Obstructive sleep apnea and structural and functional brain alterations: a brain-wide investigation from clinical association to genetic causality by Kang Wu, Qiming Gan, Yuhong Pi, Yanjuan Wu, Wenjin Zou, Xiaofen Su, Sun Zhang, Xinni Wang, Xinchun Li, Nuofu Zhang

“…Additionally, large-scale Mendelian randomization analyses were performed using genome-wide association study (GWAS) data on OSA and 3935 brain imaging-derived phenotypes (IDPs), assessed in up to 33,224 individuals between December 2023 and March 2024, to explore potential genetic causality between OSA and alterations in whole brain structure and function. …”
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Proteomic analysis to explore potential mechanism underlying pseudomale sperm defect in Cynoglossus semilaevis by Xihong Li, Lu Li, Zhongkai Cui, Ming Li, Xuexue Sun, Zhijie Li, Zhangfan Chen, Lanqing Ding, Dongdong Xu, Wenteng Xu

“…Females of Chinese tongue sole (Cynoglossus semilaevis) grow 2–4 times faster and bigger than males, but some genetic females can sex reverse into phenotypic males (called pseudomales, ZW karyotype) that presents similar slow growth to normal males. …”
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New insights into the immunomodulatory potential of sialic acid on monocyte-derived dendritic cells by Zélia Silva, João Amorim Rabaça, Vanessa Luz, Rita Adubeiro Lourenço, Mariolina Salio, Alexandra Couto Oliveira, Pedro Bule, Sebastian Springer, Paula Alexandra Videira

“…In this study, we focused on the impact of sialic acid remodelling by treatment with Clostridium perfringens sialidase on MoDCs' phenotypic and functional characteristics. Our investigation juxtaposes this novel approach with the conventional cytokine-based maturation regimen commonly employed in clinical settings. …”
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Assessment of Antibiotic Resistance Among Isolates of <i>Klebsiella</i> spp. and <i>Raoultella</i> spp. in Wildlife and Their Environment from Portugal: A Positive Epidemiologic Ou... by Carolina Sabença, Rani de la Rivière, Paulo Barros, João Alexandre Cabral, Roberto Sargo, Luís Sousa, Maria de Lurdes Enes Dapkevicius, Filipe Silva, Filipa Lopes, Ana Carolina Abrantes, Madalena Vieira-Pinto, Manuela Caniça, Gilberto Igrejas, Carmen Torres, Patrícia Poeta

“…Antibiograms were performed for 15 antibiotics to determine the phenotypic resistance profile in these isolates. Extended-spectrum β-lactamase (ESBL) production was tested by the double-disc synergy test, and one ESBL-producing <i>K. pneumoniae</i> isolate was screened by PCR and whole-genome sequencing. …”
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Genome-wide association mapping and genomic prediction analyses reveal the genetic architecture of grain yield and agronomic traits under drought and optimum conditions in maize by Manigben Kulai Amadu, Yoseph Beyene, Vijay Chaikam, Pangirayi B. Tongoona, Eric Y. Danquah, Beatrice E. Ifie, Juan Burgueno, Boddupalli M. Prasanna, Manje Gowda

“…Among these QTNs, 17 QTNs explained over 10% of the phenotypic variation (R 2  ≥ 10%). Furthermore, 43 candidate genes were discovered and annotated. …”
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Prevalence and Molecular Characterization of Carbapenemase-Producing Multidrug-Resistant Bacteria in Diabetic Foot Ulcer Infections by Mohd Saleem, Soha Abdallah Moursi, Tahani Nasser Almofeed Altamimi, Mohammed Salem Alharbi, Alwaleed Mohammad Alaskar, Sahar Adly Hassan Hammam, Ehab Rakha, Ozair Ilyas Syed Muhammad, Hamoud Abdulmohsin Almalaq, Metab Nasser Alshammari, Azharuddin Sajid Syed Khaja

“…A total of 200 clinical isolates from DFU patients were analyzed via phenotypic assays, including the modified Hodge test (MHT) and the Carba NP test, alongside molecular techniques to detect carbapenemase-encoding genes (<i>blaKPC</i>, <i>blaNDM</i>, <i>blaVIM</i>, <i>blaIMP</i>, and <i>blaOXA-48</i>). …”
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Antibiotic Susceptibility Patterns and Virulence Profiles of Classical and Hypervirulent <i>Klebsiella pneumoniae</i> Strains Isolated from Clinical Samples in Khyber Pakhtunkhwa,... by Azra, Taj Ali Khan, Ihtisham Ul Haq, Woranich Hinthong, Susana Campino, Aisha Gohar, Noman Khan, Muhammad Kashif, Ihsan Ullah, Taane G. Clark

“…Among these, 64 <i>K. pneumoniae</i> strains were isolated and subsequently subjected to antimicrobial susceptibility testing (AST) and phenotypic virulence detection. Among the 64 isolates, 21 (32.8%) exhibited hypermucoviscosity, a characteristic associated with increased pathogenicity. …”
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Identification of patient demographic, clinical, and SARS-CoV-2 genomic factors associated with severe COVID-19 using supervised machine learning: a retrospective multicenter study by Kuganya Nirmalarajah, Patryk Aftanas, Shiva Barati, Emily Chien, Gloria Crowl, Amna Faheem, Lubna Farooqi, Alainna J. Jamal, Saman Khan, Jonathon D. Kotwa, Angel X. Li, Mohammad Mozafarihashjin, Jalees A. Nasir, Altynay Shigayeva, Winfield Yim, Lily Yip, Xi Zoe Zhong, Kevin Katz, Robert Kozak, Andrew G. McArthur, Nick Daneman, Finlay Maguire, Allison J. McGeer, Venkata R. Duvvuri, Samira Mubareka

“…Therefore, we aimed to establish a COVID-19 patient dataset with linked clinical and viral genomic data to then examine associations between SARS-CoV-2 genomic signatures and clinical disease phenotypes. Methods A cohort of adult patients with laboratory confirmed SARS-CoV-2 from 11 participating healthcare institutions in the Greater Toronto Area (GTA) were recruited from March 2020 to April 2022. …”
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Co-isolation of human donor eye cells and development of oncogene-mutated melanocytes to study uveal melanoma by Yunxi Chen, Eva Jin, Mohamed Abdouh, Éric Bonneil, Daniel Alexander Jimenez Cruz, Thupten Tsering, Qianqian Zhou, Aurélie Fuentes-Rodriguez, Alexandra Bartolomucci, Alicia Goyeneche, Solange Landreville, Miguel N. Burnier, Julia V. Burnier

“…We describe efficient methods for the isolation and growth of NCMs and report their phenotypic, proteomic, and transcriptomic characteristics, which will facilitate the investigation of UM development and progression. …”
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Sex differences in epigenetic ageing for older people living with HIVResearch in context by Carrie D. Johnston, Alina P.S. Pang, Eugenia L. Siegler, Charlene Thomas, Chelsie O. Burchett, Mia Crowley, Rochelle O'Brien, Lishomwa C. Ndhlovu, Marshall J. Glesby, Michael J. Corley

“…Hence, we generated a more representative epigenetic dataset to examine sex differences in epigenetic ageing and relationships to clinical phenotypes and proteomics. Methods: We calculated first, second, and third-generation epigenetic ages using DNA methylation data in an observational cohort of 52 females and 106 males with HIV age 50 and over. …”
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Unraveling the immunological landscape and gut microbiome in sepsis: a comprehensive approach to diagnosis and prognosisResearch in context by Yali Luo, Jian Gao, Xinliang Su, Helian Li, Yingcen Li, Wenhao Qi, Xuling Han, Jingxuan Han, Yiran Zhao, Alin Zhang, Yan Zheng, Feng Qian, Hongyu He

“…In addition, T cell phenotypes within adaptive immunity are correlated with sepsis severity and may serve as reliable prognostic markers. …”
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Modeling feed efficiency over productive lifetime and integrating a submodel for body reserve management in Nordic dairy cattle by R.B. Stephansen, J. Lassen, V.M. Thorup, B.G. Poulsen, J. Jensen, G. Sahana, O.F. Christensen

“…Those results suggest the importance of recording phenotypes in most time periods within and across lactations. …”
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Association of pituitary neuroendocrine tumors and neurofibromatosis type 1: assessing causation versus coincidence. Case report by Mercedes Aguilar-Soto, Julia M. Zuarth-Vázquez, Laura Leyva-Figueroa, Karla Zarco-Ávila, Armando Gamboa-Domínguez, Aldo Eguiluz-Melendez, Laura C. Hernández-Ramírez

“…Two individuals developed multiple endocrine neoplasia-like phenotypes but tested negative for other relevant genetic defects.ConclusionsAlthough the association of NF1 and PitNETs could be coincidental, the clinical characteristics of the reviewed cases differ from those of typical incidentalomas. …”
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Comparative Genomics Reveals Evidence of the Genome Reduction and Metabolic Potentials of <i>Aliineobacillus hadale</i> Isolated from Challenger Deep Sediment of the Mariana Trench by Shaofeng Yang, Jie Liu, Yang Liu, Weichao Wu, Jiahua Wang, Yuli Wei

“…Based on the GTDB taxonomy and phenotypic data, strain Lsc_1132^T could represent a novel species of a novel genus, proposed as <i>Aliineobacillus hadale</i> gen. nov. sp. nov. …”
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An Easy and Quick Risk-Stratified Early Forewarning Model for Septic Shock in the Intensive Care Unit: Development, Validation, and Interpretation Study by Guanghao Liu, Shixiang Zheng, Jun He, Zi-Mei Zhang, Ruoqiong Wu, Yingying Yu, Hao Fu, Li Han, Haibo Zhu, Yichang Xu, Huaguo Shao, Haidan Yan, Ting Chen, Xiaopei Shen

“…Among patients forewarned as high risk, similar pathophysiological phenotypes and high mortality were observed in both those subsequently diagnosed as having SS and those without such a diagnosis. …”
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Multidrug-Resistant <i>Acinetobacter baumannii</i>: Risk Factors for Mortality in a Tertiary Care Teaching Hospital by Kristina Černiauskienė, Astra Vitkauskienė

“…Carbapenemase-producing isolates were detected phenotypically. To determine risk factors for in-hospital mortality, logistic regression analysis was performed. …”
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Selection of terminal Piétrain pigs improves vitality and prevalence of congenital defects in crossbred piglets by Wim Gorssen, Wim Gorssen, Carmen Winters, Roel Meyermans, Léa Chapard, Katrijn Hooyberghs, Jaro De Kort, Alice Van den Broeke, Jürgen Depuydt, Steven Janssens, Nadine Buys

“…Moreover, vitality scores were genetically moderately correlated with preweaning mortality (rg=-0.59) and porcine congenital splay leg syndrome (rg=-0.52). Evolutions of phenotypic records and estimated breeding values since the start of the breeding program indicate a positive impact on piglet survival and prevalence of porcine congenital splay leg syndrome. …”
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Autoimmune glial fibrillary acidic protein astrocytopathy misdiagnosed as intracranial infectious diseases: case reports and literature review by Runhua Bai, Runhua Bai, Li An, Wei Du, Zhiwei Wang, Xiaokun Qi, Jianguo Liu, Ming Ren, Yingxin Yu

“…The most common clinical phenotypes among 40 patients were mimicked meningitis, meningoencephalitis, meningoencephalomyelitis, encephalitis and encephalomyelitis.ConclusionA-GFAP-A is a specific autoimmune meningoencephalomyelitis associated with GFAP-IgG, with lesions involved the brain, meninges, and spinal cord. …”
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Characterization of Listeria monocytogenes strains isolated from soil under organic carrot farming by Maciej Nowak, Zbigniew Paluszak, Natalia Wiktorczyk-Kapischke, Katarzyna Grudlewska-Buda, Anna Budzyńska, Joanna Skonieczna-Kurpiel, Ewa Wałecka-Zacharska, Monika Huse-Kutowska, Krzysztof Skowron

“…These rods can vary in phenotypic characteristics and virulence levels.DiscussionThe research conducted allows to draw attention to the occurrence of pathogens, including L. monocytogenes in crops from organic farming. …”
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Dysplasie faciale chez les chimpanzés sauvages de Sebitoli, Parc national de Kibale, Ouganda : la pollution environnementale en cause ? by Sabrina Krief, Jean-Michel Krief, Andrew Seguya

“…Dans le parc national de Kibale, en Ouganda, notre travail d’habituation dans la zone nord de Sebitoli nous a permis d’observer des phénotypes faciaux singuliers. Huit des 80 chimpanzés (Pan troglodytes schweinfurthii) présentent un nez aplati avec des narines réduites ou absentes et une face concave, sans qu’aucune lésion de la peau ne soit visible. …”
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