE mouse model recapitulating aspects of the disease phenotype with the electrophysiological and transcriptome analysis providing insights into KCNQ2 DEE mechanisms that can be leveraged for future therapy development.…”
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The phytohormone abscisic acid enhances remyelination in mouse models of multiple sclerosis by Femke Van Gaever, Femke Van Gaever, Fleur Mingneau, Fleur Mingneau, Sam Vanherle, Sam Vanherle, Yasmine Driege, Yasmine Driege, Mira Haegman, Mira Haegman, Elien Van Wonterghem, Elien Van Wonterghem, Junhua Xie, Junhua Xie, Roosmarijn E. Vandenbroucke, Roosmarijn E. Vandenbroucke, Jerome J. A. Hendriks, Jerome J. A. Hendriks, Rudi Beyaert, Rudi Beyaert, Jens Staal, Jens Staal, Jens Staal

“…Furthermore, ABA’s ability to improve remyelination together with its ability to reduce microglial activation, make ABA a promising candidate for modulating macrophage phenotype and reducing neuroinflammation in MS.…”
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CD4 T cell depletion increases memory differentiation of endogenous and CAR T cells and enhances the efficacy of Super2 and IL-33-armored CAR T cells against solid tumors by Chrystal Paulos, Mary Jo Turk, Megen C Wittling, Yina H Huang, Asmaa O Mohamed, David Tyler Boone, Shannon L Ferry, Melanie C Peck, Alicia M Santos, Haille E Soderholm

“…In contrast, S233-armored CAR T cells exhibited an activated effector phenotype and differentiated inefficiently into CAR effector and central memory T cells. …”
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Congenital Glaucoma: a Novel Ocular Manifestation of Hajdu-Cheney Syndrome by L. Swan, G. Gole, V. Sabesan, J. Cardinal, D. Coman

“…Hajdu-Cheney Syndrome (HSC) is a rare multisystem disease in which the phenotype involves acro-osteolysis, severe osteoporosis, short stature, wormian bones, facial dysmorphism, central neurological abnormalities, cardiovascular defects, and polycystic kidneys. …”
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Understanding Experimental LCMV Infection of Mice: The Role of Mathematical Models by Gennady Bocharov, Jordi Argilaguet, Andreas Meyerhans

“…The model formulations should be tightly linked to a fundamental step called “coordinatization” (Hermann Weyl), that is, the definition of observables, parameters, and structures that enable the link with a biological phenotype. In this review, we analyse the mathematical modelling approaches to LCMV infection in mice that resulted in quantification of some fundamental parameters of the CTL-mediated virus control including the rates of T cell turnover, infected target cell elimination, and precursor frequencies. …”
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