Human Cardiac Fibroblast Number and Activation State Modulate Electromechanical Function of hiPSC-Cardiomyocytes in Engineered Myocardium by Cassady E. Rupert, Tae Yun Kim, Bum-Rak Choi, Kareen L. K. Coulombe

“…Second, hCFs undergo myofibroblast activation in traditional two-dimensional culture, and this altered phenotype ablated the functional benefits of hCFs when incorporated into engineered cardiac tissues. …”
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Whole genome studies of origin, selection and adaptation of the Russian cattle breeds by N. S. Yudin, D. M. Larkin

“…Whole-genome association studies of Russian cattle breeds pointed to a novel gene which could be related to the “white-faced” phenotype and to a gene which is related to body temperature support under the acute cold stress. …”
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Human epididymis protein 4-annexin II binding promotes aberrant epithelial-fibroblast crosstalk in pulmonary fibrosis by Weishuai Zheng, Menglin Zou, Xingxing Hu, Han Gao, Weiwei Song, Qinhui Hou, Yuan Liu, Zhenshun Cheng

“…Mechanistic analysis shows that HE4 and annexin II (ANXA2) specific binding enhances the profibrotic phenotype in epithelial cells, and directly promotes lung fibroblast activation, leading to aberrant epithelial-fibroblast crosstalk and the persistent myofibroblast phenotype. …”
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Investigation of Vitamin D-Binding Protein Polymorphism Impact on Coronary Artery Disease and Relationship with Longevity: Own Data and a Review by Donatas Stakisaitis, Vita Lesauskaitė, Milda Girdauskaitė, Ernestas Janulionis, Albertas Ulys, Rimantas Benetis

“…Isoelectric focusing of DBP phenotypes in serum was performed on polyacrylamide gel. …”
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Phytochrome-mediated shade avoidance responses impact the structure and composition of the bacterial phyllosphere microbiome of Arabidopsis by James A. O’Rourke, Stacey A. Vincent, Isabel E. I. Williams, Eleanor L. Gascoyne, Paul F. Devlin

“…Bacteria that increased in abundance on plants with a shade-avoidance phenotype corresponded to genera associated with beneficial traits such as enhanced disease resistance and growth promotion. …”
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A Novel COL7A1 Mutation in a Patient With Dystrophic Epidermolysis Bullosa. Successful Treatment With Upadacitinib by Lai S, Lin C, Guo Z, Lai Y, Xie L, Wan C, Yang T, Li L

“…In different DEB subtypes, the severity of the phenotype is associated, to some extent, with the outcome of Type VII collagen caused by mutations in the COL7A1 gene, which may be reduced in expression, remarkably reduced, or completely absent. …”
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Development and characterization of a reverse genetics system for the lineage II Chicava strain of Machupo virus in a guinea pig model. by Emily Mantlo, Junki Maruyama, John T Manning, Rachel A Reyna, Cheng Huang, Slobodan Paessler

“…We characterized the multiplication kinetics of rMACV-Chicava in African green monkey kidney epithelial Vero cells, followed by determining the virulence phenotype in outbred Hartley guinea pigs.<h4>Principal findings</h4>We demonstrated that the multiplication kinetics in Vero cells, virulence phenotype in guinea pigs, and neutralizing antibody titers are indistinguishable between rMACV-Chicava and the wild-type parental virus.…”
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Multiple Group Testing Procedures for Analysis of High-Dimensional Genomic Data by Hyoseok Ko, Kipoong Kim, Hokeun Sun

“…Moreover, detecting only a few of genes associated with a phenotype outcome among tens of thousands of genes is of main interest in genetic association studies. …”
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Haptoglobin Genotype-Dependent Anti-Inflammatory Signaling in CD163+ Macrophages by R. Clive Landis, Pandelis Philippidis, Jan Domin, Joseph J. Boyle, Dorian O. Haskard

“…Intraplaque hemorrhage causes adaptive remodelling of macrophages towards a protective phenotype specialized towards handling iron and lipid overload, denoted Mhem. …”
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Clinical Report of a 17q12 Microdeletion with Additionally Unreported Clinical Features by Jennifer L. Roberts, Stephanie K. Gandomi, Melissa Parra, Ira Lu, Chia-Ling Gau, Majed Dasouki, Merlin G. Butler

“…Since syndrome-specific DNA sequencing studies failed to provide an explanation for this patient’s unusual habitus, we postulate that this case represents an expansion of the 17q12 microdeletion phenotype. Further analysis of the deleted interval is recommended for new genotype-phenotype correlations.…”
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Intestinal Short-Chain Fatty Acids in Patients with Bronchial Asthma by O. Yu. Zolnikova, N. D. Potskhverashvili, N. I. Kokina, A. S. Trukhmanov, V. T. Ivashkin

“…The change in the metabolic profile did not depend on the phenotype of the disease.Conclusion. Changes in SCFAs indicate pronounced disorders in the microbiocenosis of the intestinal biotope. …”
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VEIKIANTIS GENOMAS - VISUMINIS POŽYMIS: DABARTIES ŽVILGSNIS Į GENETIKĄ by Jonas Rubikas

“…The genomics and proteomes as well as the data evaluation mark the beginning of the new methodological level: the functioning genome - phenotype. Keywords: genome, genomics, DNA microarrays, proteome. …”
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Regulation of stress granule maturation and dynamics by poly(ADP-ribose) interaction with PARP13 by Shang-Jung Cheng, Temitope Gafaar, Jijin R. A. Kuttiyatveetil, Aleksandr Sverzhinsky, Carla Chen, Minghui Xu, Allison Lilley, John M. Pascal, Anthony K. L. Leung

“…Notably, this fragmented phenotype is conserved across a variety of stresses that trigger stress granule formation via diverse pathways. …”
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Sézary Syndrome with CD4/CD8 Double-Negative Neoplastic T Cells in Peripheral Blood by Yuki Kageyama, Kenshiro Tsuda, Yuma Nato, Keiki Nagaharu, Kazutaka Suzuki, Akihiko Sawaki, Hiroyuki Miyashita

“…Intriguingly, the Sézary cells showed a typical CD4+CD8–CD7– phenotype in the skin even though the cells in the peripheral blood lacked CD4. …”
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Gender-associated features in diabetic kidney disease by S.S. Safarova

“…Gender differences have been studied in relation to the incidence and prevalence of DKD, their phenotypes and clinical manifestations, and several risk factors that have different effects on both sexes. …”
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Mowat-Wilson Syndrome: The First Clinical and Molecular Report of an Indonesian Patient by Farmaditya E. P. Mundhofir, Helger G. Yntema, Ineke van der Burgt, Ben C. J. Hamel, Sultana M. H. Faradz, Bregje W. M. van Bon

“…Mowat-Wilson syndrome (OMIM 235730) is a genetic condition characterized by moderate-to-severe intellectual disability, a recognizable facial phenotype, and multiple congenital anomalies. The striking facial phenotype in addition to other features such as severely impaired speech, hypotonia, microcephaly, short stature, seizures, corpus callosum agenesis, congenital heart defects, hypospadias, and Hirschsprung disease are particularly important clues for the initial clinical diagnosis. …”
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A pathogenic COL7A1 variant highlights semi-dominant inheritance in dystrophic epidermolysis bullosa by Saira Sattar, Thashi Bharadwaj, Umm-e- Kalsoom, Anushree Acharya, Saadullah Khan, Suzanne M. Leal, Isabelle Schrauwen

“…The inheritance pattern observed was consistent with a semi-dominant model, where heterozygous parents exhibited a mild phenotype, and homozygous children were more severely affected. …”
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Macrophage MST1 protects against schistosomiasis-induced liver fibrosis by promoting the PPARγ-CD36 pathway and suppressing NF-κB signaling. by Jianyang Li, Xinyuan Cai, Yan Yang, Yulin Mao, Lin Ding, Qian Xue, Xunhao Hu, Yan Huang, Cong Sui, Yuxia Zhang

“…Overall, our data identified MST1 as a novel regulator for egg-induced liver fibrosis via modulation of macrophage function and phenotype by CD36-mediated phagocytosis and suppression of NF-κB pathway.…”
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Age-associated microglial transcriptome leads to diminished immunogenicity and dysregulation of MCT4 and P2RY12/P2RY13 related functions by Martin Škandík, Lara Friess, Guillermo Vázquez-Cabrera, Lily Keane, Kathleen Grabert, Mireia Cruz De los Santos, Mercedes Posada-Pérez, Austeja Baleviciute, Mathilde Cheray, Bertrand Joseph

“…However, the specific phenotype adopted by microglia during aging remains a subject of debate and is contingent on the chosen experimental model. …”
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Human placental extract improves liver cirrhosis in mice with regulation of macrophages and senescent cells by Natsuki Ishikawa, Yusuke Watanabe, Yuichirou Maeda, Tomoaki Yoshida, Naruhiro Kimura, Hiroyuki Abe, Akira Sakamaki, Hiroteru Kamimura, Takeshi Yokoo, Kenya Kamimura, Atsunori Tsuchiya, Shuji Terai

“…Furthermore, there was a decrease in the number of senescent cells in the liver and the mRNA levels of secrete senescence-associated secretory phenotype factors and Cdkn2a (p16). In vitro, HPE induced macrophage polarization to the anti-inflammatory M2 phenotype. …”
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