Optimizing fully-efficient two-stage models for genomic selection using open-source software by Javier Fernández-González, Julio Isidro y Sánchez

“…Single-stage models predict GEBVs from phenotypic observations in one step, fully accounting for the entire variance-covariance structure among genotypes, but face computational challenges. …”
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Regions enriched for DNA repeats in chromosomes of Macrostomum mirumnovem, a species with a recent Whole Genome Duplication by K. S. Zadesenets, N. B. Rubtsov

“…Taking together, karyotype peculiarities (a high level of intraspecific karyotypic diversity associated with chromosome number variation, structural chromosomal rearrangements, and the formation of new regions enriched for DNA repeats) and some phenotypic features of M. mirumnovem (small body size, short lifecycle, easy maintenance in the laboratory) make this species a perspective model in the studies of genomic and karyotypic evolution in species passed through a recent WGD event.…”
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Comparison of Adult Hippocampal Neurogenesis and Susceptibility to Treadmill Exercise in Nine Mouse Strains by Jong Whi Kim, Sung Min Nam, Dae Young Yoo, Hyo Young Jung, Il Yong Kim, In Koo Hwang, Je Kyung Seong, Yeo Sung Yoon

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Genetic aspects of major blood metabolites in the Italian Simmental cattle population by S. Magro, A. Costa, A. Cesarani, L. Degano, M. De Marchi

“…In the present study, we estimated h2 of BHB, NEFA, and urea in blood predicted from milk mid-infrared spectra and assessed their genetic correlation with milk yield and composition traits in the Italian Simmental cattle breed using phenotypes of 3,549 cows in 207 herds. Two sets were considered: early (1,920 records, 1 per cow, between 5 and 35 DIM) and whole (14,378 records, at least 3 per cow, between 5 and 305 DIM) lactation. …”
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Integrating univariate and multivariate stability indices for breeding clime-resilient barley cultivars by Ammar Elakhdar, Ahmed A. El-Naggar, Sally El-Wakeell, Anas H. Ahmed

“…Abstract Studying genetic variability through the phenotypic performance of genotypes is crucial in the breeding program. …”
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Genetic Variability Analysis and Association of Traits in Common Bean (Phaseolus vulgaris L.) Landraces Collected from Ethiopia at Jimma by Eyuel Mesera, Garome Shifaraw, Sentayehu Alamerew, Birhanu Amsalu

“…This highly significant difference indicates the existence of large variability among genotypes. High phenotypic coefficients of variation and genotypic coefficients of variation were obtained for plant height (19.43, 11.73), pod length (11.27, 10.69), and 100-seed weight (15.42, 12.74). …”
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Molecular Detection and Multidrug Resistance of Shigella spp. Isolated from Wild Waterfowl and Migratory Birds in Bangladesh by Jarna Karmoker, Md. Saiful Islam, Md. Liton Rana, Md. Ashek Ullah, Fahim Haque Neloy, Nahian Muniath Oishy, Pritom Kumar Pramanik, Mahbubul Pratik Siddique, Sukumar Saha, Md. Tanvir Rahman

“…A disk diffusion assay was employed to investigate antibiotic phenotypes, while the resistance genes were detected by PCR. …”
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Chinese cabbage orphan gene BR3 confers bolting resistance to Arabidopsis through the gibberellin pathway by Yuting Zhang, Mingliang Jiang, Shurui Sun, Zongxiang Zhan, Xiaonan Li, Zhongyun Piao

“…BR3OE plants showed no significant phenotypic differences after vernalization treatment. …”
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Between-strain differences in hypothermic response in mice after intranasal administration of PtO nanoparticles by D. V. Petrovskii, A. V. Romashchenko, S. Yu. Troitskii, M. P. Moshkin

“…The correlation found between our data and some well-known phenotypic characteristics (phenome.jax.org) of the mouse strains used confirms this hypothesis.…”
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Dissecting macrophage heterogeneity and kaempferol in lung adenocarcinoma: a single-cell transcriptomic approach and network pharmacology by Laiyi Wan, Wentao Hao, Leilei Li, Lin Wang, Yanzheng Song

“…Results Our scRNA-seq analysis identified notable heterogeneity among macrophages, revealing predominant M2-like phenotypes within TAMs. Network pharmacology highlighted active TCM ingredients, including quercetin, isorhamnetin, and kaempferol, targeting genes related to macrophage function. …”
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A Mendelian randomization study: physical activities and chronic kidney disease by Rui Xiao, Li Dong, Bo Xie, Beizhong Liu

“…Genome-wide association studies from the UK Biobank baseline data were used for physical activity phenotypes and included 460,376 participants. For kidney function (estimated Glomerular Filtration Rate (eGFR) and CKD, with eGFR < 60 mL/min/1.73 m2), CKDGen Consortium data were used, which included 480,698 CKD participants of European ancestry. …”
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Enhanced Bayesian model for multienvironmental selection of winter hybrids maize: assessing grain yield using ‘ProbBreed’ by Bikas Basnet, Chitra Bahadur Kunwar, Umisha Upreti

“…Abstract Background Crossover interactions stemming from phenotypic plasticity complicate selection decisions when evaluating hybrid maize with superior grain yield and consistent performance. …”
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Assessment of Genetic Parameters for Vitamin A, Vitamin C, and TSS Content Results in Melon Line Crosses at Five Maturity Stages by Achmad Amzeri, Kaswan Badami, Amin Zuhri, Gita Pawana, Suhartono Suhartono, Syaiful Khoiri, Ahmad Syaiful Umam, Yudi Asmoro, Siti Rohmatin, Halimatus Sa’diyah, Badriyah Badriyah

“…The vitamin A, vitamin C, and TSS content characteristics had higher phenotypic diversity coefficients than genetic diversity coefficients, while heritability values in the broad sense for the three melon genotypic characteristics ranged from 0.613 to 0.968. …”
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Genetic potential of quality in spring bread wheat cultivars bred at Kurgan agricultural research institute by A. I. Abugalieva, L. T. Maltsevа, E. A. Filippova, A. I. Morgunov, Y. I. Zelensky, J. Peña

“…The aim of the study was to characterize the genetic potential of grain quality and its phenotypic implementation in promising cultivars bred at Kurgan Agricultural Research Institute and officially released for cultivation in the region.Materials and methods. …”
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An X-Linked Hyper-IgM Patient Followed Successfully for 23 Years without Hematopoietic Stem Cell Transplantation by Necil Kutukculer, Neslihan Edeer Karaca, Guzide Aksu, Ayca Aykut, Erhan Pariltay, Ozgur Cogulu

“…His initial immunologic evaluation revealed low IgG and normal IgA and IgM levels with normal lymphocyte phenotyping and inadequate specific antibody responses. …”
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Evaluating reproduction traits in a crossbreeding program between indigenous and exotic sheep in semi-arid lands by E. Oyieng, J.M.K. Ojango, M. Gauly, R. Mrode, R. Dooso, A.M. Okeyo, C. Kalinda, S. König

“…LI had negative genetic correlations with LBWT (−0.53 ± 0.08) and LWWT (−0.28 ± 19.59) while AFL had positive genetic correlations with LBWT (0.27 ± 0.46) and LWWT (0.31 ± 0.34). The phenotypic trends for AFL and LWWT showed a negative and positive association, respectively, with the rainfall index over the years. …”
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Genetic Determinants and Biofilm Properties Useful in Estimation of UTI Pathogenicity of the <i>Escherichia coli</i> Strains Isolated from Free-Living Birds by Bartosz Rybak, Tomasz Jarzembowski, Agnieszka Daca, Beata Krawczyk, Lidia Piechowicz

“…<b>Methods</b>: In this study, we assessed the virulence potential of environmental strains isolated from wild waterfowl using genetic analysis (Clermont phylogroup classification) and phenotypic methods, including analysis of the human monocyte response to biofilm formation. …”
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Ruxolitinib and oHSV combination therapy increases CD4 T cell activity and germinal center B cell populations in murine sarcoma by Ravi Dhital, Yeaseul Kim, Doyeon Kim, Ilse Hernandez-Aguirre, Jack Hedberg, Alexia Martin, Kevin A. Cassady

“…RUX+oHSV therapy also increased cytokine-expressing CD4(+) populations, predominantly granzyme B(+) cytotoxic-like, interferon (IFN)-γ(+) T helper type 1 (Th1)-like, and interleukin (IL)-21(+) T follicular helper (Tfh)-like phenotypes, within the tumor infiltrates, suggestive of potential tertiary lymphoid structure development in the treated tumors. …”
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Epigallocatechin gallate (EGCG) modulates senescent endothelial cell-monocyte communication in age-related vascular inflammation by Sarvatit Patel, Kai Ellis, Kai Ellis, Corey A. Scipione, Jason E. Fish, Jason E. Fish, Jason E. Fish, Jason E. Fish, Kathryn L. Howe, Kathryn L. Howe, Kathryn L. Howe, Kathryn L. Howe, Kathryn L. Howe

“…EGCG reduced senescence-associated phenotypes in ECs, as evidenced by decreased senescence-associated (SA)-β-Gal activity and reversal of Etoposide-induced senescence markers. …”
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Linking obesity-associated genotype to child language development: the role of early-life neurology-related proteomics and brain myelinationResearch in context by Jian Huang, Jinyi Che, Michelle Z.L. Kee, Ai Peng Tan, Evelyn C. Law, Patricia Pelufo Silveira, Irina Pokhvisneva, Sachin Patel, Keith M. Godfrey, Lourdes Mary Daniel, Kok Hian Tan, Yap Seng Chong, Shiao-Yng Chan, Johan G. Eriksson, Dennis Wang, Jonathan Yinhao Huang

“…Interpretation: This study demonstrates the potential of examining early-life proteomics in conjunction with deep genotyping and phenotyping and provides biological insights into the shared genomic links between obesity and language development. …”
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