High Serum Level of IL-17 in Patients with Chronic Obstructive Pulmonary Disease and the Alpha-1 Antitrypsin PiZ Allele by Margarita Y. Pervakova, Alexandra V. Mazing, Sergey V. Lapin, Olga Y. Tkachenko, Anna I. Budkova, Elena A. Surkova, Vladimir L. Emanuel, Olga N. Titova

“…COPD patients with both PiZZ and PiMZ phenotypes demonstrated elevated IL-17 and decreased IFN-γ levels in comparison to patients with the PiMM phenotype of A1AT. …”
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Increased CCR7loPD-1hiCXCR5+CD4+ T Cells in Peripheral Blood Mononuclear Cells Are Correlated with Immune Activation in Patients with Chronic HBV Infection by Ya-Xin Huang, Qi-Yi Zhao, Li-Li Wu, Dong-Ying Xie, Zhi-Liang Gao, Hong Deng

“…The CCR7loPD-1hi Tfh subset has a partial Tfh effector phenotype and is associated with active Tfh differentiation, whereas the CCR7hiPD-1lo Tfh subset is a resting phenotype. …”
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Colony Formation, Migratory, and Differentiation Characteristics of Multipotential Stromal Cells (MSCs) from “Clinically Accessible” Human Periosteum Compared to Donor-Matched Bone... by Heather E. Owston, Payal Ganguly, Giuseppe Tronci, Stephen J. Russell, Peter V. Giannoudis, Elena A. Jones

“…This study is aimed at comparing human periosteum and donor-matched iliac crest BM MSC content and characterising MSCs in terms of colony formation, growth kinetics, phenotype, cell migration patterns, and trilineage differentiation capacity. …”
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C5a/C5aR regulates Th1/Th2 imbalance in sepsis-associated lung injury by promoting neutrophil activation to increase PAD4 expression by Zhenbing Lu, Ling Zhu, Changlin Yi, Bi Su, Renying Wang

“…T helper (Th) cell activation and phenotypic imbalance among them contribute significantly to sepsis-associated lung injury. …”
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Single‐Cell Simultaneous Metabolome and Transcriptome Profiling Revealing Metabolite‐Gene Correlation Network by Xiying Mao, Dandan Xia, Miao Xu, Yan Gao, Le Tong, Chen Lu, Weiqi Li, Runmin Xie, Qinghuai Liu, Dechen Jiang, Songtao Yuan

“…Abstract Metabolic studies at the single cell level can directly define the cellular phenotype closest to physiological or disease states. …”
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Gastritis Stages in Monozygotic and Dizygotic Dyspeptic Twins by Mindaugas Urba, Jurgita Skieceviciene, Dainius Janciauskas, Laimas Jonaitis, Limas Kupcinskas, Matteo Fassan, Massimo Rugge, Juozas Kupcinskas

“…Studies that explore the possible involvement of host-related versus environmental factors in the development of gastritis phenotype induced by H. pylori are highly needed. Aims. …”
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Nephropathy in Hypertensive Animals Is Linked to M2 Macrophages and Increased Expression of the YM1/Chi3l3 Protein by Paula Andréa Malveira Cavalcante, Natalia Alenina, Alexandre Budu, Leandro Ceotto Freitas-Lima, Thaís Alves-Silva, Juan Sebastian Henao Agudelo, Fatimunnisa Qadri, Niels Olsen Saraiva Camara, Michael Bader, Ronaldo Carvalho Araújo

“…The cells were treated with murine M-CSF and subsequently with LPS+IFN-γ to promote their polarization into M1 macrophages and IL-4+IL-13 to trigger the M2 phenotype. We examined the kidneys of TGM123-FVB/N animals to assess macrophage polarization and end-organ damage. mRNA expression was evaluated using real-time PCR, and protein levels were assessed through ELISA, CBA, Western blot, and immunofluorescence. …”
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Advantages of using biofilms to obtain high-value molecules by microbial biotransformations by Nicoly Subtil de Oliveira, Romeu Cassiano Pucci da Silva Ramos, Rafaela Caldas de Paula, Matheus Gonçalves da Costa Pereira, Rosimeire Takaki Rosa, Luiz Fernando Bianchini, Edvaldo Antonio Ribeiro Rosa

“…These reactions are often carried out by cells grown under a planktonic phenotype. However, microbial cells grown under a phenotype of biofilm can improve biotransformation bioprocesses once they form more biomass per volume, are more resistant to extreme conditions (pH, temperature, and toxic substances), remain active for extended periods, are less prone to cell washouts, and reduce re-inoculation demands, leading to increased production rates due to their unique physiological features. …”
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Frontotemporal Dementia as a Possible Manifestation of Primary Lateral Sclerosis: A Case Report and Literature Review by Kevin Qosja, Nicole M. Absar, Allen T. Yu

“…Primary lateral sclerosis (PLS) is currently defined as a restricted phenotype of amyotrophic lateral sclerosis (ALS), a neurodegenerative disease with upper motor neuron (UMN) symptoms that causes slowly progressive spasticity. …”
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Bilateral Glaucoma as Possible Additional Feature for PGAP3-Associated Hyperphosphatasia by Osama Obaid, Reem Batawi, Heba Alqurashi, Thana Ewis, Ahmad A. Obaid

“…A brain MRI scan also revealed brain abnormalities. The observed phenotype in a seven-month-old boy is in agreement with the phenotypic features of HPRMS type-4. …”
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A Case of True Hermaphroditism Presenting as a Testicular Tumour by Michelle Ceci, Edward Calleja, Edith Said, Noel Gatt

“…Our case report presents a true hermaphrodite with normal male phenotype that presented as a left testicular mass, two years after being diagnosed with Sertoli cell only syndrome in the contralateral testis. …”
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Atypical Omenn Syndrome due to Adenosine Deaminase Deficiency by Avni Y. Joshi, Erin K. Ham, Neel B. Shah, Xiangyang Dong, Shakila P. Khan, Roshini S. Abraham

“…We present here a novel case of an atypical Omenn syndrome (OS) phenotype due to mutations in the ADA gene encoding adenosine deaminase. …”
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Tolerance in Kidney Transplantation: What Is on the B Side? by Laura Carreras-Planella, Francesc E. Borràs, Marcella Franquesa

“…Their study is, however, in its infancy with still little knowledge and consensus on their origin, phenotype, and mechanism of action. All this hampers the pursuit of an effective Breg induction method for therapeutic purposes. …”
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Identification of Pentatricopeptide Repeat Proteins in the Model Organism Dictyostelium discoideum by Sam Manna, Jessica Brewster, Christian Barth

“…For one of the gene products, we show that it localizes to the mitochondria, and we also demonstrate that antisense inhibition of its expression leads to slower growth, a phenotype associated with mitochondrial dysfunction.…”
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Multiple Sulfatase Deficiency (MSD): Review of the Literature and Case Reports of Two Siblings with Dental Caries and Trauma by Lorna Hirst, Gehan Abou-Ameira, Mari-Liis Uudelepp

“…Multiple sulfatase deficiency (MSD) (MIM # 272200) is an extraordinarily rare inborn error of metabolism (IEM). The phenotypic spectrum is largely heterogeneous and attributed to the combined effects of deficiencies in the nine sulfatases currently known to be related to human diseases. …”
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Diversité génétique de l’allèle O dans des populations berbères by Silvayn Amory, Jean-Michel Dugoujon, Stéphanie Despiau, Francis Roubinet, Farha El-Chennawi, Antoine Blancher

“…We analysed the O allele polymorphism in a sample of 33 Berbers from the Siwa population, all of them of phenotype O and unrelated to one another. The results show an important genetic diversity considering the limited number of individuals under study. …”
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Population-Based Surveillance for Hypermucoviscosity Klebsiella pneumoniae Causing Community-Acquired Bacteremia in Calgary, Alberta by Gisele Peirano, Johann DD Pitout, Kevin B Laupland, Bonnie Meatherall, Daniel B Gregson

“…The hypermucoviscous phenotype was present in 8.2% of K pneumoniae isolates, and was associated with rmpA and the K2 serotype; liver abscesses were the most common clinical presentation. …”
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SpatialLeiden: spatially aware Leiden clustering by Niklas Müller-Bötticher, Shashwat Sahay, Roland Eils, Naveed Ishaque

“…For single-cell omics, clustering finds cells with similar molecular phenotype after which cell types are annotated. Leiden clustering is one of the algorithms of choice in the single-cell community. …”
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The Genetics of Racing Performance in Arabian Horses by K. Ropka-Molik, M. Stefaniuk-Szmukier, A. D. Musiał, B. D. Velie

“…The analysis of polymorphisms at the genome level has also been applied to the detection of genetic variants associated with exercise phenotype in the Arabian breed. The presented review summarizes these findings, with a focus on the genetics underlying flat racing and endurance performance traits in different Arabian horse populations.…”
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The Mechanisms Underlying Chronic Inflammation in Rheumatoid Arthritis from the Perspective of the Epigenetic Landscape by Yasuto Araki, Toshihide Mimura

“…Epigenetic changes possibly provide RASFs with an activated phenotype. In this paper, we review the roles of epigenetic mechanisms relevant for the progression of RA.…”
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