T-Cell Traffic Jam in Hodgkin's Lymphoma: Pathogenetic and Therapeutic Implications by Claudio Fozza, Maurizio Longinotti

“…In hematologic malignancies, the microenvironment is often characterized by nonneoplastic cells with peculiar phenotypic and functional features. This is particularly true in Hodgkin's lymphoma (HL), in which T lymphocytes surrounding Hodgkin's Reed-Sternberg cells are essentially polarized towards a memory T-helper type 2 phenotype. …”
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The Role of Lipid Rafts in Cancer Cell Adhesion and Migration by Toshiyuki Murai

“…The dynamic features of the cancer cell surface may modulate the malignant phenotype of cancer, including adhesion disorders and aggressive phenotypes of migration and invasion. …”
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IMMUNOBIOLOGICAL PROPERTIES OF FOWLPOX VIRUS CULTURAL VARIANTS by K. Yu. Fedoseyev, M. S. Kukushkina, V. Yu. Kulakov, L. V. Malakhova

“…It was established that the strains retain dermatotropic phenotype manifested as local skin lesions in chicks, typical for Avipoxvirus family. …”
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Plasmacytoid Dendritic Cells: From Heart to Vessels by Rosalinda Sorrentino, Silvana Morello, Aldo Pinto

“…They highly produce IFN type I that promote the polarization of T cells towards a Th1 phenotype; however, pDCs can also participate to suppressive networks via the recruitment of T regulatory cells that downmodulate proinflammatory responses. …”
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A Newborn with Panhypopituitarism and Seizures by Trupti Kale, Rachit Patil, Ramesh Pandit

“…Interstitial deletions on the short arm of chromosome 20 are uncommon, and therefore the clinical phenotype is poorly defined. Very few cases have been reported in the literature so far. …”
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Masculinization on tilapia (Oreochromis sp.) by natural hormone steroid agent from bee resin through artificial diet by Dinar Tri Soelistyowati, Agus Oman Sudrajat, Harton Arfah

“…Average of masculine phenotype percentage increased significantly (P…”
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Unlocking the potential of engineered immune cell therapy for solid tumors by Víctor Albarrán-Fernández, Laura Angelats, Julio Delgado, Alena Gros, Álvaro Urbano-Ispizua, Sònia Guedan, Aleix Prat

“…Genetic engineering techniques represent an exciting area of research for the development of cellular products with enhanced cytotoxicity, phenotype, and metabolism.…”
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Derivative 11;22 (Emanuel) Syndrome: A Case Report and A Review by Madan Gopal Choudhary, Prashant Babaji, Nitin Sharma, Dilip Dhamankar, Gururaj Naregal, Vijay Sunil Reddy

“…Emanuel syndrome (ES) is a rare anomaly characterized by a distinctive phenotype, consisting of characteristic facial dysmorphism, microcephaly, severe mental retardation, developmental delay, renal anomalies, congenital cardiac defects, and genital anomalies in boys. …”
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Preeclampsia, Natural History, Genes, and miRNAs Associated with the Syndrome by Laura Parada-Niño, Luisa Fernanda Castillo-León, Adrien Morel

“…Poor invasion of the spiral arteries is a phenomenon well described in PE; this leads to a hypoxic uterine bed and imbalance of antiangiogenic and proangiogenic factors in the uteroplacental region, which in turn triggers the disease phenotype. The causes of the pathology are unclear; nevertheless, numerous approaches, including next-generation sequencing, association, and case control and miRNA studies, have shed light on the genetic/molecular basis of PE. …”
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Hypertension and Its Impact on Stroke Recovery: From a Vascular to a Parenchymal Overview by Benjamin Maïer, Nathalie Kubis

“…Here, we sought to review the impact of isolated hypertension or hypertension associated to stroke on brain atrophy, neuron connectivity and neurogenesis, and phenotype modification of microglia and astrocytes. …”
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Microarray Analysis of Suppression Subtracted Hybridisation Libraries Identifies Genes Associated with Breast Cancer Progression by Dong Liu Barraclough, Susan Sewart, Philip S. Rudland, Balvinder S. Shoker, D. Ross Sibson, Roger Barraclough, Michael P. A. Davies

“…Background: A major challenge of cancer research is to identify key molecules which are responsible for the development of the malignant metastatic phenotype, the major cause of cancer death.…”
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Insights into quorum sensing (QS): QS-regulated biofilm and inhibitors by Wen-Si Tan, Jodi Woan-Fei Law, Lydia Ngiik-Shiew Law, Vengadesh Letchumanan, Kok-Gan Chan

“…Hence, understanding the details of quorum sensing mechanisms, its phenotype regulation (biofilm), and QS inhibitors (which attenuate virulence/pathogenicity) may open a new avenue for controlling bacterial infections. …”
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Panhypopituitarism due to Absence of the Pituitary Stalk: A Rare Aetiology of Liver Cirrhosis by Marta Gonzalez Rozas, Lidia Hernanz Roman, Diego Gonzalez Gonzalez, José Luis Pérez-Castrillón

“…Patients with hypopituitarism can develop a metabolic syndrome-like phenotype. Insulin resistance is the main pathophysiological axis of metabolic syndrome and is the causal factor in the development of nonalcoholic fatty liver disease (NAFLD). …”
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An Inguinal Perivascular Epithelioid Cell Tumor Metastatic to the Orbit by Zofia Tynski, Way Chiang, Albert Barrett

“…These tumors harbor distinct myomelanocytic phenotype. The PEComa family of tumors includes lymphangioleiomyomatosis, angiomyolipoma, clear cell sugar tumor of the lung, and myomelanocytic tumor of the falciparum ligament/ligamentum teres. …”
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Novel variant of FBN2 in a patient with congenital contractual arachnodactyly by Mina Nakama, Yuki Miwa, Sayaka Manabe, Shigeru Shimamoto, Hidenori Ohnishi

“…This patient was diagnosed with CCA based on his phenotype, and the pathogenicity of this variant was classified according to cDNA analysis and protein modeling.…”
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Pharmacological Modulation of the Unfolded Protein Response as a Therapeutic Approach in Cutaneous T-Cell Lymphoma by Nadia St. Thomas, Benjamin N. Christopher, Leticia Reyes, Reeder M. Robinson, Lena Golick, Xiaoyi Zhu, Eli Chapman, Nathan G. Dolloff

“…Patients experience recurrent infections due to a compromised skin barrier and generalized immunodeficiency resulting from a dominant Th2 immune phenotype of CTCL cells. Given the role of the unfolded protein response (UPR) in normal and malignant T-cell development, we investigated the impact of UPR-inducing drugs on the viability, transcriptional networks, and Th2 phenotype of CTCL. …”
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Theranostic nanoemulsions suppress macrophage-mediated acute inflammation in rats by Riddhi Vichare, Yalcin Kulahci, Rebecca McCallin, Fatih Zor, Fatma Nurefsan Selek, Lu Liu, Caitlin Crelli, Anneliese Troidle, Michele Herneisey, James M. Nichols, Andrew J. Shepherd, Vijay S. Gorantla, Jelena M. Janjic

“…Macrophages infiltrate and polarize toward a pro-inflammatory phenotype (M1-like), thereby increasing the severity of inflammation. …”
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Deep learning and hyperspectral features for seedling stage identification of barnyard grass in paddy field by Siqiao Tan, Qiang Xie, Wenshuai Zhu, Yangjun Deng, Lei Zhu, Xiaoqiao Yu, Zheming Yuan, Zheming Yuan, Yuan Chen, Yuan Chen

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Systems immunology integrates the complex endotypes of recessive dystrophic epidermolysis bullosa by Nell Hirt, Enzo Manchon, Qian Chen, Clara Delaroque, Aurelien Corneau, Patrice Hemon, Safaa Saker-Delye, Pauline Bataille, Jean-David Bouaziz, Emmanuelle Bourrat, Alain Hovnanian, Helene Le Buanec, Fawzi Aoudjit, Hicham El Costa, Nabila Jabrane-Ferrat, Reem Al-Daccak

“…Abstract Endotypes are characterized by the immunological, inflammatory, metabolic, and remodelling pathways that explain the mechanisms underlying the clinical presentation (phenotype) of a disease. Recessive dystrophic epidermolysis bullosa (RDEB) is a severe blistering disease caused by COL7A1 pathogenic variants. …”
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In Vitro Effect of Estradiol and Progesterone on Ovine Amniotic Epithelial Cells by Annunziata Mauro, Hashimita Sanyal, Angelo Canciello, Paolo Berardinelli, Valentina Russo, Nicola Bernabò, Luca Valbonetti, Barbara Barboni

“…In conclusion, media supplementation with high doses of steroids may be adopted to modulate phenotype and plasticity during oAEC amplification. …”
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